Cited by 229Neurotransmitter Receptor Influence on BehaviorNeuroendocrine regulation and behaviorBullying, Victimization, and Aggression

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Understanding Genetic Risk for Aggression: Clues From the Brain’s Response to Social Exclusion

Eisenberger, Naomi I., Way, Baldwin M., Taylor, Shelley E., Welch, William T., Lieberman, Matthew D.·2007·Biological Psychiatry

DOI 10.1016/j.biopsych.2006.08.007

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Abstract

Background Although research indicates a relationship between the monoamine oxidase-A (MAOA) gene and aggression, the intervening neural and psychological mechanisms are unknown. Individuals with the low expression allele (MAOA-L) of a functional polymorphism in the MAOA gene might be prone to aggression because they are socially or emotionally hyposensitive and thus care less about harming others or because they are socially or emotionally hypersensitive and thus respond to negative social experiences with defensively aggressive behavior.Methods We investigated the relationships between the MAOA polymorphism, trait aggression, trait interpersonal hypersensitivity, and neural responses to social exclusion in 32 healthy men and women.Results The MAOA-L individuals (men and women) reported higher trait aggression than individuals with the high expression allele (MAOA-H). The MAOA-L individuals reported higher trait interpersonal hypersensitivity and showed greater dorsal anterior cingulate cortex (dACC) activity (associated with rejection-related distress) to social exclusion compared with MAOA-H individuals, consistent with a social hypersensitivity hypothesis. Moreover, the MAOA-aggression relationship was mediated by greater dACC reactivity to social exclusion, suggesting that MAOA might relate to aggression through socioemotional hypersensitivity.Conclusions These data suggest that the relationship between MAOA and aggression might be due to a heightened rather than a reduced sensitivity to negative socioemotional experiences like social rejection.

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Authors: Eisenberger, N. I., Way, B. M., Taylor, S. E., Welch, W. T., & Lieberman, M. D.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Eisenberger, Naomi I.
ORCID: Eisenberger, Naomi I.
Way, Baldwin M.
Lieberman, Matthew D.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2007-05
Volume: 61
Issue: 9
Pages: 1100-1108
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2006.08.007
OpenAlex: W2148207563
Cited by: 229
References: 40
Citations by year: 2026: 2 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 2 · 2020: 10 · 2019: 11 · 2018: 3 · 2017: 7 · 2016: 21 · 2015: 19 · 2014: 27 · 2013: 16 · 2012: 17
FWCI: 5.43
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (R01MH056880, R01MH56880, R21MH066709, MH15750, T32MH019925, R21MH071521, R21MH66709, T32MH015750)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Social Sciences › Psychology › Social Psychology › Bullying, Victimization, and Aggression
Keywords: monoamine oxidase A, aggression, social exclusion, social rejection, dorsal anterior cingulate cortex, trait aggression, genetic risk
MeSH terms: Adult, Aggression, Alleles, Brain Chemistry, Cerebral Cortex, Emotions, Female, Genotype, Humans, Interpersonal Relations, Magnetic Resonance Imaging, Male, Polymorphism, Genetic, Psychological Tests, Risk, Social Environment, Clinical Trials Data Monitoring Committees

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Understanding Genetic Risk for Aggression: Clues From the Brain’s Response to Social Exclusion

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