Neural correlates of hypothalamic–pituitary–adrenal regulation of mothers with their infants
Open accessAbstract
Background Neural correlates of stress regulation via the hypothalamic-pituitary-adrenal (HPA) axis have been identified, but little is known about how these apply to real-world interpersonal stress contexts such as mother-infant interaction. We extended stress regulation research by examining maternal neural activation to infant cry related to HPA regulation with their infants.Methods Twenty-two primiparous mothers listened to the cry sounds of their own 18-month-old infant and an unfamiliar infant and a control sound during functional magnetic resonance imaging scanning. Salivary cortisol was collected at four timepoints in a separate session involving the Strange Situation stressor. Cortisol trajectories were modeled with hierarchical linear modeling, and trajectory terms were used to predict neural response to own infant cry.Results Mothers who showed less HPA reactivity-indexed by trajectory curvature rather than level-showed increased activation to the cry of their infant relative to control sound across limbic/paralimbic and prefrontal circuits. These included periaqueductal gray, right insula, and bilateral orbitofrontal cortex as well as anterior cingulate-medial prefrontal cortex. Activations overlapped to some extent with previous HPA regulation findings and converged more extensively with circuits identified in other maternal response paradigms.Conclusions Maternal stress regulation involves both circuits found across stressor types (i.e., prefrontal) and areas unique to the mother-infant relationship (i.e., limbic/paralimbic). The shape of the HPA response trajectory of mothers was more important than the level of such response in defining stress-related neural correlates. Future research should consider dimensions of the stress context and of physiological trajectories to define stress-regulatory circuits.
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Reduced reactivity to stress in the HPA axis was associated with greater activation in the midbrain and striatum, the insula and OFC, and the dorsolateral PFC and ACC.
“Reduced reactivity to stress in the HPA axis was associated with greater activation in the midbrain and striatum, areas involved in maternal motivation; the insula and OFC, areas involved in negative-emotion processing; and the dorsolateral PFC and ACC, areas involved in emotion regulation.”
From The maternal brain and its plasticity in humans (2016) · cites this paper as Laurent et al., 2011
Greater cortisol reactivity to stress is associated with reduced neural responses to own baby cries vs other baby cries among primiparous mothers (Laurent et al., 2011).
“By contrast, greater cortisol reactivity to stress has also been associated with reduced neural responses to own baby cries (vs. other baby cries) among primiparous mothers (Laurent et al., 2011).”
From Approaching the biology of human parental attachment: Brain imaging, oxytocin and coordinated assessments of mothers and fathers (2014) · cites this paper as Laurent et al., 2011
The reduced neural responses associated with cortisol reactivity were in emotion regulation regions (anterior cingulate cortex, medial PFC) and maternal motivation regions (limbic area, periaqueductal gray).
“The reduced neural responses were detected in the regions important for emotion regulation (anterior cingulate cortex and medial PFC) and maternal motivation (limbic area and periaqueductal gray).”
From Approaching the biology of human parental attachment: Brain imaging, oxytocin and coordinated assessments of mothers and fathers (2014) · cites this paper as Laurent et al., 2011
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Cites
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267 · see citing works
(1978) · Medical Entomology and Zoology · Cited by 12,570 · see citing works
Stress signalling pathways that impair prefrontal cortex structure and function
Arnsten, A. F. T. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2648 · Cited by 3,299 · see citing works
Neural mechanisms of empathy in humans: a relay from neural systems for imitation to limbic areas
Carr, L., Iacoboni, M., Dubeau, M.-C., Mazziotta, J. C., & Lenzi, G. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0935845100 · Cited by 1,978 · see citing works
Depression and cortisol responses to psychological stress: A meta-analysis
Burke, H. M., Davis, M. C., Otte, C., & Mohr, D. C. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.02.010 · Cited by 1,194 · see citing works
Kober, H., Barrett, L. F., Joseph, J., Bliss-Moreau, E., Lindquist, K., & Wager, T. D. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.03.059 · Cited by 1,144 · see citing works
Ochsner, K. N., Knierim, K., Ludlow, D. H., Hanelin, J., Ramachandran, T., Glover, G., & Mackey, S. C. (2004) · Journal of Cognitive Neuroscience · doi:10.1162/0898929042947829 · Cited by 850 · see citing works
Adult attachment predicts maternal brain and oxytocin response to infant cues.
Strathearn, L., Fonagy, P., Amico, J., & Montague, P. R. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.103 · Cited by 773 · see citing works
Mapping the functional connectivity of anterior cingulate cortex
Margulies, D. S., Kelly, C. A. M., Uddin, L. Q., Biswal, B. B., Castellanos, F. X., & Milham, M. P. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.05.019 · Cited by 751 · see citing works
The brain and the stress axis: the neural correlates of cortisol regulation in response to stress
Dedovic, K., Duchesne, A., Andrews, J., Engert, V., & Pruessner, J. C. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.074 · Cited by 699 · see citing works
From emotion resonance to empathic understanding: A social developmental neuroscience account
Decety, J., & Meyer, M. (2008) · Development and Psychopathology · doi:10.1017/s0954579408000503 · Cited by 597 · see citing works
Pruessner, J. C., Dedovic, K., Khalili-Mahani, N., Engert, V., Pruessner, M., Buss, C., Renwick, R., Dagher, A., Meaney, M. J., & Lupien, S. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.04.041 · Cited by 593 · see citing works
Swain, J. E., Lorberbaum, J. P., Kose, S., & Strathearn, L. (2007) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2007.01731.x · Cited by 499 · see citing works
Orbitofrontal cortex tracks positive mood in mothers viewing pictures of their newborn infants
Nitschke, J. B., Nelson, E. E., Rusch, B. D., Fox, A. S., Oakes, T. R., & Davidson, R. J. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.10.005 · Cited by 371 · see citing works
The Functional Neuroanatomy of Maternal Love: Mother’s Response to Infant’s Attachment Behaviors
Noriuchi, M., Kikuchi, Y., & Senoo, A. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.018 · Cited by 334 · see citing works
Neurobiology of empathy and callousness: Implications for the development of antisocial behavior
Shirtcliff, E. A., Vitacco, M. J., Graf, A., Gostisha, A. J., Merz, J., & Zahn‐Waxler, C. (2009) · Behavioral Sciences & the Law · doi:10.1002/bsl.862 · Cited by 244 · see citing works
Zeskind, P. S., & Lester, B. M. (1978) · Child Development · doi:10.2307/1128224 · Cited by 238 · see citing works
Powers, S. I., Pietromonaco, P. R., Gunlicks, M., & Sayer, A. (2006) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.90.4.613 · Cited by 237 · see citing works
The human parental brain: In vivo neuroimaging
Swain, J. E. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.10.017 · Cited by 234 · see citing works
Kondo, H., Osaka, N., & Osaka, M. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.06.014 · Cited by 227 · see citing works
A cry in the dark: depressed mothers show reduced neural activation to their own infant’s cry
Laurent, H. K., & Ablow, J. C. (2012) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsq091 · Cited by 224 · see citing works
Neural correlates of processing stressful information: An event-related fMRI study
Dedovic, K., Rexroth, M., Wolff, E., Duchesne, A., Scherling, C., Beaudry, T., Lue, S. D., Lord, C., Engert, V., & Pruessner, J. C. (2009) · Brain Research · doi:10.1016/j.brainres.2009.06.044 · Cited by 174 · see citing works
Oxytocin, cortisol, and triadic family interactions
Gordon, I., Zagoory-Sharon, O., Leckman, J. F., & Feldman, R. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.08.008 · Cited by 158 · see citing works
Martorell, G. A., & Bugental, D. B. (2006) · Journal of Family Psychology · doi:10.1037/0893-3200.20.4.641 · Cited by 128 · see citing works
Emotion regulation in emerging adult couples: temperament, attachment, and HPA response to conflict
Laurent, H., & Powers, S. (2007) · Biological Psychology · doi:10.1016/j.biopsycho.2007.06.002 · Cited by 124 · see citing works
Self-citationAttunement of maternal and child adrenocortical response to child challenge
Sethre-Hofstad, L. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00077-4 · Cited by 115 · see citing works
Psychophysiological correlates of parenting behavior in mothers of young children
Mills-Koonce, R., Propper, C. B., Gariépy, J., Barnett, M. A., Moore, G. A., Calkins, S. D., & Cox, M. J. (2009) · Developmental Psychobiology · doi:10.1002/dev.20400 · Cited by 113 · see citing works
Laurent, H. K., Ablow, J. C., & Measelle, J. R. (2011) · Development and Psychopathology · doi:10.1017/s0954579411000083 · Cited by 101 · see citing works
Sukikara, M. H., Ortiz, S. R. M., Baldo, M. V. C., Felício, L. F., & Canteras, N. S. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.01.048 · Cited by 87 · see citing works
Children’s Vocal Properties as Mobilizers of Stress-Related Physiological Responses in Adults
Lin, E. K., Bugental, D. B., Turek, V. F., Martorell, G. A., & Olster, D. H. (2002) · Personality and Social Psychology Bulletin · doi:10.1177/0146167202286006 · Cited by 17 · see citing works
Flagged first, then by citations
1 of the 31 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [26]Strathearn L Fonagy P Amico J Montague PR Adult attachment predicts maternal brain and oxytocin response to infant cues Neuropsychopharm 2009 34 2655 2666 PMC3041266 19710635
Cited by
Sorted by citations
The adaptive human parental brain: implications for children's social development
Feldman, R. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.04.004 · Cited by 419 · see citing works
The Neurobiology of Postpartum Anxiety and Depression
Pawluski, J. L., Lonstein, J. S., & Fleming, A. S. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2016.11.009 · Cited by 325 · see citing works
Swain, J. E., Kim, P., Spicer, J., Ho, S. S., Dayton, C. J., Elmadih, A., & Abel, K. M. (2014) · Brain Research · doi:10.1016/j.brainres.2014.03.007 · Cited by 290 · see citing works
The maternal brain and its plasticity in humans
Kim, P., Strathearn, L., & Swain, J. E. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.08.001 · Cited by 278 · see citing works
Barba‐Müller, E., Craddock, S., Carmona, S., & Hoekzema, E. A. (2018) · Archives of Women s Mental Health · doi:10.1007/s00737-018-0889-z · Cited by 240 · see citing works
The neural and hormonal bases of human parentalcare
Rilling, J. K. (2013) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2012.12.017 · Cited by 230 · see citing works
Lonstein, J. S., Lévy, F., & Fleming, A. S. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.06.011 · Cited by 151 · see citing works
Douglas, P. S., & Hill, P. S. (2013) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0b013e31829cafa6 · Cited by 129 · see citing works
Piallini, G., Palo, F. D., & Simonelli, A. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01625 · Cited by 106 · see citing works
Less can be more: Fine tuning the maternal brain
Pawluski, J. L., Hoekzema, E., Leuner, B., & Lonstein, J. S. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.11.045 · Cited by 91 · see citing works
Behavioral and genetic correlates of the neural response to infant crying among human fathers
Mascaro, J. S., Hackett, P. D., Gouzoules, H., Lori, A., & Rilling, J. K. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst166 · Cited by 89 · see citing works
Abraham, E., Raz, G., Zagoory‐Sharon, O., & Feldman, R. (2017) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.04.015 · Cited by 78 · see citing works
How stress can influence brain adaptations to motherhood
Kim, P. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100875 · Cited by 73 · see citing works
Numan, M. (2020) · doi:10.1093/oso/9780190848675.001.0001 · Cited by 101 · see citing works
Kim, P., Capistrano, C. G., Erhart, A., Gray-Schiff, R., & Xu, N. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.02.001 · Cited by 69 · see citing works
Explaining individual variation in paternal brain responses to infant cries
Li, T., Horta, M., Mascaro, J. S., Bijanki, K. R., Arnal, L. H., Adams, M. K., Barr, R. G., & Rilling, J. K. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.12.033 · Cited by 66 · see citing works
Vaillancourt, K., Pawlby, S. J., & Fearon, P. R. M. (2017) · Infant Mental Health Journal · doi:10.1002/imhj.21634 · Cited by 58 · see citing works
Mothering revisited: A role for cortisol?
Almanza-Sepúlveda, M. L., Fleming, A. S., & Jonas, W. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104679 · Cited by 48 · see citing works
Pechtel, P., Murray, L., Brumariu, L. E., & Lyons‐Ruth, K. (2013) · Translational Developmental Psychiatry · doi:10.3402/tdp.v1i0.19673 · Cited by 37 · see citing works
A neurobiological model for cry-fuss problems in the first three to four months of life
Douglas, P., & Hill, P. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2013.09.004 · Cited by 36 · see citing works
The orbitofrontal cortex modulates parenting stress in the maternal brain
Noriuchi, M., Kikuchi, Y., Mori, K., & Kamio, Y. (2019) · Scientific Reports · doi:10.1038/s41598-018-38402-9 · Cited by 29 · see citing works
Motivated Attention and Reward in Parenting
Ferrey, A. E., Santascoy, N., McCrory, E. J. P., Thompson‐Booth, C., Mayes, L. C., & Rutherford, H. J. V. (2016) · Parenting · doi:10.1080/15295192.2016.1184928 · Cited by 27 · see citing works
Swain, J. E., & Ho, S.-H. S. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12770 · Cited by 26 · see citing works
Nguyen, A. J., Hoyer, E. A., Rajhans, P., Strathearn, L., & Kim, S. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12794 · Cited by 27 · see citing works
Understanding the maternal brain in the context of the mental load of motherhood
Callaghan, B. L., McCormack, C. A., Kim, P., & Pawluski, J. L. (2024) · Nature Mental Health · doi:10.1038/s44220-024-00268-4 · Cited by 25 · see citing works
Epigenetic and Neural Circuitry Landscape of Psychotherapeutic Interventions
Miller, C. W. T. (2017) · Psychiatry Journal · doi:10.1155/2017/5491812 · Cited by 24 · see citing works
Child Maltreatment and Mother–Child Transmission of Stress Physiology
Hibel, L. C., Mercado, E., & Valentino, K. (2019) · Child Maltreatment · doi:10.1177/1077559519826295 · Cited by 22 · see citing works
Firk, C., Dahmen, B., Lehmann, C., Herpertz‐Dahlmann, B., & Konrad, K. (2017) · Emotion · doi:10.1037/emo0000373 · Cited by 22 · see citing works
Bortolini, T., Laport, M. C., Latgé-Tovar, S., Fischer, R. D., Zahn, R., de Oliveira‐Souza, R., & Moll, J. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105584 · Cited by 20 · see citing works
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Bonfig, J., Herpertz, S. C., & Schneider, I. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105822 · Cited by 16 · see citing works
Lan, X.-Y., Gu, Y., Li, M., Song, T.-J., Zhai, F.-J., Zhang, Y., Zhan, J., Böckers, T. M., Yue, X.-N., Wang, J., et al. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1054381 · Cited by 14 · see citing works
Pawluski, J. L. (2024) · Seminars in Perinatology · doi:10.1016/j.semperi.2024.151951 · Cited by 14 · see citing works
Badovinac, S. D., Chow, C. H. T., Lorenzo-Klas, M. G. D., Edgell, H., Flora, D. B., & Riddell, R. P. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105229 · Cited by 12 · see citing works
Schulz, A., Richter, S., de Sá, D. S. F., Vögele, C., & Schächinger, H. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.112792 · Cited by 11 · see citing works
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Kern, S., & Laurent, H. K. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.04.023 · Cited by 11 · see citing works
Neural correlates of parent–child HPA axis coregulation
Saxbe, D., Piero, L. B. D., & Margolin, G. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.07.010 · Cited by 10 · see citing works
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Kołacz, J., & Porges, S. W. (2024) · Springer eBooks · doi:10.1007/978-3-031-48627-2_11 · Cited by 8 · see citing works
Apego, cortisol y estrés, en infantes: una revisión narrativa
Nieto, E. A. R. (2014) · Revista de la Asociación Española de Neuropsiquiatría · doi:10.4321/s0211-57352014000400008 · Cited by 9 · see citing works
Doi, H., Sulpizio, S., Esposito, G., Katou, M., Nishina, E., Iriguchi, M., Honda, M., Oohashi, T., Bornstein, M. H., & Shinohara, K. (2019) · The Journal of Physiological Sciences · doi:10.1007/s12576-019-00729-x · Cited by 9 · see citing works
Erhart, A., Watamura, S. E., Olsavsky, A. K., Dufford, A. J., Tribble, R. C., YEH, T. P., & Kim, P. (2024) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2024.107207 · Cited by 5 · see citing works
Stress-Sensitive Parental Brain Systems Regulate Emotion Response and Motivate Sensitive Child Care
Swain, J. E. (2017) · Springer eBooks · doi:10.1007/978-3-319-65077-7_14 · Cited by 5 · see citing works
Challenges to the parental brain: Neuroethological and translational considerations
Lambert, K. G., & Byrnes, E. M. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.04.004 · Cited by 5 · see citing works
Parenthood, Stress, and the Brain
Carter, C. S., & Porges, E. C. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.003 · Cited by 4 · see citing works
A biopsychosocial perspective on maternal parenting in the first two years of infant life
Wu, Q. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113375 · Cited by 2 · see citing works
A Call to Integrate Measures of Environmental Context into Research on Maternal Brain Health
Cárdenas, S. I., & Callaghan, B. L. (2025) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph22060818 · Cited by 2 · see citing works
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0008 · Cited by 2 · see citing works
Hormonal Control of Maternal Behavior in Nonhuman Mammals
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0003 · Cited by 2 · see citing works
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0002 · Cited by 1 · see citing works
Chen, B., Ou, Y., Kung, C., Yeh, D.-R., Rho, S., & Wang, J.-F. (2014) · Multimedia Tools and Applications · doi:10.1007/s11042-014-2020-4 · Cited by 1 · see citing works
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0001 · Cited by 1 · see citing works
Central Neural Circuits Regulating Maternal Behavior in Nonhuman Mammals
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0005 · Cited by 1 · see citing works
Alloparental Behavior and Paternal Behavior in Nonhuman Mammals
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0007 · Cited by 1 · see citing works
(2015) · Monographs of the Society for Research in Child Development · doi:10.1111/mono.12215 · Cited by 1 · see citing works
Misner, S. J. (2013) · ProQuest Demo Repository
Noll, L. K. (2019) · Scholars' Bank (University of Oregon)
Yu, Y., Li, M., & Chen, H. (2019) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2020.00128
Evolutionary Perspectives on the Parental Brain
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0011
Anxiety Reduction and Maternal Aggression in Postpartum Nonhuman Mammals
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0006
Development of the Parental Brain in Nonhuman Mammals
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0009
Development of the Parental Brain in Humans
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0010
Brain Mechanisms Regulating Maternal Behavior in Nonhuman Mammals
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0004
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0006
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0003
Abbreviations Used for Major Brain Regions
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0007
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0004
Xerxa, Y., Lamballais, S., Muetzel, R. L., Ikram, M. A., & Tiemeier, H. W. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.2156-23.2024 · Cited by 2 · see citing works
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Tang, P., Wu, K., Pan, Y., Yang, S., Cai, Z., Liang, Y., Mai, F., Chen, P., Peng, M., 王玉玮, et al. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02458-y
- Authors
- Laurent, H. K., Stevens, A., & Ablow, J. C.
- Affiliations
- University of Wyoming (US)
- Oregon Health & Science University (US)
- University of Oregon (US)
- Corresponding author
- Laurent, Heidemarie K.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 70
- Issue
- 9
- Pages
- 826-832
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC3655534
- OpenAlex
- W1976812022
- Cited by
- 67
- References
- 31
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 6 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 18 · 2019: 10 · 2018: 2 · 2017: 7 · 2016: 1 · 2015: 6 · 2014: 3 · 2013: 6
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation (0643393)
- National Institute of Mental Health (F32MH083462-02)
- University of Oregon Brain Biology Machine Initiative
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Health Professions › Pharmacy › Infant Health and Development
- Keywords
- hypothalamic-pituitary-adrenal axis, mother-infant interaction, infant crying, salivary cortisol, periaqueductal gray, insula, orbitofrontal cortex, anterior cingulate cortex, medial prefrontal cortex, limbic system, Strange Situation, primiparous women
- MeSH terms
- Adult, Cerebral Cortex, Crying, Data Interpretation, Statistical, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Image Processing, Computer-Assisted, Infant, Magnetic Resonance Imaging, Male, Maternal Behavior, Pituitary-Adrenal System, Stress, Psychological, Prefrontal Cortex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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