Deactivation of the limbic system during acute psychosocial stress: evidence from positron emission tomography and functional magnetic resonance imaging studies
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Background Stress-induced metabolic changes can have detrimental health effects. Newly developed paradigms to investigate stress in neuroimaging environments allow the assessment of brain activation changes in association with the perception of and the metabolic response to stress.Methods We exposed human subjects to a psychosocial stressor in one positron emission tomography (n = 10) and one functional magnetic resonance imaging (fMRI; n = 40) experiment.Results We observed a profound deactivation of limbic system components including hippocampus, hypothalamus, medio-orbitofrontal cortex and anterior cingulate cortex in subjects who reacted to the stressor with a significant increase of the endocrine stress marker cortisol. Further, in the fMRI study, the degree of deactivation in the hippocampus was correlated with the release of cortisol in response to the stress task.Conclusions The observed deactivation of limbic system structures suggests elevated activation at rest and during nonstressful situations. A model is proposed where the observed reduction in limbic system activity is essential for the initiation of the stress response.
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Prefrontal regions affected by high pregnancy anxiety are involved in regulation of stress hormone secretion.
“Interestingly, a recent functional MRI study in humans found that prefrontal regions, that we found are affected by high pregnancy anxiety, are involved in the regulation of stress hormone secretion (Pruessner et al., 2008).”
From High pregnancy anxiety during mid-gestation is associated with decreased gray matter density in 6-9-year-old children. (2010) · cites this paper as Pruessner et al., 2008
Dagher et al (2009) found that a psychosocial stressor task elicited widespread limbic changes including BNST activity, and that these limbic changes predicted subsequent increased BNST activity to smoking cues in nicotine-addicted participants.
“In a study of nicotine-addicted participants, Dagher et al (2009) showed that a psychosocial stressor task elicited widespread changes in limbic (including BNST) activity-a marker of stress response (Pruessner et al, 2008) -and that changes in limbic activity were predictive of subsequent increased BNST activity to smoking cues.”
From The human BNST: functional role in anxiety and addiction (2016) · cites this paper as Pruessner et al, 2008
Changes in limbic activity have been proposed as a marker of stress response, and limbic activity size is proportional to cortisol release during stress.
“Changes in limbic activity have been proposed to be a marker of stress response, and limbic activity is proportional in size to cortisol release during stress (Pruessner et al, 2008).”
From The human BNST: functional role in anxiety and addiction (2016) · cites this paper as Pruessner et al, 2008
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Cognitive and emotional influences in anterior cingulate cortex
Bush, G., Luu, P., & Posner, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01483-2 · Cited by 6,259 · see citing works
Kirschbaum, C., Pirke, K.-M., & Hellhammer, D. H. (2008) · Neuropsychobiology · doi:10.1159/000119004 · Cited by 6,093 · see citing works
Dickerson, S. S., & Kemeny, M. E. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.3.355 · Cited by 5,881 · see citing works
Searching for a baseline: Functional imaging and the resting human brain
Gusnard, D. A., & Raichle, M. E. (2001) · Nature Reviews Neuroscience · doi:10.1038/35094500 · Cited by 3,371 · see citing works
From Psychological Stress to the Emotions: A History of Changing Outlooks
Lazarus, R. S. (1993) · Annual Review of Psychology · doi:10.1146/annurev.ps.44.020193.000245 · Cited by 2,596 · see citing works
JACOBSON, L., & SAPOLSKY, R. (1991) · Endocrine Reviews · doi:10.1210/edrv-12-2-118 · Cited by 1,739 · see citing works
Herman, J. P., Figueiredo, H., Mueller, N. K., Ulrich-Lai, Y., Ostrander, M. M., Choi, D. C., & Cullinan, W. E. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2003.07.001 · Cited by 1,586 · see citing works
Limbic system mechanisms of stress regulation: Hypothalamo-pituitary-adrenocortical axis
Herman, J. P., Ostrander, M. M., Mueller, N. K., & Figueiredo, H. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.08.006 · Cited by 1,322 · see citing works
Why stress is bad for your brain
Sapolsky, R. M. (1996) · Science · doi:10.1126/science.273.5276.749 · Cited by 1,306 · see citing works
Stress and cognition: are corticosteroids good or bad guys?
de Kloet, E. R., Oitzl, M. S., & Joëls, M. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01438-1 · Cited by 1,258 · see citing works
A General Statistical Analysis for fMRI Data
Worsley, K. J., Liao, C. H., Aston, J. A. D., Petre, V., Duncan, G. H., Morales, F., & Evans, A. C. (2002) · NeuroImage · doi:10.1006/nimg.2001.0933 · Cited by 1,170 · see citing works
Diorio, D., Viau, V, & Meaney, M. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-09-03839.1993 · Cited by 1,151 · see citing works
Self-citationAnxiety and affective style: role of prefrontal cortex and amygdala
Davidson, R. J. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01328-2 · Cited by 1,139 · see citing works
Dorsal anterior cingulate cortex: A role in reward-based decision making
Bush, G., Vogt, B. A., Holmes, J., Dale, A. M., Greve, D., Jenike, M. A., & Rosen, B. R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012470999 · Cited by 1,096 · see citing works
Brain blood flow measured with intravenous H2(15)O. II. Implementation and validation.
Raichle, M. E., Martin, W. R. W., Herscovitch, P., Mintun, M. A., & Markham, J. (1983) · PubMed · Cited by 1,015 · see citing works
Dressendörfer, R. A., Kirschbaum, C., Rohde, W., Stahl, F., & Strasburger, C. J. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90294-s · Cited by 882 · see citing works
Role of adrenal stress hormones in forming lasting memories in the brain
McGaugh, J. L., & Roozendaal, B. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00306-9 · Cited by 818 · see citing works
Dedovic, K., Renwick, R., Khalili‐Mahani, N., Engert, V., LUPIEN, S. J., & Pruessner, J. C. (2005) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0541 · Cited by 731 · see citing works
Self-citationPruessner, J. C., Champagne, F., Meaney, M. J., & Dagher, A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3422-03.2004 · Cited by 709 · see citing works
Self-citationKirschbaum, C., Prussner, J. C., Stone, A. A., Federenko, I., Gaab, J., Lintz, D., Schommer, N., & Hellhammer, D. H. (1995) · Psychosomatic Medicine · doi:10.1097/00006842-199509000-00009 · Cited by 666 · see citing works
Perfusion functional MRI reveals cerebral blood flow pattern under psychological stress
Wang, J., Rao, H., Wetmore, G. S., Furlan, P. M., Korczykowski, M., Dinges, D. F., & Detre, J. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503082102 · Cited by 513 · see citing works
Glucocorticoids, stress, and their adverse neurological effects: relevance to aging
Sapolsky, R. M. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00047-9 · Cited by 507 · see citing works
Ullsperger, M., & von Cramon, D. Y. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-10-04308.2003 · Cited by 484 · see citing works
Herman, J. P., Schafer, M., Young, E. A., Thompson, R. C., DOUGLASS, J. O., Akil, H., & Watson, S. J. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-09-03072.1989 · Cited by 467 · see citing works
Pruessner, M., Hellhammer, D. H., Pruessner, J. C., & LUPIEN, S. J. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000040950.22044.10 · Cited by 434 · see citing works
Self-citationBreaking up is Hard to Do: The Heartbreak of Dichotomizing Continuous Data
Streiner, D. L. (2002) · The Canadian Journal of Psychiatry · doi:10.1177/070674370204700307 · Cited by 434 · see citing works
Everitt, B. J., Cardinal, R. N., Parkinson, J. A., & Robbins, T. W. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07085.x · Cited by 416 · see citing works
Appetitive behavior: impact of amygdala-dependent mechanisms of emotional learning.
Everitt, B. J., Cardinal, R. N., Parkinson, J. A., & Robbins, T. W. (2003) · PubMed · Cited by 386 · see citing works
Sullivan, R. M., & Gratton, A. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-07-02834.1999 · Cited by 377 · see citing works
The modulatory effects of corticosteroids on cognition: studies in young human populations
Lupien, S. J., Wilkinson, C. W., Brière, S., Ménard, C., Ng Ying Kin, N. M. K., & Nair, N. P. V. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00061-0 · Cited by 353 · see citing works
Self-citationDe Quervain, D. J. ‐., Henke, K., Aerni, A., Treyer, V., McGaugh, J. L., Berthold, T., Nitsch, R. M., Buck, A., Roozendaal, B., & Hock, C. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02542.x · Cited by 342 · see citing works
Pruessner, J. C., Baldwin, M. W., Dedovic, K., Renwick, R., Mahani, N. K., Lord, C., Meaney, M., & Lupien, S. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.06.014 · Cited by 336 · see citing works
Self-citationCharacterizing the Response of PET and fMRI Data Using Multivariate Linear Models
Worsley, K. J., Poline, J., Friston, K. J., & Evans, A. C. (1997) · NeuroImage · doi:10.1006/nimg.1997.0294 · Cited by 258 · see citing works
Hypothalamic-pituitary-adrenocortical axis regulation
Jacobson, L. (2005) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2005.01.003 · Cited by 248 · see citing works
Cerebral blood flow during anticipation of public speaking in social phobia: a PET study
Tillfors, M., Furmark, T., Marteinsdóttir, Í., & Fredrikson, M. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01396-3 · Cited by 230 · see citing works
Wolf, O. T. (2003) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/s1521-690x(02)00101-x · Cited by 225 · see citing works
Low self-esteem, induced failure and the adrenocortical stress response
Pruessner, J. C., Hellhammer, D. H., & Kirschbaum, C. (1999) · Personality and Individual Differences · doi:10.1016/s0191-8869(98)00256-6 · Cited by 207 · see citing works
Self-citationCorticosteroid Actions in the Hippocampus
Joëls, M. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00688.x · Cited by 196 · see citing works
Karst, H., & Joëls, M. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00143.2005 · Cited by 183 · see citing works
Cortisol Reduces Hippocampal Glucose Metabolism in Normal Elderly, but Not in Alzheimer's Disease
de Leon, M. J., McRae, T., Rusinek, H., Convit, A. J., Santi, S. D., Tarshish, C. Y., Golomb, J. B., Volkow, N. D., Daisley, K., Orentreich∥, N., et al. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.10.4305 · Cited by 176 · see citing works
Hugdahl, K., Rund, B. R., Lund, A., Asbjørnsen, A. E., Egeland, J., Ersland, L., Landrø, N. I., Roness, A., Stordal, K. I., Sundet, K. S., et al. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.2.286 · Cited by 162 · see citing works
Menard, J. L., Champagne, D. L., & Meaney, M. J. P. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.08.009 · Cited by 137 · see citing works
Self-citationSoufer, R., Bremner, J. D., Arrighi, J. A., Cohen, I. S., Zaret, B. L., Burg, M. M., & Goldman‐Rakic, P. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6454 · Cited by 115 · see citing works
Anterior cingulate cortex regulation of sympathetic activity
Luu, P. (2003) · Brain · doi:10.1093/brain/awg257 · Cited by 114 · see citing works
Veenema, A. H., Koolhaas, J. M., & de Kloet, E. R. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.030 · Cited by 97 · see citing works
Is integer arithmetic fundamental to mental processing?: the mind's secret arithmetic
Snyder, A. W., & Mitchell, D. J. (1999) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1999.0676 · Cited by 72 · see citing works
Decreased central and peripheral catecholaminergic activation in obese Zucker rats
Pacák, K., McCarty, R. C., Palkovits, M., Cizza, G., Kopin, I. J., Goldstein, D. S., & Chrousos, G. P. (1995) · Endocrinology · doi:10.1210/endo.136.10.7664655 · Cited by 51 · see citing works
Differential involvement of amygdaloid CRH system(s) in the salience and valence of the stimuli
Merali, Z., Michaud, D. S., McIntosh, J. F., Kent, P., & Anisman, H. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2003.09.014 · Cited by 44 · see citing works
Kovács, K. J. (1999) · Progress in brain research · doi:10.1016/s0079-6123(08)61560-5 · Cited by 37 · see citing works
Goursaud, A.-P. S., Mendoza, S. P., & Capitanio, J. P. (2006) · Brain Research · doi:10.1016/j.brainres.2005.11.027 · Cited by 23 · see citing works
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McEwen, B. S., & Gianaros, P. J. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05331.x · Cited by 1,715 · see citing works
Biological and psychological markers of stress in humans: Focus on the Trier Social Stress Test
Allen, A. P., Kennedy, P. J., Cryan, J. F., Dinan, T. G., & Clarke, G. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.005 · Cited by 734 · see citing works
Hostinar, C. E., Sullivan, R. M., & Gunnar, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0032671 · Cited by 739 · see citing works
The brain and the stress axis: the neural correlates of cortisol regulation in response to stress
Dedovic, K., Duchesne, A., Andrews, J., Engert, V., & Pruessner, J. C. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.074 · Cited by 699 · see citing works
Self-citationCampbell, J., & Ehlert, U. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.12.010 · Cited by 683 · see citing works
Stress-related noradrenergic activity prompts large-scale neural network reconfiguration
Hermans, E. J., van Marle, H. J. F., Ossewaarde, L., Henckens, M. J. A. G., Qin, S., van Kesteren, M. T. R., Schoots, V. C., Cousijn, H., Rijpkema, M., Oostenveld, R., et al. (2011) · Science · doi:10.1126/science.1209603 · Cited by 627 · see citing works
Eisenberger, N. I., & Cole, S. W. (2012) · Nature Neuroscience · doi:10.1038/nn.3086 · Cited by 590 · see citing works
Early life stress and development: potential mechanisms for adverse outcomes
Smith, K. E., & Pollak, S. D. (2020) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-020-09337-y · Cited by 500 · see citing works
Attachment figures activate a safety signal-related neural region and reduce pain experience
Eisenberger, N. I., Master, S. L., Inagaki, T. K., Taylor, S. E., Shirinyan, D., Lieberman, M. D., & Naliboff, B. D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108239108 · Cited by 471 · see citing works
Buss, C., Davis, E. P., Muftuler, L. T., Head, K., & Sandman, C. A. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.07.010 · Cited by 435 · see citing works
Self-citationBrain mediators of cardiovascular responses to social threat
Wager, T. D., Waugh, C. E., Lindquist, M., Noll, D. C., Fredrickson, B. L., & Taylor, S. F. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.043 · Cited by 402 · see citing works
The human BNST: functional role in anxiety and addiction
Avery, S. N., Clauss, J. A., & Blackford, J. U. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.185 · Cited by 331 · see citing works
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Cabib, S., & Puglisi-Allegra, S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.04.012 · Cited by 329 · see citing works
Pruessner, J. C., Dedovic, K., Pruessner, M., Lord, C., Buss, C., Collins, L., Dagher, A., & Lupien, S. J. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.02.016 · Cited by 333 · see citing works
Self-citationStress and the adolescent brain
Tottenham, N., & Galván, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.030 · Cited by 324 · see citing works
Harshaw, C. (2015) · Psychological Bulletin · doi:10.1037/a0038101 · Cited by 302 · see citing works
Learning under stress impairs memory formation
Schwabe, L., & Wolf, O. T. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2009.09.009 · Cited by 297 · see citing works
Prenatal maternal depression alters amygdala functional connectivity in 6-month-old infants
Qiu, A., Anh, T. T., Li, Y., Chen, H., Rifkin-Graboi, A., Broekman, B. F. P., Kwek, K., Saw, S.-M., Chong, Y.-S., Gluckman, P. D., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.3 · Cited by 282 · see citing works
Self-citationIncreased stress-induced dopamine release in psychosis
Mizrahi, R., Addington, J., Rusjan, P. M., Suridjan, I., Ng, A., Boileau, I., Pruessner, J. C., Remington, G., Houle, S., & Wilson, A. A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.009 · Cited by 277 · see citing works
Self-citationWager, T. D., van Ast, V. A., Hughes, B. L., Davidson, M. L., Lindquist, M. A., & Ochsner, K. N. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.044 · Cited by 264 · see citing works
Prenatal maternal depression associates with microstructure of right amygdala in neonates at birth.
Rifkin-Graboi, A., Bai, J., Chen, H., Hameed, W. B., Sim, L. W., Tint, M. T., Leutscher-Broekman, B., Chong, Y.-S., Gluckman, P. D., Fortier, M. V., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.06.019 · Cited by 258 · see citing works
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Zschucke, E., Renneberg, B., Dimeo, F., Wüstenberg, T., & Ströhle, A. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.10.019 · Cited by 253 · see citing works
van Marle, H. J. F., Hermans, E. J., Qin, S., & Fernández, G. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.05.070 · Cited by 251 · see citing works
Sandman, C. A., Buss, C., Head, K., & Davis, E. P. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.06.025 · Cited by 219 · see citing works
Self-citationMaternal anxiety and infants’ hippocampal development: timing matters.
Qiu, A., Rifkin-Graboi, A., Chen, H., Chong, Y.-S., Kwek, K., Gluckman, P. D., Fortier, M. V., & Meaney, M. J. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.79 · Cited by 214 · see citing works
Self-citationGut memories: Towards a cognitive neurobiology of irritable bowel syndrome
Kennedy, P. J., Clarke, G., Quigley, E. M. M., Groeger, J. A., Dinan, T. G., & Cryan, J. F. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.07.001 · Cited by 193 · see citing works
Wen, D. J., Poh, J. S., Ni, S. N., Chong, Y.-S., Chen, H., Kwek, K., Shek, L. P., Gluckman, P. D., Fortier, M. V., Meaney, M. J., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.74 · Cited by 186 · see citing works
Self-citationSchiebener, J., & Brand, M. (2015) · Neuropsychology Review · doi:10.1007/s11065-015-9285-x · Cited by 168 · see citing works
Suicidal behaviour and memory: A systematic review and meta-analysis
Richard-Devantoy, S., Berlim, M. T., & Jollant, F. (2015) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2014.925584 · Cited by 153 · see citing works
Network Organization Unfolds over Time during Periods of Anxious Anticipation
McMenamin, B. W., Langeslag, S. J. E., Sirbu, M., Padmala, S., & Pessoa, L. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1579-14.2014 · Cited by 140 · see citing works
Kandola, A., & Stubbs, B. (2020) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-15-1792-1_23 · Cited by 140 · see citing works
Structural connectivity asymmetry in the neonatal brain
Ratnarajah, N., Rifkin-Graboi, A., Fortier, M. V., Chong, Y. S., Kwek, K., Saw, S.-M., Godfrey, K. M., Gluckman, P. D., Meaney, M. J., & Qiu, A. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.02.052 · Cited by 124 · see citing works
Self-citationBuchanan, T. W., Driscoll, D., Mowrer, S. M., Sollers, J. J., Thayer, J. F., Kirschbaum, C., & Tranel, D. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.09.006 · Cited by 128 · see citing works
Excessive sugar consumption may be a difficult habit to break: a view from the brain and body
Tryon, M. S., Stanhope, K. L., Epel, E. S., Mason, A. E., Brown, R., Medici, V., Havel, P. J., & Laugero, K. D. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-4353 · Cited by 128 · see citing works
Oxytocin facilitates the sensation of social stress
Eckstein, M., Scheele, D., Weber, K., Stoffel‐Wagner, B., Maier, W., & Hurlemann, R. (2014) · Human Brain Mapping · doi:10.1002/hbm.22508 · Cited by 119 · see citing works
Kennedy, P. J., Cryan, J. F., Quigley, E. M. M., Dinan, T. G., & Clarke, G. (2014) · Psychological Medicine · doi:10.1017/s003329171400052x · Cited by 120 · see citing works
Lataster, J., Collip, D., Ceccarini, J., Haas, D., Booij, L., van Os, J., Pruessner, J., Van Laere, K., & Myin-Germeys, I. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.07.030 · Cited by 109 · see citing works
Self-citationA social neuroscience perspective on stress and health.
Muscatell, K. A., & Eisenberger, N. I. (2012) · Social and Personality Psychology Compass · doi:10.1111/j.1751-9004.2012.00467.x · Cited by 101 · see citing works
Stress modulates illness-course of substance use disorders: a translational review
Lijffijt, M., Hu, K., & Swann, A. C. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00083 · Cited by 103 · see citing works
Mizrahi, R., Kenk, M., Suridjan, I., Boileau, I., George, T. P., McKenzie, K., Wilson, A. A., Houle, S., & Rusjan, P. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.347 · Cited by 101 · see citing works
Qin, S., Cousijn, H., Rijpkema, M., Luo, J., Franke, B., Hermans, E. J., & Fernández, G. (2012) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2012.00016 · Cited by 83 · see citing works
“After preparation outside the scanner, a numeric N-back WM task was administered twice: in one session it was embedded in a stressful context and the other one in a neutral control condition (see Stress induction for details).”
BackgroundMethodInfluentialAn acute psychosocial stress enhances the neural response to smoking cues
Dagher, A., Tannenbaum, B., Hayashi, T., Pruessner, J. C., & McBride, D. (2009) · Brain Research · doi:10.1016/j.brainres.2009.07.048 · Cited by 80 · see citing works
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Self-citation
- Authors
- Pruessner, J. C., Dedovic, K., Khalili-Mahani, N., Engert, V., Pruessner, M., Buss, C., Renwick, R., Dagher, A., Meaney, M. J., & Lupien, S.
- Affiliations
- Douglas Mental Health University Institute (CA)
- McGill University (CA)
- Corresponding author
- Pruessner, Jens C.
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 63
- Issue
- 2
- Pages
- 234-240
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2031360902
- Cited by
- 593
- References
- 50
- Citations by year
- 2026: 13 · 2025: 5 · 2024: 25 · 2023: 45 · 2022: 28 · 2021: 41 · 2020: 43 · 2019: 42 · 2018: 26 · 2017: 43 · 2016: 42 · 2015: 39 · 2014: 35 · 2013: 39 · 2012: 37
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- green
- nbn-resolving.de
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- KOPS (University of Konstanz) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- psychosocial stress, hippocampus, hypothalamus, anterior cingulate cortex, orbitofrontal cortex, cortisol, stress response, brain activation, stress paradigms
- MeSH terms
- Adult, Female, Humans, Hydrocortisone, Image Processing, Computer-Assisted, Limbic System, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Oxygen, Stress, Psychological, Positron-Emission Tomography
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