Cited by 102Schizophrenia research and treatmentHallucinations in medical conditionsMental Health and Psychiatry

Differential Relationships of Mismatch Negativity and Visual P1 Deficits to Premorbid Characteristics and Functional Outcome in Schizophrenia

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Friedman, Tamara, Sehatpour, Pejman, Dias, Elisa, Perrin, Megan, Javitt, Daniel C.·2012·Biological Psychiatry

Abstract

Background Mismatch negativity (MMN) and visual P1 are established event-related potential (ERP) markers of impaired auditory and visual sensory function in schizophrenia. Differential relationships of these measures with premorbid and present function and with clinical course have been noted previously in independent cohorts, but measures have not yet been compared within the same patient group.Methods Twenty-six schizophrenia patients and 19 control subjects participated in a simultaneous visual and auditory ERPs experiment. Attended visual ERPs were obtained to low- and high-spatial frequency stimuli. Simultaneously, MMN was obtained to unattended pitch, duration, and intensity deviant stimuli. Premorbid function, symptom, and global outcome measures were obtained as correlational measures.Results Patients showed substantial P1 reductions to low- but not high-spatial frequency stimuli, unrelated to visual acuity. Patients also exhibited reduced MMN to all deviant types. No significant correlations were observed between visual ERPs and premorbid or global outcome measures or illness duration. In contrast, MMN amplitude correlated significantly and independently with premorbid educational achievement, cognitive symptoms, global function, and illness duration. The MMN to duration versus other deviants was differentially reduced in individuals with poor premorbid function.Conclusions Visual and auditory ERP measures are differentially related to the pathophysiology of schizophrenia. Visual deficits correlate poorly with functional measures and illness duration and serve primarily as trait vulnerability markers. The MMN deficits are independently related to premorbid function and illness duration, suggesting independent neurodevelopmental and neurodegenerative contributions. The lack of correlation between auditory and visual ERPs in schizophrenia suggests contributions from divergent underlying neurophysiological processes.

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Authors
Friedman, T., Sehatpour, P., Dias, E., Perrin, M., & Javitt, D. C.
Affiliations
Nathan Kline Institute for Psychiatric Research (US)
Corresponding author
Javitt, Daniel C.
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2012-03
Volume
71
Issue
6
Pages
521-529
ISSN
0006-3223 (ISSN-L)
OpenAlex
W2038198089
Cited by
102
References
56
Citations by year
2026: 1 · 2025: 6 · 2024: 5 · 2023: 7 · 2022: 3 · 2021: 4 · 2020: 10 · 2019: 21 · 2018: 7 · 2017: 11 · 2016: 3 · 2015: 11 · 2014: 6 · 2013: 5 · 2012: 2
FWCI
2.81
Type
journal article
Language
en
Open access
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (MH084848, P50MH086385, R37MH49334)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords
schizophrenia, mismatch negativity, event-related potentials, functional outcome, disease duration, auditory deviance, cognitive symptoms, sensory processing deficits
MeSH terms
Acoustic Stimulation, Adult, Electroencephalography, Evoked Potentials, Auditory, Evoked Potentials, Visual, Female, Humans, Male, Photic Stimulation, Schizophrenia, Schizophrenic Psychology, Time Factors

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