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Cited by 151Schizophrenia research and treatmentVisual perception and processing mechanismsHallucinations in medical conditions

Impairments in generation of early-stage transient visual evoked potentials to magno- and parvocellular-selective stimuli in schizophrenia

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Schechter, Isaac, Butler, Pamela D., Zemon, Vance M., Revheim, Nadine, Saperstein, Alice M., Jalbrzikowski, Maria, Pasternak, Roey, Silipo, Gail +1 more·2005·Clinical Neurophysiology
DOI 10.1016/j.clinph.2005.06.013PMC PMC2901806
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Abstract

Objective Patients with schizophrenia demonstrate significant impairments of early visual processing, potentially implicating dysfunction of the magnocellular visual pathway. The present study evaluates transient visual evoked potential (tVEP) responses to stimuli biased toward the magnocellular (M) or parvocellular (P) systems in patients with schizophrenia vs. normal volunteers first to evaluate relative contributions of M and P systems to specific tVEP components in schizophrenia and, second, to evaluate integrity of early M and P processing in schizophrenia.Methods Seventy-four patients with schizophrenia and schizoaffective disorder were compared with 59 control subjects using separate stimuli to assess the tVEP response to M, P and mixed M/P conditions. Stimuli were biased toward M vs. P processing by manipulation of chromatic and achromatic contrast. C1, P1, N1 and P2 components were compared between patients and controls. All subjects showed 20/32 vision or better.Results Waveforms were obtained to low contrast (M), chromatic contrast (P) and high contrast (mixed M/P) stimuli in both patients and controls. C1 was present to P and mixed M/P stimuli. Patients showed a significant reduction in amplitude and an increase in latency of the C1 component. P1 was elicited primarily by M and mixed M/P stimuli, whereas N1 was elicited primarily by P and mixed M/P stimuli. Patients showed reductions in both P1 and N1 amplitudes across conditions. However, only reductions in P1 amplitude survived covariation for between group differences in visual acuity. Further, P1 amplitude reductions in the M condition correlated with a proxy measure of global outcome.Conclusions M- and P-selective stimuli elicit differential components of the tVEP. Patients with schizophrenia show significant reductions in response even to simple visual stimuli. Deficits, particularly within the M system, may correlate significantly with global outcome and level of community functioning.Significance Whereas deficits in high-order cognitive processing have been extensively documented in schizophrenia, integrity of early-stage sensory processing has been studied to a lesser degree. The present findings suggest that deficits in early-stage visual processing are significantly related to overall clinical outcome in schizophrenia. Further, between-group differences in visual acuity may influence VEP results, even for subjects with 'normal' vision (20/32 or better).

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Crossref · 10.1016/j.clinph.2005.06.013

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  • There is evidence that gain control deficits, seen in contrast detection and M-pathway deficits, are important in predicting outcome.

    “There is also evidence that gain control deficits, seen in contrast detection and M-pathway deficits, are important in predicting outcome (22,45), and are related to higher-level problems in perceptual organization (28,46) and to symptomatology (20,47–51).”

    From Visual perception and its impairment in schizophrenia (2008) · cites this paper as [45]

  • Neurophysiological studies have demonstrated impaired generation of the visual P1 potential to stimuli biased toward the magnocellular visual system.

    “Neurophysiological studies have demonstrated impaired generation of the visual P1 potential to stimuli biased toward the magnocellular visual system (65, 89–91)”

    From Sensory Processing Dysfunction in the Personal Experience and Neuronal Machinery of Schizophrenia (2015) · cites this paper as [89]

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Authors
Schechter, I., Butler, P. D., Zemon, V. M., Revheim, N., Saperstein, A. M., Jalbrzikowski, M., Pasternak, R., Silipo, G., & Javitt, D. C.
Affiliations
Nathan Kline Institute for Psychiatric Research (US)
Corresponding author
Butler, Pamela D.
ORCID
Venue
Clinical Neurophysiology
Publisher
Elsevier BV
Published
2005-09
Volume
116
Issue
9
Pages
2204-2215
ISSN
1388-2457 (ISSN-L)
DOI
10.1016/j.clinph.2005.06.013
PMC
PMC2901806
OpenAlex
W2048455378
Cited by
151
References
96
Citations by year
2026: 3 · 2025: 1 · 2024: 3 · 2023: 6 · 2022: 5 · 2021: 10 · 2020: 9 · 2019: 2 · 2018: 8 · 2017: 9 · 2016: 1 · 2015: 7 · 2014: 14 · 2013: 10 · 2012: 9
FWCI
5.21
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical Neurophysiology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Alliance for Research on Schizophrenia and Depression
  • National Institute of Mental Health (R01MH066374, K02-MH-01439, R01 MH66374, R01 MH49334, R01MH049334, K02MH001439)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
Keywords
schizophrenia, transient visual evoked potentials, early visual processing, C1 component, P1 component, N1 component, chromatic contrast, achromatic contrast, visual acuity, global outcomes, schizoaffective disorder
MeSH terms
Activities of Daily Living, Adult, Electroencephalography, Evoked Potentials, Visual, Female, Humans, Male, Neuropsychological Tests, Photic Stimulation, Psychiatric Status Rating Scales, Psychotic Disorders, Schizophrenia, Schizophrenic Psychology, Antipsychotic Agents, Visual Pathways, Contrast Sensitivity, Treatment Outcome, Basal Nucleus of Meynert

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