The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Habitual Alcohol Seeking: Time Course and the Contribution of Subregions of the Dorsal Striatum
Open accessAbstract
Background Addictions are defined by a loss of flexible control over behavior. The development of response habits might reflect early changes in behavioral control. The following experiments examined the flexibility of alcohol-seeking after different durations of self-administration training and tested the role of the dorsal striatum in the control of flexible and habitual alcohol self-administration.Methods Rats were trained to lever-press to earn unsweetened ethanol (EtOH) (10%). The sensitivity of the lever-press response to devaluation was assessed by prefeeding the rats either EtOH or sucrose before an extinction test after different amounts of training (1, 2, 4, and 8 weeks). We subsequently tested the role of the dorsomedial striatum (DMS) and dorsolateral striatum (DLS) in controlling alcohol seeking with reversible inactivation techniques (baclofen/muscimol: 1.0/.1 mmol/L, .3 μL/side).Results We find that operant responding for EtOH early in training is goal-directed and reduced by devaluation, but after 8 weeks of daily operant training, control has shifted to a habit-based system no longer sensitive to devaluation. Furthermore, after relatively limited training, when responding is sensitive to devaluation, inactivation of the DMS greatly attenuates the alcohol-seeking response, whereas inactivation of the DLS is without effect. In contrast, responding that is insensitive to devaluation after 8 weeks of training becomes sensitive to devaluation after inactivation of the DLS but is unaffected by inactivation of the DMS.Conclusions These experiments demonstrate that extended alcohol self-administration produces habit-like responding and that response control shifts from the DMS to the DLS across the course of training.
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“Corbit et al. (2012) similarly showed that instrumental alcohol seeking in rats became insensitive to devaluation after 4 weeks of training and also shown to be mirrored by a shift in control from the dorsomedial striatum (DMS) (a key region implicated in goal-directed control; Dolan and Dayan, 2013) to the DLS.”
From The role of habit in compulsivity (2016) · cites this paper as Corbit et al. (2012)
In the citing paper
“Lesion and microdialysis studies show that the formation of drug habits is associated with a shift away from engagement of the prelimbic cortex30 and dorsomedial striatum31 towards more dorsolateral parts of the striatum9 with prolonged drug use.32”
From Behavioral and neuroimaging evidence for overreliance on habit learning in alcohol-dependent patients (2013) · cites this paper as [31]
In the citing paper
“Inactivation of the dorsolateral striatum on the other hand reverses habitual drug seeking in rats that were exposed to prolonged alcohol31 or cocaine use.32”
From Behavioral and neuroimaging evidence for overreliance on habit learning in alcohol-dependent patients (2013) · cites this paper as [31]
In the citing paper
“Thus, evidence suggests increased involvement of the dorsolateral striatum in rodents31,34, 35, 36 and non-human primates37 in long-term drug seeking.”
From Behavioral and neuroimaging evidence for overreliance on habit learning in alcohol-dependent patients (2013) · cites this paper as [31]
In the citing paper
“This observed general shift towards S–R habits could be a consequence of chronic alcohol use by repeated exposure to the harmful effects of drugs of abuse31,56,57 or a predisposing trait or vulnerability for the development of compulsive and impulse regulation disorders, or both.53,58”
From Behavioral and neuroimaging evidence for overreliance on habit learning in alcohol-dependent patients (2013) · cites this paper as [31]
In the citing paper
“exposure to drugs of abuse can hasten the development of habit (or the loss of goal-direction) as measured by reinforcer devaluation techniques like the ones described above”
From Context, attention, and the switch between habit and goal-direction in behavior (2021) · cites this paper as Corbit et al., 2012
In the citing paper
“Both amygdala subregions and DMS participate in drug-seeking66,73,74 and active-avoidance behavior75.”
From A dual-pathway architecture for stress to disrupt agency and promote habit (2025) · cites this paper as [74]
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Citations
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,514
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
Everitt, B. J., & Robbins, T. W. (2005) · Nature Neuroscience · doi:10.1038/nn1579 · Cited by 3,785
The role of the basal ganglia in habit formation
Yin, H. H., & Knowlton, B. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1919 · Cited by 2,402
A neostriatal habit learning system in humans
Knowlton, B. J., Mangels, J. A., & Squire, L. R. (1996) · Science · doi:10.1126/science.273.5280.1399 · Cited by 1,777
Balleine, B. W., & O'Doherty, J. P. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.131 · Cited by 1,775
Haber, S. N., Fudge, J. L., & McFarland, N. R. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-06-02369.2000 · Cited by 1,610
Yin, H. H., Knowlton, B. J., & Balleine, B. W. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03095.x · Cited by 1,226
Actions and habits: The development of behavioural autonomy
Dickinson, A. (1985) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1985.0010 · Cited by 1,217
The role of the dorsomedial striatum in instrumental conditioning
Yin, H. H., Ostlund, S. B., Knowlton, B. J., & Balleine, B. W. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04218.x · Cited by 1,099
Building neural representations of habits.
Jog, M. S., Kubota, Y., Connolly, C. I., Hillegaart, V., & Graybiel, A. M. (1999) · Science · doi:10.1126/science.286.5445.1745 · Cited by 834
A specific role for posterior dorsolateral striatum in human habit learning
Tricomi, E., Balleine, B. W., & O’Doherty, J. P. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06796.x · Cited by 769
Drug Seeking Becomes Compulsive After Prolonged Cocaine Self-Administration
Vanderschuren, L. J. M. J., & Everitt, B. J. (2004) · Science · doi:10.1126/science.1098975 · Cited by 733
Belin, D., & Everitt, B. J. (2008) · Neuron · doi:10.1016/j.neuron.2007.12.019 · Cited by 697
Instrumental Responding following Reinforcer Devaluation
Adams, C. D., & Dickinson, A. (1981) · The Quarterly Journal of Experimental Psychology Section B · doi:10.1080/14640748108400816 · Cited by 687
Variations in the Sensitivity of Instrumental Responding to Reinforcer Devaluation
Adams, C. D. (1982) · The Quarterly Journal of Experimental Psychology Section B · doi:10.1080/14640748208400878 · Cited by 635
Activity of striatal neurons reflects dynamic encoding and recoding of procedural memories
Barnes, T. D., Kubota, Y., Hu, D., Jin, D. Z., & Graybiel, A. M. (2005) · Nature · doi:10.1038/nature04053 · Cited by 595
Belin, D., Jonkman, S., Dickinson, A., Robbins, T. W., & Everitt, B. J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.09.027 · Cited by 520
It could be habit forming: drugs of abuse and striatal synaptic plasticity
Gerdeman, G. L., Partridge, J. G., Lupica, C. R., & Lovinger, D. M. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00065-1 · Cited by 480
Yin, H. H., Knowlton, B. J., & Balleine, B. W. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04219.x · Cited by 447
Amphetamine Exposure Enhances Habit Formation
Nelson, A., & Killcross, S. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4305-05.2006 · Cited by 445
A cognitive processing model of alcohol craving and compulsive alcohol use
Tiffany, S. T., & Conklin, C. A. (2000) · Addiction · doi:10.1046/j.1360-0443.95.8s2.3.x · Cited by 445
Lesion to the nigrostriatal dopamine system disrupts stimulus-response habit formation
Faure, A., Haberland, U., Condé, F., & Massioui, N. E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3894-04.2005 · Cited by 402
Prelude to Passion: Limbic Activation by “Unseen” Drug and Sexual Cues
Childress, A. R., Ehrman, R. N., Wang, Z., Li, Y., Sciortino, N., Hakun, J. G., Jens, W., Suh, J. J., Listerud, J., Marquez, K., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001506 · Cited by 395
The integrative function of the basal ganglia in instrumental conditioning
Balleine, B. W., Liljeholm, M., & Ostlund, S. B. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.10.034 · Cited by 356
The effect of the instrumental training contingency on susceptibility to reinforcer devaluation
Dickinson, A., Nicholas, D. J., & Adams, C. D. (1983) · The Quarterly Journal of Experimental Psychology Section B · doi:10.1080/14640748308400912 · Cited by 338
Shift from goal-directed to habitual cocaine seeking after prolonged experience in rats
Zapata, A., Minney, V. L., & Shippenberg, T. S. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4072-10.2010 · Cited by 296
Alcohol seeking by rats: action or habit?
Dickinson, A., Wood, N., & Smith, J. W. (2002) · The Quarterly Journal of Experimental Psychology Section B · doi:10.1080/0272499024400016 · Cited by 268
A cognitive processing model of alcohol craving and compulsive alcohol use
Tiffany, S. T., & Conklin, C. A. (2000) · Addiction · doi:10.1080/09652140050111717 · Cited by 261
RACK1 and Brain-Derived Neurotrophic Factor: A Homeostatic Pathway That Regulates Alcohol Addiction
McGough, N. N. H., He, D., Logrip, M. L., Jeanblanc, J., Phamluong, K., Luong, K., Kharazia, V., Janak, P. H., & Dorit Ron, A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3714-04.2004 · Cited by 244
Self-citationSeparate neural substrates for skill learning and performance in the ventral and dorsal striatum
Atallah, H. E., Lopez-Paniagua, D., Rudy, J. W., & O'Reilly, R. C. (2007) · Nature Neuroscience · doi:10.1038/nn1817 · Cited by 241
Contributions of Striatal Subregions to Place and Response Learning
Yin, H. H., & Knowlton, B. J. (2004) · Learning & Memory · doi:10.1101/lm.81004 · Cited by 238
Endogenous BDNF in the Dorsolateral Striatum Gates Alcohol Drinking
Jeanblanc, J., He, D., Carnicella, S., Kharazia, V., Janak, P. H., & Dorit Ron, A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2243-09.2009 · Cited by 186
Self-citationHopf, F. W., Chang, S., Sparta, D. R., Bowers, M. S., & Bonci, A. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01241.x · Cited by 183
Wang, J., Carnicella, S., Phamluong, K., Jeanblanc, J., Ronesi, J. A., Chaudhri, N., Janak, P. H., Lovinger, D. M., & Dorit Ron, A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4749-06.2007 · Cited by 183
Self-citationWang, J., Lanfranco, M. F., Gibb, S. L., Yowell, Q. V., Carnicella, S., & Dorit Ron, A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2268-10.2010 · Cited by 181
Oral cocaine seeking by rats: Action or habit?
Miles, F. J., Everitt, B. J., & Dickinson, A. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.5.927 · Cited by 175
Corbit, L. H., & Janak, P. H. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07153.x · Cited by 159
Self-citationAugmented reinforcer value and accelerated habit formation after repeated amphetamine treatment
Nordquist, R. E., Voorn, P., Malsen, J. G. D. M., Joosten, R. N. J. M. A., Pennartz, C. M. A., & Vanderschuren, L. J. M. J. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2006.12.005 · Cited by 144
Behavioral and neural mechanisms of compulsive drug seeking
Vanderschuren, L. J. M. J., & Everitt, B. J. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.09.037 · Cited by 138
The Dopamine D3Receptor Is Part of a Homeostatic Pathway Regulating Ethanol Consumption
Jeanblanc, J., He, D., McGough, N. N. H., Logrip, M. L., Phamluong, K., Janak, P. H., & Dorit Ron, A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3786-05.2006 · Cited by 108
Self-citationEthanol reverses the direction of long‐term synaptic plasticity in the dorsomedial striatum
Yin, H. H., Park, B. S., Adermark, L., & Lovinger, D. M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05606.x · Cited by 106
Featherstone, R. E., & McDonald, R. J. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.10.038 · Cited by 103
Inflexible and Indifferent Alcohol Drinking in Male Mice
Lesscher, H. M. B., van Kerkhof, L. W. M., & Vanderschuren, L. J. M. J. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01199.x · Cited by 95
An ethopharmacological approach to the development of drug addiction
Wolffgramm, J. (1991) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80142-3 · Cited by 92
Glycine Transporter-1 Blockade Leads to Persistently Reduced Relapse-like Alcohol Drinking in Rats
Vengeliene, V., Leonardi‐Essmann, F., Sommer, W. H., Marston, H. M., & Spanagel, R. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.05.029 · Cited by 76
Chen, J., Nam, H. W., Lee, M. R., Hinton, D. J., Choi, S. H., Kim, T. H., Kawamura, T., Janak, P. H., & Choi, D. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.01.011 · Cited by 57
Self-citationDevaluation of ethanol reinforcement
Samson, H. H., Cunningham, C. L., Czachowski, C. L., Chappell, A. M., Legg, B. H., & Shannon, E. E. (2004) · Alcohol · doi:10.1016/j.alcohol.2004.02.002 · Cited by 54
Alterations of Rat Corticostriatal Synaptic Plasticity After Chronic Ethanol Exposure and Withdrawal
Xia, J. X. R., Li, J., Zhou, R., Zhang, X., Ge, Y. B., & Yuan, X. R. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00095.x · Cited by 50
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Everitt, B. J., & Robbins, T. W. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.02.010 · Cited by 675
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Lüscher, C., Robbins, T. W., & Everitt, B. J. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-0289-z · Cited by 512
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Self-citationStress and multiple memory systems: from ‘thinking’ to ‘doing’
Schwabe, L., & Wolf, O. T. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2012.12.001 · Cited by 355
Metadata
- Authors
- Corbit, L. H., Nie, H., & Janak, P. H.
- Affiliations
- The University of Sydney (AU)
- University of California, San Francisco (US)
- Corresponding author
- Corbit, Laura H.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 72
- Issue
- 5
- Pages
- 389-395
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC3674580
- OpenAlex
- W2053170041
- Cited by
- 486
- References
- 48
- Citations by year
- 2026: 12 · 2025: 19 · 2024: 36 · 2023: 35 · 2022: 30 · 2021: 34 · 2020: 88 · 2019: 49 · 2018: 29 · 2017: 44 · 2016: 29 · 2015: 29 · 2014: 25 · 2013: 18 · 2012: 9
- FWCI
- 10.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA018025)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- dorsal striatum, dorsomedial striatum, dorsolateral striatum, currency devaluation, goal-directed behavior, habit formation, alcohol self-administration, response flexibility, baclofen, muscimol, reversible inactivation
- MeSH terms
- Ethanol, Analysis of Variance, Animals, Conditioning, Operant, Corpus Striatum, Extinction, Psychological, Habits, Learning, Male, Self Administration, Behavior, Addictive, Rats, Long-Evans, Models, Animal, Rats
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