Cited by 241Memory and Neural MechanismsNeurotransmitter Receptor Influence on BehaviorMotor Control and Adaptation

Separate neural substrates for skill learning and performance in the ventral and dorsal striatum

Atallah, Hisham E, Lopez-Paniagua, Dan, Rudy, Jerry W, O'Reilly, Randall C·2007·Nature Neuroscience

Abstract

It is widely accepted that the striatum of the basal ganglia is a primary substrate for the learning and performance of skills. We provide evidence that two regions of the rat striatum, ventral and dorsal, play distinct roles in instrumental conditioning (skill learning), with the ventral striatum being critical for learning and the dorsal striatum being important for performance but, notably, not for learning. This implies an actor (dorsal) versus director (ventral) division of labor, which is a new variant of the widely discussed actor-critic architecture. Our results also imply that the successful performance of a skill can ultimately result in its establishment as a habit outside the basal ganglia.

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Crossref · 10.1038/nn1817

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Authors
Atallah, H. E., Lopez-Paniagua, D., Rudy, J. W., & O'Reilly, R. C.
Affiliations
University of Colorado Boulder (US)
Corresponding author
Atallah, Hisham E
Venue
Nature Neuroscience
Published
2006-12-24
Volume
10
Issue
1
Pages
126-131
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W2095819174
Cited by
241
References
54
Citations by year
2026: 2 · 2025: 5 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 5 · 2020: 7 · 2019: 9 · 2018: 9 · 2017: 10 · 2016: 18 · 2015: 11 · 2014: 21 · 2013: 18 · 2012: 22
FWCI
7.45
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (R01MH069597, MH 069597-01)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
Keywords
ventral striatum, dorsal striatum, basal ganglia, skill acquisition, skill performance, operant conditioning, actor-critic architecture, habit formation
MeSH terms
Analysis of Variance, Animals, Behavior, Animal, Conditioning, Classical, Conditioning, Operant, Corpus Striatum, Male, Muscimol, Psychomotor Performance, Reaction Time, 2-Amino-5-phosphonovalerate, Excitatory Amino Acid Antagonists, GABA Agonists, Rats, Long-Evans, Rats

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