Cited by 261Neurogenesis and neuroplasticity mechanismsStress Responses and CortisolMemory and Neural Mechanisms

The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.

Stress and Loss of Adult Neurogenesis Differentially Reduce Hippocampal Volume

Open access

Schoenfeld, Timothy J., McCausland, Hayley C., Morris, H. Douglas, Padmanaban, Varun, Cameron, Heather A.·2017·Biological Psychiatry

DOI 10.1016/j.biopsych.2017.05.013PMC PMC5683934

Open this paper in CoChat — free account

Abstract

Background Hippocampal volume loss is a hallmark of clinical depression. Chronic stress produces volume loss in the hippocampus in humans and atrophy of CA3 pyramidal cells and suppression of adult neurogenesis in rodents. Methods To investigate the relationship between decreased adult neurogenesis and stress-induced changes on hippocampal structure and volume, we compared the effects of chronic unpredictable restraint stress and inhibition of neurogenesis in a rat pharmacogenetic model. Results Chronic unpredictable restraint stress over 4 weeks decreased total hippocampal volume, reflecting loss of volume in all hippocampal subfields and in both dorsal and ventral hippocampus. In contrast, complete inhibition of adult neurogenesis for 4 weeks led to volume reduction only in the dentate gyrus. With prolonged inhibition of neurogenesis, for 8 or 16 weeks, volume loss spread to the CA3 region, but not CA1. Combining stress and inhibition of adult neurogenesis did not have additive effects on the magnitude of volume loss but did produce a volume reduction throughout the hippocampus. One month of chronic unpredictable restraint stress and inhibition of adult neurogenesis both led to atrophy of pyramidal cell apical dendrites in dorsal CA3, and neuronal reorganization in ventral CA3. Stress significantly affected granule cell dendrites as well. Discussion The findings suggest that adult neurogenesis is required to maintain hippocampal volume but is not responsible for stress-induced volume loss.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.biopsych.2017.05.013

Cites

95 of 95 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Sleep Drives Metabolite Clearance from the Adult Brain
Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321
Animal models of neuropsychiatric disorders
Nestler, E. J., & Hyman, S. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2647 · Cited by 2,023
Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant
Willner, P., Towell, A., Sampson, D., Sophokleous, S., & Muscat, R. (1987) · Psychopharmacology · doi:10.1007/bf00187257 · Cited by 1,993
Hippocampal atrophy in recurrent major depression
Sheline, Y. I., Wang, P. W., Gado, M. H., Csernansky, J. G., & Vannier, M. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.3908 · Cited by 1,932
Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation
Willner, P. (1997) · Psychopharmacology · doi:10.1007/s002130050456 · Cited by 1,832
Hippocampal Volume Reduction in Major Depression
Bremner, J. D., Narayan, M., Anderson, E. R., Staib, L. H., Miller, H. L., & Charney, D. S. (2000) · American Journal of Psychiatry · doi:10.1176/ajp.157.1.115 · Cited by 1,670
Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons
Vyas, A., Mitra, R., Shankaranarayana Rao, B. S., & Chattarji, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06810.2002 · Cited by 1,662
MRI-based measurement of hippocampal volume in patients with combat- related posttraumatic stress disorder
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.7.973 · Cited by 1,610
Adult hippocampal neurogenesis buffers stress responses and depressive behaviour
Snyder, J. S., Soumier, A., Brewer, M., Pickel, J., & Cameron, H. A. (2011) · Nature · doi:10.1038/nature10287 · Cited by 1,473
Self-citation
Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus
Schmidt-Hieber, C., Jonas, P., & Bischofberger, J. (2004) · Nature · doi:10.1038/nature02553 · Cited by 1,292
Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report
Bremner, J. D., Randall, P., Vermetten, E., Staib, L., Bronen, R. A., Mazure, C., Capelli, S., McCarthy, G., Innis, R. B., & Charney, D. S. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00162-x · Cited by 1,283
Untreated Depression and Hippocampal Volume Loss
Sheline, Y. I., Gado, M. H., & Kraemer, H. C. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.8.1516 · Cited by 1,180
Exposure to excess glucocorticoids alters dendritic morphology of adult hippocampal pyramidal neurons
Woolley, C. S., Gould, E., & McEwen, B. S. (1990) · Brain Research · doi:10.1016/0006-8993(90)90778-a · Cited by 1,020
Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus
Saxe, M. D., Battaglia, F., Wang, J.-W., Malleret, G., David, D. J., Monckton, J. E., Garcia, A. D. R., Sofroniew, M. V., Kandel, E. R., Santarelli, L., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607207103 · Cited by 1,020
Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus
Cameron, H. A., & Gould, E. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90224-0 · Cited by 999
Self-citation
Chronic Psychosocial Stress Causes Apical Dendritic Atrophy of Hippocampal CA3 Pyramidal Neurons in Subordinate Tree Shrews
Magariños, A. M., McEwen, B. S., Flügge, G., & Fuchs, E. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03534.1996 · Cited by 864
Reorganization of the morphology of hippocampal neurites and synapses after stress-induced damage correlates with behavioral improvement
Sousa, N., Lukoyanov, N. V., Madeira, M. D., Almeida, O. F. X., & Paula-Barbosa, M. M. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00050-6 · Cited by 758
Stress duration modulates the spatiotemporal patterns of spine formation in the basolateral amygdala
Mitra, R., Jadhav, S., McEwen, B. S., Vyas, A., & Chattarji, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504011102 · Cited by 663
Repeated restraint stress suppresses neurogenesis and induces biphasic PSA‐NCAM expression in the adult rat dentate gyrus
Pham, K., Nacher, J., Hof, P. R., & McEwen, B. S. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02513.x · Cited by 657
Effects of Adult Neurogenesis on Synaptic Plasticity in the Rat Dentate Gyrus
Snyder, J. S., Kee, N., & Wojtowicz, J. M. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.6.2423 · Cited by 633
Astrocyte Pathology in Major Depressive Disorder: Insights from Human Postmortem Brain Tissue
Rajkowska, G., & Stockmeier, C. (2013) · Current Drug Targets · doi:10.2174/13894501113149990156 · Cited by 603
Chronic stress promotes palatable feeding, which reduces signs of stress: Feedforward and feedback effects of chronic stress
Pecoraro, N., Reyes, F., Gomez, F., Bhargava, A., & Dallman, M. F. (2004) · Endocrinology · doi:10.1210/en.2004-0305 · Cited by 574
An animal model of anhedonia: attenuation of sucrose consumption and place preference conditioning by chronic unpredictable mild stress
Papp, M., Willner, P., & Muscat, R. (1991) · Psychopharmacology · doi:10.1007/bf02244188 · Cited by 542
Sex differences in dendritic atrophy of CA3 pyramidal neurons in response to chronic restraint stress
Galea, L. A. M., McEwen, B. S., Tanapat, P., Deak, T., Spencer, R. L., & Dhabhar, F. S. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00233-9 · Cited by 540
Antidepressants recruit new neurons to improve stress response regulation
Surget, A., Tanti, A., Leonardo, E. D., Laugeray, A., Rainer, Q., Touma, C., Palme, R., Griebel, G., Ibarguen-Vargas, Y., Hen, R., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.48 · Cited by 471
Decrease in cortisol reverses human hippocampal atrophy following treatment of Cushing’s disease
Starkman, M. N., Giordani, B., Gebarski, S. S., Berent, S., Schork, M. A., & Schteingart, D. E. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00203-6 · Cited by 455
Stress, stress hormones, and adult neurogenesis
Schoenfeld, T. J., & Gould, E. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.01.008 · Cited by 449
Self-citation
Astroglial Plasticity in the Hippocampus is Affected by Chronic Psychosocial Stress and Concomitant Fluoxetine Treatment
Czéh, B., Simon, M., Schmelting, B., Hiemke, C., & Fuchs, E. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300982 · Cited by 434
Strain differences in sucrose preference and in the consequences of unpredictable chronic mild stress
Pothion, S., Bizot, J., Trovero, F., & Belzung, C. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.04.008 · Cited by 429
What causes the hippocampal volume decrease in depression?: Are neurogenesis, glial changes and apoptosis implicated?
Czéh, B., & Lucassen, P. J. (2007) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-007-0728-0 · Cited by 419
Chronic Social Stress Inhibits Cell Proliferation in the Adult Medial Prefrontal Cortex: Hemispheric Asymmetry and Reversal by Fluoxetine Treatment
Czéh, B., Keuker, J. I. H., Ryguła, R., Abumaria, N., Hiemke, C., Domenici, E., & Fuchs, E. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301275 · Cited by 409
Exposure to fox odor inhibits cell proliferation in the hippocampus of adult rats via an adrenal hormone‐dependent mechanism
Tanapat, P., Hastings, N. B., Rydel, T. A., Galea, L. A. M., & Gould, E. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1297 · Cited by 385
Quantitative MRI of the hippocampus and amygdala in severe depression
Mervaala, E., Föhr, J., Könönen, M., Valkonen‐Korhonen, M., Vainio, P. A., Partanen, K. P. L., Partanen, J. V., Tiihonen, J., Viinamäki, H. T., Karjalainen, A.-M., et al. (2000) · Psychological Medicine · doi:10.1017/s0033291799001567 · Cited by 382
Hippocampal volume in geriatric depression
Steffens, D. C., Byrum, C. E., McQuoid, D. R., Greenberg, D. L., Payne, M. E., Blitchington, T. F., MacFall, J. R., & Krishnan, K. R. R. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00829-5 · Cited by 375
Charting of Type II glucocorticoid receptor-like immunoreactivity in the rat central nervous system
Ahima, R. S., & Harlan, R. E. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90244-x · Cited by 360
Phenytoin prevents stress‐ and corticosterone‐induced atrophy of CA3 pyramidal neurons
Watanabe, Y., Gould, E., Cameron, H. A., Daniels, D. C., & McEwen, B. S. (1992) · Hippocampus · doi:10.1002/hipo.450020410 · Cited by 350
Self-citation
Tianeptine attenuates stress-induced morphological changes in the hippocampus
Watanabe, Y., Gould, E., Daniels, D. C., Cameron, H. A., & McEwen, B. S. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90830-w · Cited by 338
Self-citation
Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice
Murray, F., Smith, D., & Hutson, P. H. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.01.014 · Cited by 334
Illness progression, recent stress, and morphometry of hippocampal subfields and medial prefrontal cortex in major depression
Treadway, M. T., Waskom, M. L., Dillon, D. G., Holmes, A. J., Park, M. T. M., Chakravarty, M. M., Dutra, S. J., Polli, F. E., Iosifescu, D. V., Fava, M., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.06.018 · Cited by 331
Adult Neurogenesis: Beyond Learning and Memory
Cameron, H. A., & Glover, L. R. (2014) · Annual Review of Psychology · doi:10.1146/annurev-psych-010814-015006 · Cited by 322
Self-citation
Reliable Activation of Immature Neurons in the Adult Hippocampus
Mongiat, L. A., Esposito, M. S., Lombardi, G., & Schinder, A. F. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005320 · Cited by 292
Reduced hippocampal volume in unmedicated, remitted patients with major depression versus control subjects
Neumeister, A., Wood, S. E., Bonne, O. B., Nugent, A. C., Luckenbaugh, D. A., Young, T. A., Bain, E., Charney, D. S., & Drevets, W. C. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.016 · Cited by 285
Density of GFAP-immunoreactive astrocytes is decreased in left hippocampi in major depressive disorder
Cobb, J. A., O’Neill, K., Milner, J., Mahajan, G. J., Lawrence, T. J., May, W. L., Miguel-Hidalgo, J., Rajkowska, G., & Stockmeier, C. A. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.12.044 · Cited by 254
What Is the Functional Significance of Chronic Stress-Induced CA3 Dendritic Retraction Within the Hippocampus?
Conrad, C. D. (2006) · Behavioral and Cognitive Neuroscience Reviews · doi:10.1177/1534582306289043 · Cited by 221
Gray matter reduction associated with psychopathology and cognitive dysfunction in unipolar depression: A voxel-based morphometry study
Vasić, N., Walter, H., Höse, A., & Wolf, R. C. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.11.011 · Cited by 215
Hippocampal structural and functional changes associated with electroconvulsive therapy response
Abbott, C., Jones, T., Lemke, N. T., Gallegos, P., McClintock, S. M., Mayer, A. R., Bustillo, J., & Calhoun, V. D. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.124 · Cited by 205
Adult neurogenesis: a substrate for experience-dependent change
Opendak, M., & Gould, E. (2015) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.01.001 · Cited by 200
Stress suppresses and learning induces plasticity in CA3 of rat hippocampus: A three-dimensional ultrastructural study of thorny excrescences and their postsynaptic densities
Stewart, M. G., Davies, H. A., Sandi, C., Kraev, I. V., Rogachevsky, V. V., Peddie, C. J., Rodriguez, J. J., Cordero, M. I., Donohue, H. S., Gabbott, P. L. A., et al. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.10.031 · Cited by 197
Vulnerability to Depression: From Brain Neuroplasticity to Identification of Biomarkers
Blugeot, A., Rivat, C., Bouvier, E., Molet, J., Mouchard, A., Zeau, B., Bernard, C., Benoliel, J. J., & Becker, C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1309-11.2011 · Cited by 196
Adult Neurogenesis and Mental Illness
Schoenfeld, T. J., & Cameron, H. A. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.230 · Cited by 192
Self-citation
Chronic stress selectively reduces hippocampal volume in rats: a longitudinal magnetic resonance imaging study
Lee, T., Jarome, T., Li, S.-J., Kim, J. J., & Helmstetter, F. J. (2009) · NeuroReport · doi:10.1097/wnr.0b013e328332bb09 · Cited by 173
Hippocampal Volume in Adult Burn Patients With and Without Posttraumatic Stress Disorder
Winter, H., & Irle, E. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.12.2194 · Cited by 172
Morphological changes in the hippocampal CA3 region induced by non-invasive glucocorticoid administration: a paradox
Magariños, A. M., Orchinik, M., & McEwen, B. S. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00882-8 · Cited by 163
A description of the amygdalo-hippocampal interconnections in the macaque monkey
Aggleton, J. P. (1986) · Experimental Brain Research · doi:10.1007/bf00340489 · Cited by 155
Chronic stress reduces the number of GABAergic interneurons in the adult rat hippocampus, dorsal-ventral and region-specific differences
Czéh, B., Varga, Z., Henningsen, K., Kovács, G. L., Miseta, A., & Wiborg, O. (2014) · Hippocampus · doi:10.1002/hipo.22382 · Cited by 145
Effect of Restraint Stress on Feeding Behavior of Rats
Ely, D. R., Dapper, V. D., Marasca, J. A., Correa, J. B. B., Gamaro, G. D., Xavier, M., Michalowski, M. B., Catelli, D. H., Rosat, R. M., & Ferreira, M. B. C. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00450-7 · Cited by 143
Chronic stress-induced hippocampal dendritic retraction requires CA3 NMDA receptors
Christian, K. M., Miracle, A. D., Wellman, C. L., & Nakazawa, K. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2010.11.033 · Cited by 138
Synapse loss from chronically elevated glucocorticoids: Relationship to neuropil volume and cell number in hippocampal area CA3
Tata, D. Α., Marciano, V. A., & Anderson, B. J. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21071 · Cited by 135
Effects of stressful life events on human brain structure: A longitudinal voxel-based morphometry study
Papagni, S. A., Benetti, S., Arulanantham, S., McCrory, E., McGuire, P., & Mechelli, A. (2011) · Stress · doi:10.3109/10253890.2010.522279 · Cited by 126
Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress
Maras, P. M., Molet, J., Chen, Y., Rice, C., Ji, S. G., Solodkin, A., & Baram, T. Z. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.12 · Cited by 118
Corticosterone-Induced Inhibition of Gliogenesis in Rat Hippocampus is Counteracted by Electroconvulsive Seizures
Wennström, M., Hellsten, J., Ekstrand, J., Lindgren, H. S., & Tingström, A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.08.032 · Cited by 112
Diurnal Variation in the Effect of Chronic Mild Stress on Sucrose Intake and Preference
D’Aquila, P. S., Newton, J., & Willner, P. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00042-5 · Cited by 107
Chronic stress and hippocampal dendritic complexity: Methodological and functional considerations
Conrad, C. D., Ortiz, J. B., & Judd, J. M. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.11.017 · Cited by 101
Rank Order Coding: a Retinal Information Decoding Strategy Revealed by Large-Scale Multielectrode Array Retinal Recordings
Portelli, G., Barrett, J. M., Hilgen, G., Masquelier, T., Maccione, A., Marco, S. D., Berdondini, L., Kornprobst, P., & Sernagor, E. (2016) · eNeuro · doi:10.1523/eneuro.0134-15.2016 · Cited by 97
Hippocampal volume in first episode and recurrent depression
Kronmüller, K., Schröder, J., Köhler, S., Götz, B., Victor, D., Unger, J., Giesel, F., Magnotta, V. A., Mundt, C., Essig, M., et al. (2009) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2008.08.001 · Cited by 94
Environmental enrichment protects against the effects of chronic stress on cognitive and morphological measures of hippocampal integrity
Hutchinson, K. M., McLaughlin, K. J., Wright, R. L., Ortiz, J. B., Anouti, D. P., Mika, A., Diamond, D. M., & Conrad, C. D. (2012) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.01.003 · Cited by 93
Experience-Dependent Regulation of Dentate Gyrus Excitability by Adult-Born Granule Cells
Park, E., Burghardt, N. S., Dvořák, D., Hen, R., & Fenton, A. A. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0885-15.2015 · Cited by 80
Differential impact of chronic stress along the hippocampal dorsal–ventral axis
Pinto, V., Costa, J. C., Morgado, P. F., Mota, C., Miranda, A. M., Bravo, F. V., Oliveira, T. G., Cerqueira, J., & Sousa, N. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0713-0 · Cited by 77
Adult neurogenesis: Optimizing hippocampal function to suit the environment
Glasper, E. R., Schoenfeld, T. J., & Gould, E. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.05.013 · Cited by 73
Self-citation
Hippocampal neuron and glial cell numbers in Parkinson's disease—A stereological study
Joelving, F. C., Billeskov, R., Christensen, J. R., West, M. J., & Pakkenberg, B. (2006) · Hippocampus · doi:10.1002/hipo.20212 · Cited by 72
Repeated restraint stress exerts different impact on structure of neurons in the lateral and basal nuclei of the amygdala
Padival, M., Blume, S. R., & Rosenkranz, J. A. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.061 · Cited by 70
A reduced number of hippocampal granule cells does not associate with an anhedonia-like phenotype in a rat chronic mild stress model of depression
Jayatissa, M. N., Henningsen, K., Nikolajsen, G., West, M. J., & Wiborg, O. (2010) · Stress · doi:10.3109/10253890902951786 · Cited by 69
Learning and Memory Alterations Are Associated with Hippocampal N-acetylaspartate in a Rat Model of Depression as Measured by 1H-MRS
Xi, G., Hui, J., Zhang, Z., Liu, S., Zhang, X., Teng, G., Chan, K. C., Wu, E. X., Nie, B., Shan, B., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028686 · Cited by 69
Postpartum Corticosterone Administration Reduces Dendritic Complexity and Increases the Density of Mushroom Spines of Hippocampal CA 3 Arbours in Dams
Workman, J. L., Brummelte, S., & Galea, L. A. M. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02380.x · Cited by 68
New Hippocampal Neurons Mature Rapidly in Response to Ketamine But Are Not Required for Its Acute Antidepressant Effects on Neophagia in Rats
Soumier, A., Carter, R. M., Schoenfeld, T. J., & Cameron, H. A. (2016) · eNeuro · doi:10.1523/eneuro.0116-15.2016 · Cited by 67
Self-citation
Early hippocampal volume loss as a marker of eventual memory deficits caused by repeated stress
Rahman, M. M., Callaghan, C. K., Kerskens, C., Chattarji, S., & O’Mara, S. M. (2016) · Scientific Reports · doi:10.1038/srep29127 · Cited by 66
Hippocampal subfield analysis in medication-naïve female patients with major depressive disorder
Han, K.-M., Won, E., Sim, Y., & Tae, W.-S. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.01.019 · Cited by 63
A Transgenic Rat for Specifically Inhibiting Adult Neurogenesis
Snyder, J. S., Grigereit, L., Russo, A., Seib, D. R., Brewer, M., Pickel, J. M., & Cameron, H. A. (2016) · eNeuro · doi:10.1523/eneuro.0064-16.2016 · Cited by 54
Self-citation
Quantitative changes in hippocampal microvasculature of chronically stressed rats: No effect of fluoxetine treatment
Czéh, B., Abumaria, N., Ryguła, R., & Fuchs, E. (2009) · Hippocampus · doi:10.1002/hipo.20599 · Cited by 51
Stress-Induced Anxiety- and Depressive-Like Phenotype Associated with Transient Reduction in Neurogenesis in Adult Nestin-CreERT2/Diphtheria Toxin Fragment A Transgenic Mice
Yun, S., Donovan, M. H., Ross, M. N., Richardson, D. R., Reister, R., Farnbauch, L. A., Fischer, S. J., Riethmacher, D., Gershenfeld, H. K., Lagace, D. C., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147256 · Cited by 51
Hippocampal Shape Deformation in Female Patients with Unremitting Major Depressive Disorder
Tae, W., Kim, S. S., Lee, K. U., Nam, E., Choi, J. W., & Park, J. I. (2011) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2367 · Cited by 48
Ongoing neurogenesis in the adult dentate gyrus mediates behavioral responses to ambiguous threat cues
Glover, L. R., Schoenfeld, T. J., Karlsson, R., Bannerman, D. M., & Cameron, H. A. (2017) · PLoS Biology · doi:10.1371/journal.pbio.2001154 · Cited by 48
Self-citation
Effect of maternal separation and chronic stress on hippocampal-dependent memory in young adult rats: evidence for the match-mismatch hypothesis
Zalosnik, M. I., Pollano, A., Trujillo, V., Suárez, M. M., & Durando, P. E. (2014) · Stress · doi:10.3109/10253890.2014.936005 · Cited by 47
Oxotremorine treatment restores hippocampal neurogenesis and ameliorates depression-like behaviour in chronically stressed rats
Veena, J., Srikumar, B. N., Mahati, K., Raju, T. R., & Rao, B. S. S. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2279-3 · Cited by 46
Interaction between repeated restraint stress and concomitant midazolam administration on sweet food ingestion in rats
Silveira, P. P., Xavier, M. H., Souza, F. H., Manoli, L. P., Rosat, R. M., Ferreira, M. B. C., & Dalmaz, C. (2000) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2000001100013 · Cited by 46
Hippocampal Subfields and Major Depressive Disorder
Samuels, B. A., Leonardo, E. D., & Hen, R. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.11.007 · Cited by 44
Hippocampal Volume in Healthy Controls Given 3-Day Stress Doses of Hydrocortisone
Brown, E. S., Jeon‐Slaughter, H., Lu, H., Jamadar, R., Issac, S., Shad, M. U., Denniston, D., Tamminga, C. A., Nakamura, A., & Thomas, B. P. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.307 · Cited by 43
Dynamic study of the hippocampal volume by structural MRI in a rat model of depression
Luo, Y., Cao, Z., Wang, D., Wu, L., Li, Y., Sun, W., & Zhu, Y. (2014) · Neurological Sciences · doi:10.1007/s10072-014-1837-y · Cited by 38
Atrophy of pyramidal neurons and increased stress-induced glutamate levels in CA3 following chronic suppression of adult neurogenesis
Schloesser, R. J., Jimenez, D. V., Hardy, N. F., Paredes, D., Catlow, B. J., Manji, H. K., McKay, R. D. G., & Martinowich, K. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0532-8 · Cited by 32
Volumetric analysis of hippocampal sub-regions in late onset depression: A 3 tesla magnetic resonance imaging study
Sivakumar, P. T., Kalmady, S. V., Venkatasubramanian, G., Bharath, S., Reddy, N. N., Rao, N. P., Kovoor, J. M. E., Jain, S., & Varghese, M. (2014) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2014.11.005 · Cited by 23
Electroconvulsive stimulation, but not chronic restraint stress, causes structural alterations in adult rat hippocampus—A stereological study
Olesen, M. V., Wörtwein, G., & Pakkenberg, B. (2014) · Hippocampus · doi:10.1002/hipo.22351 · Cited by 21
Tianeptine reverses stress-induced asymmetrical hippocampal volume and N -acetylaspartate loss in rats: An in vivo study
Liu, W., Shu, X., Chen, F.-Y., Zhu, C., Sun, X.-H., Liú, L., Ai, Y.-X., Li, Y., & Zhao, H. (2011) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2011.02.007 · Cited by 20
Stress during Adolescence Alters Palatable Food Consumption in a Context-Dependent Manner
Handy, C., Yanaga, S., Reiss, A., Zona, N., Robinson, E., & Saxton, K. B. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148261 · Cited by 8
Untitled work
Merchenthaler (1999) · doi:10.1002/(sici)1096-9861(19990111)403:2

Sorted by citations

Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism
Satterstrom, F. K., Kosmicki, J. A., Wang, J., Breen, M. S., De Rubeis, S., An, J.-Y., Peng, M., Collins, R., Grove, J., Klei, L., et al. (2020) · Cell · doi:10.1016/j.cell.2019.12.036 · Cited by 2,321
Chronic unpredictable mild stress for modeling depression in rodents: Meta-analysis of model reliability
Antoniuk, S., Bijata, M., Ponimaskin, E., & Wlodarczyk, J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.12.002 · Cited by 750
The Hippocampus in Depression: More Than the Sum of Its Parts? Advanced Hippocampal Substructure Segmentation in Depression
Roddy, D. W., Farrell, C., Doolin, K., Roman, E., Tozzi, L., Frodl, T., O’Keane, V., & O’Hanlon, E. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.08.021 · Cited by 287
Adult neurogenesis, glia, and the extracellular matrix
Cope, E. C., & Gould, E. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.03.023 · Cited by 236
Chronic Stress-Associated Depressive Disorders: The Impact of HPA Axis Dysregulation and Neuroinflammation on the Hippocampus—A Mini Review
Lei, A. A., Phang, V. W. X., Lee, Y. Z., Kow, A. S. F., Tham, C. L., Ho, Y.-C., & Lee, M. T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26072940 · Cited by 207
“Stress and glucocorticoids were identified to be the principal factors contributing to the shrinkage of dendrites and loss of spines in the hippocampus [93].”

See all 261

Authors: Schoenfeld, T. J., McCausland, H. C., Morris, H. D., Padmanaban, V., & Cameron, H. A.
Affiliations: National Institutes of Health (US)
Corresponding author: Schoenfeld, Timothy J.
ORCID: Schoenfeld, Timothy J.
McCausland, Hayley C.
Morris, H. Douglas
Padmanaban, Varun
Cameron, Heather A.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2017-12
Volume: 82
Issue: 12
Pages: 914-923
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2017.05.013
PMC: PMC5683934
OpenAlex: W2619025546
Semantic Scholar: d965b5035746d3357348c477b0e3012745e0bef6
Cited by: 260
References: 95
Citations by year: 2026: 19 · 2025: 25 · 2024: 24 · 2023: 35 · 2022: 30 · 2021: 42 · 2020: 32 · 2019: 26 · 2018: 24 · 2017: 3
FWCI: 9.84
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (Z01‐MH002784)
National Institute of Mental Health (ZIAMH002784)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: hippocampal atrophy, adult neurogenesis, chronic stress, depression, CA3 pyramidal cells, dentate gyrus, brain reorganization, dendritic atrophy, hippocampal subfields
MeSH terms: Animals, Atrophy, Chronic Disease, Depression, Hippocampus, Male, Neurons, Organ Size, Restraint, Physical, Stress, Psychological, Rats, Long-Evans, Uncertainty, Adult Stem Cells, Neurogenesis, Rats, Transgenic, Neural Stem Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Stress and Loss of Adult Neurogenesis Differentially Reduce Hippocampal Volume

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks