Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia

LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development

Gong, Y., Slee, R. B., Fukai, N., Rawadi, G., Roman-Roman, S., Reginato, A. M., Wang, H., Cundy, T., Glorieux, F. H., Lev, D., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00571-2 · Cited by 2,235

Wnt/β-Catenin Signaling in Mesenchymal Progenitors Controls Osteoblast and Chondrocyte Differentiation during Vertebrate Skeletogenesis

Day, T. F., Guo, X., Garrett-Beal, L., & Yang, Y. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.03.016 · Cited by 1,616

High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5

Boyden, L. M., Mao, J., Belsky, J., Mitzner, L., Farhi, A., Mitnick, M. A., Wu, D., Insogna, K., & Lifton, R. P. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013444 · Cited by 1,591

Secreted antagonists of the Wnt signalling pathway

Kawano, Y., & Kypta, R. (2003) · Journal of Cell Science · doi:10.1242/jcs.00623 · Cited by 1,584

The Role of the Wnt-Signaling Antagonist DKK1 in the Development of Osteolytic Lesions in Multiple Myeloma

Tian, E., Zhan, F., Walker, R., Rasmussen, E., Ma, Y., Barlogie, B., & Shaughnessy, J. D. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030847 · Cited by 1,503

A Mutation in the LDL Receptor–Related Protein 5 Gene Results in the Autosomal Dominant High–Bone-Mass Trait

Little, R. D., Folz, C., Manning, S. P., Swain, P. M., Zhao, S.-C., Eustace, B., Lappe, M. M., Spitzer, L., Zweier, S., Braunschweiger, K., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/338450 · Cited by 1,282

WNT Signals Are Required for the Initiation of Hair Follicle Development

Andl, T., Reddy, S. T., Gaddapara, T., & Millar, S. E. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00167-3 · Cited by 1,088

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

Kato, M., Patel, M. S., Levasseur, R., Lobov, I., Chang, B. H.-J., Glass, D. A., Hartmann, C., Li, L., Hwang, T.-H., Brayton, C. F., et al. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200201089 · Cited by 1,086

Canonical Wnt/β-Catenin Signaling Prevents Osteoblasts from Differentiating into Chondrocytes

Hill, T. P., Später, D., Taketo, M. M., Birchmeier, W., & Hartmann, C. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.02.013 · Cited by 1,084

LDL-receptor-related protein 6 is a receptor for Dickkopf proteins

Mao, B., Wu, W., Li, Y., Hoppe, D., Stannek, P., Glinka, A., & Niehrs, C. (2001) · Nature · doi:10.1038/35077108 · Cited by 1,041

Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling

Mao, B., Wu, W., Davidson, G., Marhold, J., Li, M., Mechler, B. M., Delius, H., Hoppe, D., Stannek, P., Walter, C., et al. (2002) · Nature · doi:10.1038/nature756 · Cited by 1,038

Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs.

Brinster, R. L., Chen, H. Y., Trumbauer, M. E., Yagle, M. K., & Palmiter, R. D. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.13.4438 · Cited by 1,027

Vascular Development in the Retina and Inner Ear

Xu, Q., Wang, Y., Dabdoub, A., Smallwood, P. M., Williams, J., Woods, C., Kelley, M. W., Jiang, L., Tasman, W., Zhang, K., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00216-8 · Cited by 875

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

Bafico, A., Liu, G., Yaniv, A., Gazit, A., & Aaronson, S. A. (2001) · Nature Cell Biology · doi:10.1038/35083081 · Cited by 772

BMP-2 Controls Alkaline Phosphatase Expression and Osteoblast Mineralization by a Wnt Autocrine Loop

Rawadi, G., Vayssière, B., Dunn, F., Baron, R., & Roman-Roman, S. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.10.1842 · Cited by 764

Sequential roles of Hedgehog and Wnt signaling in osteoblast development

Hu, H., Hilton, M. J., Tu, X., Yu, K., Ornitz, D. M., & Long, F. (2005) · Development · doi:10.1242/dev.01564 · Cited by 682

Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1

Kuhnert, F., Davis, C. R., Wang, H.-T., Chu, P., Lee, M., Yuan, J., Nusse, R., & Kuo, C. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2536800100 · Cited by 636

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

Semënov, M. V., Tamai, K., Brott, B. K., Kühl, M., Sokol, S., & He, X. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00290-1 · Cited by 616

Six Novel Missense Mutations in the LDL Receptor-Related Protein 5 (LRP5) Gene in Different Conditions with an Increased Bone Density

Van Wesenbeeck, L., Cleiren, E., Gram, J., Beals, R. K., Bénichou, O., Scopelliti, D., Key, L., Renton, T., Bartels, C., Gong, Y., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/368277 · Cited by 568

High Bone Mass in Mice Expressing a Mutant LRP5 Gene

Babij, P., Zhao, W., Small, C., Kharode, Y., Yaworsky, P. J., Bouxsein, M. L., Reddy, P. S., Bodine, P. V., Robinson, J. A., Bhat, B., et al. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.6.960 · Cited by 497

Mutations in LRP5 or FZD4 Underlie the Common Familial Exudative Vitreoretinopathy Locus on Chromosome 11q

Toomes, C., Bottomley, H. M., Jackson, R. M., Towns, K. V., Scott, S., Mackey, D. A., Craig, J. E., Jiang, L., Yang, Z., Trembath, R., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/383202 · Cited by 378

Decreased BMD and Limb Deformities in Mice Carrying Mutations in Both Lrp5 and Lrp6

Holmen, S. L., Giambernardi, T. A., Zylstra, C. R., Buckner-Berghuis, B. D., Resau, J. H., Hess, J. F., Glatt, V., Bouxsein, M. L., Ai, M., Warman, M. L., et al. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040907 · Cited by 344

Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation

Li, X., Liu, P., Liu, W., Maye, P., Zhang, J., Zhang, Y., Hurley, M., Guo, C., Boskey, A., Sun, L., et al. (2005) · Nature Genetics · doi:10.1038/ng1614 · Cited by 342

Kremen2 modulates Dickkopf2 activity during Wnt/lRP6 signaling

Mao, B., & Niehrs, C. (2003) · Gene · doi:10.1016/s0378-1119(02)01106-x · Cited by 325

Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis

Chu, E. Y., Hens, J., Andl, T., Kairo, A., Yamaguchi, T. P., Brisken, C., Glick, A., Wysolmerski, J. J., & Millar, S. E. (2004) · Development · doi:10.1242/dev.01347 · Cited by 299

The Wnt Signaling Inhibitor Dickkopf-1 Is Required for Reentry into the Cell Cycle of Human Adult Stem Cells from Bone Marrow

Gregory, C. A., Singh, H., Perry, A. S., & Prockop, D. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300373200 · Cited by 282

Reduced Affinity to and Inhibition by DKK1 Form a Common Mechanism by Which High Bone Mass-Associated Missense Mutations in LRP5 Affect Canonical Wnt Signaling

Ai, M., Holmen, S. L., Van Hul, W., Williams, B. O., & Warman, M. L. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.12.4946-4955.2005 · Cited by 253

Polymorphisms in the Low-Density Lipoprotein Receptor–Related Protein 5 (LRP5) Gene Are Associated with Variation in Vertebral Bone Mass, Vertebral Bone Size, and Stature in Whites

Ferrari, S. L., Deutsch, S., Choudhury, U., Chevalley, T., Bonjour, J.-P., Dermitzakis, E. T., Rizzoli, R., & Antonarakis, S. E. (2004) · The American Journal of Human Genetics · doi:10.1086/420771 · Cited by 248

Osteoporosis-pseudoglioma syndrome, a disorder affecting skeletal strength and vision, is assigned to chromosome region 11q12-13.

Gong, Y., Vikkula, M., Boon, L. M., Liu, J., Beighton, P., Ramesar, R., Peltonen, L., Somer, H., Hirose, T., Dallapiccola, B., et al. (1996) · PubMed Central · Cited by 245

Fundamental principles of in situ hybridization.

Wilcox, J. N. (1993) · Journal of Histochemistry & Cytochemistry · doi:10.1177/41.12.8245419 · Cited by 244

Autosomal Recessive Familial Exudative Vitreoretinopathy Is Associated with Mutations in LRP5

Jiao, X., Ventruto, V., Trese, M. T., Shastry, B. S., & Hejtmancik, J. F. (2004) · The American Journal of Human Genetics · doi:10.1086/425080 · Cited by 210

Bone biomechanical properties in LRP5 mutant mice

Akhter, M. P., Wells, D. J., Short, S. J., Cullen, D. M., Johnson, M. L., Haynatzki, G. R., Babij, P., Allen, K. M., Yaworsky, P. J., Bex, F., et al. (2004) · Bone · doi:10.1016/j.bone.2004.02.018 · Cited by 158

Downregulation of Wnt Signaling by Increased Expression of Dickkopf-1 and -2 is a Prerequisite for Late-Stage Osteoblast Differentiation of KS483 Cells

van der Horst, G., van der Werf, S. M., Farih-Sips, H. C. M., van Bezooijen, R. L., Löwik, C. W. G. M., & Karperien, M. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050614 · Cited by 150

The LRP5 High-Bone-Mass G171V Mutation Disrupts LRP5 Interaction with Mesd

Zhang, Y., Wang, Y., Li, X., Zhang, J., Mao, J., Li, Z., Zheng, J., Li, L., Harris, S., & Wu, D. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.11.4677-4684.2004 · Cited by 142

OPG and PTH-(1-34) have additive effects on bone density and mechanical strength in osteopenic ovariectomized rats.

Kostenuik, P. J., Capparelli, C., Morony, S., Adamu, S., Shimamoto, G., Shen, V., Lacey, D. L., & Dunstan, C. R. (2001) · Endocrinology · doi:10.1210/endo.142.10.8437 · Cited by 140

Influence of LRP5 Polymorphisms on Normal Variation in BMD

Koay, M. A., Woon, P. Y., Zhang, Y. L., Miles, L. J., Duncan, E. L., Ralston, S. H., Compston, J. E., Cooper, C. C., Keen, R. W., Langdahl, B. L., et al. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040704 · Cited by 135

Loci for regulation of bone mineral density in men and women identified by genome wide linkage scan: the FAMOS study

Ralston, S. H., Galwey, N. W., Mackay, I., Albagha, O., Cardon, L. R., Compston, J. E., Cooper, C. C., Duncan, E. L., Keen, R. W., Langdahl, B. L., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi088 · Cited by 133

LRP5, low-density-lipoprotein-receptor-related protein 5, is a determinant for bone mineral density

Mizuguchi, T., Furuta, I., Watanabe, Y., Tsukamoto, K., Tomita, H., Tsujihata, M., Ohta, T., Kishino, T., Matsumoto, N., Minakami, H., et al. (2004) · Journal of Human Genetics · doi:10.1007/s10038-003-0111-6 · Cited by 126

Kremen proteins interact with Dickkopf1 to regulate anteroposterior CNS patterning

Davidson, G., Mao, B., del Barco Barrantes, I., & Niehrs, C. (2002) · Development · doi:10.1242/dev.00154 · Cited by 120

Upstream regulatory elements necessary for expression of the rat COL1A1 promoter in transgenic mice

Bogdanovic, Z., Bedalov, A., Krebsbach, P. H., Pavlin, D., Woody, C. O., Clark, S. H., Thomas, H. F., Rowe, D. W., Kream, B. E., & Lichtler, A. C. (1994) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650090218 · Cited by 103

Contribution of the LRP5 Gene to Normal Variation in Peak BMD in Women

Koller, D. L., Ichikawa, S., Johnson, M. L., Lai, D., Xuei, X., Edenberg, H. J., Conneally, P. M., Hui, S. L., Johnston, C. C., Peacock, M., et al. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.041019 · Cited by 92

Marked osteoblastopenia and reduced bone formation in a model of multiple myeloma bone disease in severe combined immunodeficiency mice.

Hjorth-Hansen, H., Seifert, M. F., Börset, M., Aarset, H., Östlie, A., Sundan, A., & Waage, A. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.2.256 · Cited by 71

Association between Bone Mineral Density and LDL Receptor-Related Protein 5 Gene Polymorphisms in Young Korean Men

Koh, J., Jung, M. H., Hong, J. S., Park, H. J., Chang, J. S., Shin, H. D., Kim, S., & Kim, G. S. (2004) · Journal of Korean Medical Science · doi:10.3346/jkms.2004.19.3.407 · Cited by 64

Regulation of COL1A1 expression in type I collagen producing tissues: Identification of a 49 base pair region which is required for transgene expression in bone of transgenic mice

Bedalov, A., Salvatori, R., Dodig, M., Kronenberg, M. S., Kapural, B., Bogdanovic, Z., Kream, B. E., Woody, C. O., Clark, S. H., Mack, K., et al. (1995) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650101004 · Cited by 46

WNT signaling in bone homeostasis and disease: From human mutations to treatments

Baron, R., & Kneissel, M. (2013) · Nature Medicine · doi:10.1038/nm.3074 · Cited by 2,093

Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin

Robling, A. G., Niziolek, P. J., Baldridge, L. A., Condon, K. W., Allen, M. R., Alam, I., Mantila, S. M., Gluhak-Heinrich, J., Bellido, T. M., Harris, S. E., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705092200 · Cited by 1,350

The Osteocyte: An Endocrine Cell … and More

Dallas, S. L., Prideaux, M., & Bonewald, L. F. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1026 · Cited by 1,042

Function and biological roles of the Dickkopf family of Wnt modulators

Niehrs, C. (2006) · Oncogene · doi:10.1038/sj.onc.1210054 · Cited by 995

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

Akhmetshina, A., Palumbo, K., Dees, C., Bergmann, C., Venalis, P., Zerr, P., Horn, A., Kireva, T., Beyer, C., Zwerina, J., et al. (2012) · Nature Communications · doi:10.1038/ncomms1734 · Cited by 843