Orbital and Medial Prefrontal Cortex Functional Connectivity of Major Depression Vulnerability and Disease
Open accessAbstract
Background Pathophysiology models of major depression (MD) center on the dysfunction of various cortical areas within the orbital and medial prefrontal cortex. While independent structural and functional abnormalities in these areas are consistent findings in MD, the complex interactions among them and the rest of the cortex remain largely unexplored. Methods We used resting-state functional magnetic resonance imaging connectivity to systematically map alterations in the communication between orbital and medial prefrontal cortex fields and the rest of the brain in MD. Functional connectivity (FC) maps from participants with current MD (n = 35), unaffected first-degree relatives (n = 36), and healthy control subjects (n = 38) were subjected to conjunction analyses to distinguish FC markers of MD vulnerability and FC markers of MD disease. Results FC abnormalities in MD vulnerability were found for dorsal medial wall regions and the anterior insula and concerned altered communication of these areas with the inferior parietal cortex and dorsal posterior cingulate, occipital areas and the brainstem. FC aberrations in current MD included the anterior insula, rostral and dorsal anterior cingulate cortex, and lateral orbitofrontal areas and concerned altered communication with the dorsal striatum, the cerebellum, the precuneus, the anterior prefrontal cortex, somatomotor cortex, dorsolateral prefrontal cortex, and visual areas in the occipital and inferior temporal lobes. Conclusions Functionally delineated parcellation maps can be used to identify putative connectivity markers in extended cortical regions such as the orbital and medial prefrontal cortex. The anterior insula and the rostral anterior cingulate cortex play a central role in the pathophysiology of MD, being consistently implicated both in the MD vulnerability and MD disease states.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Current major depressive disorder was uniquely characterized by abnormal resting state functional connectivity between various orbital and medial prefrontal cortex sub-regions and prefrontal, subcortical, and cortical regions.
“However, current MDD was uniquely characterized by abnormal rsFC between various orbital and mPFC sub-regions (pgACC, dACC, lateral and central OFC) and PFC (dlPFC), subcortical (e.g., dorsal striatum), as well as cortical (e.g., precuneus, inferior temporal lobes) regions.”
From Prefrontal cortex and depression (2022) · cites this paper as [73]
Current major depressive disorder and increased risk for major depressive disorder shared several abnormalities, including dysregulated coupling involving the perigenual anterior cingulate cortex, dorsomedial prefrontal cortex, and dorsal anterior cingulate cortex to other cortical regions.
“Current MDD and increased risk for MDD shared several abnormalities, including dysregulated coupling involving the pgACC, dmPFC and dorsal ACC (dACC) to other cortical regions (Fig. 4a).”
From Prefrontal cortex and depression (2022) · cites this paper as [73]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., Mazoyer, B., & Joliot, M. (2002) · NeuroImage · doi:10.1006/nimg.2001.0978 · Cited by 16,319 · see citing works
Community structure in social and biological networks
Girvan, M., & Newman, M. E. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122653799 · Cited by 15,502 · see citing works
Control of goal-directed and stimulus-driven attention in the brain
Corbetta, M., & Shulman, G. L. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn755 · Cited by 12,881 · see citing works
Complex network measures of brain connectivity: Uses and interpretations
Rubinov, M., & Sporns, O. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.10.003 · Cited by 11,522 · see citing works
The organization of the human cerebral cortex estimated by intrinsic functional connectivity
Thomas Yeo, B. T., Krienen, F. M., Sepulcre, J., Sabuncu, M. R., Lashkari, D., Hollinshead, M., Roffman, J. L., Smoller, J. W., Zöllei, L., Polimeni, J. R., et al. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00338.2011 · Cited by 9,182 · see citing works
The human brain is intrinsically organized into dynamic, anticorrelated functional networks
Fox, M. D., Snyder, A. Z., Vincent, J. L., Corbetta, M., Van Essen, D. C., & Raichle, M. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504136102 · Cited by 8,553 · see citing works
Power, J. D., Barnes, K. A., Snyder, A. Z., Schlaggar, B. L., & Petersen, S. E. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.10.018 · Cited by 7,429 · see citing works
The organization of the human cerebellum estimated by intrinsic functional connectivity
Buckner, R. L., Krienen, F. M., Castellanos, A., Diaz, J. C., & Yeo, B. T. T. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00339.2011 · Cited by 7,304 · see citing works
The brief symptom inventory: an introductory report.
Derogatis, L. R., & Melisaratos, N. (1983) · Psychological Medicine · doi:10.1017/s0033291700048017 · Cited by 6,650 · see citing works
Cognitive and emotional influences in anterior cingulate cortex
Bush, G., Luu, P., & Posner, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01483-2 · Cited by 6,259 · see citing works
Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients
Beck, A. T., Steer, R. A., Ball, R., & Ranieri, W. F. (1996) · Journal of Personality Assessment · doi:10.1207/s15327752jpa6703_13 · Cited by 5,965 · see citing works
Rush, A. J., Trivedi, M. H., Ibrahim, H. M., Carmody, T. J., Arnow, B., Klein, D. N., Markowitz, J. C., Ninan, P. T., Kornstein, S., Manber, R., et al. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01866-8 · Cited by 3,829 · see citing works
Ongur, D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.206 · Cited by 2,627 · see citing works
The influence of head motion on intrinsic functional connectivity MRI
Van Dijk, K. R. A., Sabuncu, M. R., & Buckner, R. L. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.07.044 · Cited by 2,344 · see citing works
Kaiser, R. H., Andrews-Hanna, J. R., Wager, T. D., & Pizzagalli, D. A. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.0071 · Cited by 2,281 · see citing works
Greicius, M. D., Flores, B. H., Menon, V., Glover, G. H., Solvason, H. B., Kenna, H., Reiss, A. L., & Schatzberg, A. F. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.020 · Cited by 2,214 · see citing works
Uncertainty and anticipation in anxiety: an integrated neurobiological and psychological perspective
Grupe, D. W., & Nitschke, J. B. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3524 · Cited by 2,007 · see citing works
Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., Egan, M. F., Mattay, V. S., Hariri, A. R., & Weinberger, D. R. (2005) · Nature Neuroscience · doi:10.1038/nn1463 · Cited by 1,980 · see citing works
Neurocircuitry of Mood Disorders
Price, J. L., & Drevets, W. C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.104 · Cited by 1,606 · see citing works
Etkin, A., Egner, T., Peraza, D. M., Kandel, E. R., & Hirsch, J. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.029 · Cited by 1,360 · see citing works
Neural mechanisms of autonomic, affective, and cognitive integration
Critchley, H. D. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20749 · Cited by 1,214 · see citing works
Sheline, Y. I., Price, J. L., Yan, Z., & Mintun, M. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000446107 · Cited by 1,196 · see citing works
Mayberg, H. S. (2003) · British Medical Bulletin · doi:10.1093/bmb/65.1.193 · Cited by 1,166 · see citing works
The ventral visual pathway: an expanded neural framework for the processing of object quality
Kravitz, D. J., Saleem, K. S., Baker, C. I., Ungerleider, L. G., & Mishkin, M. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2012.10.011 · Cited by 1,154 · see citing works
Goldapple, K., Segal, Z., Garson, C., Lau, M., Bieling, P., Kennedy, S., & Mayberg, H. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.1.34 · Cited by 1,068 · see citing works
The anatomical basis of functional localization in the cortex
Passingham, R. E., Stephan, K. E., & Kötter, R. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn893 · Cited by 1,024 · see citing works
Action sets and decisions in the medial frontal cortex
RUSHWORTH, M., WALTON, M., KENNERLEY, S., & BANNERMAN, D. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.07.009 · Cited by 1,004 · see citing works
Precuneus shares intrinsic functional architecture in humans and monkeys
Margulies, D. S., Vincent, J. L., Kelly, C., Lohmann, G., Uddin, L. Q., Biswal, B. B., Villringer, A., Castellanos, F. X., Milham, M. P., & Petrides, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905314106 · Cited by 965 · see citing works
Coherent spontaneous activity identifies a hippocampal-parietal memory network
Vincent, J. L., Snyder, A. Z., Fox, M. D., Shannon, B. J., Andrews, J. R., Raichle, M. E., & Buckner, R. L. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00048.2006 · Cited by 959 · see citing works
When fear is near: threat imminence elicits prefrontal periaqueductal gray shifts in humans.
Mobbs, D., Petrovic, P., Marchant, J. L., Hassabis, D., Weiskopf, N., Seymour, B., Dolan, R. J., & Frith, C. D. (2007) · Science · doi:10.1126/science.1144298 · Cited by 951 · see citing works
Disrupted brain connectivity networks in drug-naive, first-episode major depressive disorder
Zhang, J., Wang, J., Wu, Q., Kuang, W., Huang, X., He, Y., & Gong, Q. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.018 · Cited by 951 · see citing works
Frontocingulate Dysfunction in Depression: Toward Biomarkers of Treatment Response
Pizzagalli, D. A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.166 · Cited by 945 · see citing works
Architecture and intrinsic connections of the prefrontal cortex in the rhesus monkey
Barbas, H., & Pandya, D. Ν. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902860306 · Cited by 937 · see citing works
Resting-state functional connectivity in major depressive disorder: A review
Mulders, P. C., van Eijndhoven, P. F., Schene, A. H., Beckmann, C. F., & Tendolkar, I. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.07.014 · Cited by 884 · see citing works
Ventromedial prefrontal–subcortical systems and the generation of affective meaning
Roy, M., Shohamy, D., & Wager, T. D. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2012.01.005 · Cited by 856 · see citing works
Neural circuits underlying the pathophysiology of mood disorders
Price, J. L., & Drevets, W. C. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.12.011 · Cited by 788 · see citing works
When the Brain Loses Its Self: Prefrontal Inactivation during Sensorimotor Processing
Goldberg, I. I., Harel, M., & Malach, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.015 · Cited by 593 · see citing works
Central circuits mediating patterned autonomic activity during active vs. passive emotional coping
Bandler, R., Keay, K. A., Floyd, N., & Price, J. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00313-0 · Cited by 582 · see citing works
Toward a Neuroimaging Treatment Selection Biomarker for Major Depressive Disorder
McGrath, C. L., Kelley, M. E., Holtzheimer, P. E., Dunlop, B. W., Craighead, W. E., Franco, A. R., Craddock, R. C., & Mayberg, H. S. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.143 · Cited by 561 · see citing works
The subcallosal cingulate gyrus in the context of major depression
Hamani, C., Mayberg, H., Stone, S., Laxton, A., Haber, S., & Lozano, A. M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.034 · Cited by 508 · see citing works
Dissociable Neural Systems Resolve Conflict from Emotional versus Nonemotional Distracters
Egner, T., Etkin, A., Gale, S. A., & Hirsch, J. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm179 · Cited by 499 · see citing works
Posterior cingulate cortex: adapting behavior to a changing world
Pearson, J. M., Heilbronner, S. R., Barack, D. L., Hayden, B. Y., & Platt, M. L. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.02.002 · Cited by 482 · see citing works
Mars, R. B., Jbabdi, S., Sallet, J., O’Reilly, J. X., Croxson, P. L., Olivier, E., Noonan, M. P., Bergmann, C., Mitchell, A. S., Baxter, M. G., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5102-10.2011 · Cited by 472 · see citing works
The cortical connectivity of the prefrontal cortex in the monkey brain
Yeterian, E. H., Pandya, D. Ν., Tomaiuolo, F., & Petrides, M. (2011) · Cortex · doi:10.1016/j.cortex.2011.03.004 · Cited by 404 · see citing works
Neuroimaging of the periaqueductal gray: State of the field
Linnman, C., Moulton, E. A., Barmettler, G., Becerra, L. R., & Borsook, D. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.11.095 · Cited by 402 · see citing works
Differential remoteness and emotional tone modulate the neural correlates of autobiographical memory
Piefke, M. (2003) · Brain · doi:10.1093/brain/awg064 · Cited by 391 · see citing works
Manoliu, A., Meng, C., Brandl, F., Doll, A., Tahmasian, M., Scherr, M., Schwerthöffer, D., Zimmer, C., Förstl, H., Bäuml, J., et al. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00930 · Cited by 382 · see citing works
Fu, C. H. Y., Williams, S. C. R., Cleare, A. J., Scott, J., Mitterschiffthaler, M. T., Walsh, N. D., Donaldson, C., Suckling, J., Andrew, C., Steiner, H., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.04.033 · Cited by 349 · see citing works
Emotion and perception: the role of affective information
Zadra, J. R., & Clore, G. L. (2011) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.147 · Cited by 348 · see citing works
Receptor architecture of human cingulate cortex: Evaluation of the four‐region neurobiological model
Palomero‐Gallagher, N., Vogt, B. A., Schleicher, A., Mayberg, H. S., & Zilles, K. (2008) · Human Brain Mapping · doi:10.1002/hbm.20667 · Cited by 346 · see citing works
A systematic review of resting-state functional-MRI studies in major depression
Wang, L., Hermens, D. F., Hickie, I. B., & Lagopoulos, J. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.04.013 · Cited by 333 · see citing works
A Treatment-Resistant Default Mode Subnetwork in Major Depression
Li, B., Liu, L., Friston, K. J., Shen, H., Wang, L., Zeng, L.-L., & Hu, D. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.11.007 · Cited by 333 · see citing works
The organization of neocortex in mammals: are species differences really so different?
Krubitzer, L. A. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93938-t · Cited by 298 · see citing works
Prestimulus functional connectivity determines pain perception in humans
Ploner, M., Lee, M., Wiech, K., Bingel, U., & Tracey, I. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906186106 · Cited by 297 · see citing works
How do we empathize with someone who is not like us? A functional magnetic resonance imaging study.
Lamm, C., Meltzoff, A. N., & Decety, J. (2010) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21186 · Cited by 278 · see citing works
Horn (2010) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2010.00033 · Cited by 276 · see citing works
Connectivity‐based parcellation: Critique and implications
Eickhoff, S. B., Thirion, B., Varoquaux, G. P., & Bzdok, D. (2015) · Human Brain Mapping · doi:10.1002/hbm.22933 · Cited by 267 · see citing works
New targets for rTMS in depression: A review of convergent evidence
Downar, J., & Daskalakis, Z. J. (2013) · Brain Stimulation · doi:10.1016/j.brs.2012.08.006 · Cited by 257 · see citing works
Perceived Controllability Modulates the Neural Response to Pain
Salomons, T. V., Johnstone, T., Backonja, M.-M., & Davidson, R. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1315-04.2004 · Cited by 253 · see citing works
Caspers, S., Eickhoff, S. B., Tobias Rick, A., Anette Von Kapri, A., Kuhlen, T., Huang, R., Shah, N. J., & Zilles, K. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.06.027 · Cited by 246 · see citing works
Organization of the Human Inferior Parietal Lobule Based on Receptor Architectonics
Caspers, S., Schleicher, A., Bacha-Trams, M., Palomero-Gallagher, N., Amunts, K., & Zilles, K. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhs048 · Cited by 236 · see citing works
Electric current stimulates laughter
Fried, I., Wilson, C. L., MacDonald, K. A., & Behnke, E. J. (1998) · Nature · doi:10.1038/35536 · Cited by 227 · see citing works
Sliz, D., & Hayley, S. P. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00323 · Cited by 224 · see citing works
Chen, J., Zhou, C., Wu, B. C., Wang, Y., Li, Q., Wei, Y., Yang, D., Mu, J., Zhu, D., Zou, D., et al. (2013) · Psychiatry Research · doi:10.1016/j.psychres.2013.09.007 · Cited by 213 · see citing works
Wang, L., LaBar, K. S., Smoski, M., Rosenthal, M. Z., Dolcos, F., Lynch, T. R., Krishnan, R. R., & McCarthy, G. (2008) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2007.10.004 · Cited by 210 · see citing works
Using Attentional Bias Modification as a Cognitive Vaccine Against Depression
Browning, M., Holmes, E. A., Charles, M., Cowen, P. J., & Harmer, C. J. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.04.014 · Cited by 197 · see citing works
Foland-Ross, L. C., & Gotlib, I. H. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00489 · Cited by 197 · see citing works
The role of the ventromedial prefrontal cortex in memory consolidation
Nieuwenhuis, I. L. C., & Takashima, A. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.12.009 · Cited by 195 · see citing works
Zaki, J., Ochsner, K. N., Hanelin, J., Wager, T. D., & Mackey, S. (2007) · Social Neuroscience · doi:10.1080/17470910701401973 · Cited by 186 · see citing works
Interpretation of Ambiguous Information in Girls at Risk for Depression
Dearing, K. F., & Gotlib, I. H. (2008) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-008-9259-z · Cited by 171 · see citing works
Functional activity mapping of the mesial hemispheric wall during anticipation of pain
Porro, C. A., Cettolo, V., Francescato, M. P., & Baraldi, P. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00184-8 · Cited by 150 · see citing works
Emotion regulation, attention to emotion, and the ventral attentional network
Viviani, R. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00746 · Cited by 150 · see citing works
From affective value to decision‐making in the prefrontal cortex
Fabian Grabenhorst, B., Rolls, E. T., & Parris, B. A. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06489.x · Cited by 124 · see citing works
Identifying basal ganglia divisions in individuals using resting-state functional connectivity MRI
Barnes (2010) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2010.00018 · Cited by 123 · see citing works
Sundermann, B., Beverborg, M. O. L., & Pfleiderer, B. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00692 · Cited by 109 · see citing works
Neural correlates of a 'pessimistic' attitude when anticipating events of unknown emotional valence
Herwig, U., Kaffenberger, T., Baumgartner, T., & Jäncke, L. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.09.035 · Cited by 90 · see citing works
Patterns of attentional deficits and emotional bias in bipolar and major depressive disorder
Kerr, N., Scott, J. L., & Phillips, M. L. (2005) · British Journal of Clinical Psychology · doi:10.1348/014466505x57755 · Cited by 86 · see citing works
Resting-state functional connectivity abnormalities in first-onset unmedicated depression
Chen, J., Guo, H., Chen, C., Cao, X., Xiang, J., & Zhang, K. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.125344 · Cited by 76 · see citing works
Goulas, A., Uylings, H. B. M., & Stiers, P. L. J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5852-11.2012 · Cited by 72 · see citing works
Self-citationMultiple cognitive control mechanisms associated with the nature of conflict
Kim, C., Chung, C., & Kim, J. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.04.019 · Cited by 64 · see citing works
Rey, G., Desseilles, M., Favre, S., Dayer, A. G., Piguet, C., Aubry, J., & Vuilleumier, P. O. (2014) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2014.04.016 · Cited by 57 · see citing works
Detaching from the negative by reappraisal: the role of right superior frontal gyrus (BA9/32)
Falquez, R., Couto, B., Ibanez, A., Freitag, M. T., Berger, M., Arens, E., Lang, S., & Barnow, S. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00165 · Cited by 55 · see citing works
Mapping multiple visual areas in the human brain with a short fMRI sequence
Stiers, P. L. J., Peeters, R. R., Lagae, L. G., Hecke, P. V., & Sunaert, S. G. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.07.033 · Cited by 52 · see citing works
Self-citationCampbell, D. W., Wallace, M., Modirrousta, M., Polimeni, J. O., McKeen, N. A., & Reiss, J. P. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.10.013 · Cited by 44 · see citing works
Riva‐Posse, P., Holtzheimer, P. E., Garlow, S. J., & Mayberg, H. S. (2012) · World Neurosurgery · doi:10.1016/j.wneu.2012.11.074 · Cited by 41 · see citing works
Feeling light or dark? Emotions affect perception of brightness
Zhang, X., Zuo, B., Erskine, K., & Hu, T. (2016) · Journal of Environmental Psychology · doi:10.1016/j.jenvp.2016.05.007 · Cited by 33 · see citing works
Samara, Z., Evers, E. A. T., Goulas, A., Uylings, H. B. M., Rajkowska, G., Ramaekers, J. G., & Stiers, P. L. J. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1378-2 · Cited by 32 · see citing works
Self-citationNeurobiological Markers of Familial Risk for Depression
Foland‐Ross, L. C., Hardin, M. G., & Gotlib, I. H. (2012) · Current topics in behavioral neurosciences · doi:10.1007/7854_2012_213 · Cited by 20 · see citing works
Flagged first, then by citations
2 of the 90 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [1]American Psychiatric Association 1994 Diagnostic and Statistical Manual of Mental Disorders 4th Washington DC American Psychiatric Press
Cited by
Sorted by citations
Prefrontal cortex and depression
Pizzagalli, D. A., & Roberts, A. C. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01101-7 · Cited by 644 · see citing works
Childhood trauma history is linked to abnormal brain connectivity in major depression
Yu, M., Linn, K. A., Shinohara, R. T., Oathes, D. J., Cook, P. A., Duprat, R., Moore, T. M., Oquendo, M. A., Phillips, M. L., McInnis, M. G., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1900801116 · Cited by 229 · see citing works
Javaheripour, N., Li, M., Chand, T., Krug, A., Kircher, T. T. J., Dannlowski, U., Nenadić, I., Hamilton, J. P., Sacchet, M. D., Gotlib, I. H., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01619-w · Cited by 139 · see citing works
A network model of depressive and anxiety symptoms: a statistical evaluation
Cai, H. X., Chen, M., Li, X.-H., Zhang, L., Su, Z., Cheung, T. C. C., Tang, Y., Malgaroli, M., Jackson, T., Zhang, Q., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-023-02369-5 · Cited by 77 · see citing works
Popovic, D., Ruef, A., Dwyer, D., Antonucci, L. A., Eder, J., Sanfelici, R., Kambeitz‐Ilankovic, L., Oztuerk, O. F., Dong, M. S., Paul, R., et al. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.05.020 · Cited by 59 · see citing works
Magaraggia, I., Kuiperes, Z., & Schreiber, R. (2021) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2021.107467 · Cited by 50 · see citing works
Li, J.-L., Yang, R., Xia, K., Wang, T., Nie, B., Gao, K., Chen, J., Zhao, H., Li, Y., & Wang, W. (2018) · BMC Psychiatry · doi:10.1186/s12888-018-1880-y · Cited by 43 · see citing works
Kayyal, H., Chandran, S. K., Yiannakas, A., Gould, N. L., Khamaisy, M., & Rosenblum, K. (2021) · eLife · doi:10.7554/elife.66686 · Cited by 29 · see citing works
Intrinsic Connectivity Networks of Glutamate-Mediated Antidepressant Response: A Neuroimaging Review
Demchenko, I., Tassone, V. K., Kennedy, S. H., Dunlop, K., & Bhat, V. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.864902 · Cited by 29 · see citing works
Barbour, T. A., Holmes, A. J., Farabaugh, A. H., DeCross, S. N., Coombs, G., Boeke, E. A., Wolthusen, R. P. F., Nyer, M., Pedrelli, P., D, M. F. M., et al. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.10.010 · Cited by 29 · see citing works
Lai, H., Kong, X., Zhao, Y., Pan, N., Zhang, X., He, M., Wang, S., & Gong, Q. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119009 · Cited by 28 · see citing works
Song, W., Zhang, Z., Lv, B., Li, J., Chen, H., Zhang, S., Zu, J., Dong, L., Xu, C., Zhou, M., et al. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1354455 · Cited by 25 · see citing works
Increased prefrontal cortex connectivity associated with depression vulnerability and relapse
Zhang, Z., Yang, M., Guo, Z., Liao, D., Sörös, P., Li, M., Walter, M., Wang, L., & Liu, C. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.02.059 · Cited by 24 · see citing works
Sacu, S., Wackerhagen, C., Erk, S., Romanczuk‐Seiferth, N., Schwarz, K., Schweiger, J. I., Tost, H., Meyer‐Lindenberg, A., Heinz, A., Razi, A., et al. (2022) · Psychological Medicine · doi:10.1017/s0033291722000824 · Cited by 23 · see citing works
Zeng, J., Wang, Z., Zhang, X., Zhao, A., Qi, H., Jiang, Y., Cai, D., & Zeng, N. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156927 · Cited by 20 · see citing works
Treating depression at home with transcranial direct current stimulation: a feasibility study
Dragon, K., Abdelnaim, M. A., Weber, F. C., Heuschert, M., ENGLERT, L. F., Langguth, B., Hebel, T., & Schecklmann, M. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1335243 · Cited by 9 · see citing works
Marano, G., Anesini, M. B., Milintenda, M., Acanfora, M., Calderoni, C., Bardi, F., Lisci, F. M., Brisi, C., Traversi, G., Mazza, O., et al. (2025) · Pediatric Reports · doi:10.3390/pediatric17030065 · Cited by 9 · see citing works
Xu, S., Zhang, R., & Feng, T. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.11.015 · Cited by 9 · see citing works
Fu, X., Chen, Y., Luo, X., Ide, J. S., & Li, C.-S. R. (2024) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2024.06.004 · Cited by 8 · see citing works
Guo, Z., Chen, L., Tang, L.-R., Gao, Y., Qu, M., Wang, L., & Liu, C.-H. (2024) · NeuroImage Clinical · doi:10.1016/j.nicl.2024.103717 · Cited by 8 · see citing works
Ma, X., Yu, W., Yao, P., Zhu, Y., Dai, J., He, X., Liu, B., Xu, C., Shao, X., Fang, J., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.960868 · Cited by 8 · see citing works
He, M., Cheng, Y., Chu, Z., Xu, J., Lü, Y., Shen, Z., & Xu, X. (2022) · Neuroreport · doi:10.1097/wnr.0000000000001773 · Cited by 7 · see citing works
Reduced neural suppression at occipital cortex in subthreshold depression
Li, J., Tan, Y., Zheng, Z., Feng, C., Fang, W., Huang, X., Lin, S., So, K., Huang, L., Ren, C., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03446-9 · Cited by 9 · see citing works
Fu, S., Liang, S., Lin, C., Wu, Y., Xie, S., Li, M., Lei, Q., Li, J., Yu, K., Yin, Y., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1143780 · Cited by 7 · see citing works
Mato‐Abad, V., Jiménez, I., García, R., Aldrey, J. M., Rivero, D., Cacabelos, P., Andrade-Garda, J., Peleteiro, J. M. P., & Rodríguez, S. (2018) · Applied Sciences · doi:10.3390/app8091629 · Cited by 6 · see citing works
Altered local and matrix functional connectivity in depressed essential tremor patients
Duan, X., Fang, Z., Tao, L., Chen, H., Zhang, X., Li, Y., Wang, H., Li, A., Zhang, X., Pang, Y., et al. (2021) · BMC Neurology · doi:10.1186/s12883-021-02100-3 · Cited by 6 · see citing works
Elmaghraby, R., Blank, E., Miyakoshi, M., Gilbert, D. L., Wu, S. W., Larsh, T., Westerkamp, G., Liu, Y., Horn, P. S., Erickson, C. A., et al. (2025) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2024.0109 · Cited by 5 · see citing works
Wu, D., Du, J., Zhao, T., Li, N., Qiao, X., Peng, F., Wang, D., Shi, J., Zhang, S., Diao, C., et al. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70347 · Cited by 5 · see citing works
Genetic Associations of Anhedonia: Insights into Overlap of Mental and Somatic Disorders
Kasyanov, E. D., Pinakhina, D. V., Rakitko, A., Vergasova, E., Yermakovich, D., Рукавишников, Г. В., Malyshko, L. V., Popov, I., Kovalenko, E. V., Ilinskaya, A. Y., et al. (2024) · Consortium Psychiatricum · doi:10.17816/cp15494 · Cited by 4 · see citing works
Lim, S., & Park, J. (2024) · Acta Psychologica · doi:10.1016/j.actpsy.2024.104571 · Cited by 2 · see citing works
Dong, Y., Wu, Y., Zhao, Y.-L., Chen, Y.-M., Liu, T.-Y., Zhang, Y.-H., Xie, J.-Y., Zhang, J., Zhang, H., Chen, H., et al. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01643-2 · Cited by 1 · see citing works
Identifying Prefrontal Networks for Disease Vulnerability Versus Acute Illness in Major Depression
Fettes, P., & Downar, J. H. (2018) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2018.02.004 · Cited by 1 · see citing works
Dopamine-related polymorphisms and Affective Working Memory in aging
Fairfield, B., Padulo, C., Mammarella, N., Fontanella, S., Sarra, A., Konstantinidou, F., Stuppia, L., & Gatta, V. (2022) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2022.107623 · Cited by 1 · see citing works
Polygenic Risks for Depression and Neural Responses to Reward and Punishment in Young Adults
Chen, Y., Li, H.-T., Luo, X., Li, G., Ide, J. S., & Li, C.-S. R. (2025) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2025.05.008 · Cited by 1 · see citing works
Zhang, Y., Ma, K., Yang, Y., Yin, Y., Hou, Z., Zhang, D., & Yuan, Y. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.575771 · Cited by 1 · see citing works
Neurocognitive Mechanisms for Detecting Early Phase of Depressive Disorder
Tarai, S. (2019) · Advances in medical technologies and clinical practice book series · doi:10.4018/978-1-5225-8567-1.ch010
Li, L., Li, R., & Shen, F. (2020) · International Symposium on Image Computing and Digital Medicine (ISICDM) · doi:10.1145/3451421.3451451
Network analysis of depression symptoms and physical activity levels before and after menopause
Chen, S., Wu, D., Nie, K., Tian, Y., Ma, R., Gao, F., & Ma, G. (2025) · PLoS ONE · doi:10.1371/journal.pone.0325965
Duan, X., Fang, Z., Tao, L., Chen, H., Zhang, X., Li, Y., Wang, H., Li, A., Zhang, X., Pang, Y., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13939966
Nadei, O. V., & Prokopenko, E. S. (2026) · Journal of Molecular Neuroscience · doi:10.1007/s12031-026-02491-3
- Authors
- Samara, Z., Evers, E. A. T., Peeters, F., Uylings, H. B. M., Rajkowska, G., Ramaekers, J. G., & Stiers, P.
- Affiliations
- Maastricht University (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Samara, Zoe
- Venue
- Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 3
- Issue
- 4
- Pages
- 348-357
- ISSN
- 2451-9022 (ISSN-L)
- PMC
- PMC5894884
- OpenAlex
- W2786176443
- Cited by
- 40
- References
- 90
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 7 · 2023: 1 · 2022: 8 · 2021: 6 · 2020: 3 · 2019: 3 · 2018: 3
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Biological Psychiatry Cognitive Neuroscience and Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Netherlands Initiative Brain and Cognition (056-13-012)
- National Institutes of Health (5P30GM103328)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- major depressive disorder, orbitofrontal cortex, medial prefrontal cortex, functional connectivity, depression vulnerability, depression pathophysiology, anterior insula, rostral anterior cingulate cortex, resting-state functional connectivity, first-degree relatives, brain parcellation
- MeSH terms
- Adult, Cerebral Cortex, Depression, Major Depressive Disorder, Depressive Disorder, Major, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Parietal Lobe, Temporal Lobe, Prefrontal Cortex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
