Cited by 191Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchRedox biology and oxidative stress

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Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD

Reed, Tanea T., Pierce, William M., Markesbery, William R., Butterfield, D. Allan·2009·Brain Research

DOI 10.1016/j.brainres.2009.04.009

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Abstract

Early Alzheimer's disease (EAD) is the intermediary stage between mild cognitive impairment (MCI) and late-stage Alzheimer's disease (AD). The symptoms of EAD mirror the disease advancement between the two phases. Dementia, memory deficits, and cognitive decline are more pronounced as the disease progresses. Oxidative stress in brain is reported in MCI and AD, including lipid peroxidation indexed by protein-bound 4-hydroxy-2-nonenal (HNE). There are limited data regarding the proteomics analysis of brain from subjects with EAD and even less concerning the possible relationship of EAD HNE-modified brain proteins with HNE-modified proteins in MCI and AD. Proteomics was utilized to investigate excessively HNE-bound brain proteins in EAD compared to those in control. These new results provide potentially valuable insight into connecting HNE-bound brain proteins in EAD to those previously identified in MCI and AD, since EAD is a transitional stage between MCI and late-stage AD. In total, six proteins were found to be excessively covalently bound by HNE in EAD inferior parietal lobule (IPL) compared to age-related control brain. These proteins play roles in antioxidant defense (manganese superoxide dismutase), neuronal communication and neurite outgrowth (dihydropyriminidase-related protein 2), and energy metabolism (alpha-enolase, malate dehydrogenase, triosephosphate isomerase, and F1 ATPase, alpha subunit). This study shows that there is an overlap of brain proteins in EAD with previously identified oxidatively modified proteins in MCI and late-stage AD. The results are consistent with the hypothesis that oxidative stress, in particular lipid peroxidation, is an early event in the progression of AD, and is the first to identify in EAD identical brain proteins previously identified as HNE-modified in MCI and late-state AD.

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Neurotrophic factors in neurodegenerative disorders: Model of parkinson’s disease
de Yébenes, J. G., & Mena, M. A. (2000) · Neurotoxicity Research · doi:10.1007/bf03033789 · Cited by 31

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Mitochondrial dysfunction and oxidative stress in aging and cancer
Kudryavtseva, A. V., Krasnov, G. S., Dmitriev, A. A., Alekseev, B. Y., Kardymon, O. L., Садритдинова, А. Ф., Fedorova, M., Pokrovsky, A. V., Melnikova, N. V., Каприн, А. Д., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9821 · Cited by 564
Amyloid β -Peptide (1–42)-Induced Oxidative Stress in Alzheimer Disease: Importance in Disease Pathogenesis and Progression
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Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration
Masaldan, S., Bush, A. I., Devos, D., Rolland, A., & Moreau, C. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.033 · Cited by 494
Pathological aspects of lipid peroxidation
Nègre‐Salvayre, A., Augè, N., Ayala, V., Başağa, H., Boada, J., Brenke, R., Chapple, S. J., Cohen, G., Fehér, J., Grune, T., et al. (2010) · Free Radical Research · doi:10.3109/10715762.2010.498478 · Cited by 465
Interaction of aldehydes derived from lipid peroxidation and membrane proteins
Pizzimenti, S., Ciamporcero, E. S., Daga, M., Pettazzoni, P., Arcaro, A., Cetrangolo, G., Minelli, R., Dianzani, C., Lepore, A., Gentile, F., et al. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00242 · Cited by 382

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Authors: Reed, T. T., Pierce, W. M., Markesbery, W. R., & Butterfield, D. A.
Affiliations: University of Kentucky (US)
University of Louisville (US)
Corresponding author: Butterfield, D. Allan
ORCID: Reed, Tanea T.
Butterfield, D. Allan
Venue: Brain Research
Publisher: Elsevier BV
Published: 2009-06
Volume: 1274
Pages: 66-76
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/j.brainres.2009.04.009
OpenAlex: W2076534507
Cited by: 190
References: 79
Citations by year: 2026: 3 · 2025: 2 · 2024: 1 · 2023: 8 · 2022: 7 · 2021: 13 · 2020: 12 · 2019: 9 · 2018: 11 · 2017: 8 · 2016: 14 · 2015: 13 · 2014: 14 · 2013: 16 · 2012: 16
FWCI: 13.03
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG-0288383, P01AG010836, P01AG005119, AG 10836, AG0 5119)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: early Alzheimer's disease, 4-hydroxynonenal, lipid peroxidation, oxidative stress, protein oxidation, brain proteomics, inferior parietal lobule, manganese superoxide dismutase, alpha-enolase, malate dehydrogenase, triosephosphate isomerase, F1-ATPase, antioxidant defense, energy metabolism, neural communication, disease progression
MeSH terms: Aged, Aged, 80 and over, Aldehydes, Alzheimer Disease, Brain, Female, Humans, Male, Proteins, Blotting, Western, Lipid Peroxidation, Oxidative Stress, Disease Progression, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Proteomics

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Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD

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