Acute Changes in Motor Cortical Excitability During Slow Oscillatory and Constant Anodal Transcranial Direct Current Stimulation
Abstract
Transcranial oscillatory current stimulation has recently emerged as a noninvasive technique that can interact with ongoing endogenous rhythms of the human brain. Yet, there is still little knowledge on how time-varied exogenous currents acutely modulate cortical excitability. In ten healthy individuals we used on-line single-pulse transcranial magnetic stimulation (TMS) to search for systematic shifts in corticospinal excitability during anodal sleeplike 0.8-Hz slow oscillatory transcranial direct current stimulation (so-tDCS). In separate sessions, we repeatedly applied 30-s trials (two blocks at 20 min) of either anodal so-tDCS or constant tDCS (c-tDCS) to the primary motor hand area during quiet wakefulness. Simultaneously and time-locked to different phase angles of the slow oscillation, motor-evoked potentials (MEPs) as an index of corticospinal excitability were obtained in the contralateral hand muscles 10, 20, and 30 s after the onset of tDCS. MEPs were also measured off-line before, between, and after both stimulation blocks to detect any lasting excitability shifts. Both tDCS modes increased MEP amplitudes during stimulation with an attenuation of the facilitatory effect toward the end of a 30-s tDCS trial. No phase-locking of corticospinal excitability to the exogenous oscillation was observed during so-tDCS. Off-line TMS revealed that both c-tDCS and so-tDCS resulted in a lasting excitability increase. The individual magnitude of MEP facilitation during the first tDCS trials predicted the lasting MEP facilitation found after tDCS. We conclude that sleep slow oscillation-like excitability changes cannot be actively imposed on the awake cortex with so-tDCS, but phase-independent on-line as well as off-line facilitation can reliably be induced.
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Phase-locked electrical and transmagnetic stimulation has revealed the depolarizing up-phase as a period of distinctly enhanced neuronal network excitability.
“Indeed, phase-locked electrical and transmagnetic stimulation has revealed the depolarizing up-phase as a period of distinctly enhanced neuronal network excitability (83,792,1200).”
From About Sleep's Role in Memory (2013) · cites this paper as [83]
These results agree with findings that reveal increased cortical excitability following oscillatory electrical stimulation in the wake state and provided initial hints at a causal role of EEG theta activity for the encoding of new memories in humans.
“These results agree with findings that reveal increased cortical excitability following oscillatory electrical stimulation in the wake state (83,484) and provided initial hints at a causal role of EEG theta activity for the encoding of new memories in humans (646, 647, 687).”
From About Sleep's Role in Memory (2013) · cites this paper as [83]
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- Authors
- Bergmann, T. O., Groppa, S., Seeger, M., Mölle, M., Marshall, L., & Siebner, H. R.
- Affiliations
- Christian-Albrechts-Universität zu Kiel (DE)
- University of Lübeck (DE)
- Hvidovre Hospital (DK)
- Corresponding author
- Bergmann, Til Ole
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 2009-10
- Volume
- 102
- Issue
- 4
- Pages
- 2303-2311
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W1980097906
- Cited by
- 75
- References
- 27
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 4 · 2015: 7 · 2013: 7 · 2012: 1
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- slow oscillations, anodal tDCS, motor cortex excitability, corticospinal excitability, motor evoked potentials, phase locking, sleep slow oscillations, primary motor cortex
- MeSH terms
- Adult, Analysis of Variance, Electric Stimulation, Hand, Humans, Male, Motor Cortex, Periodicity, Pyramidal Tracts, Surveys and Questionnaires, Sleep, Time Factors, Wakefulness, Linear Models, Muscle, Skeletal, Evoked Potentials, Motor, Transcranial Magnetic Stimulation, Young Adult
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