Immunomodulation and antitumor activities of different-molecular-weight polysaccharides from Porphyridium cruentum
Abstract
The extracellular polysaccharides (EPSs) isolated from Porphyridium cruentum were degraded by hermetical–microwave and H₂O₂ under ultrasonic waves. Six products were obtained with molecular weights of 6.53, 256, 606, 802.6, 903.3 and 1002kDa. The antitumor and immunomodulatory activities of different-molecular-weight (MW) polysaccharides were evaluated by the S180-tumor-bearing mouse model in vivo and peritoneal macrophage activation in vitro. The degraded EPSs all showed clear immunomodulation to different extents. The MW of the EPSs had a notable effect on their activity. The 6.53-kDa fragment had the strongest immunoenhancing activity. Different doses of EPS all inhibited the growth of the implanted S180 tumor. The tumor inhibition index at high, middle and low doses was 53.3%, 47.5% and 40.5%, respectively. In addition, three different concentrations of EPS significantly increased lymphocyte proliferation, which indicated the unique mechanism of the antitumor effect of EPS.
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The microwave technique is economical, easy to use, non-toxic and green.
“Therefore, the use of this technique offers several clear advantages: it is economical, easy to use, non-toxic and is green, since the energetic and time consumption are not environmentally harmful [132].”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [132]
Extraction processes based on physical methods are the most efficient ones, since they present minimal or no adverse effects on human health, do not alter the original structure of compounds, and are environmentally friendly.
“Extraction processes based on physical methods are the most efficient ones, since they present minimal or no adverse effects on human health. Besides that, these methods do not alter the original structure of the compounds and are environmentally friendly [132].”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [132]
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- Authors
- Sun, L., Wang, L., & Zhou, Y.
- Affiliations
- Yantai University (CN)
- Corresponding author
- Sun, Liqin
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 87
- Issue
- 2
- Pages
- 1206-1210
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W2094028683
- Cited by
- 249
- References
- 15
- Citations by year
- 2026: 15 · 2025: 22 · 2024: 23 · 2023: 20 · 2022: 23 · 2021: 26 · 2020: 24 · 2019: 26 · 2018: 20 · 2017: 7 · 2016: 13 · 2015: 11 · 2014: 9 · 2013: 9 · 2012: 1
- FWCI
- 9.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Carbohydrate Polymers (publishedVersion)
- Funders
- Natural Science Foundation of Shandong Province, China (Y2007D59, Y2008B21)
- Yantai Sci & Tech. Development Plan (2009219)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Health Sciences › Medicine › Pharmacology › Fungal Biology and Applications
- Keywords
- Porphyridium cruentum, exopolysaccharides, molecular weight, immunomodulation, anticancer activity, S180 tumor, hydrogen peroxide decomposition, ultrasonic degradation, lymphocyte proliferation, red microalgae
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