Polycystic Ovarian Syndrome: Correlation Between Hyperandrogenism, Insulin Resistance and Obesity.

Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome

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Recommendations from the international evidence‐based guideline for the assessment and management of polycystic ovary syndrome

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Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome

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Anti-Mullerian Hormone Serum Concentrations in Normoovulatory and Anovulatory Women of Reproductive Age

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Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling

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11-Oxygenated C19 steroids are the predominant androgens in polycystic ovary syndrome

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Impact of electro-acupuncture and physical exercise on hyperandrogenism and oligo/amenorrhea in women with polycystic ovary syndrome: a randomized controlled trial

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Adiponectin Induces Periovulatory Changes in Ovarian Follicular Cells

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Chronic testosterone treatment induces selective insulin resistance in subcutaneous adipocytes of women

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Differential Gene Expression Profile in Omental Adipose Tissue in Women with Polycystic Ovary Syndrome

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Increased Oocyte Degeneration and Follicular Atresia during the Estrous Cycle in Anti-Mullerian Hormone Null Mice

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Insulin Augmentation of 17α-Hydroxylase Activity Is Mediated by Phosphatidyl Inositol 3-Kinase But Not Extracellular Signal-Regulated Kinase-1/2 in Human Ovarian Theca Cells

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Adiponectin increases insulin-like growth factor I-induced progesterone and estradiol secretion in human granulosa cells

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Polycystic ovary syndrome, adipose tissue and metabolic syndrome

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Interactive Stimulation by Luteinizing Hormone and Insulin of the Steroidogenic Acute Regulatory (StAR) Protein and 17α-Hydroxylase/17, 20-Lyase (CYP17) Genes in Porcine Theca Cells1

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Evaluation of different ranges of LH:FSH ratios in polycystic ovarian syndrome (PCOS) – Clinical based case control study

Malini, N. A., & George, K. R. (2017) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2017.12.007 · Cited by 114 · see citing works

11-oxygenated C19 steroids Do not decline with age in women

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Factors Influencing Follicle-Stimulating Hormone-Responsive Steroidogenesis in Marmoset Granulosa Cells: Effects of Androgens and the Stage of Follicular Maturity*

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Follicular hyperandrogenism downregulates aromatase in luteinized granulosa cells in polycystic ovary syndrome women

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Combined Lifestyle and Herbal Medicine in Overweight Women with Polycystic Ovary Syndrome ( PCOS ): A Randomized Controlled Trial

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Cellular Insulin Resistance in Adipocytes from Obese Polycystic Ovary Syndrome Subjects Involves Adenosine Modulation of Insulin Sensitivity 1

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Thecal Cell Sensitivity to Luteinizing Hormone and Insulin in Polycystic Ovarian Syndrome

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Identification of a Functional Polymorphism of the Human Type 5 17β-Hydroxysteroid Dehydrogenase Gene Associated with Polycystic Ovary Syndrome

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SHBG expression is correlated with PI3K/AKT pathway activity in a cellular model of human insulin resistance

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Effect of the combined oral contraceptive pill and/or metformin in the management of polycystic ovary syndrome: A systematic review with meta‐analyses

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Oral contraceptives versus physical exercise on cardiovascular and metabolic risk factors in women with polycystic ovary syndrome: a randomized controlled trial

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miR-323-3p regulates the steroidogenesis and cell apoptosis in polycystic ovary syndrome (PCOS) by targeting IGF-1

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Polycystic ovarian syndrome is accompanied by repression of gene signatures associated with biosynthesis and metabolism of steroids, cholesterol and lipids

Salilew‐Wondim, D., Wang, Q., Tesfaye, D., Schellander, K., Hoelker, M., Hossain, M. M., & Tsang, B. K. (2015) · Journal of Ovarian Research · doi:10.1186/s13048-015-0151-5 · Cited by 74 · see citing works

Cellular Insulin Resistance in Adipocytes from Obese Polycystic Ovary Syndrome Subjects Involves Adenosine Modulation of Insulin Sensitivity

Ciaraldi, T. P. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.5.1421 · Cited by 72 · see citing works

Dysregulation of the Anti-Müllerian Hormone System by Steroids in Women With Polycystic Ovary Syndrome

Pierre, A., Taieb, J., Giton, F., Grynberg, M., Touleimat, S., Hachem, H. E., Fanchin, R. R. F., Monniaux, D., Cohen-Tannoudji, J., di Clemente, N., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00308 · Cited by 72 · see citing works

GnRH secretion is inhibited by adiponectin through activation of AMP-activated protein kinase and extracellular signal-regulated kinase

Cheng, X., Wen, J., Yang, J., Yang, Y., Ning, G., & Li, X.-Y. (2010) · Endocrine · doi:10.1007/s12020-010-9375-8 · Cited by 71 · see citing works

Elevated androgens during puberty in female rhesus monkeys lead to increased neuronal drive to the reproductive axis: a possible component of polycystic ovary syndrome

McGee, W. K., Bishop, C. V., Bahar, A., Pohl, C. R., Chang, R. J., Marshall, J. C., Pau, F. K.-Y., Stouffer, R. L., & Cameron, J. L. (2011) · Human Reproduction · doi:10.1093/humrep/der393 · Cited by 71 · see citing works

Dynamics and control of the ERK signaling pathway: Sensitivity, bistability, and oscillations

Arkun, Y., & Yasemi, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195513 · Cited by 71 · see citing works

Comparison of ovarian stromal blood flow between fertile women with normal ovaries and infertile women with polycystic ovary syndrome

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Functional microarray analysis of differentially expressed genes in granulosa cells from women with polycystic ovary syndrome related to MAPK/ERK signaling

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Metformin induces a prompt decrease in LH-stimulated testosterone response in women with PCOS independent of its insulin-sensitizing effects

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Direct actions of androgens on the survival, growth and secretion of steroids and anti-Mullerian hormone by individual macaque follicles during three-dimensional culture

Rodrigues, J. K., Navarro, P. A., Zelinski, M. B., Stouffer, R. L., & Xu, J. (2015) · Human Reproduction · doi:10.1093/humrep/deu335 · Cited by 66 · see citing works

Insulin and Insulin-Like Growth Factor Stimulation of Vascular Endothelial Growth Factor Production by Luteinized Granulosa Cells: Comparison between Polycystic Ovarian Syndrome (PCOS) and Non-PCOS Women

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The obesogen tributyltin induces abnormal ovarian adipogenesis in adult female rats

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Study of visceral and subcutaneous abdominal fat thickness and its correlation with cardiometabolic risk factors and hormonal parameters in polycystic ovary syndrome

Choudhury, A., Jena, D., Mangaraj, S., Singh, M., Mohanty, B., & Baliarsinha, A. K. (2018) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/ijem.ijem_646_17 · Cited by 64 · see citing works

Regulation of androgen receptor signaling by ubiquitination during folliculogenesis and its possible dysregulation in polycystic ovarian syndrome

Lim, J. J., Lima, P., Salehi, R., Lee, D. R., & Tsang, B. K. (2017) · Scientific Reports · doi:10.1038/s41598-017-09880-0 · Cited by 64 · see citing works

Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in granulosa cells through the phosphatidylinositol 3-kinase pathway

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Adiponectin synthesis and secretion by subcutaneous adipose tissue is impaired during obesity by endoplasmic reticulum stress

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The orphan nuclear receptor NR4A1 regulates transcription of key steroidogenic enzymes in ovarian theca cells

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Vitamin D3 regulates steroidogenesis in granulosa cells through AMP‐activated protein kinase (AMPK) activation in a mouse model of polycystic ovary syndrome

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MicroRNA-27a-3p affects estradiol and androgen imbalance by targeting Creb1 in the granulosa cells in mouse polycytic ovary syndrome model

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Molecular characterization of insulin resistance and glycolytic metabolism in the rat uterus

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Dehydroepiandrosterone-induced activation of mTORC1 and inhibition of autophagy contribute to skeletal muscle insulin resistance in a mouse model of polycystic ovary syndrome

Song, X., Shen, Q., Fan, L., Yu, Q., Jia, X., Sun, Y., Bai, W., & Kang, J. (2018) · Oncotarget · doi:10.18632/oncotarget.24190 · Cited by 59 · see citing works

Loss of TIGAR Induces Oxidative Stress and Meiotic Defects in Oocytes from Obese Mice

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Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1

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Crocetin attenuates DHT-induced polycystic ovary syndrome in mice via revising kisspeptin neurons

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A Hyperandrogenic Environment Causes Intrinsic Defects That Are Detrimental to Follicular Dynamics in a PCOS Mouse Model

Bertoldo, M. J., Caldwell, A. S. L., Riepsamen, A. H., Lin, D., Gonzalez, M. B., Robker, R. L., Ledger, W. J., Gilchrist, R. B., Handelsman, D. J., & Walters, K. A. (2019) · Endocrinology · doi:10.1210/en.2018-00966 · Cited by 52 · see citing works

Extracellular signal-regulated kinases (ERK) 1, 2 are required for luteinizing hormone (LH)-induced steroidogenesis in primary Leydig cells and control steroidogenic acute regulatory (StAR) expression

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Inflammatory markers in human follicular fluid correlate with lipid levels and Body Mass Index

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Leptin-Induced CART (Cocaine- and Amphetamine-Regulated Transcript) Is a Novel Intraovarian Mediator of Obesity-Related Infertility in Females

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Cytochrome b5 Activates the 17,20-Lyase Activity of Human Cytochrome P450 17A1 by Increasing the Coupling of NADPH Consumption to Androgen Production

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In PCOS patients the addition of low-dose spironolactone induces a more marked reduction of clinical and biochemical hyperandrogenism than metformin alone

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Increased expression of P450scc and CYP17 in development of endogenous hyperandrogenism in a rat model of PCOS

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Dysregulation of Ovarian Follicular Development in Female Rat: LH Decreases FSH Sensitivity During Preantral-Early Antral Transition

Orisaka, M., Hattori, K., Fukuda, S., Mizutani, T., Miyamoto, K., Sato, T., Tsang, B. K., Kotsuji, F., & Yoshida, Y. (2013) · Endocrinology · doi:10.1210/en.2012-2173 · Cited by 48 · see citing works

Metformin InhibitsStARExpression in Human Endometriotic Stromal Cells via AMPK-Mediated Disruption of CREB-CRTC2 Complex Formation

Xu, J., Zeng, C., Zhou, Y., Peng, C., Zhou, Y.-F., & Xue, Q. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1593 · Cited by 43 · see citing works

Ring Finger Protein 6 Mediates Androgen-Induced Granulosa Cell Proliferation and Follicle Growth via Modulation of Androgen Receptor Signaling

Lim, J. J., Han, C. Y., Lee, D. R., & Tsang, B. K. (2017) · Endocrinology · doi:10.1210/en.2016-1866 · Cited by 42 · see citing works

Cryptotanshinone Reverses Reproductive and Metabolic Disturbances in PCOS Model Rats via Regulating the Expression of CYP17 and AR

Yu, J., Zhai, D., Li, H., Zhang, D., Bai, L., Cai, Z., & Yu, C. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/670743 · Cited by 41 · see citing works

Metformin and pioglitazone combination therapy ameliorate polycystic ovary syndrome through AMPK/PI3K/JNK pathway

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Luteinizing Hormone Facilitates Antral Follicular Maturation and Survival via Thecal Paracrine Signaling in Cattle

Hattori, K., Orisaka, M., Fukuda, S., Tajima, K., Yamazaki, Y., Mizutani, T., & Yoshida, Y. (2018) · Endocrinology · doi:10.1210/en.2018-00123 · Cited by 39 · see citing works

SIRT7 functions in redox homeostasis and cytoskeletal organization during oocyte maturation

Gao, M., Li, X., He, Y., Han, L., Qiu, D., Li, L., Liu, H., Liu, J., & Gu, L. (2018) · The FASEB Journal · doi:10.1096/fj.201800078rr · Cited by 39 · see citing works

Follicular hyperandrogenism and insulin resistance in polycystic ovary syndrome patients with normal circulating testosterone levels

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The Involvement of Granulosa Cells in the Regulation by Gonadotropins of Cyp17a1 in Theca Cells

Kakuta, H., Iguchi, T., & Sato, T. (2018) · In Vivo · doi:10.21873/invivo.11391 · Cited by 34 · see citing works

Effect of Body Weight on Metabolic Hormones and Fatty Acid Metabolism in Follicular Fluid of Women Undergoing In Vitro Fertilization: A Pilot Study

Nemer, L. B., Shi, H., Carr, B. R., Word, R. A., & Bükülmez, O. (2018) · Reproductive Sciences · doi:10.1177/1933719118776787 · Cited by 33 · see citing works

Hyperandrogenism Enhances Muscle Strength After Progressive Resistance Training, Independent of Body Composition, in Women With Polycystic Ovary Syndrome

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Expression of genes controlling steroid metabolism and action in granulosa-lutein cells of women with polycystic ovaries

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Resveratrol prevents insulin resistance caused by short-term elevation of free fatty acids in vivo

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Effect of acute physiological free fatty acid elevation in the context of hyperinsulinemia on fiber type-specific IMCL accumulation

Chow, L. S., Mashek, D. G., Wang, Q., Shepherd, S. O., Goodpaster, B. H., & Dubé, J. J. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00209.2017 · Cited by 31 · see citing works

High-molecular-weight adiponectin is inversely associated with sympathetic activity in polycystic ovary syndrome

Shorakae, S., Abell, S. K., Hiam, D., Lambert, É., Eikelis, N., Jona, E., Sari, C. I., Stepto, N. K., Lambert, G. W., de Courten, B. V., et al. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.11.020 · Cited by 30 · see citing works

Causes, patterns and severity of androgen excess in 487 consecutively recruited pre- and post-pubertal children

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Hyperandrogenism stimulates inflammation and promote apoptosis of cumulus cells

Xu, F., Liu, R., & Cao, X. (2017) · Cellular and Molecular Biology · doi:10.14715/cmb/2017.63.10.10 · Cited by 28 · see citing works

Body Fat Mass Is Associated With Ratio of Steroid Metabolites Reflecting 17,20-Lyase Activity in Prepubertal Girls

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Mechanisms of Granulosa Cell Programmed Cell Death and Follicular Atresia in Polycystic Ovary Syndrome

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Low-Calorie Ketogenic Diet: Potential Application in the Treatment of Polycystic Ovary Syndrome in Adolescents

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The Effectiveness and Safety of Exenatide Versus Metformin in Patients with Polycystic Ovary Syndrome: A Meta-Analysis of Randomized Controlled Trials

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Evolving global trends in PCOS burden: a three-decade analysis (1990–2021) with projections to 2036 among adolescents and young adults

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Metabolic Surgery on Patients With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

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Molecular Mechanisms in the Etiology of Polycystic Ovary Syndrome (PCOS): A Multifaceted Hypothesis Towards the Disease with Potential Therapeutics

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Exploring the molecular mechanisms by which per- and polyfluoroalkyl substances induce polycystic ovary syndrome through in silico toxicogenomic data mining

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Hyperandrogenism and anthropometric parameters in women with polycystic ovary syndrome

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Chronotype: A Tool to Screen Eating Habits in Polycystic Ovary Syndrome?

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Study on the effects of Mogroside V in inhibiting NLRP3-mediated granulosa cell pyroptosis and insulin resistance to improve PCOS

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microRNA-103 Contributes to Progression of Polycystic Ovary Syndrome Through Modulating the IRS1/PI3K/AKT Signal Axis

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Immunomodulatory Effects of Metformin Treatment in Pregnant Women With PCOS

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Associations Between Asthma and Polycystic Ovary Syndrome: Current Perspectives

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Insulin Resistance and Polycystic ovary Syndrome: A Review

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Hyperinsulinism and Its Interaction With Hyperandrogenism in Polycystic Ovary Syndrome

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