The when and wheres of CDC25 phosphatases

Mitotic and G 2 Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216

Peng, C.-Y., Graves, P. R., Thoma, R. S., Wu, Z., Shaw, A. S., & Piwnica-Worms, H. (1997) · Science · doi:10.1126/science.277.5331.1501 · Cited by 1,341

Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase

Matsuoka, S. (1998) · Science · doi:10.1126/science.282.5395.1893 · Cited by 1,322

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

Sanchez, Y., Wong, C., Thoma, R. S., Richman, R., Wu, Z., Piwnica-Worms, H., & Elledge, S. J. (1997) · Science · doi:10.1126/science.277.5331.1497 · Cited by 1,320

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

Falck, J., Mailand, N., Syljuåsen, R. G., Bartek, J., & Lukas, J. (2001) · Nature · doi:10.1038/35071124 · Cited by 1,085

cdc25+ functions as an inducer in the mitotic control of fission yeast

Russell, P., & Nurse, P. (1986) · Cell · doi:10.1016/0092-8674(86)90546-5 · Cited by 970

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice

Ortega, S., Prieto, I., Odajima, J., Martín, A., Dubus, P., Sotillo, R., Barbero, J. L., Malumbres, M., & Barbacid, M. (2003) · Nature Genetics · doi:10.1038/ng1232 · Cited by 796

Rapid Destruction of Human Cdc25A in Response to DNA Damage

Mailand, N., Falck, J., Lukas, C., Syljuåsen, R. G., Welcker, M., Bartek, J., & Lukas, J. (2000) · Science · doi:10.1126/science.288.5470.1425 · Cited by 787

Cdc25 cell-cycle phosphatase as a target of c-myc

Galaktionov, K., Chen, X., & Beach, D. (1996) · Nature · doi:10.1038/382511a0 · Cited by 690

Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis.

Hoffmann, I., Clarke, P. R., Marcote, M. J., Karsenti, E., & Draetta, G. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05631.x · Cited by 684

Cdk2 Knockout Mice Are Viable

Berthet, C., Aleem, E., Coppola, V., Tessarollo, L., & Kaldis, P. (2003) · Current Biology · doi:10.1016/j.cub.2003.09.024 · Cited by 663

Active cyclin B1–Cdk1 first appears on centrosomes in prophase

Jackman, M., Lindon, C., Nigg, E. A., & Pines, J. (2003) · Nature Cell Biology · doi:10.1038/ncb918 · Cited by 612

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A

Sørensen, C. S., Syljuåsen, R. G., Falck, J., Schroeder, T., Rönnstrand, L., Khanna, K. K., Zhou, B.-B., Bartek, J., & Lukas, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00048-5 · Cited by 559

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

Bulavin, D. V., Higashimoto, Y., Popoff, I. J., Gaarde, W. A., Basrur, V., Potapova, O., Appella, E., & Fornace, A. J. (2001) · Nature · doi:10.1038/35075107 · Cited by 532

Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transition.

Hoffmann, I., Draetta, G., & Karsenti, E. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06750.x · Cited by 494

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G 2 checkpoints

Zhao, H., Watkins, J. L., & Piwnica-Worms, H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182557299 · Cited by 461

Cdc25A is a novel phosphatase functioning early in the cell cycle.

Jinno, S., Suto, K., Nagata, A., Igarashi, M., Kanaoka, Y., Nojima, H., & Okayama, H. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06417.x · Cited by 452

Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage

Busino, L., Donzelli, M., Chiesa, M., Guardavaccaro, D., Ganoth, D., Valerio Dorrello, N., Hershko, A., Pagano, M., & Draetta, G. F. (2003) · Nature · doi:10.1038/nature02082 · Cited by 447

MAPKAP Kinase-2 Is a Cell Cycle Checkpoint Kinase that Regulates the G2/M Transition and S Phase Progression in Response to UV Irradiation

Manke, I. A., Nguyen, A., Lim, D., Stewart, M. Q., Elia, A. E. H., & Yaffe, M. B. (2005) · Molecular Cell · doi:10.1016/j.molcel.2004.11.021 · Cited by 416

Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents

Xiao, Z., Chen, Z., Gunasekera, A. H., Sowin, T. J., Rosenberg, S. H., Fesik, S., & Zhang, H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300229200 · Cited by 388

Polo-like Kinase-1 Controls Recovery from a G2 DNA Damage-Induced Arrest in Mammalian Cells

van Vugt, M. A. T. M., Brás, A., & Medema, R. H. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.07.015 · Cited by 385

Cdc2–cyclin E complexes regulate the G1/S phase transition

Aleem, E., Kiyokawa, H., & Kaldis, P. (2005) · Nature Cell Biology · doi:10.1038/ncb1284 · Cited by 383

Centrosome-associated Chk1 prevents premature activation of cyclin-B–Cdk1 kinase

Krämer, A., Mailand, N., Lukas, C., Syljuåsen, R. G., Wilkinson, C. J., Nigg, E. A., Bartek, J., & Lukas, J. (2004) · Nature Cell Biology · doi:10.1038/ncb1165 · Cited by 342

Plk1 promotes nuclear translocation of human Cdc25C during prophase

Toyoshima‐Morimoto, F., Taniguchi, E., & Nishida, E. (2002) · EMBO reports · doi:10.1093/embo-reports/kvf069 · Cited by 337

Regulation of G2/M events by Cdc25A through phosphorylation‐dependent modulation of its stability

Mailand, N., Podtelejnikov, A. V., Groth, A., Mann, M., Bartek, J., & Lukas, J. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf567 · Cited by 315

Cdc25 Phosphatases and Cancer

Kristjánsdóttir, K., & Rudolph, J. (2004) · Chemistry & Biology · doi:10.1016/j.chembiol.2004.07.007 · Cited by 313

The cdc25B phosphatase is essential for the G 2/M phase transition in human cells

Lammer1, C., Wagerer, S., Saffrich, R., Mertens, D., Ansorge, W., & Hoffmann, I. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.16.2445 · Cited by 306

Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25

Kumagai, A., & Dunphy, W. G. (1999) · Genes & Development · doi:10.1101/gad.13.9.1067 · Cited by 305

Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation

Lincoln, A. J., Wickramasinghe, D., Stein, P., Schultz, R. M., Palko, M. E., De Miguel, M. P. D., Tessarollo, L., & Donovan, P. J. (2002) · Nature Genetics · doi:10.1038/ng856 · Cited by 300

Ectopic Expression of Cdc25A Accelerates the G 1 /S Transition and Leads to Premature Activation of Cyclin E- and Cyclin A-Dependent Kinases

Blomberg, I., & Hoffmann, I. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.9.6183 · Cited by 291

Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2–M transition

Dutertre, S., Cazales, M., Quaranta, M., Froment, C., Trabut, V., Dozier, C., Mirey, G., Bouché, J.-P., Theis-Febvre, N., Schmitt, E., et al. (2004) · Journal of Cell Science · doi:10.1242/jcs.01108 · Cited by 284

Cytoplasmic Localization of Human cdc25C during Interphase Requires an Intact 14-3-3 Binding Site

Dalal, S. N., Schweitzer, C. M., Gan, J., & DeCaprio, J. A. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.4465 · Cited by 279

14-3-3 proteins associate with cdc25 phosphatases.

Conklin, D. S., Galaktionov, K., & Beach, D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7892 · Cited by 246

Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding

Chen, M.-S., Ryan, C. E., & Piwnica-Worms, H. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.21.7488-7497.2003 · Cited by 238

Cytoplasmic accumulation of cdc25B phosphatase in mitosis triggers centrosomal microtubule nucleation in HeLa cells

Gabrielli, B. G., Souza, C. P. C. D., Tonks, I. D., Clark, J. M., Hayward, N. K., & Ellem, K. A. O. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.5.1081 · Cited by 236

p55CDC25 is a nuclear protein required for the initiation of mitosis in human cells.

Millar, J. B. A., Blevitt, J. M., Gerace, L., Sadhu, K., Featherstone, C., & Russell, P. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10500 · Cited by 234

C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding.

Peng, C. Y., Graves, P. R., Ogg, S., Thoma, R. S., Byrnes, M. J., Wu, Z., Stephenson, M. T., & Piwnica-Worms, H. M. (1998) · PubMed · Cited by 223

The DNA damage response: sensing and signaling

McGowan, C. H., & Russell, P. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.09.005 · Cited by 203

Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis

Molinari, M., Mercurio, C., Dominguez, J., Goubin, F., & Draetta, G. F. (2000) · EMBO reports · doi:10.1093/embo-reports/kvd018 · Cited by 203

Cdc25B cooperates with Cdc25A to induce mitosis but has a unique role in activating cyclin B1–Cdk1 at the centrosome

Lindqvist, A., Källström, H., Lundgren, A., Barsoum, E., & Rosenthal, C. K. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200503066 · Cited by 200

Dual mode of degradation of Cdc25 A phosphatase

Donzelli, M. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf491 · Cited by 194

Absence of Apparent Phenotype in Mice Lacking Cdc25C Protein Phosphatase

Chen, M.-S., Hurov, J., White, L. S., Woodford-Thomas, T., & Piwnica-Worms, H. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.12.3853-3861.2001 · Cited by 194

Discovery and Biological Evaluation of a New Family of Potent Inhibitors of the Dual Specificity Protein Phosphatase Cdc25

Lazo, J. S., Aslan, D. C., Southwick, E. C., Cooley, K. A., Ducruet, A. P., Joo, B., Vogt, A., & Wipf, P. (2001) · Journal of Medicinal Chemistry · doi:10.1021/jm0102046 · Cited by 190

Identification of a Potent and Selective Pharmacophore for Cdc25 Dual Specificity Phosphatase Inhibitors.

Lazo, J. S., Nemoto, K., Pestell, K. E., Cooley, K., Southwick, E. C., Mitchell, D. A., Furey, W., Gussio, R., Zaharevitz, D. W., Joo, B., et al. (2002) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12321-8 · Cited by 182

Dual phosphorylation controls Cdc25 phosphatases and mitotic entry

Bulavin, D. V., Higashimoto, Y., Demidenko, Z. N., Meek, S., Graves, P., Phillips, C., Zhao, H., Moody, S. A., Appella, E., Piwnica-Worms, H., et al. (2003) · Nature Cell Biology · doi:10.1038/ncb994 · Cited by 169

Normal Cell Cycle and Checkpoint Responses in Mice and Cells Lacking Cdc25B and Cdc25C Protein Phosphatases

Ferguson, A. M., White, L. S., Donovan, P. J., & Piwnica-Worms, H. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.7.2853-2860.2005 · Cited by 164

Centrosomal and Cytoplasmic Cdc2/Cyclin B1 Activation Precedes Nuclear Mitotic Events

Souza, C. P. C. D., Ellem, K. A. O., & Gabrielli, B. G. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4872 · Cited by 154

CDC25B Phosphorylation by Aurora A Occurs at the G2/M Transition and is Inhibited by DNA Damage

Cazalès, M., Schmitt, E., Montembault, É., Dozier, C., Prigent, C., & Ducommun, B. (2005) · Cell Cycle · doi:10.4161/cc.4.9.1964 · Cited by 131

β-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases

Kanemori, Y., Uto, K., & Sagata, N. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501873102 · Cited by 128

Regulation of CDC25B phosphatases subcellular localization

Davezac, N., Baldin, V., Gabrielli, B. G., Forrest, A. R. R., Theis‐Febvre, N., Yashida, M., & Ducommun, B. (2000) · Oncogene · doi:10.1038/sj.onc.1203545 · Cited by 114

Hyperphosphorylation of the N-terminal Domain of Cdc25 Regulates Activity toward Cyclin B1/Cdc2 But Not Cyclin A/Cdk2

Gabrielli, B. G., Clark, J. M., McCormack, A. K., & Ellem, K. A. O. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.45.28607 · Cited by 112

Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation

Davezac, N., Baldin, V., Blot, J., Ducommun, B., & Tassan, J. (2002) · Oncogene · doi:10.1038/sj.onc.1205870 · Cited by 109

Phosphorylation of Human CDC25B Phosphatase by CDK1-Cyclin A Triggers Its Proteasome-dependent Degradation

Baldin, V., Cans, C., Knibiehler, M., & Ducommun, B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.52.32731 · Cited by 106

Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase

Mils, V., Baldin, V., Goubin, F., Pinta, I., Papin, C., Waye, M. M. Y., Eychène, A., & Ducommun, B. (2000) · Oncogene · doi:10.1038/sj.onc.1203419 · Cited by 102

Purification of a serine kinase that associates with and phosphorylates human Cdc25C on serine 216.

Ogg, S., Gabrielli, B. G., & Piwnica-Worms, H. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43836-7 · Cited by 100

Regulation of Human Cdc25A Stability by Serine 75 Phosphorylation Is Not Sufficient to Activate a S-phase Checkpoint

Goloudina, A. R., Yamaguchi, H., Chervyakova, D. B., Appella, E., Fornace, A. J., & Bulavin, D. V. (2003) · Cell Cycle · doi:10.4161/cc.2.5.482 · Cited by 92

Functional cdc25C Dual-Specificity Phosphatase Is Required for S-Phase Entry in Human Cells

Turowski, P., Franckhauser, C., Morris, M. C., Vaglio, P., Fernandez, A., & Lamb, N. J. C. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-08-0515 · Cited by 89

Dual G1 and G2 Phase Inhibition by a Novel, Selective Cdc25 Inhibitor 7-Chloro-6-(2-morpholin-4-ylethylamino)- quinoline-5,8-dione

Pu, L., Amoscato, A. A., Bier, M. E., & Lazo, J. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207902200 · Cited by 88

Protein kinase CK2 regulates CDC25B phosphatase activity

Theis‐Febvre, N., Filhol, O., Froment, C., Cazalès, M., Cochet, C., Monsarrat, B., Ducommun, B., & Baldin, V. (2003) · Oncogene · doi:10.1038/sj.onc.1206107 · Cited by 77

Characterisation of Cdc25B localisation and nuclear export during the cell cycle and in response to stress

Lindqvist, A., Källström, H., & Karlsson, C. (2004) · Journal of Cell Science · doi:10.1242/jcs.01395 · Cited by 69

Cdc25A localisation and shuttling: characterisation of sequences mediating nuclear export and import

Källström, H., Lindqvist, A., Pospíšil, V., LUNDGREN, A., & Karlsson, C. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.09.012 · Cited by 50

An Essential Phosphorylation-site Domain of Human cdc25C Interacts with Both 14-3-3 and Cyclins

Morris, M. C., Heitz, A., Méry, J., Heitz, F., & Divita, G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002942200 · Cited by 44

Activation of the Raf‐1/MEK/Erk kinase pathway by a novel Cdc25 inhibitor in human prostate cancer cells

Nemoto, K., Vogt, A., Oguri, T., & Lazo, J. S. (2003) · The Prostate · doi:10.1002/pros.10292 · Cited by 33

ATR: an essential regulator of genome integrity

Cimprich, K. A., & Cortez, D. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2450 · Cited by 1,798

The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites

Kaiko, G. E., Ryu, S. H., Koues, O. I., Collins, P. L., Solnica-Krezel, L., Pearce, E. J., Pearce, E. L., Oltz, E. M., & Stappenbeck, T. S. (2016) · Cell · doi:10.1016/j.cell.2016.05.018 · Cited by 733

The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation

Bardhan, K., Anagnostou, T., & Boussiotis, V. A. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00550 · Cited by 606

Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation

Patsoukis, N., Brown, J., Petkova, V., Liu, F., Li, L., & Boussiotis, V. A. (2012) · Science Signaling · doi:10.1126/scisignal.2002796 · Cited by 529

G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer

Bucher, N., & Britten, C. D. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604208 · Cited by 349