The retardation of aging by caloric restriction: its significance in the transgenic era

Barger, Jamie L; Walford, Roy L; Weindruch, Richard

doi:10.1016/j.exger.2003.10.017

Cited by 160Genetics, Aging, and Longevity in Model OrganismsDietary Effects on HealthSirtuins and Resveratrol in Medicine

The retardation of aging by caloric restriction: its significance in the transgenic era

Barger, Jamie L, Walford, Roy L, Weindruch, Richard·2003·Experimental Gerontology

DOI 10.1016/j.exger.2003.10.017

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Abstract

The retardation of aging and diseases by caloric restriction (CR) is a widely-studied and robust phenomenon. Recent publications describe transgenic and other mutant rodents displaying lifespan extension, and the rapid pace at which these animals are being generated raises the possibility that the importance of the CR paradigm is declining. Here we discuss these models and evaluate the evidence whether or not the aging process is retarded based on longevity, disease patterns and age-associated biological changes. A comparison to rodents on CR is made. Because CR has been investigated for approximately 70 years with increasing intensity, there exists extensive data to document aging retardation. In contrast, for nearly all of the genetically abnormal models of lifespan extension, such data are minimal and often unconvincing; additional studies will be required to validate these strains as suitable models for aging research.

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Calorie restriction is the only known non-pharmacological intervention that alleviates age-related chronic diseases.
“The only non-pharmacological intervention known to date to alleviate these deleterious conditions is calorie restriction.”
From Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans (2011) · cites this paper as Barger et al., 2003
Reducing calorie intake by 30-50% below ad libitum or every-other-day feeding delays age-related disease onset, improves stress resistance, and slows functional decline.
“Reduction of calorie intake to 30-50% below ad libitum levels, or every-other-day feeding, can delay the onset of age-related diseases, improve stress resistance, and decelerate functional decline (Barger et al., 2003; Goodrick et al., 1990; McCay et al., 1935).”
From Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans (2011) · cites this paper as Barger et al., 2003

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Authors: Barger, J. L., Walford, R. L., & Weindruch, R.
Affiliations: University of Wisconsin–Madison (US)
University of California, Los Angeles (US)
Corresponding author: Weindruch, Richard
ORCID: Barger, Jamie L
Venue: Experimental Gerontology
Publisher: Elsevier BV
Published: 2003-11
Volume: 38
Issue: 11-12
Pages: 1343-1351
ISSN: 0531-5565 (ISSN-L)
DOI: 10.1016/j.exger.2003.10.017
OpenAlex: W2087300435
Cited by: 160
References: 42
Citations by year: 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 6 · 2019: 2 · 2018: 6 · 2017: 5 · 2016: 2 · 2015: 7 · 2014: 8 · 2013: 5 · 2012: 11
FWCI: 0.92
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Experimental Gerontology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute on Aging (P01-AG-11915, T32-AG-00213, R01AG018922, P01AG011915, T32AG000213, R01AG18922)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Physiology › Dietary Effects on Health
Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Keywords: caloric restriction, aging retardation, lifespan extension, transgenic rodents, longevity, age-related diseases, aging models
MeSH terms: Aging, Animals, Longevity, Mice, Mutant Strains, Mice, Transgenic, Models, Genetic, Models, Animal, Caloric Restriction, Mice

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The retardation of aging by caloric restriction: its significance in the transgenic era

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