The DNA Damage Machinery and Homologous Recombination Pathway Act Consecutively to Protect Human Telomeres

Shelterin: the protein complex that shapes and safeguards human telomeres

de Lange, T. (2005) · Genes & Development · doi:10.1101/gad.1346005 · Cited by 3,056

Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693

Mammalian Telomeres End in a Large Duplex Loop

Griffith, J. D., Comeau, L., Rosenfield, S., Stansel, R. M., Bianchi, A., Moss, H., & de Lange, T. (1999) · Cell · doi:10.1016/s0092-8674(00)80760-6 · Cited by 2,447

p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2

Karlseder, J., Broccoli, D., Dai, Y., Hardy, S., & de Lange, T. (1999) · Science · doi:10.1126/science.283.5406.1321 · Cited by 1,086

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

Jazayeri, A., Falck, J., Lukas, C., Bartek, J., Smith, G. C. M., Lukas, J., & Jackson, S. P. (2006) · Nature Cell Biology · doi:10.1038/ncb1337 · Cited by 1,064

Protection of mammalian telomeres

de Lange, T. (2002) · Oncogene · doi:10.1038/sj.onc.1205080 · Cited by 942

An alternative pathway for yeast telomere maintenance rescues est1− senescence

Lundblad, V., & Blackburn, E. H. (1993) · Cell · doi:10.1016/0092-8674(93)90234-h · Cited by 942

Long G Tails at Both Ends of Human Chromosomes Suggest a C Strand Degradation Mechanism for Telomere Shortening

Makarov, V. L., Hirose, Y., & Langmore, J. P. (1997) · Cell · doi:10.1016/s0092-8674(00)81908-x · Cited by 922

Telomere maintenance by recombination in human cells

Dunham, M. A., Neumann, A. A., Fasching, C. L., & Reddel, R. R. (2000) · Nature Genetics · doi:10.1038/82586 · Cited by 879

Human Rad51 Protein Promotes ATP-Dependent Homologous Pairing and Strand Transfer Reactions In Vitro

Baumann, P., Benson, F. E., & West, S. C. (1996) · Cell · doi:10.1016/s0092-8674(00)81394-x · Cited by 689

Single-Stranded DNA Arising at Telomeres in cdc13 Mutants May Constitute a Specific Signal for the RAD9 Checkpoint

Garvik, B., Carson, M., & Hartwell, L. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.11.6128 · Cited by 631

Defective Telomere Lagging Strand Synthesis in Cells Lacking WRN Helicase Activity

Crabbe, L., Verdun, R. E., Haggblom, C. I., & Karlseder, J. (2004) · Science · doi:10.1126/science.1103619 · Cited by 610

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

Zhu, X.-D., Küster, B., Mann, M., Petrini, J. H. J., & Lange, T. D. (2000) · Nature Genetics · doi:10.1038/77139 · Cited by 606

Partners and pathways

Haber, J. E. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(00)02022-9 · Cited by 563

Yeast Rad55 and Rad57 proteins form a heterodimer that functions with replication protein A to promote DNA strand exchange by Rad51 recombinase.

Sung, P. (1997) · Genes & Development · doi:10.1101/gad.11.9.1111 · Cited by 540

T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang

M.Stansel, R. (2001) · The EMBO Journal · doi:10.1093/emboj/20.19.5532 · Cited by 534

Homologous Recombination Generates T-Loop-Sized Deletions at Human Telomeres

Wang, R. C., Smogorzewska, A., & de Lange, T. (2004) · Cell · doi:10.1016/j.cell.2004.10.011 · Cited by 512

The Mre11 complex is required for ATM activation and the G2/M checkpoint

Carson, C. T., Schwartz, R. A., Stracker, T. H., Lilley, C. E., Lee, D. V., & Weitzman, M. D. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg630 · Cited by 502

A small-scale procedure for preparation of nuclear extracts that support efficient transcription and pre-mRNA splicing

Lee, K. A. W., Bindereif, A., & Green, M. R. (1988) · Gene Analysis Techniques · doi:10.1016/0735-0651(88)90023-4 · Cited by 469

Replication protein A-mediated recruitment and activation of Rad17 complexes

Zou, L., Liu, D., & Elledge, S. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2336100100 · Cited by 431

Initiation of Eukaryotic DNA Replication

Walter, J., & Newport, J. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80241-5 · Cited by 425

RAD50 and RAD51 Define Two Pathways That Collaborate to Maintain Telomeres in the Absence of Telomerase

Le, S., Moore, J. K., Haber, J. E., & Greider, C. W. (1999) · Genetics · doi:10.1093/genetics/152.1.143 · Cited by 410

Genetic Requirements for the Single-Strand Annealing Pathway of Double-Strand Break Repair in Saccharomyces cerevisiae

Ivanov, E. L., Sugawara, N., Fishman-Lobell, J., & Haber, J. E. (1996) · Genetics · doi:10.1093/genetics/142.3.693 · Cited by 390

Telomerase-Mediated Telomere Addition In Vivo Requires DNA Primase and DNA Polymerases α and δ

Diede, S. J., & Gottschling, D. E. (1999) · Cell · doi:10.1016/s0092-8674(00)81670-0 · Cited by 379

Trading Places: How Do DNA Polymerases Switch during Translesion DNA Synthesis?

Friedberg, E. C., Lehmann, A. R., & Fuchs, R. P. P. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.03.032 · Cited by 375

In Vivo Roles of Rad52, Rad54, and Rad55 Proteins in Rad51-Mediated Recombination

Sugawara, N., Wang, X., & Haber, J. E. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00269-7 · Cited by 355

Polymerases and the Replisome: Machines within Machines

Baker, T. A., & Bell, S. P. (1998) · Cell · doi:10.1016/s0092-8674(00)80923-x · Cited by 344

RAD51C Is Required for Holliday Junction Processing in Mammalian Cells

Liu, Y., Masson, J.-Y., Shah, R., O'Regan, P., & West, S. C. (2004) · Science · doi:10.1126/science.1093037 · Cited by 311

MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans

Ahmed, S., & Hodgkin, J. (2000) · Nature · doi:10.1038/35003120 · Cited by 301

Functional Human Telomeres Are Recognized as DNA Damage in G2 of the Cell Cycle

Verdun, R. E., Crabbe, L., Haggblom, C., & Karlseder, J. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.09.024 · Cited by 284

Semi-conservative DNA replication through telomeres requires Taz1

Miller, K. M., Rog, O., & Cooper, J. P. (2006) · Nature · doi:10.1038/nature04638 · Cited by 266

Interactions of TLC1 (Which Encodes the RNA Subunit of Telomerase), TEL1, and MEC1 in Regulating Telomere Length in the Yeast Saccharomyces cerevisiae

Ritchie, K. B., Mallory, J. C., & Petes, T. D. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.9.6065 · Cited by 263

The generation of proper constitutive G-tails on yeast telomeres is dependent on the MRX complexPreprint

Larrivée, M., LeBel, C., & Wellinger, R. J. (2004) · Genes & Development · doi:10.1101/gad.1199404 · Cited by 260

Rad54 protein possesses chromatin-remodeling activity stimulated by the Rad51–ssDNA nucleoprotein filament

Alexeev, A., Mazin, A., & Kowalczykowski, S. C. (2003) · Nature Structural & Molecular Biology · doi:10.1038/nsb901 · Cited by 241

Circular chromosome formation in a fission yeast mutant defective in two ATM homologues

Naito, T., Matsuura, A., & Ishikawa, F. (1998) · Nature Genetics · doi:10.1038/2517 · Cited by 235

Telomere Maintenance Requires the RAD51D Recombination/Repair Protein

Tarsounas, M., Muñoz, P., Claas, A., Smiraldo, P. G., Pittman, D. L., Blasco, M. A., & West, S. C. (2004) · Cell · doi:10.1016/s0092-8674(04)00337-x · Cited by 217

Cell cycle-regulated generation of single-stranded G-rich DNA in the absence of telomerase

Dionne, I., & Wellinger, R. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13902 · Cited by 210

A yeast origin of replication is activated late in S phase

Ferguson, B. M., Brewer, B. J., Reynolds, A. E., & Fangman, W. L. (1991) · Cell · doi:10.1016/0092-8674(91)90468-e · Cited by 198

Stringent sequence requirements for the formation of human telomeres.

Hanish, J. P., Yanowitz, J. L., & de Lange, T. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.8861 · Cited by 192

Characterization of DNA-binding and strand-exchange stimulation properties of y-RPA, a yeast single-strand-DNA-binding protein

Alani, E., Thresher, R., Griffith, J. D., & Kolodner, R. D. (1992) · Journal of Molecular Biology · doi:10.1016/0022-2836(92)90681-9 · Cited by 188

Telomerase and ATM/Tel1p Protect Telomeres from Nonhomologous End Joining

Chan, S. W.-L., & Blackburn, E. H. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00174-6 · Cited by 167

XRCC3 and Rad51 Modulate Replication Fork Progression on Damaged Vertebrate Chromosomes

Henry-Mowatt, J., Jackson, D., Masson, J.-Y., Johnson, P. A., Clements, P. M., Benson, F. E., Thompson, L. H., Takeda, S., West, S. C., & Caldecott, K. W. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00132-1 · Cited by 164

C. elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein

Ahmed, S., Alpi, A., Hengartner, M. O., & Gartner, A. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00604-2 · Cited by 163

Tailed duplex DNA is the preferred substrate for Rad51 protein‐mediated homologous pairing

Mazin, A. V., Zaitseva, E. M., Sung, P., & Kowalczykowski, S. C. (2000) · The EMBO Journal · doi:10.1093/emboj/19.5.1148 · Cited by 152

TRF1 promotes parallel pairing of telomeric tracts in vitro

Griffith, J., Bianchi, A., & de Lange, T. (1998) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.1686 · Cited by 148

Normal Human Telomeres Are Not Late Replicating

Wright, W. E., Tesmer, V. M., Liao, M., & Shay, J. W. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4602 · Cited by 139

Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells

Varley, H., Pickett, H. A., Foxon, J. L., Reddel, R. R., & Royle, N. J. (2002) · Nature Genetics · doi:10.1038/ng834 · Cited by 138

Mammalian Rad9 Plays a Role in Telomere Stability, S- and G2-Phase-Specific Cell Survival, and Homologous Recombinational Repair

PANDITA, R. K., Sharma, G. G., Laszlo, A., Hopkins, K. M., Davey, S. K., Chakhparonian, M., Gupta, A. K. D., Wellinger, R. J., Zhang, J., Powell, S. N., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.5.1850-1864.2006 · Cited by 130

The efficiency and timing of initiation of replication of multiple replicons of Saccharomyces cerevisiae chromosome VI

Yamashita, M., Hori, Y., Shinomiya, T., Obuse, C., Tsurimoto, T., Yoshikawa, H., & Shirahige, K. (1997) · Genes to Cells · doi:10.1046/j.1365-2443.1997.1530351.x · Cited by 125

Accumulation of Single-Stranded DNA and Destabilization of Telomeric Repeats in Yeast Mutant Strains Carrying a Deletion of RAD27

Parenteau, J., & Wellinger, R. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.4143 · Cited by 124

The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase and increases its DNA substrate utilisation efficiency: implications for DNA repair

Toueille, M. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh652 · Cited by 122

Reconstitution of the strand invasion step of double-strand break repair using human Rad51 Rad52 and RPA proteins

McIlwraith, M. J., Dyck, E. V., Masson, J., Stasiak, A. Z., Stasiak, A., & West, S. C. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.4180 · Cited by 121

Switching from high-fidelity replicases to low-fidelity lesion-bypass polymerases

Plosky, B. S., & Woodgate, R. (2004) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2004.02.002 · Cited by 110

The Function of DNA Polymerase α at Telomeric G Tails Is Important for Telomere Homeostasis

Martin, A. A., Dionne, I., Wellinger, R. J., & Holm, C. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.3.786-796.2000 · Cited by 109

The human Rad9–Rad1–Hus1 checkpoint complex stimulates flap endonuclease 1

Wang, W., Brandt, P., Rossi, M. L., Lindsey-Boltz, L., Podust, V., Fanning, E., Sancar, A., & Bambara, R. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407686101 · Cited by 98

Reciprocal Association of the Budding Yeast ATM-Related Proteins Tel1 and Mec1 with Telomeres In Vivo

Takata, H., Kanoh, Y., Gunge, N., Shirahige, K., & Matsuura, A. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00262-x · Cited by 95

Late S Phase-Specific Recruitment of Mre11 Complex Triggers Hierarchical Assembly of Telomere Replication Proteins in Saccharomyces cerevisiae

Takata, H., Tanaka, Y., & Matsuura, A. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.01.014 · Cited by 91

Role of Mammalian Rad54 in Telomere Length Maintenance

Jaco, I., Muñoz, P., Goytisolo, F. A., Wesoły, J., Bailey, S. M., Taccioli, G. E., & Blasco, M. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.16.5572-5580.2003 · Cited by 89

Role of the Nuclease Activity of Saccharomyces cerevisiae Mre11 in Repair of DNA Double-Strand Breaks in Mitotic Cells

Lewis, L. K., Storici, F., Komen, S. V., Calero, S., Sung, P., & Resnick, M. A. (2004) · Genetics · doi:10.1534/genetics.166.4.1701 · Cited by 89

Human Rad54 Protein Stimulates DNA Strand Exchange Activity of hRad51 Protein in the Presence of Ca2+

Mazina, O. M., & Mazin, A. V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410244200 · Cited by 83

The Two DNA Clamps Rad9/Rad1/Hus1 Complex and Proliferating Cell Nuclear Antigen Differentially Regulate Flap Endonuclease 1 Activity

Friedrich-Heineken, E., Toueille, M., Tännler, B., Bürki, C., Ferrari, E., Hottiger, M. O., & Hübscher, U. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.09.018 · Cited by 76

Coordinate Regulation of G- and C Strand Length during New Telomere Synthesis

Fan, X., & Price, C. M. (1997) · Molecular Biology of the Cell · doi:10.1091/mbc.8.11.2145 · Cited by 70

Telomere Repeat Binding Factor 2 Interacts with Base Excision Repair Proteins and Stimulates DNA Synthesis by DNA Polymerase β

Müftüoğlu, M., Wong, H. K., Imam, S. Z., Wilson, D. M., Bohr, V. A., & Opresko, P. L. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2742 · Cited by 66

Regulation of Telomere Length by Checkpoint Genes inSchizosaccharomyces pombe

Dahlén, M., Olsson, T., Kanter-Smoler, G., Ramne, A., & Sunnerhagen, P. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.3.611 · Cited by 65

ATM and ATR make distinct contributions to chromosome end protection and the maintenance of telomeric DNA in ArabidopsisPreprint

Vespa, L., Couvillion, M., Spangler, E. A., & Shippen, D. E. (2005) · Genes & Development · doi:10.1101/gad.1333805 · Cited by 63

Comparison of checkpoint responses triggered by DNA polymerase inhibition versus DNA damaging agents

Liu, J.-S., Kuo, S.-R., & Melendy, T. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2003.08.018 · Cited by 50

Alterations of DNA and Chromatin Structures at Telomeres and Genetic Instability in Mouse Cells Defective in DNA Polymerase α

Nakamura, M., Nabetani, A., Mizuno, T., Hanaoka, F., & Ishikawa, F. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.24.11073-11088.2005 · Cited by 44

Structural and Temporal Analysis of Telomere Replication in YeastPreprint

Wellinger, R. J., Wolf, A. J., & Zakian, V. A. (1993) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1993.058.01.080 · Cited by 15

Telomeres and Aging

Aubert, G., & Lansdorp, P. M. (2008) · Physiological Reviews · doi:10.1152/physrev.00026.2007 · Cited by 1,188

Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-loop Formation

Doksani, Y., Wu, J. Y., de Lange, T., & Zhuang, X. (2013) · Cell · doi:10.1016/j.cell.2013.09.048 · Cited by 493

Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins

Martínez, P., & Blasco, M. A. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3025 · Cited by 468

Replication and protection of telomeres

Verdun, R. E., & Karlseder, J. (2007) · Nature · doi:10.1038/nature05976 · Cited by 463

Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres

O'Sullivan, R. J., Kubicek, S., Schreiber, S. L., & Karlseder, J. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1897 · Cited by 416