The Mre11 complex is required for ATM activation and the G2/M checkpoint

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,178 · see citing works

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Bakkenist, C. J., & Kastan, M. B. (2003) · Nature · doi:10.1038/nature01368 · Cited by 3,466 · see citing works

Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693 · see citing works

ATM and related protein kinases: safeguarding genome integrity

Shiloh, Y. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1011 · Cited by 2,577 · see citing works

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

Paull, T. T., Rogakou, E. P., Yamazaki, V., Kirchgessner, C. U., Gellert, M., & Bonner, W. M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00610-2 · Cited by 2,098 · see citing works

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

Carney, J. P., Maser, R. S., Olivares, H., Davis, E. M., Le Beau, M., Yates, J. R., Hays, L., Morgan, W. F., & Petrini, J. H. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81175-7 · Cited by 1,226 · see citing works

Requirement of the MRN complex for ATM activation by DNA damage

Uziel, T., Lerenthal, Y., Moyal, L., Andegeko, Y., Mittelman, L., & Shiloh, Y. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg541 · Cited by 1,075 · see citing works

The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder

Stewart, G. S., Maser, R. S., Stankovic, T., Bressan, D. A., Kaplan, M. I., Jaspers, N. G. J., Raams, A., Byrd, P. J., Petrini, J. H. J., & Taylor, A. M. R. (1999) · Cell · doi:10.1016/s0092-8674(00)81547-0 · Cited by 1,060 · see citing works

Untitled work

(1999) · PubMed · Cited by 1,030 · see citing works

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

Celeste, A., Fernandez-Capetillo, O., Kruhlak, M. J., Pilch, D. R., Staudt, D. W., Lee, A., Bonner, R. F., Bonner, W. M., & Nussenzweig, A. (2003) · Nature Cell Biology · doi:10.1038/ncb1004 · Cited by 989 · see citing works

The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling

D'Amours, D., & Jackson, S. P. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm805 · Cited by 874 · see citing works

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

Lim, D.-S., Kim, S.-T., Xu, B., Maser, R. S., Lin, J., Petrini, J. H. J., & Kastan, M. B. (2000) · Nature · doi:10.1038/35007091 · Cited by 786 · see citing works

The many substrates and functions of ATM.

Kastan, M. B., & Lim, D.-S. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35043058 · Cited by 779 · see citing works

Interfaces Between the Detection, Signaling, and Repair of DNA Damage

Rouse, J. W., & Jackson, S. P. (2002) · Science · doi:10.1126/science.1074740 · Cited by 688 · see citing works

DNA damage-induced G2–M checkpoint activation by histone H2AX and 53BP1

Fernández-Capetillo, Ó., Chen, H. T., Celeste, A., Ward, I. M., Romanienko, P. J., Morales, J. C., Naka, K., Xia, Z., Camerini‐Otero, R. D., Motoyama, N., et al. (2002) · Nature Cell Biology · doi:10.1038/ncb884 · Cited by 644 · see citing works

Involvement of Brca1 in S-Phase and G 2 -Phase Checkpoints after Ionizing Irradiation

Xu, B., Kim, S., & Kastan, M. B. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3445-3450.2001 · Cited by 540 · see citing works

Overexpression of a kinase‐inactive ATR protein causes sensitivity to DNA‐damaging agents and defects in cell cycle checkpoints

Cliby, W. A., Roberts, C. J., Cimprich, K. A., Stringer, C. M., Lamb, J. R., Schreiber, S. L., & Friend, S. H. (1998) · The EMBO Journal · doi:10.1093/emboj/17.1.159 · Cited by 534 · see citing works

Adenovirus oncoproteins inactivate the Mre11–Rad50–NBS1 DNA repair complex

Stracker, T. H., Carson, C. T., & Weitzman, M. D. (2002) · Nature · doi:10.1038/nature00863 · Cited by 522 · see citing works

Human Rad50/Mre11 Is a Flexible Complex that Can Tether DNA Ends

de Jager, M., van Noort, J., van Gent, D. C., Dekker, C., Kanaar, R., & Wyman, C. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00381-1 · Cited by 512 · see citing works

Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance

Brown, E. J., & Baltimore, D. (2003) · Genes & Development · doi:10.1101/gad.1067403 · Cited by 511 · see citing works

In situ visualization of DNA double-strand break repair in human fibroblasts

Nelms, B. E., Maser, R. S., MacKay, J. F., Lagally, M. G., & Petrini, J. H. J. (1998) · Science · doi:10.1126/science.280.5363.590 · Cited by 500 · see citing works

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

Zhao, S., Weng, Y., Yuan, S. F., Lin, Y.-T., Hsu, H.-C., Lin, S. J., Gerbino, E., Song, M., Zdzienicka, M. Z., Gatti, R. A., et al. (2000) · Nature · doi:10.1038/35013083 · Cited by 483 · see citing works

Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complexPreprint

Querido, E., Blanchette, P., Yan, Q., Kamura, T., Morrison, M. R., Boivin, D., Kaelin, W. G., Conaway, R. C., Conaway, J. W., & Branton, P. E. (2001) · Genes & Development · doi:10.1101/gad.926401 · Cited by 480 · see citing works

Two Molecularly Distinct G2/M Checkpoints Are Induced by Ionizing Irradiation

Xu, B., Kim, S., Lim, D., & Kastan, M. B. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.4.1049-1059.2002 · Cited by 470 · see citing works

ATM-dependent phosphorylation of nibrin in response to radiation exposure

Gatei, M., Young, D., Cerosaletti, K. M., Desai-Mehta, A., Spring, K., Kozlov, S., Lavin, M. F., Gatti, R. A., Concannon, P., & Khanna, K. (2000) · Nature Genetics · doi:10.1038/75508 · Cited by 468 · see citing works

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

Wu, X., Ranganathan, V., Weisman, D., Heine, W. F., Ciccone, D. N., O'Neill, T. B., Crick, K. E., Pierce, K. A., Lane, W. S., Rathbun, G. A., et al. (2000) · Nature · doi:10.1038/35013089 · Cited by 446 · see citing works

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

DiTullio, R. A., Mochan, T. A., Venere, M., Bártková, J., Sehested, M., Bártek, J., & Halazonetis, T. D. (2002) · Nature Cell Biology · doi:10.1038/ncb892 · Cited by 399 · see citing works

The DNA damage-dependent intra–S phase checkpoint is regulated by parallel pathways

Falck, J., Petrini, J. H. J., Williams, B. R., Lukas, J., & Bartek, J. (2002) · Nature Genetics · doi:10.1038/ng845 · Cited by 392 · see citing works

DNA Damage-Dependent Nuclear Dynamics of the Mre11 Complex

Mirzoeva, O. K., & Petrini, J. H. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.1.281-288.2001 · Cited by 387 · see citing works

A DNA Damage Response Pathway Controlled by Tel1 and the Mre11 Complex

Usui, T., Ogawa, H., & Petrini, J. H. J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00270-2 · Cited by 384 · see citing works

ATR inhibition selectively sensitizes G ₁ checkpoint-deficient cells to lethal premature chromatin condensation

Nghiem, P., Park, P. K., Kim, Y.-S., Vaziri, C., & Schreiber, S. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161281798 · Cited by 290 · see citing works

Nuclear Retention of ATM at Sites of DNA Double Strand Breaks

Andegeko, Y., Moyal, L., Rotman, G., Shiloh, Y., Mittelman, L., & Tsarfaty, I. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102986200 · Cited by 276 · see citing works

Mre11 Protein Complex Prevents Double-Strand Break Accumulation during Chromosomal DNA Replication

Costanzo, V., Robertson, K., Bibikova, M., Kim, E., Grieco, D., Gottesman, M., Carroll, D., & Gautier, J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00294-5 · Cited by 239 · see citing works

The yeast Xrs2 complex functions in S phase checkpoint regulation

D'Amours, D., & Jackson, S. P. (2001) · Genes & Development · doi:10.1101/gad.208701 · Cited by 228 · see citing works

Analysis of the Adenovirus E1B-55K-Anchored Proteome Reveals Its Link to Ubiquitination Machinery

Harada, J. N., Shevchenko, A., Shevchenko, A., Pallas, D. C., & Berk, A. J. (2002) · Journal of Virology · doi:10.1128/jvi.76.18.9194-9206.2002 · Cited by 218 · see citing works

A Murine Model of Nijmegen Breakage Syndrome

Williams, B. R., Mirzoeva, O. K., Morgan, W. F., Lin, J., Dunnick, W., & Petrini, J. H. J. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00763-7 · Cited by 208 · see citing works

Chk2 Activation Dependence on Nbs1 after DNA Damage

Buscemi, G., Savio, C., Zannini, L., Miccichè, F., Masnada, D., Nakanishi, M., Tauchi, H., Komatsu, K., Mizutani, S., Khanna, K., et al. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.15.5214-5222.2001 · Cited by 201 · see citing works

The Mammalian Mre11-Rad50-Nbs1 Protein Complex: Integration of Functions in the Cellular DNA–Damage Response

Petrini, J. H. J. (1999) · The American Journal of Human Genetics · doi:10.1086/302391 · Cited by 185 · see citing works

Nuclear export of the E1B 55‐kDa and E4 34‐kDa adenoviral oncoproteins mediated by a rev‐like signal sequence

Dobbelstein, M., Roth, J., Kimberly, W. T., et al. (1997) · The EMBO Journal · doi:10.1093/emboj/16.14.4276 · Cited by 183 · see citing works

Interaction of adenoviral E4 and E1b products in late gene expression

Bridge, E., & Ketner, G. W. (1990) · Virology · doi:10.1016/0042-6822(90)90088-9 · Cited by 145 · see citing works

Localization of the E1 B proteins of adenovirus 5 in transformed cells, as revealed by interaction with monoclonal antibodies

ZANTEMA, A., Fransen, J. A. M., Davis-Olivier, A., Ramaekers, F. C. S., Vooijs, G. P., Deleys, B., & van der Eb, A. J. (1985) · Virology · doi:10.1016/0042-6822(85)90421-0 · Cited by 138 · see citing works

Identification of Three Functions of the Adenovirus E4orf6 Protein That Mediate p53 Degradation by the E4orf6-E1B55K Complex

Querido, E., Morrison, M. R., Dang, H. C. P., Thirlwell, S. W.-L., Boivin, D., & Branton, P. E. (2001) · Journal of Virology · doi:10.1128/jvi.75.2.699-709.2001 · Cited by 110 · see citing works

Adenovirus early region 4 34-kilodalton protein directs the nuclear localization of the early region 1B 55-kilodalton protein in primate cells

Goodrum, F. D., Shenk, T. E., & Ornelles, D. A. (1996) · Journal of Virology · doi:10.1128/jvi.70.9.6323-6335.1996 · Cited by 100 · see citing works

Structural analysis of the adenovirus type 5 E1B 55-kilodalton-E4orf6 protein complex

Rubenwolf, S., SCHÜTT, H., Nevels, M. M., Wolf, H. J., & Dobner, T. (1997) · Journal of Virology · doi:10.1128/jvi.71.2.1115-1123.1997 · Cited by 96 · see citing works

Dissection of functional domains in the adenovirus 2 early 1b 55k polypeptide by suppressor-linker insertional mutagenesis

Yew, P. R., Kao, C. C., & Berk, A. J. (1990) · Virology · doi:10.1016/0042-6822(90)90147-j · Cited by 85 · see citing works

Analyses of Single-Amino-Acid Substitution Mutants of Adenovirus Type 5 E1B-55K Protein

Shen, Y., Kitzes, G., Nye, J. A., et al. (2001) · Journal of Virology · doi:10.1128/jvi.75.9.4297-4307.2001 · Cited by 81 · see citing works

A Functional Complex of Adenovirus Proteins E1B-55kDa and E4orf6 Is Necessary To Modulate the Expression Level of p53 but Not Its Transcriptional Activity

Cathomen, T., & Weitzman, M. D. (2000) · Journal of Virology · doi:10.1128/jvi.74.23.11407-11412.2000 · Cited by 74 · see citing works

Cell-cycle checkpoints and cancer

Kastan, M. B., & Bartek, J. (2004) · Nature · doi:10.1038/nature03097 · Cited by 2,836 · see citing works

Choreography of the DNA Damage Response

Lisby, M., Barlow, J. H., Burgess, R. C., & Rothstein, R. (2004) · Cell · doi:10.1016/j.cell.2004.08.015 · Cited by 891 · see citing works

Checking on DNA damage in S phase

Bartek, J., Lukas, C., & Lukas, J. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1493 · Cited by 758 · see citing works

A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

Sun, Y., Jiang, X., Chen, S., Fernandes, N., & Price, B. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504211102 · Cited by 738 · see citing works

Initiating Cellular Stress Responses

Bakkenist, C. J., & Kastan, M. B. (2004) · Cell · doi:10.1016/j.cell.2004.06.023 · Cited by 544 · see citing works

Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

Lee, J.-H., & Paull, T. T. (2007) · Oncogene · doi:10.1038/sj.onc.1210872 · Cited by 545 · see citing works

Replication and protection of telomeres

Verdun, R. E., & Karlseder, J. (2007) · Nature · doi:10.1038/nature05976 · Cited by 463 · see citing works

The MRN complex in double‐strand break repair and telomere maintenance

Lamarche, B. J., Orazio, N. I., & Weitzman, M. D. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.07.029 · Cited by 446 · see citing works

Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time

Lukas, J., Lukas, C., & Bartek, J. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.03.006 · Cited by 381 · see citing works

Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography

Thompson, L. H. (2012) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2012.06.002 · Cited by 357 · see citing works

DNA repair deficiency and neurological disease

McKinnon, P. J. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2559 · Cited by 323 · see citing works

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

Greenberg, R. A., Sobhian, B., Pathania, S., Cantor, S. B., Nakatani, Y., & Livingston, D. M. (2006) · Genes & Development · doi:10.1101/gad.1381306 · Cited by 308 · see citing works

Functional Human Telomeres Are Recognized as DNA Damage in G2 of the Cell Cycle

Verdun, R. E., Crabbe, L., Haggblom, C., & Karlseder, J. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.09.024 · Cited by 284 · see citing works

Common mechanisms of PIKK regulation

Lovejoy, C. A., & Cortez, D. (2009) · DNA Repair · doi:10.1016/j.dnarep.2009.04.006 · Cited by 277 · see citing works

The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together

Stracker, T. H., Theunissen, J.-W. F., Morales, M., & Petrini, J. H. J. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.03.014 · Cited by 263 · see citing works

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

Difilippantonio, S., Celeste, A., Fernandez-Capetillo, O., Chen, H.-T., Martin, B. R. S., Laethem, F. V., Yang, Y.-P., Petukhova, G. V., Eckhaus, M., Feigenbaum, L., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1270 · Cited by 227 · see citing works

H2AX phosphorylation after UV irradiation is triggered by DNA repair intermediates and is mediated by the ATR kinase

Hanasoge, S., & Ljungman, M. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm157 · Cited by 216 · see citing works

Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex

Adams, K. E., Medhurst, A. L., Dart, D. A., & Lakin, N. D. (2006) · Oncogene · doi:10.1038/sj.onc.1209426 · Cited by 164 · see citing works

Mdm2 Binds to Nbs1 at Sites of DNA Damage and Regulates Double Strand Break Repair

Alt, J. R., Bouska, A., Fernandez, M. R., Cerny, R. L., Xiao, H., & Eischen, C. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413387200 · Cited by 131 · see citing works

The Mre11/Rad50/Nbs1 complex limits adeno-associated virus transduction and replication

Schwartz, R. A., Palacios, J. A., Cassell, G. D., Adam, S., Giacca, M., & Weitzman, M. D. (2007) · Journal of Virology · doi:10.1128/jvi.01523-07 · Cited by 130 · see citing works

Mechanisms of eukaryotic DNA double strand break repair

Cahill, D. (2006) · Frontiers in bioscience · doi:10.2741/1938 · Cited by 129 · see citing works

The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control

Zhang, Y., Zhou, J., & Lim, C. U. (2006) · Cell Research · doi:10.1038/sj.cr.7310007 · Cited by 118 · see citing works

ATM protein kinase: the linchpin of cellular defenses to stress

Bhatti, S., Kozlov, S., Farooqi, A. A., Naqi, A., Lavin, M., & Khanna, K. K. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0683-9 · Cited by 116 · see citing works

Adeno-Associated Virus Replication Induces a DNA Damage Response Coordinated by DNA-Dependent Protein Kinase

Schwartz, R. A., Carson, C. T., Schuberth, C., & Weitzman, M. D. (2009) · Journal of Virology · doi:10.1128/jvi.00318-09 · Cited by 115 · see citing works

Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway

Nakada, D., Hirano, Y., & Sugimoto, K. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.22.10016-10025.2004 · Cited by 113 · see citing works

Mre11 Assembles Linear DNA Fragments into DNA Damage Signaling Complexes

Costanzo, V., Paull, T., Gottesman, M., & Gautier, J. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020110 · Cited by 106 · see citing works

Unwind and slow down: checkpoint activation by helicase and polymerase uncoupling: Figure 1.

Cortez, D. (2005) · Genes & Development · doi:10.1101/gad.1316905 · Cited by 84 · see citing works

Insight into the mechanism of inhibition of adeno-associated virus by the Mre11/Rad50/Nbs1 complex

Lentz, T. B., & Samulski, R. J. (2015) · Journal of Virology · doi:10.1128/jvi.01990-14 · Cited by 48 · see citing works

Werner syndrome protein: Functions in the response to DNA damage and replication stress in S-phase

Cheng, W.-H., Muftuoglu, M., & Bohr, V. A. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.04.011 · Cited by 30 · see citing works

Resisting Arrest: Recovery from Checkpoint Arrest Through Dephosphorylation of Chk1 by PP1

den Elzen, N. R., Kosoy, A., Christopoulos, H., & O’Connell, M. J. (2004) · Cell Cycle · doi:10.4161/cc.3.5.820 · Cited by 25 · see citing works

Nek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylation

Lee, M., Kim, H., Kim, M.-A., Jee, H. J., Kim, A. J., Bae, Y., Park, J., Chung, J. H., & Yun, J. (2008) · Cell Cycle · doi:10.4161/cc.7.17.6551 · Cited by 65 · see citing works

Establishment of and Recovery from Damage Checkpoint Requires Sequential Interactions of Crb2 with Protein Kinases Rad3, Chk1, and Cdc2Preprint

Esashi, F., Mochida, S., Matsusaka, T., OBARA, T., OGAWA, A., Tamai, K., & Yanagida, M. (2000) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2000.65.443 · Cited by 8 · see citing works

Elevated Cyclin G2 Expression Intersects with DNA Damage Checkpoint Signaling and Is Required for a Potent G2/M Checkpoint Arrest Response to Doxorubicin

Zimmermann, M., Don, A. S. A., Donaldson, M. S., Dallapiazza, R. F., Cowan, C. E., & Horne, M. C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.376855 · Cited by 58 · see citing works

The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway

Cohen‐Fix, O., & Koshland, D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14361 · Cited by 158 · see citing works