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MUTYH as an Emerging Predictive Biomarker in Ovarian Cancer

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Structural basis of 5′ flap recognition and protein–protein interactions of human flap endonuclease 1

Xu, H., Shi, R., Han, W., Cheng, J., Xu, X., Cheng, K., Wang, L., Tian, B., Zheng, L., Shen, B., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky911 · Cited by 32 · see citing works

9-1-1: PCNA's specialized cousin

Eichinger, C. S., & Jentsch, S. (2011) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2011.08.002 · Cited by 29 · see citing works

The Tousled-Like Kinases as Guardians of Genome Integrity

Benedetti, A. D. (2012) · ISRN Molecular Biology · doi:10.5402/2012/627596 · Cited by 29 · see citing works

Understanding the role of the Q338H MUTYH variant in oxidative damage repair

Turco, E., Ventura, I., Minoprio, A., Russo, M. T., Torreri, P., Degan, P., Molatore, S., Ranzani, G. N., Bignami, M., & Mazzei, F. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt130 · Cited by 29 · see citing works

Succinylation at a key residue of FEN1 is involved in the DNA damage response to maintain genome stability

Shi, R., Wang, Y., Gao, Y., Xu, X., Mao, S., Xiao, Y., Song, S., Wang, L., Tian, B., Zhao, Y., et al. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00137.2020 · Cited by 25 · see citing works

Interaction between human mismatch repair recognition proteins and checkpoint sensor Rad9-Rad1-Hus1

Bai, H., Madabushi, A., Guan, X., & Lu, A.-L. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.01.011 · Cited by 24 · see citing works

A Conserved Physical and Functional Interaction between the Cell Cycle Checkpoint Clamp Loader and DNA Ligase I of Eukaryotes

Song, W., Levin, D. S., Varkey, J., Post, S. M., Bermudez, V. P., Hurwitz, J., & Tomkinson, A. E. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703774200 · Cited by 24 · see citing works

Specific interactions of three proliferating cell nuclear antigens with replication‐related proteins in Aeropyrum pernix

Imamura, K., Fukunaga, K., Kawarabayasi, Y., & Ishino, Y. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05645.x · Cited by 23 · see citing works

Integrative Modeling of Macromolecular Assemblies from Low to Near-Atomic Resolution

Xu, X., Yan, C., Wohlhueter, R. M., & Ivanov, I. N. (2015) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2015.08.005 · Cited by 23 · see citing works

Increased Sensitivity of DNA Damage Response-Deficient Cells to Stimulated Microgravity-Induced DNA Lesions

Li, N., An, L., & Hang, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125236 · Cited by 21 · see citing works

Conditional inactivation of the mouse cell cycle checkpoint gene

Levitt, P. S., Liu, H., Manning, C., & WEISS, R. (2005) · Genomics · doi:10.1016/j.ygeno.2005.04.007 · Cited by 19 · see citing works

Rad9 modulates the P21 WAF1 pathway by direct association with p53

Ishikawa, K., Ishii, H., Murakumo, Y., Mimori, K., Kobayashi, M., Yamamoto, K.-I., Mori, M., Nishino, H., Furukawa, Y., & Ichimura, K. (2007) · BMC Molecular Biology · doi:10.1186/1471-2199-8-37 · Cited by 18 · see citing works

Genome Maintenance Defects in Cultured Cells and Mice following Partial Inactivation of the Essential Cell Cycle Checkpoint Gene Hus1

Levitt, P. S., Zhu, M., Cassano, A., Yazinski, S. A., Liu, H., Darfler, J. H. L., Peters, R. M., & Weiss, R. S. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01763-06 · Cited by 18 · see citing works

Genome Protection by the 9-1-1 Complex Subunit HUS1 Requires Clamp Formation, DNA Contacts, and ATR Signaling-independent Effector Functions

Lim, P. X., Patel, D. R., Poisson, K. E., Basuita, M., Tsai, C., Lyndaker, A. M., Hwang, B., Lu, A.-L., & Weiss, R. S. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.630640 · Cited by 17 · see citing works

Rad9 Is Required for B Cell Proliferation and Immunoglobulin Class Switch Recombination

An, L., Wang, Y., Liu, Y., Yang, X. Y., Liu, C., Hu, Z., He, W., Song, W., & Hang, H. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.161208 · Cited by 17 · see citing works

The Rad9 protein enhances survival and promotes DNA repair following exposure to ionizing radiation

Brandt, P. D., Helt, C. E., Keng, P. C., & Bambara, R. A. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.06.064 · Cited by 17 · see citing works

Regulation of NEIL1 protein abundance by RAD9 is important for efficient base excision repair

Panigrahi, S. K., Hopkins, K. M., & Lieberman, H. B. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv327 · Cited by 16 · see citing works

Clamping down on mammalian meiosis

Lyndaker, A. M., Vasileva, A., Wolgemuth, D. J., Weiss, R. S., & Lieberman, H. B. (2013) · Cell Cycle · doi:10.4161/cc.26061 · Cited by 15 · see citing works

Need telomere maintenance? Call 911

Francia, S., Weiss, R. S., & di Fagagna, F. D. (2007) · Cell Division · doi:10.1186/1747-1028-2-3 · Cited by 14 · see citing works

Intramolecular Binding of the Rad9 C Terminus in the Checkpoint Clamp Rad9-Hus1-Rad1 Is Closely Linked with Its DNA Binding

Takeishi, Y., Iwaya-Omi, R., Ohashi, E., & Tsurimoto, T. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.669002 · Cited by 13 · see citing works

Defining Genetic Factors That Modulate Intergenerational CAG Repeat Instability inDrosophila melanogaster

Jung, J., van Jaarsveld, M. T. M., Shieh, S.-Y., Xu, K., & Bonini, N. M. (2010) · Genetics · doi:10.1534/genetics.110.121418 · Cited by 12 · see citing works

Apurinic/Apyrimidinic Endonuclease 2 (APE2): An ancillary enzyme for contextual base excision repair mechanisms to preserve genome stability

Chaudhari, S., Ware, A. P., Jayaram, P., Gorthi, S. P., El‐Khamisy, S. F., & Satyamoorthy, K. (2021) · Biochimie · doi:10.1016/j.biochi.2021.07.006 · Cited by 12 · see citing works

HUS1 regulates in vivo responses to genotoxic chemotherapies

Balmus, G., Lim, P. X., Oswald, A. B., Hume, K. R., Cassano, A., Pierre, J., Hill, A., Huang, W., August, A., Stokol, T., et al. (2015) · Oncogene · doi:10.1038/onc.2015.118 · Cited by 11 · see citing works

Crystal Structure of hFen1 in apo form

Han, W., Hua, Y., & Zhao, Y. (2018) · Worldwide Protein Data Bank · doi:10.2210/pdb5zod/pdb · Cited by 11 · see citing works

Opening pathways of the DNA clamps proliferating cell nuclear antigen and Rad9-Rad1-Hus1

Xu, X., Guardiani, C., Yan, C., & Ivanov, I. N. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt810 · Cited by 10 · see citing works

Multiple Functions of Rad9 for Preserving Genomic Integrity

Ishikawa, K., Ishii, H., Saito, T., & Ichimura, K. (2006) · Current Genomics · doi:10.2174/138920206779315746 · Cited by 10 · see citing works

The tumor suppressor homolog in fission yeast, myh1+, displays a strong interaction with the checkpoint gene rad1+

Jansson, K., Warringer, J., Farewell, A., Park, H.-O., Hoe, K., Kim, D.-U., Hayles, J., & Sunnerhagen, P. (2008) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2008.07.001 · Cited by 9 · see citing works

Flap endonuclease 1 and its role in eukaryotic DNA metabolism

Nazarkina, Z. K., Lavrik, O. I., & Khodyreva, S. N. (2008) · Molecular Biology · doi:10.1134/s0026893308030035 · Cited by 8 · see citing works

A role for Myh1 in DNA repair after treatment with strand‐breaking and crosslinking chemotherapeutic agents

Jansson, K., Alao, J. P., Viktorsson, K., Warringer, J., Lewensohn, R., & Sunnerhagen, P. (2013) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21784 · Cited by 7 · see citing works

Role of the Checkpoint Clamp in DNA Damage Response

Kai, M. (2013) · Biomolecules · doi:10.3390/biom3010075 · Cited by 7 · see citing works

Yeast 9-1-1 complex acts as a sliding clamp for DNA synthesis by DNA polymerase ε

Acharya, N., Prakash, L., & Prakash, S. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102727 · Cited by 6 · see citing works

Blockade of Base Excision Repair

Vascotto, C., & Fishel, M. L. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-384999-1.10003-4 · Cited by 6 · see citing works

The post translational modification of key regulators of ATR signaling in DNA replication

Chen, Y., & Yuan, J. (2021) · Genome Instability & Disease · doi:10.1007/s42764-021-00036-z · Cited by 6 · see citing works

Structural basis for molecular interactions on the eukaryotic DNA sliding clamps PCNA and RAD9-RAD1-HUS1

Hashimoto, H., Hara, K., & Hishiki, A. (2022) · The Journal of Biochemistry · doi:10.1093/jb/mvac053 · Cited by 4 · see citing works

Genetic Instability of Cancer: Biological Predictions and Clinical Implications

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Ring Structures and Six-fold Symmetry in DNA Replication

Cox, L. S., & Kearsey, S. E. (2009) · Royal Society of Chemistry eBooks · doi:10.1039/9781847559852-00047 · Cited by 2 · see citing works

The Rad9-Rad1-Hus1 complex and Bif-1 regulate multiple mechanisms that affect sensitivity to DNA damage

Meyerkord, C. L. (2009) · Digital Commons - University of South Florida (University of South Florida)

Investigating the genetics and pharmacogenetics of bowel cancer

West, H. D. (2013) · ORCA Online Research @Cardiff (Cardiff University)

HUS1 (HUS1 checkpoint homolog (S. pombe))

Madabushi, A., Gunther, R., & Al, L. (2011) · Atlas of Genetics and Cytogenetics in Oncology and Haematology · doi:10.4267/2042/45024

BMC Molecular Biology

Canfield, C., Rains, J., & Benedetti, A. D. (2009)

Molecular Cloning and Activity Analysis of the Promoter of Proliferating Cell Nuclear Antigen Gene in Wheat

Yong, Y. (2015) · Zhongguo shengwu huaxue yu fenzi shengwu xuebao

The Function of FEN1 is Regulated by Post-Translational Modification

Wu, Z., Mo, X., Lang, C., & Luo, J. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.96635

Characterization of homologous recombination proteins in telomere processing and t-circle formation

Stockton, P. D. Q. (2009) · eScholarship (California Digital Library)

OXIDATIVE DAMAGE TO DNA IN ALZHEIMER'S DISEASE

Soman, S. (2013) · UKnowledge (University of Kentucky)

The human Rad9–Rad1–Hus1 checkpoint complex stimulates flap endonuclease 1

Wang, W., Brandt, P., Rossi, M. L., Lindsey-Boltz, L., Podust, V., Fanning, E., Sancar, A., & Bambara, R. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407686101 · Cited by 98 · see citing works

Repair complexes of FEN1 endonuclease, DNA, and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability

Querol‐Audí, J., Yan, C., Xu, X., Tsutakawa, S. E., Tsai, M.-S., Tainer, J. A., Cooper, P. K., Nogales, E., & Ivanov, I. N. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121116109 · Cited by 52 · see citing works

Dial 9–1–1 for DNA damage: the Rad9–Hus1–Rad1 (9–1–1) clamp complex

Parrilla-Castellar, E. R., Arlander, S. J. H., & Karnitz, L. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.03.032 · Cited by 342 · see citing works

The tumour suppressor protein flap endonuclease 1 interacts physically with the heterotrimeric checkpoint protein complex Rad9, Rad1 and Hus1

Tännler, B. (2004) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-163179

9-1-1 Complex Involvement in DNA Repair: Evidence that DNA Damage Detection Machinery Participates in DNA Repair

Helt, C. E., Wang, W., Keng, P. C., & Bambara, R. A. (2005) · Cell Cycle · doi:10.4161/cc.4.4.1598 · Cited by 90 · see citing works