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Cited by 1,351

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

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Wang, Lai, Du, Fenghe, Wang, Xiaodong·2008·Cell
DOI 10.1016/j.cell.2008.03.036
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Research works printed but not linked: 35

  1. Bignell, 2000, Identification of the familial cylindromatosis tumour-suppressor gene, Nat. Genet., 25, 160, 10.1038/76006 · DOI · Paper page
  2. Chai, 2000, Structural and biochemical basis of apoptotic activation by Smac/DIABLO, Nature, 406, 855, 10.1038/35022514 · DOI · Paper page
  3. Chen, 2002, TNF-R1 signaling: a beautiful pathway, Science, 296, 1634, 10.1126/science.1071924 · DOI
  4. Chu, 1997, Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control, Proc. Natl. Acad. Sci. USA, 94, 10057, 10.1073/pnas.94.19.10057 · DOI · Paper page
  5. Conze, 2005, Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo, Mol. Cell. Biol., 25, 3348, 10.1128/MCB.25.8.3348-3356.2005 · DOI
  6. Deng, 2003, A JNK-dependent pathway is required for TNFalpha-induced apoptosis, Cell, 115, 61, 10.1016/S0092-8674(03)00757-8 · DOI · Paper page
  7. Du, 2000, Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition, Cell, 102, 33, 10.1016/S0092-8674(00)00008-8 · DOI · Paper page
  8. Ea, 2006, Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO, Mol. Cell, 22, 245, 10.1016/j.molcel.2006.03.026 · DOI · Paper page
  9. Feldmann, 2003, Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases, Nat. Med., 9, 1245, 10.1038/nm939 · DOI · Paper page
  10. Holler, 2000, Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule, Nat. Immunol., 1, 489, 10.1038/82732 · DOI
  11. Irmler, 1997, Inhibition of death receptor signals by cellular FLIP, Nature, 388, 190, 10.1038/40657 · DOI
  12. Jin, 2006, Distinct signaling pathways in TRAIL- versus tumor necrosis factor-induced apoptosis, Mol. Cell. Biol., 26, 8136, 10.1128/MCB.00257-06 · DOI
  13. Kelliher, 1998, The death domain kinase RIP mediates the TNF-induced NF-kappaB signal, Immunity, 8, 297, 10.1016/S1074-7613(00)80535-X · DOI · Paper page
  14. Kreuz, 2001, NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling, Mol. Cell. Biol., 21, 3964, 10.1128/MCB.21.12.3964-3973.2001 · DOI · Paper page
  15. Li, 2004, A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death, Science, 305, 1471, 10.1126/science.1098231 · DOI · Paper page
  16. Liu, 2000, Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain, Nature, 408, 1004, 10.1038/35050006 · DOI · Paper page
  17. Micheau, 2001, NF-kappaB signals induce the expression of c-FLIP, Mol. Cell. Biol., 21, 5299, 10.1128/MCB.21.16.5299-5305.2001 · DOI · Paper page
  18. Muppidi, 2004, Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction, Immunity, 21, 461, 10.1016/j.immuni.2004.10.001 · DOI · Paper page
  19. O'Donnell, 2007, Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling, Curr. Biol., 17, 418, 10.1016/j.cub.2007.01.027 · DOI · Paper page
  20. Panka, 2001, Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells, J. Biol. Chem., 276, 6893, 10.1074/jbc.C000569200 · DOI · Paper page
  21. Petersen, 2007, Autocrine TNFalpha Signaling Renders Human Cancer Cells Susceptible to Smac-Mimetic-Induced Apoptosis, Cancer Cell, 12, 445, 10.1016/j.ccr.2007.08.029 · DOI · Paper page
  22. Stanger, 1995, RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death, Cell, 81, 513, 10.1016/0092-8674(95)90072-1 · DOI
  23. Tinel, 2004, The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress, Science, 304, 843, 10.1126/science.1095432 · DOI · Paper page
  24. Ting, 1996, RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis, EMBO J., 15, 6189, 10.1002/j.1460-2075.1996.tb01007.x · DOI · Paper page
  25. Varfolomeev, 2004, Tumor necrosis factor: an apoptosis JuNKie?, Cell, 116, 491, 10.1016/S0092-8674(04)00166-7 · DOI · Paper page
  26. Verhagen, 2000, Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins, Cell, 102, 43, 10.1016/S0092-8674(00)00009-X · DOI · Paper page
  27. Vince, 2007, IAP Antagonists Target cIAP1 to Induce TNFalpha-Dependent Apoptosis, Cell, 131, 682, 10.1016/j.cell.2007.10.037 · DOI
  28. Wang, 1998, NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation, Science, 281, 1680, 10.1126/science.281.5383.1680 · DOI · Paper page
  29. Wright, 2007, Regulation of Early Wave of Germ Cell Apoptosis and Spermatogenesis by Deubiquitinating Enzyme CYLD, Dev. Cell, 13, 705, 10.1016/j.devcel.2007.09.007 · DOI
  30. Wu, 2006, Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation, Nat. Cell Biol., 8, 398, 10.1038/ncb1384 · DOI · Paper page
  31. Wu, 2000, Structural basis of IAP recognition by Smac/DIABLO, Nature, 408, 1008, 10.1038/35050012 · DOI
  32. Yang, 2004, Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells, J. Biol. Chem., 279, 16963, 10.1074/jbc.M401253200 · DOI
  33. Yang, 2000, Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli, Science, 288, 874, 10.1126/science.288.5467.874 · DOI · Paper page
  34. Zheng, 2006, Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1, Mol. Cell. Biol., 26, 3505, 10.1128/MCB.26.9.3505-3513.2006 · DOI
  35. Zou, 1999, An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9, J. Biol. Chem., 274, 11549, 10.1074/jbc.274.17.11549 · DOI · Paper page

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Metadata

Authors
Wang, L., Du, F., & Wang, X.
Venue
Cell
Publisher
Elsevier BV
Published
2008-05
Volume
133
Issue
4
Pages
693-703
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2008.03.036
OpenAlex
W1998423564
Cited by
1,351
References
7
FWCI
26.30
Type
journal article
Language
en
Open access
bronze
Licence

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Wang, L., Du, F., & Wang, X. (2008). TNF-α Induces Two Distinct Caspase-8 Activation Pathways. Cell. https://doi.org/10.1016/j.cell.2008.03.036

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