Cited by 903Circadian rhythm and melatoninSleep and Work-Related FatigueDietary Effects on Health

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The Meter of Metabolism

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Green, Carla B., Takahashi, Joseph S., Bass, Joseph·2008·Cell

DOI 10.1016/j.cell.2008.08.022PMC PMC3760165

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Abstract

The circadian system orchestrates the temporal organization of many aspects of physiology, including metabolism, in synchrony with the 24 hr rotation of the Earth. Like the metabolic system, the circadian system is a complex feedback network that involves interactions between the central nervous system and peripheral tissues. Emerging evidence suggests that circadian regulation is intimately linked to metabolic homeostasis and that dysregulation of circadian rhythms can contribute to disease. Conversely, metabolic signals also feed back into the circadian system, modulating circadian gene expression and behavior. Here, we review the relationship between the circadian and metabolic systems and the implications for cardiovascular disease, obesity, and diabetes.

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Authors: Green, C. B., Takahashi, J. S., & Bass, J.
Affiliations: University of Virginia (US)
Northwestern University (US)
Corresponding author: Takahashi, Joseph S.
Bass, Joseph
ORCID: Green, Carla B.
Takahashi, Joseph S.
Bass, Joseph
Venue: Cell
Publisher: Elsevier BV
Published: 2008-09
Volume: 134
Issue: 5
Pages: 728-742
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2008.08.022
PMC: PMC3760165
OpenAlex: W2063946784
Cited by: 902
References: 145
Citations by year: 2026: 22 · 2025: 29 · 2024: 29 · 2023: 33 · 2022: 51 · 2021: 49 · 2020: 36 · 2019: 44 · 2018: 35 · 2017: 52 · 2016: 56 · 2015: 51 · 2014: 65 · 2013: 61 · 2012: 74
FWCI: 7.74
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1816 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
Amylin Pharmaceuticals
National Institutes of Health (5p50mh074924-05)
National Institute on Aging (P01AG011412)
National Heart, Lung, and Blood Institute (R01HL075029)
National Institute of Mental Health (P50 MH-074924, R01MH078024)
National Institute of General Medical Sciences (R01GM076626)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
Keywords: circadian rhythm, metabolism, circadian regulation, metabolic homeostasis, circadian gene expression, central nervous system, peripheral tissues, cardiovascular disease, obesity, diabetes mellitus
MeSH terms: Animals, Biological Clocks, Circadian Rhythm, Feeding Behavior, Humans, Metabolic Networks and Pathways

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