The Meter of Metabolism

Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice

Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485

Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index

Taheri, S., Lin, L., Austin, D., Young, T., & Mignot, E. (2004) · PLoS Medicine · doi:10.1371/journal.pmed.0010062 · Cited by 2,477

Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite

Spiegel, K., Tasali, E., Penev, P., & Cauter, E. V. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-141-11-200412070-00008 · Cited by 2,459

Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus

Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.183500 · Cited by 2,394

PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues

Yoo, S.-H., Yamazaki, S., Lowrey, P. L., Shimomura, K., Ko, C. H., Buhr, E. D., Siepka, S. M., Hong, H.-K., Oh, W. J., Yoo, O. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308709101 · Cited by 2,329

Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock

Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,310

The biology of incretin hormones

Drucker, D. J. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.004 · Cited by 2,210

The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator

Preitner, N., Damiola, F., Luis-Lopez-Molina, Zakany, J., Duboule, D., Albrecht, U., & Schibler, U. (2002) · Cell · doi:10.1016/s0092-8674(02)00825-5 · Cited by 2,198

Metabolic control through the PGC-1 family of transcription coactivators

Lin, J., Handschin, C., & Spiegelman, B. M. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.004 · Cited by 2,130

A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells

Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001

Resetting central and peripheral circadian oscillators in transgenic rats

Yamazaki, S., Numano, R., Abe, M., Hida, A., Takahashi, R.-I., Ueda, M., Block, G. D., Sakaki, Y., Menaker, M., & Tei, H. (2000) · Science · doi:10.1126/science.288.5466.682 · Cited by 1,907

Resetting of circadian time in peripheral tissues by glucocorticoid signaling

Balsalobre, A., Brown, S. A., Marcacci, L., Tronche, F., Kellendonk, C., Reichardt, H. M., Schütz, G., & Schibler, U. (2000) · Science · doi:10.1126/science.289.5488.2344 · Cited by 1,859

Transplanted Suprachiasmatic Nucleus Determines Circadian Period

Ralph, M. R., Foster, R. G., Davis, F. C., & Menaker, M. (1990) · Science · doi:10.1126/science.2305266 · Cited by 1,853

Entrainment of the circadian clock in the liver by feeding

Stokkan, K.-A., Yamazaki, S., Tei, H., Sakaki, Y., & Menaker, M. (2001) · Science · doi:10.1126/science.291.5503.490 · Cited by 1,800

Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight

Kalra, S. P., Dube, M. G., Pu, S., Xu, B., Horváth, T. L., & Kalra, P. S. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.1.0357 · Cited by 1,564

Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight

Kalra, S. P. (1999) · Endocrine Reviews · doi:10.1210/er.20.1.68 · Cited by 1,554

High-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice

Kohsaka, A., Laposky, A. D., Ramsey, K. M., Estrada, C., Joshu, C., Kobayashi, Y., Turek, F. W., & Bass, J. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.006 · Cited by 1,528

Extensive and divergent circadian gene expression in liver and heart

Storch, K.-F., Lipan, O., Leykin, I., Viswanathan, N., Davis, F. C., Wong, W. H., & Weitz, C. J. (2002) · Nature · doi:10.1038/nature744 · Cited by 1,509

Plant Circadian Clocks Increase Photosynthesis, Growth, Survival, and Competitive Advantage

Dodd, A. N., Salathia, N. S., Hall, A. J. W., Kevei, É., Tóth, R., Nagy, F., Hibberd, J. M., Millar, A. J., & Webb, A. A. R. (2005) · Science · doi:10.1126/science.1115581 · Cited by 1,489

Leptin

Ahima, R. S., & Flier, J. S. (2000) · Annual Review of Physiology · doi:10.1146/annurev.physiol.62.1.413 · Cited by 1,428

The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control

Nakahata, Y., Kaluzova, M., Grimaldi, B., Sahar, S., Hirayama, J., Chen, D., Guarente, L. P., & Sassone-Corsi, P. (2008) · Cell · doi:10.1016/j.cell.2008.07.002 · Cited by 1,427

Positional Cloning of the Mouse Circadian Gene

King, D. P., Zhao, Y., Sangoram, A. M., Wilsbacher, L. D., Tanaka, M., Antoch, M. P., Steeves, T. D. L., Vitaterna, M. H., Kornhauser, J. M., Lowrey, P. L., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80245-7 · Cited by 1,382

SIRT1 regulates circadian clock gene expression through PER2 deacetylation

Asher, G., Gatfield, D., Stratmann, M., Reinke, H., Dibner, C., Kreppel, F., Mostoslavsky, R., Alt, F. W., & Schibler, U. (2008) · Cell · doi:10.1016/j.cell.2008.06.050 · Cited by 1,376

A role for lateral hypothalamic orexin neurons in reward seeking

Harris, G. C., Wimmer, M., & Aston-Jones, G. (2005) · Nature · doi:10.1038/nature04071 · Cited by 1,311

The Circadian Gene Period2 Plays an Important Role in Tumor Suppression and DNA Damage Response In Vivo

Fu, L., Pelicano, H., Liu, J., Huang, P., & Lee, C. C. (2002) · Cell · doi:10.1016/s0092-8674(02)00961-3 · Cited by 1,268

Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock

Kondratov, R. V., Kondratova, A. A., Gorbacheva, V. Y., Vykhovanets, O. V., & Antoch, M. P. (2006) · Genes & Development · doi:10.1101/gad.1432206 · Cited by 1,188

A Functional Genomics Strategy Reveals Rora as a Component of the Mammalian Circadian Clock

Sato, T. K., Panda, S., Miraglia, L. J., Reyes, T. M., Rudic, R. D., McNamara, P., Naik, K. A., FitzGerald, G. A., Kay, S. A., & Hogenesch, J. B. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.018 · Cited by 1,146

Control Mechanism of the Circadian Clock for Timing of Cell Division in Vivo

Matsuo, T., Yamaguchi, S., Mitsui, S., Emi, A., Shimoda, F., & Okamura, H. (2003) · Science · doi:10.1126/science.1086271 · Cited by 1,132

Expression of ghrelin receptor mRNA in the rat and the mouse brain

Zigman, J. M., Jones, J. E., Lee, C. E., Saper, C. B., & Elmquist, J. K. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.20823 · Cited by 1,074

BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis

Rudic, R. D., McNamara, P., Curtis, A.-M., Boston, R. C., Panda, S., Hogenesch, J. B., & FitzGerald, G. A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020377 · Cited by 1,059

Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors

Rutter, J., Reick, M., Wu, L. C., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1060698 · Cited by 1,059

Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems

Date, Y., Ueta, Y., Yamashita, H., Yamaguchi, H., Matsukura, S., Kangawa, K., Sakurai, T., Yanagisawa, M., & Nakazato, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.2.748 · Cited by 1,050

The PAS Superfamily: Sensors of Environmental and Developmental Signals

Gu, Y.-Z., Hogenesch, J. B., & Bradfield, C. A. (2000) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.40.1.519 · Cited by 1,044

Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite

Abizaid, A., Liu, Z.-W., Andrews, Z. B., Shanabrough, M., Borok, E., Elsworth, J. D., Roth, R. H., Sleeman, M. W., Picciotto, M. R., Tschöp, M. H., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29867 · Cited by 984

Mammalian circadian biology: elucidating genome-wide levels of temporal organization

Lowrey, P. L., & Takahashi, J. S. (2004) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.5.061903.175925 · Cited by 976

Hypothalamic Orexin Neurons Regulate Arousal According to Energy Balance in Mice

Yamanaka, A., Beuckmann, C. T., Willie, J. T., Hara, J., Tsujino, N., Mieda, M., Tominaga, M., Yagami, K.-I., Sugiyama, F., Goto, K., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00331-3 · Cited by 958

PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis

Leone, T. C., Lehman, J. J., Finck, B. N., Schaeffer, P. J., Wende, A. R., Boudina, S., Courtois, M., Wozniak, D. F., Sambandam, N., Bernal-Mizrachi, C., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030101 · Cited by 951

Nuclear Receptor Expression Links the Circadian Clock to Metabolism

Yang, X., Downes, M., Yu, R. T., Bookout, A. L., He, W., Straume, M., Mangelsdorf, D. J., & Evans, R. M. (2006) · Cell · doi:10.1016/j.cell.2006.06.050 · Cited by 946

Is there an association between shift work and having a metabolic syndrome? Results from a population based study of 27 485 people

Karlsson, B., Knutsson, A., & Lindahl, B. (2001) · Occupational and Environmental Medicine · doi:10.1136/oem.58.11.747 · Cited by 924

Slow-wave sleep and the risk of type 2 diabetes in humans

Tasali, E., Leproult, R., Ehrmann, D. A., & Van Cauter, E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706446105 · Cited by 921

Circadian Regulator CLOCK Is a Histone Acetyltransferase

Doi, M., Hirayama, J., & Sassone‐Corsi, P. (2006) · Cell · doi:10.1016/j.cell.2006.03.033 · Cited by 910

A transcription factor response element for gene expression during circadian night

Ueda, H. R., Chen, W., Adachi, A. A., Wakamatsu, H., Hayashi, S., Takasugi, T., Nagano, M., Nakahama, K., Suzuki, Y., Sugano, S., et al. (2002) · Nature · doi:10.1038/nature00906 · Cited by 865

Circadian oscillation of a mammalian homologue of the Drosophila period gene

Tei, H., Okamura, H., Shigeyoshi, Y., Fukuhara, C., Ozawa, R., Hirose, M., & Sakaki, Y. (1997) · Nature · doi:10.1038/39086 · Cited by 792

Gut hormones and the regulation of energy homeostasis

Murphy, K. G., & Bloom, S. R. (2006) · Nature · doi:10.1038/nature05484 · Cited by 778

Circadian Cycling of the Mouse Liver Transcriptome, as Revealed by cDNA Microarray, Is Driven by the Suprachiasmatic Nucleus

Akhtar, R. A., Reddy, A. B., Maywood, E. S., Clayton, J. D., King, V. M., Smith, A. G., Gant, T. W., Hastings, M. H., & Kyriacou, C. P. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00759-5 · Cited by 777

Resonating circadian clocks enhance fitness in cyanobacteria

Ouyang, Y., Andersson, C. R., Kondo, T., Golden, S. S., & Johnson, C. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8660 · Cited by 772

Rev-erbα, a Heme Sensor That Coordinates Metabolic and Circadian Pathways

Yin, L., Wu, N., Curtin, J. C., Qatanani, M., Szwergold, N. R., Reid, R. A., Waitt, G. M., Parks, D. J., Pearce, K. H., Wisely, G. B., et al. (2007) · Science · doi:10.1126/science.1150179 · Cited by 707

RIGUI, a putative mammalian ortholog of the Drosophila period gene.

Sun, Z. S., Albrecht, U., Zhuchenko, O., Bailey, J., Eichele, G., & Lee, C.-C. (1997) · Cell · doi:10.1016/s0092-8674(00)80366-9 · Cited by 706

Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity

Parton, L. E., Ye, C. P., Coppari, R., Enriori, P. J., Choi, B., Zhang, C.-Y., Xu, C., Vianna, C. R., Balthasar, N., Lee, C. E., et al. (2007) · Nature · doi:10.1038/nature06098 · Cited by 700

The “other” circadian system: food as a Zeitgeber

Stephan, F. K. (2002) · Journal of Biological Rhythms · doi:10.1177/074873002129002591 · Cited by 672

Functional Identification of the Mouse Circadian Clock Gene by Transgenic BAC Rescue

Antoch, M. P., Song, E.-J., Chang, A., Vitaterna, M. H., Zhao, Y., Wilsbacher, L. D., Sangoram, A. M., King, D. P., Pinto, L. H., & Takahashi, J. S. (1997) · Cell · doi:10.1016/s0092-8674(00)80246-9 · Cited by 665

System-Driven and Oscillator-Dependent Circadian Transcription in Mice with a Conditionally Active Liver Clock

Kornmann, B., Schaad, O., Bujard, H., Takahashi, J. S., & Schibler, U. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050034 · Cited by 658

Leptin Regulation of the Mesoaccumbens Dopamine Pathway

Fulton, S., Pissios, P., Manchon, R. P., Stiles, L., Frank, L., Pothos, E. N., Maratos-Flier, E., & Flier, J. S. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.006 · Cited by 644

Transcriptional coactivator PGC-1α integrates the mammalian clock and energy metabolism

Liu, C., Li, S., Liu, T., Borjigin, J., & Lin, J. D. (2007) · Nature · doi:10.1038/nature05767 · Cited by 643

Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function.

Ahima, R. S., Prabakaran, D., & Flier, J. S. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1176 · Cited by 643

Roles of Circadian Rhythmicity and Sleep in Human Glucose Regulation

Cauter, E. V., Polonsky, K. S., & Scheen, A. J. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.5.0317 · Cited by 632

Leptin Regulates Striatal Regions and Human Eating Behavior

Farooqi, I. S., Bullmore, E., Keogh, J., Gillard, J., O'Rahilly, S., & Fletcher, P. C. (2007) · Science · doi:10.1126/science.1144599 · Cited by 622

The mammalian basic helix–loop–helix/PAS family of transcriptional regulators

Kewley, R. J., Whitelaw, M. L., & Chapman‐Smith, A. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(03)00211-5 · Cited by 602

The Molecular Clock Mediates Leptin-Regulated Bone Formation

Fu, L., Patel, M. S., Bradley, A., Wagner, E. F., & Karsenty, G. (2005) · Cell · doi:10.1016/j.cell.2005.06.028 · Cited by 590

Mitochondrial Energetics in the Heart in Obesity-Related Diabetes

Boudina, S., Sena, S., Theobald, H., Sheng, X., Wright, J. J., Hu, X. X., Aziz, S., Johnson, J. I., Bugger, H., Zaha, V. G., et al. (2007) · Diabetes · doi:10.2337/db07-0481 · Cited by 586

Identification of heme as the ligand for the orphan nuclear receptors REV-ERBα and REV-ERBβ

Raghuram, S., Stayrook, K. R., Huang, P., Rogers, P. M., Nosie, A. K., McClure, D. B., Burris, L. L., Khorasanizadeh, S., Burris, T. P., & Rastinejad, F. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1344 · Cited by 560

Circadian orchestration of the hepatic proteome

Reddy, A. B., Karp, N. A., Maywood, E. S., Sage, E. A., Deery, M., O'Neill, J. S., Wong, G. K. Y., Chesham, J., Odell, M., Lilley, K. S., et al. (2006) · Current Biology · doi:10.1016/j.cub.2006.04.026 · Cited by 548

Brain and muscle Arnt-like protein-1 (BMAL1), a component of the molecular clock, regulates adipogenesis

Shimba, S., Ishii, N., Ohta, Y., Ohno, T., Watabe, Y., Hayashi, M., Wada, T., Aoyagi, T., & Tezuka, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502383102 · Cited by 536

The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock

Oster, H., Damerow, S., Kiessling, S., Jakubcakova, V., Abraham, D., Tian, J., Hoffmann, M. W., & Eichele, G. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.07.002 · Cited by 528

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons

Claret, M., Smith, M. A., Batterham, R. L., Selman, C., Choudhury, A. I., Fryer, L. G. D., Clements, M., Al‐Qassab, H., Heffron, H., Xu, A. W., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31516 · Cited by 522

Playing with bone and fat

Gimble, J. M., Zvonic, S., Floyd, Z. E., Kassem, M. S., & NUTTALL, M. E. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20777 · Cited by 508

Characterization of Peripheral Circadian Clocks in Adipose Tissues

Zvonic, S., Ptitsyn, A. A., Conrad, S. A., Scott, L. K., Floyd, Z. E., Kilroy, G. E., Wu, X., Goh, B. C. K., Mynatt, R. L., & Gimble, J. M. (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-0873 · Cited by 503

The orphan nuclear receptor RORα regulates circadian transcription of the mammalian core-clock Bmal1

Akashi, M., & Takumi, T. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb925 · Cited by 501

Regulation of dopaminergic transmission and cocaine reward by the Clock gene

McClung, C. A., Sidiropoulou, K., Vitaterna, M., Takahashi, J. S., White, F. J., Cooper, D. C., & Nestler, E. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503584102 · Cited by 493

Multiple signaling pathways elicit circadian gene expression in cultured Rat-1 fibroblasts

Balsalobre, A., Marcacci, L., & Schibler, U. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00758-2 · Cited by 485

The dorsomedial hypothalamic nucleus is critical for the expression of food-entrainable circadian rhythms

Gooley, J. J., Schomer, A., & Saper, C. B. (2006) · Nature Neuroscience · doi:10.1038/nn1651 · Cited by 453

Regulation of CLOCK and MOP4 by Nuclear Hormone Receptors in the Vasculature

McNamara, P., Seo, S., Rudic, R. D., Sehgal, A., Chakravarti, D., & FitzGerald, G. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00401-9 · Cited by 445

Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism

Matsumoto, M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27047 · Cited by 435

NPAS2: A Gas-Responsive Transcription Factor

Dioum, E. M., Rutter, J. P., Tuckerman, J. R., Gonzalez, G., Gilles‐Gonzalez, M., & McKnight, S. L. (2002) · Science · doi:10.1126/science.1078456 · Cited by 432

Chronic jet-lag increases mortality in aged mice

Davidson, A. J., Sellix, M. T., Daniel, J., Yamazaki, S., Menaker, M., & Block, G. D. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.058 · Cited by 427

Circadian variation of blood pressure and the vascular response to asynchronous stress

Curtis, A. M., Cheng, Y., Kapoor, S. C., Reilly, D. F., Price, T. S., & FitzGerald, G. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611680104 · Cited by 408

A brain-liver circuit regulates glucose homeostasis

Pocai, A., Obici, S., Schwartz, G. J., & Rossetti, L. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.11.001 · Cited by 392

Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei

Elmquist, J. K., Ahima, R. S., Elias, C. F., Flier, J. S., & Saper, C. B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.2.741 · Cited by 376

Identification of the circadian transcriptome in adult mouse skeletal muscle

McCarthy, J. J., Andrews, J. L., McDearmon, E. L., Campbell, K. S., Barber, B. K., Miller, B. H., Walker, J. R., Hogenesch, J. B., Takahashi, J. S., & Esser, K. A. (2007) · Physiological Genomics · doi:10.1152/physiolgenomics.00066.2007 · Cited by 368

Reciprocal Regulation of Brain and Muscle Arnt-Like Protein 1 and Peroxisome Proliferator-Activated Receptor α Defines a Novel Positive Feedback Loop in the Rodent Liver Circadian Clock

Canaple, L., Rambaud, J., Dkhissi‐Benyahya, O., Rayet, B., Tan, N. S., Michalik, L., Delaunay, F., Wahli, W., & Laudet, V. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0052 · Cited by 359

Minireview: Entrainment of the Suprachiasmatic Clockwork in Diurnal and Nocturnal Mammals

Challet, É. (2007) · Endocrinology · doi:10.1210/en.2007-0804 · Cited by 356

Reciprocal regulation of haem biosynthesis and the circadian clock in mammals

Kaasik, K., & Lee, C. C. (2004) · Nature · doi:10.1038/nature02724 · Cited by 352

Sleep and circadian rhythms: key components in the regulation of energy metabolism

Laposky, A. D., Bass, J., Kohsaka, A., & Turek, F. W. (2008) · FEBS Letters · doi:10.1016/j.febslet.2007.06.079 · Cited by 351

Dissecting the Functions of the Mammalian Clock Protein BMAL1 by Tissue-Specific Rescue in Mice

McDearmon, E. L., Patel, K., Ko, C. H., Walisser, J. A., Schook, A. C., Chong, J. L., Wilsbacher, L. D., Song, E. J., Hong, H., Bradfield, C. A., et al. (2006) · Science · doi:10.1126/science.1132430 · Cited by 324

Long-term orexigenic effects of AgRP-(83—132) involve mechanisms other than melanocortin receptor blockade

Hagan, M. M., Rushing, P. A., Pritchard, L. M., Schwartz, M. W., Strack, A. M., der Ploeg, L. H. T. V., Woods, S. C., & Seeley, R. J. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.1.r47 · Cited by 320

Glucose Down-regulates Per1 and Per2mRNA Levels and Induces Circadian Gene Expression in Cultured Rat-1 Fibroblasts

Hirota, T., Okano, T., Kokame, K., Shirotani-Ikejima, H., Miyata, T., & Fukada, Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206233200 · Cited by 317

The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker

Mieda, M., Williams, S. C., Richardson, J. A., Tanaka, K., & Yanagisawa, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604189103 · Cited by 290

Diet-induced Obesity Alters AMP Kinase Activity in Hypothalamus and Skeletal Muscle

Martin, T. L., Alquier, T., Asakura, K., Furukawa, N., Preitner, F., & Kahn, B. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512831200 · Cited by 287

Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex

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Glucocorticoid signaling synchronizes the liver circadian transcriptome

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