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The Meter of Metabolism
Open accessAbstract
The circadian system orchestrates the temporal organization of many aspects of physiology, including metabolism, in synchrony with the 24 hr rotation of the Earth. Like the metabolic system, the circadian system is a complex feedback network that involves interactions between the central nervous system and peripheral tissues. Emerging evidence suggests that circadian regulation is intimately linked to metabolic homeostasis and that dysregulation of circadian rhythms can contribute to disease. Conversely, metabolic signals also feed back into the circadian system, modulating circadian gene expression and behavior. Here, we review the relationship between the circadian and metabolic systems and the implications for cardiovascular disease, obesity, and diabetes.
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“The term chrono-nutrition was introduced in 1986 by Delabois (10) but was not much used beyond its application in weight loss diets.”
From Meal irregularity and cardiometabolic consequences: results from observational and intervention studies (2016) · cites this paper as [10]
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“Each endpoint was adjusted for age and regularly updated information throughout follow-up on: alcohol consumption, physical exercise, multivitamin use, menopausal status and postmenopausal hormone use, physical examination in the past 2 years, healthy eating score37 (without components of multivitamin and alcohol, which were adjusted individually), smoking status, pack-years, and BMI.”
From Total and Cause-Specific Mortality of U.S. Nurses Working Rotating Night Shifts (2015) · cites this paper as [37]
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“The circadian system and its prime marker, melatonin, are considered to have antitumor effects through multiple pathways, including antioxidant activity, anti-inflammatory effects, and immune enhancement.33-37”
From Total and Cause-Specific Mortality of U.S. Nurses Working Rotating Night Shifts (2015) · cites this paper as [37]
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“Introduction Multiple aspects of behaviour and physiology show circadian rhythmicity (Green et al. 2008).”
Branche, B. L., Howard, L. E., Moreira, D. M., Roehrborn, C. G., Castro‐Santamaria, R., Andriole, G. L., Hopp, M. L., & Freedland, S. J. (2017) · The Journal of Urology · doi:10.1016/j.juro.2017.08.108 · Cited by 24
Interplay Between the Circadian Clock and Sirtuins
Zhuang, Y., Zhang, Y., Liu, C., & Zhong, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111469 · Cited by 25
Artificial light at night interacts with predatory threat to alter reef fish metabolite profiles
Hillyer, K. E., Beale, D. J., & Shima, J. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.144482 · Cited by 25
Deng, F., & Yang, K. (2019) · Journal of Cancer · doi:10.7150/jca.29212 · Cited by 24
“The abnormal expression of clock genes and disruption of circadian rhythms can markedly affect the development of several diseases, including cancer, cardiovascular disease, diabetes and depression [8,9,22,23].”
Cardiolipin Synthesis in Skeletal Muscle Is Rhythmic and Modifiable by Age and Diet
Nohara, K., Kim, E., Wirianto, M., Mileykovskaya, E., Dowhan, W., Chen, Z., & Yoo, S. H. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/5304768 · Cited by 25
“It is well established that the clock and metabolism are closely connected [12, 13].”
New policies on skin-to-skin contact warrant an oxytocin-based perspective on perinatal health care
Bergman, N. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1385320 · Cited by 30
“Signals from the olfactory bulb reach hypothalamic nuclei that control sleep and feeding, coordinating 1-h sleep cycles with suckling at the breast (Green et al., 2008).”
InfluentialParsanathan, R., & Jain, S. K. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.07.019 · Cited by 23
Gül, Ş., Aydın, C., Özcan, O., Gürkan, B., Sürme, S., Barış, İ., & Kavaklı, İ. H. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.014333 · Cited by 23
“The circadian clock modulates numerous behavioral and physiological processes through rhythmic transcriptional regulation (1, 2).”
Chrono‐nutrition – an emerging, modifiable risk factor for chronic disease?
Pot, G. K. (2021) · Nutrition Bulletin · doi:10.1111/nbu.12498 · Cited by 27
Wagner, P. M., Prucca, C. G., Caputto, B. L., & Guido, M. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158289 · Cited by 24
Disruption of the circadian rhythms and its relationship with pediatric obesity
Kawai, M. (2021) · Pediatrics International · doi:10.1111/ped.14992 · Cited by 22
Understanding the significance of biological clock and its impact on cancer incidence
Malik, S., Stokes, J. A., III, Manne, U., Singh, R., & Mishra, M. K. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.12.006 · Cited by 25
Gubin, D. G., Neroev, V. V., Malishevskaya, Т. N., Kolomeichuk, S. N., Weinert, D., Yuzhakova, N., Nelaeva, A. A., Filippova, Y., & Cornélissen, G. (2022) · Applied Sciences · doi:10.3390/app12136374 · Cited by 23
Animal clocks: a multitude of molecular mechanisms for circadian timekeeping
Pegoraro, M., & Tauber, E. (2011) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.58 · Cited by 24
Aging alters circadian regulation of redox in Drosophila
Klichko, V. I., Chow, E. S., Kotwica‐Rolinska, J., Orr, W. C., Giebultowicz, J. M., & Radyuk, S. N. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00083 · Cited by 23
“CCGs often constitute a rate-limiting step in pathways involved in metabolism, energy balance, DNA-damage repair, and xenobiotic detoxification in both mammals (Claudel et al., 2007; Green et al., 2008; Kang et al., 2009) and Drosophila (Hooven et al., 2009; Beaver et al., 2010; Xu et al., 2011).”
Aging and the Mammalian regulatory triumvirate.
Rollo, C. D. (2010) · Europe PMC (PubMed Central) · Cited by 23
The neural circadian system of mammals
Piggins, H. D., & Guilding, C. (2011) · Essays in Biochemistry · doi:10.1042/bse0490001 · Cited by 24
“The ubiquitous importance of circadian-clock genes in controlling a range of fundamental biological processes is an emerging theme in biology, highlighting the wide-ranging scope of this fi eld [69,70].”
Circadian clock genes and myocardial infarction in patients with type 2 diabetes mellitus
Škrlec, I., Milić, J., Cilenšek, I., Petrovič, D., Wagner, J., & Peterlin, B. (2019) · Gene · doi:10.1016/j.gene.2019.03.038 · Cited by 24
Sussman, W., Stevenson, M., Mowdawalla, C., Mota, S., Ragolia, L., & Pan, X. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00058.2019 · Cited by 24
“Circadian rhythms are ~24-h cycles of physiologic processes, allowing organisms to synchronize with their environment (16, 51, 52).”
Liu, Y., Zhang, Y., Yin, J., Ruan, Z., Wu, X., & Yin, Y. (2019) · Chronobiology International · doi:10.1080/07420528.2019.1637347 · Cited by 22
“The circadian system is a complex feedback network that is closely connected to metabolic homeostasis and involves interactions between the central nervous system and peripheral tissues (Green et al. 2008).”
Buckley, T. N., Omotola, O. B., Archer, L. A., Rostron, C. R., Kamineni, E. P., Llanora, J., Chalfant, J. M., Lei, F., Slade, E., & Pendergast, J. S. (2021) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00150.2020 · Cited by 21
Araújo, L. D., Roa, S. L. R., Bueno, A. C., Coeli‐Lacchini, F. B., Martins, C. S., Uchôa, E. T., Antunes‐Rodrigues, J., Elias, L. L. K., Elias, P. C. L., Moreira, A. C., et al. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00567 · Cited by 25
“Bmal1 andClock genes also increase themRNA levels of Rev-erbα and Rorα, which compete for the binding to the retinoic acidrelated orphan receptor response elements (ROREs) repressing or activating the expression of Bmal1 (Green et al., 2008).”
Circadian Clocks in Fuel Harvesting and Energy HomeostasisPreprint
Ramsey, K. M., & Bass, J. T. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.010546 · Cited by 24
“Indeed the daily fasting–feeding cycle is closely coupled with the sleep–wake cycle, and both processes are influenced by a combination of circadian and nutrient signals (Laposky et al. 2008a; Green et al. 2008).”
Self-citationCircadian rhythms and the liver
Costa, R., Mangini, C., Domenie, E. D., Zarantonello, L., & Montagnese, S. (2023) · Liver International · doi:10.1111/liv.15501 · Cited by 23
Kim, H., Lee, M., Lee, Y., Lee, B., Soo, B., & Kang, E. S. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.775753 · Cited by 22
“The concept of variability is applied to the control of metabolism and energy homeostasis, such as circadian rhythms (47).”
Shift work and risk of non-cancer mortality in a cohort of German male chemical workers
Yong, M., Nasterlack, M., Germann, C., Lang, S., & Oberlinner, C. (2013) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-013-0922-5 · Cited by 22
“…by shift work could be triggered by mismatch of circadian rhythm and sleep, maladjustment of social integration, change of health-related behaviours, and resulting metabolic disorders through a number of biological pathways (Boggild and Knutsson 1999; Green et al. 2008; Puttonen et al. 2010).”
Tseng, H.-L., Yang, S.-C., Yang, S.-H., & Shieh, K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120380 · Cited by 23
Daily rhythms of serum lipids in dogs: influences of lighting and fasting cycles.
Bertolucci, C., Fazio, F., & Piccione, G. G. (2008) · PubMed Central · Cited by 22
Kim, E., Yoo, S. H., & Chen, Z. (2022) · F1000Research · doi:10.12688/f1000research.126364.1 · Cited by 24
Metadata
- Authors
- Green, C. B., Takahashi, J. S., & Bass, J.
- Affiliations
- University of Virginia (US)
- Northwestern University (US)
- Corresponding author
- Takahashi, Joseph S.
- Bass, Joseph
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 134
- Issue
- 5
- Pages
- 728-742
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC3760165
- OpenAlex
- W2063946784
- Cited by
- 902
- References
- 145
- Citations by year
- 2026: 22 · 2025: 29 · 2024: 29 · 2023: 33 · 2022: 51 · 2021: 49 · 2020: 36 · 2019: 44 · 2018: 35 · 2017: 52 · 2016: 56 · 2015: 51 · 2014: 65 · 2013: 61 · 2012: 74
- FWCI
- 7.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- Amylin Pharmaceuticals
- National Institutes of Health (5p50mh074924-05)
- National Institute on Aging (P01AG011412)
- National Heart, Lung, and Blood Institute (R01HL075029)
- National Institute of Mental Health (P50 MH-074924, R01MH078024)
- National Institute of General Medical Sciences (R01GM076626)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Keywords
- circadian rhythm, metabolism, circadian regulation, metabolic homeostasis, circadian gene expression, central nervous system, peripheral tissues, cardiovascular disease, obesity, diabetes mellitus
- MeSH terms
- Animals, Biological Clocks, Circadian Rhythm, Feeding Behavior, Humans, Metabolic Networks and Pathways
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