The DOI matches its Crossref record; 145 of the 145 references it cites were found in a registry or an index.
The Meter of Metabolism
Open accessAbstract
The circadian system orchestrates the temporal organization of many aspects of physiology, including metabolism, in synchrony with the 24 hr rotation of the Earth. Like the metabolic system, the circadian system is a complex feedback network that involves interactions between the central nervous system and peripheral tissues. Emerging evidence suggests that circadian regulation is intimately linked to metabolic homeostasis and that dysregulation of circadian rhythms can contribute to disease. Conversely, metabolic signals also feed back into the circadian system, modulating circadian gene expression and behavior. Here, we review the relationship between the circadian and metabolic systems and the implications for cardiovascular disease, obesity, and diabetes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The term chrono-nutrition was introduced in 1986 by Delabois (10) but was not much used beyond its application in weight loss diets.”
From Meal irregularity and cardiometabolic consequences: results from observational and intervention studies (2016) · cites this paper as [10]
In the citing paper
“Each endpoint was adjusted for age and regularly updated information throughout follow-up on: alcohol consumption, physical exercise, multivitamin use, menopausal status and postmenopausal hormone use, physical examination in the past 2 years, healthy eating score37 (without components of multivitamin and alcohol, which were adjusted individually), smoking status, pack-years, and BMI.”
From Total and Cause-Specific Mortality of U.S. Nurses Working Rotating Night Shifts (2015) · cites this paper as [37]
In the citing paper
“The circadian system and its prime marker, melatonin, are considered to have antitumor effects through multiple pathways, including antioxidant activity, anti-inflammatory effects, and immune enhancement.33-37”
From Total and Cause-Specific Mortality of U.S. Nurses Working Rotating Night Shifts (2015) · cites this paper as [37]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485
Self-citationTaheri, S., Lin, L., Austin, D., Young, T., & Mignot, E. (2004) · PLoS Medicine · doi:10.1371/journal.pmed.0010062 · Cited by 2,477
Spiegel, K., Tasali, E., Penev, P., & Cauter, E. V. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-141-11-200412070-00008 · Cited by 2,459
Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.183500 · Cited by 2,394
Yoo, S.-H., Yamazaki, S., Lowrey, P. L., Shimomura, K., Ko, C. H., Buhr, E. D., Siepka, S. M., Hong, H.-K., Oh, W. J., Yoo, O. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308709101 · Cited by 2,329
Self-citationCoordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,310
Self-citationThe biology of incretin hormones
Drucker, D. J. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.004 · Cited by 2,210
Preitner, N., Damiola, F., Luis-Lopez-Molina, Zakany, J., Duboule, D., Albrecht, U., & Schibler, U. (2002) · Cell · doi:10.1016/s0092-8674(02)00825-5 · Cited by 2,198
Metabolic control through the PGC-1 family of transcription coactivators
Lin, J., Handschin, C., & Spiegelman, B. M. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.004 · Cited by 2,130
A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells
Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001
Flagged first, then by citations
Cited by
Sorted by citations
Items 301–400 of 903
Circadian clock controls rhythms in ketogenesis by interfering with PPARα transcriptional network
Mezhnina, V., Ebeigbe, O. P., Velingkaar, N., Poe, A., Sandlers, Y. I., & Kondratov, R. V. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2205755119 · Cited by 55
Epigenetic priming of the metabolic syndrome
Bruce, K. D., & Cagampang, F. R. A. (2011) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2011.559370 · Cited by 54
Circadian Epigenomic Remodeling and Hepatic Lipogenesis: Lessons from HDAC3Preprint
Sun, Z., Feng, D., Everett, L. J., Bugge, A. K., & Lazar, M. A. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.011494 · Cited by 57
“Although composed of similar molecular components, the central clock is mainly entrained by light, whereas the peripheral clocks receive systemic signals independently from both the central clock and other inputs such as feeding behavior (Green et al. 2008).”
InfluentialThe circadian clock transcriptional complex: metabolic feedback intersects with epigenetic control
Masri, S., Zocchi, L., Katada, S., Mora, E. M., & Sassone‐Corsi, P. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06649.x · Cited by 53
Timed daily exercise remodels circadian rhythms in mice
Hughes, A. T. L., Samuels, R. E., Baño‐Otálora, B., Belle, M. D. C., Wegner, S., Guilding, C., Northeast, R. C., Loudon, A. S. I., Gigg, J., & Piggins, H. D. (2021) · Communications Biology · doi:10.1038/s42003-021-02239-2 · Cited by 57
Bhoi, J. D., Goel, M., Ribelayga, C., & Mangel, S. C. (2022) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2022.101119 · Cited by 51
Vu, J. P., Larauche, M. H., Flores, M., Luong, L., Norris, J., Oh, S., Liang, L.-J. F., Waschek, J. A., Pisegna, J. R., & Germano, P. M. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0556-z · Cited by 55
“Currently, studies in rodents and humans have suggested that the timing of food intake and energy balance plays an important role in the maintenance of a healthy metabolism and body phenotype (Green et al. 2008), but the published data are still very controversial.”
Microarray Analysis of Natural Socially Regulated Plasticity in Circadian Rhythms of Honey Bees
Rodriguez‐Zas, S. L., Southey, B. R., Shemesh, Y., Rubin, E. B., Cohen, M., Robinson, G. E., & Bloch, G. (2012) · Journal of Biological Rhythms · doi:10.1177/0748730411431404 · Cited by 54
“These results are consistent with other microarray studies and other lines of evidence that the circadian clock influences many metabolic processes (Green et al., 2008; Ueda et al., 2002; Panda et al., 2002; Harbison and Sehgal, 2009; Bass and Takahashi, 2010).”
The role of circadian clocks in metabolic disease.
Li, M., Li, C.-M., & Wang, Z. (2012) · Europe PMC (PubMed Central) · Cited by 52
Malloy, J. N., Paulose, J. K., Li, Y., & Cassone, V. M. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00369.2011 · Cited by 52
“BIOLOGICAL RHYTHMS and the clocks that regulate them are important features of gastrointestinal (GI) and metabolic physiology that impact human health at several levels (5, 11, 12).”
Circadian clock components in the rat neocortex: daily dynamics, localization and regulation
Rath, M. F., Rohde, K., Fahrenkrug, J., & Møller, M. (2012) · Brain Structure and Function · doi:10.1007/s00429-012-0415-4 · Cited by 51
“In addition, variations in body temperature and restrictions in food-intake are known to entrain peripheral clocks (Green et al. 2008; Buhr et al. 2010).”
Genetic Predisposition to Long-Term Nondiabetic Deteriorations in Glucose Homeostasis
Renström, F., Shungin, D., Johansson, I., the MAGIC Investigators, Florez, J. C., Hallmans, G., Hu, F. B., & Franks, P. W. (2010) · Diabetes · doi:10.2337/db10-0933 · Cited by 52
“Some have hypothesized that effects of disturbed sleep patterns on risk of metabolic disorders (36,37) and decreased melatonin secretion might be influence by MTNR1B variation (38).”
Circadian Clock, Time-Restricted Feeding and Reproduction
Pan, X., Taylor, M. J., Cohen, E., Hanna, N. N., & Mota, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030831 · Cited by 54
“Under the control of the circadian clock, Nocturnin has rhythmic expression in multiple mouse tissues [11,100].”
Genetic dissection of sleep–metabolism interactions in the fruit fly
Yurgel, M. E., Masek, P., DiAngelo, J. R., & Keene, A. C. (2014) · Journal of Comparative Physiology A · doi:10.1007/s00359-014-0936-9 · Cited by 54
Molecular Targets for Small-Molecule Modulators of Circadian Clocks
He, B., & Chen, Z. (2016) · Current Drug Metabolism · doi:10.2174/1389200217666160111124439 · Cited by 52
Circadian clocks, diets and aging
Chaudhari, A., Gupta, R., Makwana, K., & Kondratov, R. V. (2016) · Nutrition and Healthy Aging · doi:10.3233/nha-160006 · Cited by 53
“For example, epidemiological data on shift workers show that the risk of metabolic, cardiovascular diseases and cancer is significantly increased in shift workers in comparison with the general population [2, 5, 6].”
Circadian Intraocular Pressure Rhythms in Athletic Horses under Different Lighting Regime
Bertolucci, C., Giudice, E., Fazio, F., & Piccione, G. G. (2009) · Chronobiology International · doi:10.1080/07420520902751035 · Cited by 53
“Temporal variations of IOP are driven by the SCN, which controls the activity of sympathetic and parasympathetic ocular innervations (Bartness et al., 2001).”
Asthma diagnosis: into the fourth dimension
Wang, R., Murray, C. S., Fowler, S. J., Simpson, A., & Durrington, H. J. (2021) · Thorax · doi:10.1136/thoraxjnl-2020-216421 · Cited by 52
Mice Deficient in Cryptochrome 1 (Cry1−/−) Exhibit Resistance to Obesity Induced by a High-Fat Diet
Griebel, G., Ravinet‐Trillou, C., Beeské, S., Avenet, P., & Pichat, P. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00049 · Cited by 53
Ma, X., Zhou, Z., Chen, Y., Wu, Y., & Liu, Y. (2015) · Diabetologia · doi:10.1007/s00125-015-3807-1 · Cited by 51
“The circadian clock is an intrinsic time-keeping system that enables organisms to adapt their physiological and behavioural rhythms in response to the external environment [13].”
Principles for circadian orchestration of metabolic pathways
Thurley, K., Herbst, C., Wesener, F., Koller, B., Wallach, T. E., Maier, B., Kramer, A., & Westermark, P. O. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613103114 · Cited by 54
“In mammals, circadian rhythms in the expression of thousands of genes in various metabolic tissues ensure up- or down-regulation of important metabolic processes in anticipation of daily activity and rest periods (1, 2).”
Deletion of BMAL1 in Smooth Muscle Cells Protects Mice From Abdominal Aortic Aneurysms
Lutshumba, J., Liu, S., Zhong, Y., Hou, T., Daugherty, A., Lu, H. S., Guo, Z., & Gong, M. C. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.310153 · Cited by 50
“clock gene—is essential for normal circadian rhythmicity in physiology and behavior.(6) Global deletion of BMAL1 causes”
Pandalai, S. P., Schulte, P. A., & Miller, D. B. (2013) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.3363 · Cited by 52
“Cyclic, clock-like expression of “clock genes,” in central and peripheral tissue neurons, liver, and fat cells, with expression in rhythmic patterns synced to external environments, impacts food intake, energy expenditure, and sleep (117).”
Complex dynamics of transcription regulation
Stavreva, D. A., Varticovski, L., & Hager, G. L. (2012) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2012.03.004 · Cited by 53
“Circadian clock is another autonomous system which can persist without any exogenous stimuli, however, in reality it is a subject of daily entrainment by exogenous cues like light and feeding [5,46,111,116,142,147,169].”
High-salt diet advances molecular circadian rhythms in mouse peripheral tissues
Oike, H., Nagai, K., Fukushima, T., Ishida, N., & Kobori, M. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.09.072 · Cited by 49
Sutton, G. M., Begriche, K., Kumar, K. G., Gimble, J. M., Pérez–Tilve, D., Nogueiras, R., McMillan, R. P., Hulver, M. W., Tschöp, M. H., & Butler, A. A. (2009) · The FASEB Journal · doi:10.1096/fj.09-142000 · Cited by 50
“Clock mechanisms synchronizing metabolism with the circadian day developed early during evolution and have been described in life forms ranging from prokaryotes to complex metazoans (23).”
InfluentialTakeda, Y., Kang, H. S., Angers, M., & Jetten, A. M. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq1335 · Cited by 48
DNA methylation signature is prognostic of choroid plexus tumor aggressiveness
Pieńkowska, M., Choufani, S., Turinsky, A. L., Guha, T., Merino, D. M., Novokmet, A., Brudno, M., Weksberg, R., Shlien, A., Hawkins, C. E., et al. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0708-z · Cited by 48
Wehrens, S. M. T., Hampton, S. M., Finn, R. E., & Skene, D. J. (2010) · Journal of Endocrinology · doi:10.1677/joe-10-0077 · Cited by 47
“2007, Green et al .”
Understanding circadian regulation of mammalian cell function, protein homeostasis, and metabolism
Stangherlin, A., Seinkmane, E., & O'Neill, J. S. (2021) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2021.100391 · Cited by 46
Guido, M. E., Monjes, N. M., Wagner, P. M., & Salvador, G. A. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02595-4 · Cited by 46
Circadian Regulation of Macronutrient Absorption
Hussain, M. M., & Pan, X. (2015) · Journal of Biological Rhythms · doi:10.1177/0748730415599081 · Cited by 53
“These 2 transcriptional regulatory loops largely determine the cyclic expression of several genes that show circadian rhythms (Green et al., 2008; Bass and Takahashi, 2010; Welsh et al., 2010; Asher and Schibler, 2011; Bass, 2012; Partch et al., 2014; Hussain and Pan, 2014; Asher and Sassone-Corsi, 2015).”
Rath, M. F., Rovsing, L., & Møller, M. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1878-9 · Cited by 46
“…hypothalamus controlling daily changes in secretion of neuroendocrine hormones, body temperature, and activity has been well documented; however, recent investigations have shown the presence of extra-hypothalamic peripheral clocks exhibiting autonomous rhythms in many tissues (Green et al. 2008).”
Gimble, J. M., & Floyd, Z. E. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00090.2009 · Cited by 46
“Reviews in the current Journal of Applied Physiology series and other journals (28, 48, 68) have highlighted the circadianmetabolic relationship in great detail.”
Griebel, G., Pichat, P., Boulay, D., Naimoli, V., Potestio, L., Featherstone, R. E., Sahni, S., Defex, H., Desvignes, C., Slowinski, F., et al. (2016) · Scientific Reports · doi:10.1038/srep35320 · Cited by 47
Calorie restriction effects on circadian rhythms in gene expression are sex dependent
Astaf’ev, A. A., Patel, S. A., & Kondratov, R. V. (2017) · Scientific Reports · doi:10.1038/s41598-017-09289-9 · Cited by 49
Cancer cell metabolism connects epigenetic modifications to transcriptional regulation
Morrison, A. J. (2021) · FEBS Journal · doi:10.1111/febs.16032 · Cited by 47
Multiscale model for the assessment of autonomic dysfunction in human endotoxemia
Foteinou, P. T., Calvano, S. E., Lowry, S. F., & Androulakis, I. P. (2010) · Physiological Genomics · doi:10.1152/physiolgenomics.00184.2009 · Cited by 45
Photoreceptor phagocytosis is mediated by phosphoinositide signaling
Mustafi, D., Kevany, B. M., Genoud, C., Bai, X., & Palczewski, K. (2013) · The FASEB Journal · doi:10.1096/fj.13-237537 · Cited by 46
“The prevailing idea is that circadian clocks control cellular physiology through transcription as anywhere from 3 to 20% of transcripts in various mouse tissues undergo circadian oscillations (57).”
Circadian influences on myocardial infarction
Virag, J. A. I., & Lust, R. M. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00422 · Cited by 47
“…| 1 but a few studies suggest that the circadian effects likely are real in their impact on myocardial infarction incidence (Bray and Young, 2007; Green et al., 2008; Prasai et al., 2008; Ruger and Scheer, 2009; Durgan and Young, 2010; Maury et al., 2010; Bailey et al., 2014; Nedeltcheva and…”
Metformin Corrects Abnormal Circadian Rhythm and Kir4.1 Channels in Diabetes
Alex, A., Luo, Q., Mathew, D., Di, R., & Bhatwadekar, A. D. (2020) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.61.6.46 · Cited by 48
Wang, H., Zhang, H., & Su, Y. (2022) · Animals · doi:10.3390/ani12131677 · Cited by 48
Gong, C., Li, C., Qi, X., Song, Z., Wu, J., Hughes, M. E., & Li, X. (2015) · Chronobiology International · doi:10.3109/07420528.2015.1085388 · Cited by 43
“These interlocking circadian feedback loops in turn regulate temporal gene expression and control metabolic activities in anticipation of environmental changes (Green et al., 2008).”
Does the circadian system regulate lactation?
Plaut, K. I., & Casey, T. (2011) · animal · doi:10.1017/s1751731111002187 · Cited by 48
“Metabolic function and circadian clocks are tightly interwoven such that clocks drive metabolic processes and various metabolic parameters affect clocks (Green et al., 2008).”
Glucocorticoid Regulation of Clock Gene Expression in the Mammalian Limbic Forebrain
Segall, L. A., & Amir, S. (2010) · Journal of Molecular Neuroscience · doi:10.1007/s12031-010-9341-1 · Cited by 45
“These rhythms in clock gene expression presumably serve to modulate the behavioral and physiological output of specific tissues as well as the fluctuations in cellular and metabolic activity (Schibler and Sassone-Corsi 2002; Hastings et al. 2003; Green et al. 2008 ).”
Galijatovic, E. A. A., Holst, B., Sparsø, T., Grarup, N., Banasik, K., Holmkvist, J., Jørgensen, T., Borch‐Johnsen, K., Egerod, K. L., Lauritzen, T., et al. (2010) · Diabetes · doi:10.2337/db09-1757 · Cited by 45
“Circadian rhythms are highly involved in regulation of a wide range of physiological processes including metabolism (8), and circadian disturbances including shift work and sleep disorders increase the risk of both cardiovascular and metabolic disorders (9,10).”
Wu, T., Ni, Y., Kato, H., & Fu, Z. (2010) · Chronobiology International · doi:10.3109/07420520903398625 · Cited by 45
“The circadian timing system, which is thought to be important to an organism in predicting and adapting to environmental cues of light, food, and temperature, is present in almost all living organisms (Feillet et al., 2006; Green et al., 2008).”
Global analysis of circulating metabolites in hibernating ground squirrels
Nelson, C. J., Otis, J. P., & Carey, H. V. (2010) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2010.07.002 · Cited by 45
“In association with other nuclear receptors, RORα has been implicated in regulation of the circadian clock and metabolism (Duez and Staels, 2008; Green et al., 2008).”
Developmental origins of the metabolic syndrome: Body clocks and stress responses
Cagampang, F. R. A., Poore, K. R., & Hanson, M. A. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.09.005 · Cited by 44
Circadian clock signals in the adrenal cortex
Ota, T., Fustin, J., Yamada, H., Doi, M., & Okamura, H. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.08.010 · Cited by 44
“These feedback loops generate the rhythmic expression of not only clock genes themselves, but also of output genes that control the circadian changes in physiology and behavior (Green et al., 2008; Okamura et al., 2010).”
m6A mRNA Methylation: A New Circadian Pacesetter
Hastings, M. H. (2013) · Cell · doi:10.1016/j.cell.2013.10.028 · Cited by 44
GABAergic Synaptic Plasticity during a Developmentally Regulated Sleep-Like State inC. elegans
Dabbish, N., & Raizen, D. M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0742-11.2011 · Cited by 42
“, 2006) and functions both to modulate clock timing and to act as a link between the circadian clock and metabolism (Green et al., 2008).”
NAD+ in Cancer Prevention and Treatment: Pros and Cons
Poljšak, B. (2016) · Journal of Clinical & Experimental Oncology · doi:10.4172/2324-9110.1000165 · Cited by 45
“NAD+ levels are also involved in the circadian clock regulation and this might be the missing link between the circadian clock, cell cycle control, DNA damage repair and cellular metabolism [48,49].”
Circadian Rhythms in Liver Physiology and Liver Diseases
Tong, X., & Yin, L. (2013) · Comprehensive physiology · doi:10.1002/cphy.c120017 · Cited by 50
“There is solid evidence suggesting an essential role of clock proteins in glucose metabolism based on both animal and human studies (15, 107, 133).”
Lee, Y.-J., Han, D.-H., Pak, Y. K., & Cho, S. (2012) · Experimental & Molecular Medicine · doi:10.3858/emm.2012.44.11.073 · Cited by 43
“Especially notable is metabolic clockwork which has great implications in diverse human pathologies including metabolic syndrome (reviewed in Green et al., 2008).”
Circadian Proteins and Genotoxic Stress Response
Antoch, M. P., & Kondratov, R. V. (2010) · Circulation Research · doi:10.1161/circresaha.109.207076 · Cited by 45
Gül, Ş., Akyel, Y. K., Gül, Z. M., Isin, S., Özcan, O., Korkmaz, T., Selvi, S., DANİŞ, İ., İpek, Ö. Ş., Aygenli, F., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34582-1 · Cited by 42
Circadian Oscillations of Molecular Clock Components in the Cerebellar Cortex of the Rat
Rath, M. F., Rohde, K., & Møller, M. (2012) · Chronobiology International · doi:10.3109/07420528.2012.728660 · Cited by 42
“An emerging view suggests that a circadian clock is present in most mammalian cells (Mohawk & Takahashi, 2011); however, although an extended number of clock genes are expressed in neurons of the cerebral cortex (Jilg et al., 2010; Rath et al., 2012), themolecular circadian clockwork is not a general feature of the ne…”
Tired of Diabetes Genetics? Circadian Rhythms and Diabetes: The MTNR1B Story?
Nagorny, C. L. F., & Lyssenko, V. (2012) · Current Diabetes Reports · doi:10.1007/s11892-012-0327-y · Cited by 42
“In the last decade, many studies in several species have focused on circadian clocks outside of the SCN in peripheral tissues, such as liver and heart, as well as different cell types [1].”
Prospective influences of circadian clocks in adipose tissue and metabolism
Gimble, J. M., Sutton, G. M., Bunnell, B. A., Ptitsyn, A. A., & Floyd, Z. E. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.214 · Cited by 42
Does Disruption of Circadian Rhythms Contribute to Beta-Cell Failure in Type 2 Diabetes?
Rakshit, K., Thomas, A. P., & Matveyenko, A. V. (2014) · Current Diabetes Reports · doi:10.1007/s11892-014-0474-4 · Cited by 42
Kentish, S. J., Hatzinikolas, G., Li, H., Frisby, C. L., Wittert, G., & Page, A. J. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0052-18.2018 · Cited by 41
“The timing of food intake and even the nutrient composition of a meal has a powerful influence on peripheral clocks (Ribas-Latre and Eckel-Mahan, 2016), which are intimately connected to metabolism (Green et al., 2008; Asher and Schibler, 2011; Bass, 2012; Eckel-Mahan and Sassone-Corsi, 2013).”
Hirota, T., & Kay, S. A. (2009) · Chemistry & Biology · doi:10.1016/j.chembiol.2009.09.002 · Cited by 45
“The circadian clock controls daily rhythms in a variety of physiological processes such as sleep/ wake, body temperature, hormone secretion, and metabolism (Hastings et al., 2003; Green et al., 2008; Takahashi et al., 2008; Eckel-Mahan and Sassone-Corsi, 2009).”
The bear circadian clock doesn’t ‘sleep’ during winter dormancy
Jansen, H. T., Leise, T., Stenhouse, G. B., Pigeon, K. E., Kasworm, W. F., Teisberg, J. E., Radandt, T. G., Dallmann, R., Brown, S. A., & Robbins, C. T. (2016) · Frontiers in Zoology · doi:10.1186/s12983-016-0173-x · Cited by 41
“Indeed, energy balance is maintained within rather narrow limits due the coordinated actions of central and peripheral clocks (see [34] for Review) leading to the current hypothesis that rhythmicity facilitates metabolic efficiency [38].”
Circadian events in human diseases and in cytochrome P450‐related drug metabolism and therapy
Košir, R., Španinger, K., & Rozman, D. (2013) · IUBMB Life · doi:10.1002/iub.1160 · Cited by 41
“A large number of pathways in which CYPs are involved, including drug and xenobiotic metabolism, have been shown to display circadian variation in their activity (1,19).”
InfluentialPhysiological Stress Response by Selective Autophagy
Sánchez‐Martín, P., & Komatsu, M. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.06.013 · Cited by 41
Spatiotemporal regulation of NADP(H) phosphatase Nocturnin and its role in oxidative stress response
Laothamatas, I., Gao, P., Wickramaratne, A. C., Quintanilla, C. G., Dino, A., Khan, C. A., Liou, J., & Green, C. B. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1913712117 · Cited by 42
Self-citationThe Microbiome as a Circadian Coordinator of Metabolism
Alvarez, Y., Glotfelty, L., Blank, N., Dohnalová, L., & Thaiss, C. A. (2020) · Endocrinology · doi:10.1210/endocr/bqaa059 · Cited by 39
Circadian control of β ‐cell function and stress responses
Lee, J., Liu, R., de Jesus, D. S., Kim, B. S., Ma, K., Moulik, M., & Yechoor, V. K. (2015) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12524 · Cited by 42
“Light is the primary entrainment signal to the central clock in the hypothalamic suprachiasmatic nucleus (SCN), which functions as the pacemaker [36] by synchronizing all peripheral clocks via neuro-humoral pathways [37,38] (Figure 2).”
Manipulating the Circadian and Sleep Cycles to Protect Against Metabolic Disease
Nohara, K., Yoo, S. H., & Chen, Z. (. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00035 · Cited by 43
A Circadian Surface of Entrainment: Varying T, τ, and Photoperiod in Neurospora crassa
Rémi, J., Merrow, M. W., & Roenneberg, T. (2010) · Journal of Biological Rhythms · doi:10.1177/0748730410379081 · Cited by 40
“The rules of entrainment show that a biological clock behaves much like a mechanical oscillator, even though the circadian system consists of highly complex oscillator networks both at the systemic and the cellular level (Baggs et al., 2009; Green et al., 2008; Roenneberg and Merrow, 2003).”
Yúfera, M., Perera, E., Mata-Sotres, J. A., Calduch-Giner, J. À., Martı́nez-Rodrı́guez, G., & Pérez‐Sánchez, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-13514-w · Cited by 39
The hepatocyte insulin receptor is required to program the liver clock and rhythmic gene expression
Fougeray, T., Polizzi, A., Régnier, M., Fougerat, A., Ellero‐Simatos, S., Lippi, Y., Smati, S., Lasserre, F., Tramunt, B., Huillet, M., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110674 · Cited by 40
“The mammalian clock system allows cells to anticipate environmental stimuli and synchronize daily physiological rhythms accordingly, which optimizes energy expenses (Bass and Takahashi, 2010; Green et al., 2008; Rijo-Ferreira and Takahashi, 2019; Guan and Lazar, 2021).”
Mashaqi, S., & Gozal, D. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2020.03.020 · Cited by 40
Pharmacological targeting of BMAL1 modulates circadian and immune pathways
Pu, H., Bailey, L. C., Bauer, L. G., Voronkov, M., Baxter, M. D., Huber, K., Khorasanizadeh, S., Ray, D. W., & Rastinejad, F. (2025) · Nature Chemical Biology · doi:10.1038/s41589-025-01863-x · Cited by 47
Toward a chronobiological characterization of obesity and metabolic syndrome in clinical practice
Corbalán-Tutau, M. D., Gómez-Abellán, P., Madrid, J. A., Canteras, M., Ordovás, J. M., & Garaulet, M. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2014.05.007 · Cited by 41
“Multiple aspects of behavior and physiology show daily or circadian rhythmicity [1].”
Jang, H., Lee, G., Kong, J., Choi, G., Park, Y. J., & Kim, J. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049993 · Cited by 39
“In addition, Bmal1 and Clock also increase the mRNA levels of Rev-erba and RORa, which then compete for binding to the retinoic acid-related orphan receptor response elements (ROREs) and repress or activate the expression of Bmal1, respectively.”
InfluentialCaffeine alters circadian rhythms and expression of disease and metabolic markers
Sherman, H., Gutman, R., Chapnik, N., Meylan, J., le Coutre, J., & Froy, O. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.02.008 · Cited by 41
Jeong, K., He, B., Nohara, K., Park, N., Shin, Y., Kim, S., Shimomura, K., Koike, N., Yoo, S. H., & Chen, Z. (2015) · Scientific Reports · doi:10.1038/srep12801 · Cited by 40
In the darkness of the polar night, scallops keep on a steady rhythm
Tran, D., Sow, M., Camus, L., Ciret, P., Berge, J., & Massabuau, J. (2016) · Scientific Reports · doi:10.1038/srep32435 · Cited by 41
Transcriptional repressor TIEG1 regulates Bmal1 gene through GC box and controls circadian clockwork
Hirota, T., Kon, N., Itagaki, T., Hoshina, N., Okano, T., & Fukada, Y. (2010) · Genes to Cells · doi:10.1111/j.1365-2443.2009.01371.x · Cited by 39
“These peripheral clocks are regulated by a combination of neural, humoral, and temperature signals in vivo (Schibler & Sassone-Corsi 2002; Hirota & Fukada 2004; Green et al. 2008; Kon et al. 2008).”
Imai, S. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.03.005 · Cited by 39
Li, S., Yu, Q., Wang, G.-X., & Lin, J. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070109 · Cited by 38
“In mammals, the circadian clock is responsible for synchronizing physiology and behaviors with the environment [19,20,21].”
Endocrine Physiology in Relation to Sleep and Sleep Disturbances
Cauter, E. V., & Tasali, E. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-6645-3.00026-8 · Cited by 38
Cardinali, D. P., Pagano, E. S., Bernasconi, P. A. S., Reynoso, R., & Scacchi, P. A. (2011) · PubMed · Cited by 38
Regulation of circadian gene expression in the kidney by light and food cues in rats
Wu, T., Ni, Y., Dong, Y., Xu, J., Song, X., Kato, H., & Fu, Z. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00578.2009 · Cited by 37
“IN MAMMALS, THE CIRCADIAN rhythms in behavior and physiology are organized by a circadian timing system that is comprised of a hierarchy of circadian clocks (14).”
Untimely oxidative stress in β-cells leads to diabetes – Role of circadian clock in β-cell function
Lee, J. M., Ma, K., Moulik, M., & Yechoor, V. K. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.02.022 · Cited by 40
“These are communicated to the rest of the body (peripheral clocks), including the β-cells, through neuro-humoral pathways [38,39].”
Circadian rhythm of redox state regulates membrane excitability in hippocampal CA1 neurons
Kouzehgarani, G. N., Bothwell, M. Y., & Gillette, M. U. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14334 · Cited by 38
“The redox oscillation requires functionally intact clock machinery, and clock gene expression is sensitive to changes in cellular metabolism (Bass & Takahashi, 2010; Green et al., 2008; Rutter et al., 2002).”
One Actor, Multiple Roles: The Performances of Cryptochrome in Drosophila
Damulewicz, M., & Mazzotta, G. M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00099 · Cited by 37
Wagner, P. M., Prucca, C. G., Velazquez, F. N., Alderete, L. G. S., Caputto, B. L., & Guido, M. E. (2021) · The FASEB Journal · doi:10.1096/fj.202001753r · Cited by 40
Circadian rhythms in metabolic variables in Caenorhabditis elegans
Migliori, M. L., Simonetta, S. H., Romanowski, A., & Golombek, D. A. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.01.026 · Cited by 38
“Many of these rhythms are driven, at least in part, by circadian clocks [3].”
Short‐ and long‐term sunlight radiation and stroke incidence
Kent, S. T., McClure, L. A., Judd, S. E., Howard, V. J., Crosson, W. L., Al‐Hamdan, M. Z., Wadley, V. G., Peace, F., & Kabagambe, E. K. (2012) · Annals of Neurology · doi:10.1002/ana.23737 · Cited by 38
“Because both hot and cold temperatures have been shown to have adverse relationships with stroke, we did not a priori select a temperature quartile to use a reference.(21,22)”
The effects of shift work and time of day on fine motor control during handwriting
Hölzle, P., Hermsdörfer, J., & Vetter, C. (2014) · Ergonomics · doi:10.1080/00140139.2014.935746 · Cited by 37
“Human physiology, behaviour and cognition, however, are regulated by the circadian clock (Green, Takahashi, and Bass 2008; Kyriacou and Hastings 2010), leading to systematic fluctuations in bodily functions across the 24-h day.”
Chrono-tailored drug delivery systems: recent advances and future directions
Butler, C. T., Rodgers, A. M., Curtis, A. M., & Donnelly, R. F. (2024) · Drug Delivery and Translational Research · doi:10.1007/s13346-024-01539-4 · Cited by 42
Renström, F., Koivula, R. W., Varga, T. V., Hallmans, G., Mulder, H., Florez, J. C., Hu, F. B., & Franks, P. W. (2015) · Diabetologia · doi:10.1007/s00125-015-3533-8 · Cited by 37
“Binding of melatonin to the MT2 receptor acutely inhibits insulin secretion and may thus participate in regulating the diurnal insulin secretion pattern [2].”
InfluentialMeasuring individual locomotor rhythms in honey bees, paper wasps and similar sized insects
Giannoni‐Guzmán, M. A., Avalos, A., Marrero, J., Otero‐Loperena, E. J., Kayim, M., Medina, J. A., Massey, S. E., Kence, M., Kence, A., Giray, T., et al. (2014) · Journal of Experimental Biology · doi:10.1242/jeb.096180 · Cited by 37
“Circadian rhythms are biological oscillations with a period of ~24 h that serve as endogenous timers to synchronize internal physiological processes, such as sleep and metabolism, with environmental conditions (Green et al., 2008).”
Morán‐Ramos, S., Báez‐Ruíz, A., Buijs, R. M., & Escobar, C. (2016) · Nutrition Research Reviews · doi:10.1017/s095442241600010x · Cited by 37
Disruption of clock gene expression in human colorectal liver metastases
Huisman, S. A., Ahmadi, A. R., IJzermans, J. N. M., Verhoef, C., van der Horst, G. T. J., & de Bruin, R. W. F. (2016) · Tumor Biology · doi:10.1007/s13277-016-5231-7 · Cited by 36
Circadian rhythms, nutrition and implications for longevity in urban environments
Froy, O. (2017) · Proceedings of The Nutrition Society · doi:10.1017/s0029665117003962 · Cited by 40
“Combination of this mutation with the leptin knockout (ob/ob) resulted in significantly heavier mice than the ob/ob phenotype((43)), emphasising the inter-relations between leptin and the circadian clock((24,27,44)).”
Gagliano, O., Luni, C., Li, Y., Angiolillo, S., Qin, W., Panariello, F., Cacchiarelli, D., Takahashi, J. S., & Elvassore, N. (2021) · Nature Communications · doi:10.1038/s41467-021-26294-9 · Cited by 38
Self-citation
Metadata
- Authors
- Green, C. B., Takahashi, J. S., & Bass, J.
- Affiliations
- University of Virginia (US)
- Northwestern University (US)
- Corresponding author
- Takahashi, Joseph S.
- Bass, Joseph
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 134
- Issue
- 5
- Pages
- 728-742
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC3760165
- OpenAlex
- W2063946784
- Cited by
- 902
- References
- 145
- Citations by year
- 2026: 22 · 2025: 29 · 2024: 29 · 2023: 33 · 2022: 51 · 2021: 49 · 2020: 36 · 2019: 44 · 2018: 35 · 2017: 52 · 2016: 56 · 2015: 51 · 2014: 65 · 2013: 61 · 2012: 74
- FWCI
- 7.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- Amylin Pharmaceuticals
- National Institutes of Health (5p50mh074924-05)
- National Institute on Aging (P01AG011412)
- National Heart, Lung, and Blood Institute (R01HL075029)
- National Institute of Mental Health (P50 MH-074924, R01MH078024)
- National Institute of General Medical Sciences (R01GM076626)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Keywords
- circadian rhythm, metabolism, circadian regulation, metabolic homeostasis, circadian gene expression, central nervous system, peripheral tissues, cardiovascular disease, obesity, diabetes mellitus
- MeSH terms
- Animals, Biological Clocks, Circadian Rhythm, Feeding Behavior, Humans, Metabolic Networks and Pathways
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
