Cited by 1,610Cancer-related Molecular PathwaysHeat shock proteins researchCell death mechanisms and regulation

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Modes of p53 regulation.

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Kruse, Jan-Philipp, Gu, Wei·2009·Cell

DOI 10.1016/j.cell.2009.04.050PMC PMC3737742

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Abstract

The traditional view of p53 activation includes three steps-p53 stabilization, DNA binding, and transcriptional activation. However, recent studies indicate that each step of p53 activation is more complex than originally anticipated. Moreover, both genetic studies in mice and in vitro studies with purified components suggest that the classical model may not be sufficient to explain all aspects of p53 activation in vivo. To reconcile these differences, we propose that antirepression, the release of p53 from repression by factors such as Mdm2 and MdmX, is a key step in the physiological activation of p53.

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Authors: Kruse, J.-P., & Gu, W.
Affiliations: Columbia University (US)
Corresponding author: Gu, Wei
ORCID: Gu, Wei
Venue: Cell
Publisher: Elsevier BV
Published: 2009-05
Volume: 137
Issue: 4
Pages: 609-622
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2009.04.050
PMC: PMC3737742
OpenAlex: W2025722611
Cited by: 1,610
References: 152
Citations by year: 2026: 31 · 2025: 49 · 2024: 52 · 2023: 57 · 2022: 81 · 2021: 98 · 2020: 75 · 2019: 73 · 2018: 100 · 2017: 98 · 2016: 102 · 2015: 108 · 2014: 142 · 2013: 127 · 2012: 128
FWCI: 12.22
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1538 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (2r01ca085533-16)
National Cancer Institute (R01-CA085533, R01CA131439, P01CA097403, R01CA104843, P01CA080058, R01CA098821, R01CA129627)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: p53 activation, p53 regulation, MDM2, MDMX, p53 stabilization, DNA binding, transcriptional activation, tumor suppressor
MeSH terms: Animals, Humans, Protein Processing, Post-Translational, Gene Expression Regulation, Neoplastic, Tumor Suppressor Protein p53, Proto-Oncogene Proteins c-mdm2

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