The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Metabolic Networks of Longevity
Open accessAbstract
Molecular and cellular networks implicated in aging depend on a multitude of proteins that collectively mount adaptive and contingent metabolic responses to environmental challenges. Here, we discuss the intimate links between metabolic regulation and longevity and outline new approaches for analyzing and manipulating such links to promote human health span.
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“mTOR, for the sensing of high amino acid concentrations; AMPK, which senses low energy states by detecting high AMP levels; and sirtuins, which sense low energy states by detecting high NAD+ levels”
From The Hallmarks of Aging (2013) · cites this paper as Houtkooper et al., 2010
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“The natural variation in gene expression that is present in the human population is also recapitulated in these models and therefore more honestly reflect genotype-phenotype associations than artificial loss-of-function situations, such as gene knockouts or knock-down experiments (82).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [82]
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Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
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Self-citationRapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300
Self-citationExtending Healthy Life Span—From Yeast to Humans
Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science · doi:10.1126/science.1172539 · Cited by 3,023
Kenyon, C. J. (2010) · Nature · doi:10.1038/nature08980 · Cited by 2,739
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Colman, R. J., Anderson, R. M., Johnson, S. C., Kastman, E. K., Kosmatka, K. J., Beasley, T. M., Allison, D. B., Cruzen, C., Simmons, H. A., Kemnitz, J. W., et al. (2009) · Science · doi:10.1126/science.1173635 · Cited by 2,277
Induction of autophagy by spermidine promotes longevity
Eisenberg, T., Knauer, H., Schauer, A., Büttner, S., Ruckenstuhl, C., Carmona-Gutierrez, D., Ring, J., Schroeder, S., Magnes, C., Antonacci, L., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1975 · Cited by 1,680
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
Um, S. H., Frigerio, F., Watanabe, M., Picard, F., Joaquin, M., Sticker, M., Fumagalli, S., Allegrini, P. R., Kozma, S. C., Auwerx, J., et al. (2004) · Nature · doi:10.1038/nature02866 · Cited by 1,677
Self-citationRates of Behavior and Aging Specified by Mitochondrial Function During Development
Dillin, A., Hsu, A.-L., Arantes-Oliveira, N., Lehrer-Graiwer, J., Hsin, H., Fraser, A. G., Kamath, R. S., Ahringer, J., & Kenyon, C. (2002) · Science · doi:10.1126/science.1077780 · Cited by 1,121
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Age-dependent transcriptional and epigenetic alterations in mouse hepatocytes
Sharma, A. (2021) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/155390
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Yoga may attenuates hallmarks of skin aging
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McMurtry, M. S. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0268-2_9
Martin, D. E., Cadar, A. N., Panier, H. A., Torrance, B. L., Kuchel, G. A., & Bartley, J. M. (2023) · Figshare · doi:10.6084/m9.figshare.22735507
Martin, D. E., Cadar, A. N., Panier, H. A., Torrance, B. L., Kuchel, G. A., & Bartley, J. M. (2023) · Figshare · doi:10.6084/m9.figshare.22735510
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Martin, D. E., Cadar, A. N., Panier, H. A., Torrance, B. L., Kuchel, G. A., & Bartley, J. M. (2023) · Figshare · doi:10.6084/m9.figshare.22735525
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Martin, D. E., Cadar, A. N., Panier, H. A., Torrance, B. L., Kuchel, G. A., & Bartley, J. M. (2023) · Figshare · doi:10.6084/m9.figshare.22735522
Martin, D. E., Cadar, A. N., Panier, H. A., Torrance, B. L., Kuchel, G. A., & Bartley, J. M. (2023) · Figshare · doi:10.6084/m9.figshare.22735519
Herrera, C. L. (2015) · theses.fr (ABES) · doi:10.70675/d09d7e9cz079fz4faaz985aza9cd4fc18f18
Pietrocola, F. (2015) · theses.fr (ABES) · doi:10.70675/42d6808dzc206z4e0fzb806z29f806b2f781 · Cited by 1
Aspirin recapitulates features of caloric restriction
Castoldi, F. (2018) · theses.fr (ABES) · doi:10.70675/02f5de46z9573z4f0dz9b29z3fa5274e9088
Le vieillissement dans les modèles de peau humaine reconstruite
Capallere, C. (2019) · theses.fr (ABES) · doi:10.70675/c369a08bz4786z44d5za233z3e25f161b119
Metadata
- Authors
- Houtkooper, R. H., Williams, R. W., & Auwerx, J.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- Corresponding author
- Auwerx, Johan
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 142
- Issue
- 1
- Pages
- 9-14
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC3852811
- OpenAlex
- W1993355054
- Cited by
- 217
- References
- 39
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 7 · 2023: 20 · 2022: 17 · 2021: 10 · 2020: 20 · 2019: 22 · 2018: 12 · 2017: 14 · 2016: 13 · 2015: 12 · 2014: 25 · 2013: 17 · 2012: 11
- FWCI
- 4.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (124713)
- National Institute on Alcohol Abuse and Alcoholism
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-59820, P01DK059820)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- aging, longevity, metabolic regulation, metabolic networks, healthspan, metabolic adaptation, cellular networks, molecular networks
- MeSH terms
- Aging, Amino Acids, Essential, Animals, Humans, Longevity, Methionine, Metabolic Networks and Pathways
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