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Metabolic Networks of Longevity
Open accessAbstract
Molecular and cellular networks implicated in aging depend on a multitude of proteins that collectively mount adaptive and contingent metabolic responses to environmental challenges. Here, we discuss the intimate links between metabolic regulation and longevity and outline new approaches for analyzing and manipulating such links to promote human health span.
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“mTOR, for the sensing of high amino acid concentrations; AMPK, which senses low energy states by detecting high AMP levels; and sirtuins, which sense low energy states by detecting high NAD+ levels”
From The Hallmarks of Aging (2013) · cites this paper as Houtkooper et al., 2010
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“The natural variation in gene expression that is present in the human population is also recapitulated in these models and therefore more honestly reflect genotype-phenotype associations than artificial loss-of-function situations, such as gene knockouts or knock-down experiments (82).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [82]
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Metadata
- Authors
- Houtkooper, R. H., Williams, R. W., & Auwerx, J.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- Corresponding author
- Auwerx, Johan
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 142
- Issue
- 1
- Pages
- 9-14
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC3852811
- OpenAlex
- W1993355054
- Cited by
- 217
- References
- 39
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 7 · 2023: 20 · 2022: 17 · 2021: 10 · 2020: 20 · 2019: 22 · 2018: 12 · 2017: 14 · 2016: 13 · 2015: 12 · 2014: 25 · 2013: 17 · 2012: 11
- FWCI
- 4.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (124713)
- National Institute on Alcohol Abuse and Alcoholism
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-59820, P01DK059820)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- aging, longevity, metabolic regulation, metabolic networks, healthspan, metabolic adaptation, cellular networks, molecular networks
- MeSH terms
- Aging, Amino Acids, Essential, Animals, Humans, Longevity, Methionine, Metabolic Networks and Pathways
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