Metabolic Networks of Longevity

Resveratrol improves health and survival of mice on a high-calorie diet

Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300

Extending Healthy Life Span—From Yeast to Humans

Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science · doi:10.1126/science.1172539 · Cited by 3,023

The genetics of ageing

Kenyon, C. J. (2010) · Nature · doi:10.1038/nature08980 · Cited by 2,739

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

Colman, R. J., Anderson, R. M., Johnson, S. C., Kastman, E. K., Kosmatka, K. J., Beasley, T. M., Allison, D. B., Cruzen, C., Simmons, H. A., Kemnitz, J. W., et al. (2009) · Science · doi:10.1126/science.1173635 · Cited by 2,277

Induction of autophagy by spermidine promotes longevity

Eisenberg, T., Knauer, H., Schauer, A., Büttner, S., Ruckenstuhl, C., Carmona-Gutierrez, D., Ring, J., Schroeder, S., Magnes, C., Antonacci, L., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1975 · Cited by 1,680

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

Um, S. H., Frigerio, F., Watanabe, M., Picard, F., Joaquin, M., Sticker, M., Fumagalli, S., Allegrini, P. R., Kozma, S. C., Auwerx, J., et al. (2004) · Nature · doi:10.1038/nature02866 · Cited by 1,677

Rates of Behavior and Aging Specified by Mitochondrial Function During Development

Dillin, A., Hsu, A.-L., Arantes-Oliveira, N., Lehrer-Graiwer, J., Hsin, H., Fraser, A. G., Kamath, R. S., Ahringer, J., & Kenyon, C. (2002) · Science · doi:10.1126/science.1077780 · Cited by 1,121

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982

Sirtuins as regulators of metabolism and healthspan

Houtkooper, R. H., Pirinen, E., & Auwerx, J. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3293 · Cited by 2,008

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

Cantó, C., Menzies, K. J., & Auwerx, J. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.023 · Cited by 1,648

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

Mouchiroud, L., Houtkooper, R. H., Moullan, N., Katsyuba, E., Ryu, D., Cantó, C., Mottis, A., Jo, Y.-S., Viswanathan, M., Schoonjans, K., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.016 · Cited by 1,210

Mitonuclear protein imbalance as a conserved longevity mechanism

Houtkooper, R. H., Mouchiroud, L., Ryu, D., Moullan, N., Katsyuba, E., Knott, G., Williams, R. W., & Auwerx, J. (2013) · Nature · doi:10.1038/nature12188 · Cited by 1,035

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

Quirós, P. M., Prado, M. A., Zamboni, N., D’Amico, D., Williams, R. W., Finley, D., Gygi, S. P., & Auwerx, J. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201702058 · Cited by 832

Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease

Smith, R. L., Soeters, M. R., Wüst, R. C. I., & Houtkooper, R. H. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00211 · Cited by 787

The metabolic footprint of aging in mice

Houtkooper, R. H., Argmann, C., Houten, S. M., Cantó, C., Jeninga, E. H., Andreux, P. A., Thomas, C., Doenlen, R., Schoonjans, K., & Auwerx, J. (2011) · Scientific Reports · doi:10.1038/srep00134 · Cited by 528

A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice

Roberts, M. N., Wallace, M. A., Tomilov, A. A., Zhou, Z., Marcotte, G. R., Tran, D., Perez, G., Gutierrez-Casado, E., Koike, S., Knotts, T. A., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.005 · Cited by 514

Molecular and physiological manifestations and measurement of aging in humans

Khan, S. S., Singer, B. D., & Vaughan, D. E. (2017) · Aging Cell · doi:10.1111/acel.12601 · Cited by 530

The ageing epigenome and its rejuvenation

Zhang, W., Qu, J., Liu, G.-H., & Belmonte, J. C. I. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0204-5 · Cited by 458

The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

Pols, T. W. H., Noriega, L. G., Nomura, M., Auwerx, J., & Schoonjans, K. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2010.12.004 · Cited by 454

Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

Zhu, X., Chen, Z., Shen, W., Huang, G., Sedivy, J. M., Wang, H., & Ju, Z. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00646-9 · Cited by 425

Pharmacological approaches to restore mitochondrial function

Andreux, P. A., Houtkooper, R. H., & Auwerx, J. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4023 · Cited by 383

Repairing mitochondrial dysfunction in disease

Sorrentino, V., Menzies, K. J., & Auwerx, J. (2018) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010716-104908 · Cited by 337

Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease

Liu, Y. J., McIntyre, R. L., Janssens, G. E., & Houtkooper, R. H. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111212 · Cited by 347

The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function

Yang, K., Neale, G. A. M., Green, D. R., He, W., & Chi, H. (2011) · Nature Immunology · doi:10.1038/ni.2068 · Cited by 302

Cardiovascular effects and molecular targets of resveratrol

Li, H., Xia, N., & Förstermann, U. (2012) · Nitric Oxide · doi:10.1016/j.niox.2011.12.006 · Cited by 302

Calorie Restriction: Is AMPK a Key Sensor and Effector

Cantó, C., & Auwerx, J. (2011) · Physiology · doi:10.1152/physiol.00010.2011 · Cited by 282

Ketogenic diets, mitochondria, and neurological diseases

Gano, L. B., Patel, M., & Rho, J. M. (2014) · Journal of Lipid Research · doi:10.1194/jlr.r048975 · Cited by 291

Histone Methyl Transferases and Demethylases; Can They Link Metabolism and Transcription?

Teperino, R., Schoonjans, K., & Auwerx, J. H. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.09.004 · Cited by 281

Regulation of Stem Cell Aging by Metabolism and Epigenetics

Ren, R., Ocampo, A., Liu, G., & Belmonte, J. C. I. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.07.019 · Cited by 286

NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

Yamamoto, H., Williams, E. G., Mouchiroud, L., Cantó, C., Fan, W., Downes, M., Héligon, C., Barish, G. D., Desvergne, B., Evans, R. M., et al. (2011) · Cell · doi:10.1016/j.cell.2011.10.017 · Cited by 269

Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan

Eisenberg, T., Schroeder, S., Andryushkova, A., Pendl, T., Küttner, V., Bhukel, A., Mariño, G., Pietrocola, F., Harger, A., Zimmermann, A., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.02.010 · Cited by 256

Reconsidering the Role of Mitochondria in Aging

Gonzalez-Freire, M., de Cabo, R., Bernier, M., Sollott, S. J., Fabbri, E., Navas, P., & Ferrucci, L. (2015) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glv070 · Cited by 244

AMP-activated protein kinase, stress responses and cardiovascular diseases

Wang, S., Song, P., & Zou, M. (2012) · Clinical Science · doi:10.1042/cs20110625 · Cited by 251

Mechanisms of Aging and the Preventive Effects of Resveratrol on Age-Related Diseases

Pyo, I. S., Yun, S., Yoon, Y. E., Choi, J. W., & Lee, S. (2020) · Molecules · doi:10.3390/molecules25204649 · Cited by 221

Inflammation and DNA damage: cause, effect or both

Pezone, A., Olivieri, F., Napoli, M. V., Procopio, A., Avvedimento, E. V., & Gabrielli, A. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00905-1 · Cited by 212

NAD + metabolism: A therapeutic target for age-related metabolic disease

Mouchiroud, L., Houtkooper, R. H., & Auwerx, J. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.789479 · Cited by 193

The bile acid membrane receptor TGR5: a valuable metabolic target

Pols, T. W. H., Noriega, L. G., Nomura, M., Auwerx, J., & Schoonjans, K. (2011) · Digestive Diseases · doi:10.1159/000324126 · Cited by 185

Adenosine Nucleotide Biosynthesis and AMPK Regulate Adult Life Span and Mediate the Longevity Benefit of Caloric Restriction in Flies

Stenesen, D., Suh, J. M., Seo, J. H., Yu, K., Lee, K., Kim, J.-S., Min, K., & Graff, J. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.006 · Cited by 210

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

D’Amico, D., Mottis, A., Potenza, F., Sorrentino, V., Li, H., Romani, M., Lemos, V., Schoonjans, K., Zamboni, N., Knott, G., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2018.11.034 · Cited by 159

Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting

Al‐Azab, M., Safi, M., Idiiatullina, E., Al‐Shaebi, F., & Zaky, M. Y. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-022-00366-0 · Cited by 178

The metabolomics of human aging: Advances, challenges, and opportunities

Panyard, D. J., Yu, B., & Snyder, M. P. (2022) · Science Advances · doi:10.1126/sciadv.add6155 · Cited by 159

Metabolomics signature improves the prediction of cardiovascular events in elderly subjects

Rizza, S., Copetti, M., Rossi, C., Cianfarani, M. A., Zucchelli, M., Luzi, A., Pecchioli, C., Porzio, O., Cola, G. D., Urbani, A., et al. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.10.029 · Cited by 158

FOXOs and Sirtuins in Vascular Growth, Maintenance, and Aging

Oellerich, M. F., & Potente, M. (2012) · Circulation Research · doi:10.1161/circresaha.111.246488 · Cited by 161

IL‐10 prevents aging‐associated inflammation and insulin resistance in skeletal muscle

Dağdeviren, S., Jung, D. Y., Friedline, R. H., Noh, H. L., Kim, J. H., Patel, P. R., Tsitsilianos, N., Inashima, K., Tran, D. A., Hu, X., et al. (2016) · The FASEB Journal · doi:10.1096/fj.201600832r · Cited by 151

The different axes of the mammalian mitochondrial unfolded protein response

Münch, C. (2018) · BMC Biology · doi:10.1186/s12915-018-0548-x · Cited by 158

Mitochondrial response to nutrient availability and its role in metabolic disease

Gao, A. W., Cantó, C., & Houtkooper, R. H. (2014) · EMBO Molecular Medicine · doi:10.1002/emmm.201303782 · Cited by 148

Cellular Senescence as the Causal Nexus of Aging

Bhatia‐Dey, N., Kanherkar, R. R., Stair, S. E., Makarev, E., & Csoka, A. B. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00013 · Cited by 149

FoxO1 controls lysosomal acid lipase in adipocytes: implication of lipophagy during nutrient restriction and metformin treatment

Lettieri‐Barbato, D., Tatulli, G., Aquilano, K., & Ciriolo, M. R. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.404 · Cited by 151

Mitochondria-targeted antioxidants and metabolic modulators as pharmacological interventions to slow ageing

Gruber, J., Fong, S., Chen, C.-B., Yoong, S. L., Pastorin, G., Schaffer, S., Cheah, I. K.-M., & Halliwell, B. B. (2012) · Biotechnology Advances · doi:10.1016/j.biotechadv.2012.09.005 · Cited by 143

The mitochondrial unfolded protein response–synchronizing genomes

Jovaisaite, V., & Auwerx, J. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.12.003 · Cited by 131

The PARP family: insights into functional aspects of poly ( ADP ‐ribose) polymerase‐1 in cell growth and survival

Jubin, T., Kadam, A. A., Jariwala, M., Bhatt, S., Sutariya, S., Gani, A. R., Gautam, S., & Begum, R. (2016) · Cell Proliferation · doi:10.1111/cpr.12268 · Cited by 136

Cellular Respiration: The Nexus of Stress, Condition, and Ornamentation

Hill, G. E. (2014) · Integrative and Comparative Biology · doi:10.1093/icb/icu029 · Cited by 130

LKB1 and AMPK regulate synaptic remodeling in old age

Samuel, M. A., Voinescu, P. E., Lilley, B. N., de Cabo, R., Foretz, M., Viollet, B., Pawlyk, B., Sandberg, M. A., Vavvas, D. G., & Sanes, J. R. (2014) · Nature Neuroscience · doi:10.1038/nn.3772 · Cited by 114

FUS interacts with ATP synthase beta subunit and induces mitochondrial unfolded protein response in cellular and animal models

Deng, J., Wang, P., Chen, X., Cheng, H., Liu, J., Fushimi, K., Zhu, L., & Wu, J. Y. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1806655115 · Cited by 123

From molecular promise to preclinical results: HDAC inhibitors in the race for healthy aging drugs

McIntyre, R. L., Daniels, E. G., Molenaars, M., Houtkooper, R. H., & Janssens, G. E. (2019) · EMBO Molecular Medicine · doi:10.15252/emmm.201809854 · Cited by 115

Cytosolic Proteostasis Networks of the Mitochondrial Stress Response

D'Amico, D. F., Sorrentino, V., & Auwerx, J. H. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2017.05.002 · Cited by 108

Exploring the therapeutic space around NAD+

Houtkooper, R. H., & Auwerx, J. H. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201207019 · Cited by 113

Hypothalamic microinflammation: a common basis of metabolic syndrome and aging

Tang, Y., Purkayastha, S., & Cai, D. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.10.002 · Cited by 115

Regulation of Glucose Metabolism by NAD+ and ADP-Ribosylation

Hopp, A.-K., Grüter, P., & Hottiger, M. O. (2019) · Cells · doi:10.3390/cells8080890 · Cited by 108

Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly

Andreux, P. A., van Diemen, M. P. J., Heezen, M. R., Auwerx, J. H., Rinsch, C., Groeneveld, G. J., & Singh, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-26944-x · Cited by 115

Integrating the Hallmarks of Aging Throughout the Tree of Life: A Focus on Mitochondrial Dysfunction

van der Rijt, S., Molenaars, M., McIntyre, R. L., Janssens, G. E., & Houtkooper, R. H. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.594416 · Cited by 102

Emerging role of aging in the progression of NAFLD to HCC

He, Y., Su, Y., Duan, C., Wang, S., He, W. G., Zhang, Y., An, X., & He, M. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101833 · Cited by 100

Orexin Restores Aging-Related Brown Adipose Tissue Dysfunction in Male Mice

Sellayah, D., & Sikder, D. S. (2013) · Endocrinology · doi:10.1210/en.2013-1629 · Cited by 96

The Role of Autophagy, Mitophagy and Lysosomal Functions in Modulating Bioenergetics and Survival in the Context of Redox and Proteotoxic Damage: Implications for Neurodegenerative Diseases

Redmann, M., Darley-Usmar, V. M., & Zhang, J. (2016) · Aging and Disease · doi:10.14336/ad.2015.0820 · Cited by 93

Proteomics and metabolomics in ageing research: from biomarkers to systems biology

Hoffman, J. M., Lyu, Y., Pletcher, S. D., & Promislow, D. (2017) · Essays in Biochemistry · doi:10.1042/ebc20160083 · Cited by 90

Aging Biomarkers: From Functional Tests to Multi‐Omics Approaches

Kudryashova, K. S., Burka, K., Kulaga, A. Y., Vorobyeva, N. S., & Kennedy, B. K. (2020) · PROTEOMICS · doi:10.1002/pmic.201900408 · Cited by 95

Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion

Liu, Y. J., Janssens, G. E., McIntyre, R. L., Molenaars, M., Kamble, R., Gao, A. W., Jongejan, A., van Weeghel, M., MacInnes, A. W., & Houtkooper, R. H. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1007633 · Cited by 81

The controversial links among calorie restriction, SIRT1, and resveratrol

Hu, Y., Liu, J., Wang, J., & Liu, Q. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.034 · Cited by 82

Identification of key pathways and metabolic fingerprints of longevity in C. elegans

Gao, A. W., Smith, R. L., van Weeghel, M., Kamble, R., Janssens, G. E., & Houtkooper, R. H. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.10.003 · Cited by 84

Nicotinamide adenine dinucleotide: Biosynthesis, consumption and therapeutic role in cardiac diseases

Tannous, C., Booz, G. W., Altara, R., Muhieddine, D. H., Mericskay, M., Refaat, M. M., & Zouein, F. A. (2020) · Acta Physiologica · doi:10.1111/apha.13551 · Cited by 80

A sensitive mass spectrometry platform identifies metabolic changes of life history traits in C. elegans

Gao, A. W., Chatzispyrou, I. A., Kamble, R., Liu, Y. J., Herzog, K., Smith, R. L., van Lenthe, H., Vervaart, M. A. T., van Cruchten, A., Luyf, A. C., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-02539-w · Cited by 77

An integrative metabolomics and transcriptomics study to identify metabolic alterations in aged skin of humans in vivo

Kuehne, A., Hildebrand, J., Soehle, J., Wenck, H., Terstegen, L., Gallinat, S., Knott, A., Winnefeld, M., & Zamboni, N. (2017) · BMC Genomics · doi:10.1186/s12864-017-3547-3 · Cited by 79

Nuclear matrix, nuclear envelope and premature aging syndromes in a translational research perspective

Cau, P., Navarro, C. L., Harhouri, K., Roll, P., Sigaudy, S., Kaspi, É., Perrin, S., Sandre‐Giovannoli, A. D., & Lévy, N. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.03.021 · Cited by 80

Network medicine, multimorbidity and the lung in the elderly

Faner, R., Cruz, T., López-Giraldo, A., & Agustí, A. G. N. (2014) · European Respiratory Journal · doi:10.1183/09031936.00078714 · Cited by 74

Calorie restriction alleviates the age‐related decrease in neural progenitor cell division in the aging brain

Park, J., Glass, Z., Sayed, K., Michurina, T. V., Lazutkin, A. A., Mineyeva, O. A., Velmeshev, D., Ward, W. F., Richardson, A. G., & Enikolopov, G. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12249 · Cited by 72

NAD+ regulates nucleotide metabolism and genomic DNA replication

Munk, S. H. N., Merchut‐Maya, J. M., Adelantado-Rubio, A., Hall, A., Pappas, G. D., Milletti, G., Lee, M., Johnsen, L. G., Guldberg, P., Bártek, J., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01280-z · Cited by 74

Understanding the physiology of the ageing individual: computational modelling of changes in metabolism and endurance

van Beek, H., Kirkwood, T. B. L., & Bassingthwaighte, J. B. (2016) · Interface Focus · doi:10.1098/rsfs.2015.0079 · Cited by 77

Pharmaceutical and nutraceutical activation of FOXO3 for healthy longevity

McIntyre, R. L., Liu, Y. J., Hu, I. M., Morris, B. J., Willcox, B. J., Donlon, T. A., Houtkooper, R. H., & Janssens, G. E. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101621 · Cited by 68

MicroRNAs and the metabolic hallmarks of aging

Victoria, B., López, Y. O. N., & Masternak, M. M. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.12.021 · Cited by 64

Antagonistic functions of LMNA isoforms in energy expenditure and lifespan

López‐Mejía, I. C., de Toledo, M., Chavey, C., Lapasset, L., Cavelier, P., Herrera, C. L., Chébli, K., Fort, P., Béranger, G. E., Fajas, L., et al. (2014) · EMBO Reports · doi:10.1002/embr.201338126 · Cited by 61

Metabolomics and lipidomics in Caenorhabditis elegans using a single-sample preparation

Molenaars, M., Schomakers, B. V., Elfrink, H. L., Gao, A. W., Vervaart, M. A. T., Pras‐Raves, M. L., Luyf, A. C. M., Smith, R. L., Sterken, M. G., Kammenga, J. E., et al. (2021) · Disease Models & Mechanisms · doi:10.1242/dmm.047746 · Cited by 60

Cellular Metabolism and Aging

Catic, A. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.12.003 · Cited by 58

Roles of SIRT1 in granulosa cell apoptosis during the process of follicular atresia in porcine ovary

Zhao, F., Zhao, W., Ren, S., Fu, Y., Fang, X., Wang, X., & Li, B. (2014) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2014.10.002 · Cited by 57

Amalaki rasayana, a traditional Indian drug enhances cardiac mitochondrial and contractile functions and improves cardiac function in rats with hypertrophy

Kumar, V., Asokan, A. K., Kshemada, K., Ajith, K. G. S., Raj, B., Deora, N., Sanjay, G., Jaleel, A., Muraleedharan, T. S., Anandan, E. M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-09225-x · Cited by 57

How to Slow down the Ticking Clock: Age-Associated Epigenetic Alterations and Related Interventions to Extend Life Span

Galow, A.-M., & Peleg, S. (2022) · Cells · doi:10.3390/cells11030468 · Cited by 60

The effect of dichloroacetate on health- and lifespan in C. elegans

Schaffer, S., Gruber, J., Ng, L. C., Fong, S., Wong, Y. T., Tang, S. Y., & Halliwell, B. B. (2010) · Biogerontology · doi:10.1007/s10522-010-9310-7 · Cited by 54

Role of PARP-1 in mitochondrial homeostasis

Kadam, A. A., Jubin, T., Roychowdhury, R., & Begum, R. (2020) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2020.129669 · Cited by 55

Oxysterols are potential physiological regulators of ageing

de Médina, P., Silvente‐Poirot, S., & Poirot, M. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101615 · Cited by 55

Molecular pathways of arterial aging

Paneni, F., Costantino, S., & Cosentino, F. (2014) · Clinical Science · doi:10.1042/cs20140302 · Cited by 53

Aging Research in Yeast

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Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice

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