The DOI matches its Crossref record; 178 of the 180 references it cites were found in a registry or an index.
Wnt/β-Catenin Signaling and Disease
Open accessAbstract
The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.
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In the citing paper
“In deregulated forms, it is involved in human cancers and developmental disorders [26, 27].”
From Relating simulation studies by provenance—Developing a family of Wnt signaling models (2021) · cites this paper as [26]
In the citing paper
“hotspot mutations of APC, Axin, and β-catenin have been found to drive tumorigenesis2”
From A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer (2020) · cites this paper as [2]
In the citing paper
“Aberrant activation of Wnt signaling is highly implicated in various types of cancer, including colorectal cancer, in human, for example, hotspot mutations of APC, Axin, and β-catenin have been found to drive tumorigenesis2.”
From A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer (2020) · cites this paper as [2]
Citations
Cites
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Self-citationThe metabolic and molecular bases of inherited disease
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Self-citationWnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
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Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
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Self-citationWnt signalling in stem cells and cancer
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Self-citationFunctional interaction of β-catenin with the transcription factor LEF-1
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Cited by
Sorted by citations
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
Nusse, R., & Clevers, H. (2017) · Cell · doi:10.1016/j.cell.2017.05.016 · Cited by 4,342
Self-citationTargeting PI3K/Akt signal transduction for cancer therapy
He, Y., Sun, M., Zhang, G. G., Yang, J., Chen, K. S., Xu, W. W., & Li, B. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00828-5 · Cited by 2,045
Targeting cancer stem cell pathways for cancer therapy
Yang, L., Shi, P., Zhao, G., Xu, J., Peng, W., Zhang, J., Zhang, G., Wang, X., Dong, Z., Chen, F., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0110-5 · Cited by 1,957
Feng, Y., Spezia, M., Huang, S., Yuan, C., Zeng, Z., Zhang, L., Ji, X., Liu, W., Huang, B., Luo, W., et al. (2018) · Genes & Diseases · doi:10.1016/j.gendis.2018.05.001 · Cited by 1,643
Molecular pathogenesis and mechanisms of thyroid cancer
Xing, M. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3431 · Cited by 1,452
Metadata
- Authors
- Clevers, H., & Nusse, R.
- Affiliations
- Royal Netherlands Academy of Arts and Sciences (NL)
- Corresponding author
- Clevers, Hans
- ORCID
- Clevers, Hans
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 149
- Issue
- 6
- Pages
- 1192-1205
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2006419043
- Cited by
- 5,554
- References
- 180
- Citations by year
- 2026: 252 · 2025: 296 · 2024: 318 · 2023: 333 · 2022: 418 · 2021: 498 · 2020: 442 · 2019: 399 · 2018: 432 · 2017: 486 · 2016: 458 · 2015: 454 · 2014: 364 · 2013: 347 · 2012: 52
- FWCI
- 35.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Keywords
- Wnt/β-catenin signaling, Wnt signaling, signal transduction, developmental biology, pathogenesis, aberrant signaling
- MeSH terms
- Animals, Disease, Humans, Wnt Proteins, beta Catenin, Wnt Signaling Pathway
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