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Wnt/β-Catenin Signaling and Disease
Open accessAbstract
The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.
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“In deregulated forms, it is involved in human cancers and developmental disorders [26, 27].”
From Relating simulation studies by provenance—Developing a family of Wnt signaling models (2021) · cites this paper as [26]
In the citing paper
“hotspot mutations of APC, Axin, and β-catenin have been found to drive tumorigenesis2”
From A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer (2020) · cites this paper as [2]
In the citing paper
“Aberrant activation of Wnt signaling is highly implicated in various types of cancer, including colorectal cancer, in human, for example, hotspot mutations of APC, Axin, and β-catenin have been found to drive tumorigenesis2.”
From A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer (2020) · cites this paper as [2]
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Metadata
- Authors
- Clevers, H., & Nusse, R.
- Affiliations
- Royal Netherlands Academy of Arts and Sciences (NL)
- Corresponding author
- Clevers, Hans
- ORCID
- Clevers, Hans
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 149
- Issue
- 6
- Pages
- 1192-1205
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2006419043
- Cited by
- 5,554
- References
- 180
- Citations by year
- 2026: 252 · 2025: 296 · 2024: 318 · 2023: 333 · 2022: 418 · 2021: 498 · 2020: 442 · 2019: 399 · 2018: 432 · 2017: 486 · 2016: 458 · 2015: 454 · 2014: 364 · 2013: 347 · 2012: 52
- FWCI
- 35.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Keywords
- Wnt/β-catenin signaling, Wnt signaling, signal transduction, developmental biology, pathogenesis, aberrant signaling
- MeSH terms
- Animals, Disease, Humans, Wnt Proteins, beta Catenin, Wnt Signaling Pathway
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