Wnt/β-Catenin Signaling and Disease

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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

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The metabolic and molecular bases of inherited disease

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Identification of stem cells in small intestine and colon by marker gene Lgr5

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Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

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Lessons from hereditary colorectal cancer

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Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

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Wnt signalling in stem cells and cancer

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Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon Carcinoma

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The Genomic Landscapes of Human Breast and Colorectal Cancers

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β‐catenin is a target for the ubiquitin–proteasome pathway

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Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

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Identification of FAP Locus Genes from Chromosome 5q21

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Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

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Wnt proteins are lipid-modified and can act as stem cell growth factors

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LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development

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Crypt stem cells as the cells-of-origin of intestinal cancer

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A role for Wnt signalling in self-renewal of haematopoietic stem cells

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Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor

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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

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Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

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Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

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XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

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Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

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Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

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Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

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High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5

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Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

Barker, N., Huch, M., Kujala, P., van de Wetering, M., Snippert, H. J., van Es, J. H., Sato, T., Stange, D. E., Begthel, H., van den Born, M., et al. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2009.11.013 · Cited by 1,547

The Role of the Wnt-Signaling Antagonist DKK1 in the Development of Osteolytic Lesions in Multiple Myeloma

Tian, E., Zhan, F., Walker, R. C., Rasmussen, E., Ma, Y., Barlogie, B., & Shaughnessy, J. D. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030847 · Cited by 1,505

A new member of the frizzled family from Drosophila functions as a Wingless receptor

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Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF.

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Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

de Lau, W., Barker, N., Low, T. Y., Koo, B., Li, V. S. W., Teunissen, H., Kujala, P., Haegebarth, A., Peters, P. J., van de Wetering, M., et al. (2011) · Nature · doi:10.1038/nature10337 · Cited by 1,302

A Mutation in the LDL Receptor–Related Protein 5 Gene Results in the Autosomal Dominant High–Bone-Mass Trait

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Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

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Association of the APC Gene Product with β-Catenin

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Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors

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Association of the APC Tumor Suppressor Protein with Catenins

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Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

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LDL-receptor-related proteins in Wnt signal transduction

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De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin

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WNT Signals Are Required for the Initiation of Hair Follicle Development

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Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

Kato, M., Patel, M. S., Levasseur, R., Lobov, I., Chang, B. H.-J., Glass, D. A., Hartmann, C., Li, L., Hwang, T.-H., Brayton, C. F., et al. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200201089 · Cited by 1,086

An LDL-receptor-related protein mediates Wnt signalling in mice

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LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way

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Bone Dysplasia Sclerosteosis Results from Loss of the SOST Gene Product, a Novel Cystine Knot–Containing Protein

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Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation

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Lgr5 marks cycling, yet long-lived, hair follicle stem cells

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AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

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The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse

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The Drosophila homology of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless

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Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription

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Structural Basis of Wnt Recognition by Frizzled

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R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/β-catenin signaling

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Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex

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A small molecule inhibitor of β-catenin/cyclic AMP response element-binding protein transcription

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Vascular Development in the Retina and Inner Ear

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A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

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arrow encodes an LDL-receptor-related protein essential for Wingless signalling

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Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway

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Monounsaturated Fatty Acid Modification of Wnt Protein: Its Role in Wnt Secretion

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SOST Is a Ligand for LRP5/LRP6 and a Wnt Signaling Inhibitor

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Wntless, a Conserved Membrane Protein Dedicated to the Secretion of Wnt Proteins from Signaling Cells

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R-spondin1 is essential in sex determination, skin differentiation and malignancy

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Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

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Direct and Long-Range Action of a Wingless Morphogen Gradient

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Drosophila Tcf and Groucho interact to repress Wingless signalling activity

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Three-Dimensional Structure of the Armadillo Repeat Region of β-Catenin

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Lipoprotein particles are required for Hedgehog and Wingless signalling

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Mutations in AXIN2 Cause Familial Tooth Agenesis and Predispose to Colorectal Cancer

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Wnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes

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The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors

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Small-molecule antagonists of the oncogenic Tcf/β-catenin protein complex

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Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease

Bovolenta, P., Esteve, P., Ruiz, J. M., Cisneros, E., & López-Rı́os, J. (2008) · Journal of Cell Science · doi:10.1242/jcs.026096 · Cited by 655

WNT/TCF Signaling through LEF1 and HOXB9 Mediates Lung Adenocarcinoma Metastasis

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Casein kinase 1 γ couples Wnt receptor activation to cytoplasmic signal transduction

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Unexpected complexity of the Wnt gene family in a sea anemone

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LRP6 Mutation in a Family with Early Coronary Disease and Metabolic Risk Factors

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Mitogenic Influence of Human R-Spondin1 on the Intestinal Epithelium

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Secretion of Wnt Ligands Requires Evi, a Conserved Transmembrane Protein

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Wnt/Wingless Signaling Requires BCL9/Legless-Mediated Recruitment of Pygopus to the Nuclear β-Catenin-TCF Complex

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LGR4 and LGR5 are R‐spondin receptors mediating Wnt/β‐catenin and Wnt/PCP signalling

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Wnt Signaling and the Polarity of the Primary Body Axis

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Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis.

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Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating β-catenin/TCF signalling

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Homozygous WNT3 Mutation Causes Tetra-Amelia in a Large Consanguineous Family

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Mutations in X-linked PORCN, a putative regulator of Wnt signaling, cause focal dermal hypoplasia

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Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling

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APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex

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Reduced Affinity to and Inhibition by DKK1 Form a Common Mechanism by Which High Bone Mass-Associated Missense Mutations in LRP5 Affect Canonical Wnt Signaling

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Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: The odonto-onycho-dermal dysplasia

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Pygopus, a nuclear PHD-finger protein required for Wingless signaling inDrosophila

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Next-Generation Sequencing of a 40 Mb Linkage Interval Reveals TSPAN12 Mutations in Patients with Familial Exudative Vitreoretinopathy

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The Wnt signalling effector Dishevelled forms dynamic protein assemblies rather than stable associations with cytoplasmic vesicles

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Wnt Isoform-Specific Interactions with Coreceptor Specify Inhibition or Potentiation of Signaling by LRP6 Antibodies

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The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia

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Regulation of TCF3 by Wnt-Dependent Phosphorylation during Vertebrate Axis Specification

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Association of the Gene Encoding Wingless-Type Mammary Tumor Virus Integration-Site Family Member 5B (WNT5B) with Type 2 Diabetes

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Mutations in WNT7A Cause a Range of Limb Malformations, Including Fuhrmann Syndrome and Al-Awadi/Raas-Rothschild/Schinzel Phocomelia Syndrome

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Progressive Cerebellar, Auditory, and Esophageal Dysfunction Caused by Targeted Disruption of thefrizzled-4 Gene

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WNT10B mutations in human obesity

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Increased DNA Methylation at the AXIN1 Gene in a Monozygotic Twin from a Pair Discordant for a Caudal Duplication Anomaly

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DKK1 Antagonizes Wnt Signaling without Promotion of LRP6 Internalization and Degradation

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Retinal vasculature changes in Norrie disease mice.

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Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb

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Targeted Disruption of the Wnt Regulator Kremen Induces Limb Defects and High Bone Density

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A model for familial exudative vitreoretinopathy caused by LPR5 mutations

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BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration

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Quiescent gastric stem cells maintain the adult Drosophila stomach

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Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development

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Wnt Regulates Spindle Asymmetry to Generate Asymmetric Nuclear β-Catenin in C. elegans

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In vivo role of lipid adducts on Wingless

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Characterization and Expression Pattern of thefrizzledGeneFzd9,the Mouse Homolog ofFZD9Which Is Deleted in Williams–Beuren Syndrome

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