The Hallmarks of Aging

López-Otín, Carlos, Blasco, Maria A., Partridge, Linda, Serrano, Manuel, Kroemer, Guido·2013·Cell

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Items 201–300 of 1,350

  1. SIRT1 is downregulated by autophagy in senescence and ageing
    Caiyue Xu, Lu Wang, Parinaz Fozouni, Gry Evjen, Vemika Chandra, Jing Jiang, Congcong Lu, Michael C. Nicastri, Corey L. Bretz, Jeffrey D. Winkler et al. · 2020 · Nature Cell Biology
  2. Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions
    Paolo Bernardi, Christoph Gerle, Andrew P. Halestrap, Elizabeth Ann Jonas, Jason M. Karch, Nelli Mnatsakanyan, Evgeny V. Pavlov, Shey‐Shing Sheu, Alexander A. Soukas · 2023 · Cell Death and Differentiation
  3. The quest to slow ageing through drug discovery
    Partridge, Linda, Fuentealba, Matias, Kennedy, Brian K. · 2020 · Nature Reviews Drug Discovery
  4. Immunology of aging: the birth of inflammaging
    Fulop, T., Larbi, A., Pawelec, G., Khalil, A., Cohen, A. A., Hirokawa, K., Witkowski, J. M., Franceschi, C. · 2021 · Clinical Reviews in Allergy & Immunology
  5. Essential role for autophagy in life span extension
    Madeo, Frank, Zimmermann, Andreas, Maiuri, Maria Chiara, Kroemer, Guido · 2015 · Journal of Clinical Investigation
  6. Ageing, metabolism and cardiovascular disease
    Sarah Costantino, Francesco Paneni, Francesco Cosentino · 2015 · The Journal of Physiology
  7. Age-related changes in glucose metabolism, hyperglycemia, and cardiovascular risk
    Chia, Chee W., Egan, Josephine M., Ferrucci, Luigi · 2018 · Circulation Research
  8. Inside and out: the activities of senescence in cancer
    Pérez-Mancera, Pedro A., Young, Andrew R. J., Narita, Masashi · 2014 · Nature Reviews Cancer
  9. Toll-like receptor 4 (TLR4): new insight immune and aging
    Hyojin Kim, Hyemin Kim, Jeong‐Hyung Lee, Cheol Hwangbo · 2023 · Immunity & Ageing
  10. The role of retrotransposable elements in ageing and age-associated diseases
    Gorbunova, Vera, Seluanov, Andrei, Mita, Paolo, McKerrow, Wilson, Fenyö, David, Boeke, Jef D., Linker, Sara B., Gage, Fred H., Kreiling, Jill A., Petrashen, Anna P. et al. · 2021 · Nature
  11. A synopsis on aging—Theories, mechanisms and future prospects
    João Pinto da Costa, Rui Miguel Pinheiro Vitorino, Gustavo M. Silva, Christine Vogel, Armando C. Duarte, Teresa Rocha‐Santos · 2016 · Ageing Research Reviews
  12. Mitophagy and Neuroprotection
    Guofeng Lou, Konstantinos Palikaras, Sofie Lautrup, Morten Scheibye‐Knudsen, Nektarios Tavernarakis, Evandro Fei Fang · 2019 · Trends in Molecular Medicine
  13. Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring
    Rakesh Kumar Sharma, Ashok Kumar Agarwal, Vikram K Rohra, Mourad Assidi, Muhammad M. Abu-Elmagd, Rola F. Turki · 2015 · Reproductive Biology and Endocrinology
  14. Revealing the Pathogenic and Aging-related Mechanisms of the Enigmatic Idiopathic Pulmonary Fibrosis. An Integral Model
    Moisés Selman, Annie Pardo · 2014 · American Journal of Respiratory and Critical Care Medicine
  15. Chronic inflammation and the hallmarks of aging
    Baechle, Jordan J., Chen, Nan, Makhijani, Priya, Winer, Shawn, Furman, David, Winer, Daniel A. · 2023 · Molecular Metabolism
  16. Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies
    Bowman, Robert L., Busque, Lambert, Levine, Ross L. · 2018 · Cell stem cell
  17. The role of lipid metabolism in aging, lifespan regulation, and age‐related disease
    Adiv A. Johnson, Alexandra Stolzing · 2019 · Aging Cell
  18. Taurine deficiency as a driver of aging
    Parminder Pal Singh, Kishore Gollapalli, Stefano Mangiola, Daniela Schranner, Mohd Aslam Yusuf, Manish Chamoli, Sting L. Shi, Bruno Lopes-Bastos, Tripti Nair, Annett Riermeier et al. · 2023 · Science
  19. Ageing, Cellular Senescence and Neurodegenerative Disease
    Kritsilis, Marios, V. Rizou, Sophia, Koutsoudaki, Paraskevi N., Evangelou, Konstantinos, Gorgoulis, Vassilis G., Papadopoulos, Dimitrios · 2018 · International Journal of Molecular Sciences
  20. An update on the pathophysiology of osteoarthritis
    Ali Mobasheri, Mark Edward Batt · 2016 · Annals of Physical and Rehabilitation Medicine
  21. Autophagy and cellular immune responses
    Ma, Yuting, Galluzzi, Lorenzo, Zitvogel, Laurence, Kroemer, Guido · 2013 · Immunity
  22. Brain age and other bodily ‘ages’: implications for neuropsychiatry
    James Howard Cole, Riccardo Emilio Marioni, Sarah E. Harris, Ian J. Deary · 2018 · Molecular Psychiatry
  23. Exosomes and Autophagy: Coordinated Mechanisms for the Maintenance of Cellular Fitness
    Francesc Baixauli, Carlos López-Otı́n, Marı́a Mittelbrunn · 2014 · Frontiers in Immunology
  24. Sex differences in biological aging with a focus on human studies
    Hägg, Sara, Jylhävä, Juulia · 2021 · eLife
  25. Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications
    Zhong, Qian, Xiao, Xina, Qiu, Yijie, Xu, Zhiqiang, Chen, Chunyu, Chong, Baochen, Zhao, Xinjun, Hai, Shan, Li, Shuangqing, An, Zhenmei et al. · 2023 · MedComm
  26. mTOR as a central regulator of lifespan and aging
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  27. Mitochondrial quality control and muscle mass maintenance.
    Romanello, Vanina, Sandri, Marco · 2016 · Frontiers in Physiology
  28. Redox regulation by NRF2 in aging and disease
    Cody J. Schmidlin, Matthew B. Dodson, Lalitha Madhavan, Donna D. Zhang · 2019 · Free Radical Biology and Medicine
  29. Aging of the immune system: Focus on inflammation and vaccination
    Pinti, Marcello, Appay, Victor, Campisi, Judith, Frasca, Daniela, Fülöp, Tamas, Sauce, Delphine, Larbi, Anis, Weinberger, Birgit, Cossarizza, Andrea · 2016 · European Journal of Immunology
  30. Evaluating intrinsic and non-intrinsic cancer risk factors
    Song Wu, Wei Zhu, Patricia A. Thompson, Yusuf Awni Hannun · 2018 · Nature Communications
  31. Can physical activity ameliorate immunosenescence and thereby reduce age-related multi-morbidity?
    Duggal, Niharika A., Niemiro, Grace, Harridge, Stephen D. R., Simpson, Richard J., Lord, Janet M. · 2019 · Nature Reviews Immunology
  32. Skeletal Muscle Extracellular Matrix – What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review
    Robert Csapo, Matthias Gumpenberger, Barbara Wessner · 2020 · Frontiers in Physiology
  33. Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin
    Salminen, Antero, Kaarniranta, Kai, Kauppinen, Anu · 2022 · Inflammation Research
  34. Aging of hematopoietic stem cells
    de Haan, Gerald, Lazare, Seka Simone · 2018 · Blood
  35. Aging Hallmarks and the Role of Oxidative Stress
    Edio Maldonado, Sebastián Morales-Pison, Fabiola Urbina, A. Solari · 2023 · Antioxidants
  36. Mitochondrial homeostasis: The interplay between mitophagy and mitochondrial biogenesis
    Konstantinos Palikaras, Nektarios Tavernarakis · 2014 · Experimental Gerontology
  37. An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance
    He, Ming, Chiang, Hou-Hsien, Luo, Hanzhi, Zheng, Zhifang, Qiao, Qi, Wang, Li, Tan, Mingdian, Ohkubo, Rika, Mu, Wei-Chieh, Zhao, Shimin et al. · 2020 · Cell Metabolism
  38. Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6
    Daniel J. Tyrrell, Daniel R. Goldstein · 2020 · Nature Reviews Cardiology
  39. Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging
    Mihaylova, Maria M., Cheng, Chia-Wei, Cao, Amanda Q., Tripathi, Surya, Mana, Miyeko D., Bauer-Rowe, Khristian E., Abu-Remaileh, Monther, Clavain, Laura, Erdemir, Aysegul, Lewis, Caroline A. et al. · 2018 · Cell Stem Cell
  40. Autophagy and the cell biology of age-related disease
    Leidal, Andrew M., Levine, Beth, Debnath, Jayanta · 2018 · Nature Cell Biology
  41. Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity
    Palmer, Allyson K., Tchkonia, Tamara, LeBrasseur, Nathan K., Chini, Eduardo N., Xu, Ming, Kirkland, James L. · 2015 · Diabetes
  42. Aging, inflammation and the environment
    Arsun Bektas, Shepherd H. Schurman, Ranjan Sen, Luigi Ferrucci · 2017 · Experimental Gerontology
  43. The Mitochondrial Basis of Aging and Age-Related Disorders
    Sarika Srivastava · 2017 · Genes
  44. Age of patients undergoing surgery
    Alexander James Fowler, Tom E.F. Abbott, John Richard Prowle, Rupert M. Pearse · 2019 · British journal of surgery
  45. Eleven Telomere, Epigenetic Clock, and Biomarker-Composite Quantifications of Biological Aging: Do They Measure the Same Thing?
    Daniel W. Belsky, Terrie E. Moffitt, Alan Arthur Cohen, David L. Corcoran, Morgan E. Levine, Joseph A. Prinz, Jonathan D. Schaefer, Karen Sugden, Benjamin S. Williams, Richie Poulton et al. · 2017 · American Journal of Epidemiology
  46. Inflammaging and Osteoarthritis
    F. Motta, Elisabetta Barone, A. Sica, C. Selmi · 2022 · Clinical reviews in allergy and immunology
  47. Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis
    Matsumura, Hiroyuki, Mohri, Yasuaki, Binh, Nguyen Thanh, Morinaga, Hironobu, Fukuda, Makoto, Ito, Mayumi, Kurata, Sotaro, Hoeijmakers, Jan, Nishimura, Emi K. · 2016 · Science
  48. The landscape of aging
    Yusheng Cai, Wei Song, Jiaming Li, Ying Jing, Chuqian Liang, Liyuan Zhang, Xia Zhang, Wenhui Zhang, Beibei Liu, Yongpan An et al. · 2022 · Science China Life Sciences
  49. Exercise Attenuates the Major Hallmarks of Aging
    Garatachea, Nuria, Pareja-Galeano, Helios, Sanchis-Gomar, Fabian, Santos-Lozano, Alejandro, Fiuza-Luces, Carmen, Morán, María, Emanuele, Enzo, Joyner, Michael J., Lucia, Alejandro · 2015 · Rejuvenation Research
  50. Osteoporosis and periodontal diseases – An update on their association and mechanistic links
    Bo Yu, Cun-Yu Wang · 2022 · Periodontology 2000
  51. A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging
    Haopeng Xiao, Mark P. Jedrychowski, Devin K. Schweppe, Edward L. Huttlin, Qing Yu, David E. Heppner, Jiaming Li, Jiani Long, Evanna L. Mills, John Szpyt et al. · 2020 · Cell
  52. Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?
    Korolchuk, Viktor I., Miwa, Satomi, Carroll, Bernadette, von Zglinicki, Thomas · 2017 · EBioMedicine
  53. Biomarkers of cellular senescence and skin aging
    Wang, Audrey S., Dreesen, Oliver · 2018 · Frontiers in Genetics
  54. Autophagy in metabolic disease and ageing
    Munehiro Kitada, Daisuke Koya · 2021 · Nature Reviews Endocrinology
  55. Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis <i>ex vivo</i>
    Lehmann, Mareike, Korfei, Martina, Mutze, Kathrin, Klee, Stephan, Skronska-Wasek, Wioletta, Alsafadi, Hani N., Ota, Chiharu, Costa, Rita, Schiller, Herbert B., Lindner, Michael et al. · 2017 · European Respiratory Journal
  56. Personal aging markers and ageotypes revealed by deep longitudinal profiling
    Ahadi, Sara, Zhou, Wenyu, Schüssler-Fiorenza Rose, Sophia Miryam, Sailani, M. Reza, Contrepois, Kévin, Avina, Monika, Ashland, Melanie, Brunet, Anne, Snyder, Michael · 2020 · Nature Medicine
  57. Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing
    Ana Latorre-Pellicer, Raquel Moreno‐Loshuertos, Ana Victoria Lechuga‐Vieco, Fátima Sánchez‐Cabo, Carlos Torroja, Rebeca Acín‐Pérez, Enrique Calvo, Esther Aix, Andrés González-Guerra, Angela Logan et al. · 2016 · Nature
  58. Mitochondria as central regulators of neural stem cell fate and cognitive function
    Mireille Khacho, Richard Harris, Ruth S. Slack · 2018 · Nature reviews. Neuroscience
  59. A multidimensional systems biology analysis of cellular senescence in aging and disease
    Avelar, Roberto A., Ortega, Javier Gómez, Tacutu, Robi, Tyler, Eleanor J., Bennett, Dominic, Binetti, Paolo, Budovsky, Arie, Chatsirisupachai, Kasit, Johnson, Emily, Murray, Alex et al. · 2020 · Genome Biology
  60. Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention
    Xudong Zhu, Zhiyang Chen, Weiyan Shen, Gang Huang, John M. Sedivy, Hu Wang, Zhenyu Ju · 2021 · Signal Transduction and Targeted Therapy
  61. A toolkit for quantification of biological age from blood chemistry and organ function test data: BioAge
    Kwon, Dayoon, Belsky, Daniel W. · 2021 · GeroScience
  62. Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice
    Cai, Yusheng, Zhou, Huanhuan, Zhu, Yinhua, Sun, Qi, Ji, Yin, Xue, Anqi, Wang, Yuting, Chen, Wenhan, Yu, Xiaojie, Wang, Longteng et al. · 2020 · Cell Research
  63. Mechanisms and Regulation of Cellular Senescence
    Roger, Lauréline, Tomas, Fanny, Gire, Véronique · 2021 · International Journal of Molecular Sciences
  64. From geroscience to precision geromedicine: Understanding and managing aging
    Kroemer, Guido, Maier, Andrea B., Cuervo, Ana Maria, Gladyshev, Vadim N., Ferrucci, Luigi, Gorbunova, Vera, Kennedy, Brian K., Rando, Thomas A., Seluanov, Andrei, Sierra, Felipe et al. · 2025 · Cell
  65. Sarcopenia
    Avan Aihie Sayer, Rachel Cooper, Hidenori Arai, Peggy Mannen Cawthon, Marie-Josiane Ntsama Essomba, Roger A. Fielding, Miranda D. Grounds, Miles D. Witham, Alfonso José Cruz-Jentoft · 2024 · Nature Reviews Disease Primers
  66. TGF-β Signaling in Cellular Senescence and Aging-Related Pathology
    Tominaga, Kana, Suzuki, Hiroshi I. · 2019 · International Journal of Molecular Sciences
  67. Resurrection of endogenous retroviruses during aging reinforces senescence
    Liu, Xiaoqian, Liu, Zunpeng, Wu, Zeming, Ren, Jie, Fan, Yanling, Sun, Liang, Cao, Gang, Niu, Yuyu, Zhang, Baohu, Ji, Qianzhao et al. · 2023 · Cell
  68. Combinatorial Strategies for the Induction of Immunogenic Cell Death
    Lucillia Bezu, Lígia Catarina Gomes-da-Silva, Heleen Dewitte, Karine Breckpot, Jitka Palich Fucikova, Radek Špíšek, Lorenzo Galluzzi, Oliver Kepp, Guido Kroemer · 2015 · Frontiers in Immunology
  69. Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche
    Maria Maryanovich, Ali H. Zahalka, Halley Pierce, Sandra Pinho, Fumio Nakahara, Noboru Asada, Qiaozhi Wei, Xizhe Wang, Paul Ciero, Jianing Xu et al. · 2018 · Nature Medicine
  70. Aging and the immune system: An overview
    Amir A. Sadighi Akha · 2018 · Journal of Immunological Methods
  71. The National Institute on Aging Health Disparities Research Framework
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  72. Mitochondrial quality control mechanisms as molecular targets in cardiac ageing
    Anna Picca, Robert T. Mankowski, Jonathon L. Burman, Luca Donisi, Kim Js, Emanuele Marzetti, Christiaan Leeuwenburgh · 2018 · Nature Reviews Cardiology
  73. Nuclear DNA damage signalling to mitochondria in ageing
    Fang, Evandro Fei, Scheibye-Knudsen, Morten, Chua, Katrin F., Mattson, Mark P., Croteau, Deborah L., Bohr, Vilhelm A. · 2016 · Nature Reviews Molecular Cell Biology
  74. Ageing and the telomere connection: An intimate relationship with inflammation
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  75. Mediterranean diet and health status: Active ingredients and pharmacological mechanisms
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  76. Immune ageing at single-cell resolution
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  77. Recurrent turnover of senescent cells during regeneration of a complex structure
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  78. Insights into the Evolution of Longevity from the Bowhead Whale Genome
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  80. Identification and characterization of Cardiac Glycosides as senolytic compounds
    Triana-Martínez, Francisco, Picallos-Rabina, Pilar, Da Silva-Álvarez, Sabela, Pietrocola, Federico, Llanos, Susana, Rodilla, Verónica, Soprano, Enrica, Pedrosa, Pablo, Ferreirós, Alba, Barradas, Marta et al. · 2019 · Nature Communications
  81. Multi-tissue DNA methylation age predictor in mouse
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  82. DNA damage and repair in age-related inflammation
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  83. Endocannabinoid signalling and the deteriorating brain
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