The Hallmarks of Aging

López-Otín, Carlos, Blasco, Maria A., Partridge, Linda, Serrano, Manuel, Kroemer, Guido·2013·Cell

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Items 301–400 of 1,350

  1. A meta-analysis of genome-wide association studies identifies multiple longevity genes
    Deelen, Joris, Evans, Daniel S., Arking, Dan E., Tesi, Niccolò, Nygaard, Marianne, Liu, Xiaomin, Wojczynski, Mary K., Biggs, Mary L., van der Spek, Ashley, Atzmon, Gil et al. · 2019 · Nature Communications
  2. The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis
    Fransquet, Peter D., Wrigglesworth, Jo, Woods, Robyn L., Ernst, Michael E., Ryan, Joanne · 2019 · Clinical Epigenetics
  3. Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence
    Vizioli, Maria Grazia, Liu, Tianhui, Miller, Karl N., Robertson, Neil A., Gilroy, Kathryn, Lagnado, Anthony B., Perez-Garcia, Arantxa, Kiourtis, Christos, Dasgupta, Nirmalya, Lei, Xue et al. · 2020 · Genes & Development
  4. The genetics of human ageing
    David R. Melzer, Luke C. Pilling, Luigi Ferrucci · 2019 · Nature Reviews Genetics
  5. Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence
    Annika Höhn, Daniela Weber, Tobias Jung, Christiane Ott, Martín Hugo, Bastian Kochlik, Richard Kehm, Jeannette König, Tilman Grune, José Pedro Castro · 2016 · Redox Biology
  6. Targeting cancer-promoting inflammation — have anti-inflammatory therapies come of age?
    Jiajie Hou, Michael Karin, Beicheng Sun · 2021 · Nature Reviews Clinical Oncology
  7. Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities
    Migliavacca, Eugenia, Tay, Stacey K. H., Patel, Harnish P., Sonntag, Tanja, Civiletto, Gabriele, McFarlane, Craig, Forrester, Terence, Barton, Sheila J., Leow, Melvin K., Antoun, Elie et al. · 2019 · Nature Communications
  8. Mitophagy in neurodegeneration and aging
    Fivenson, Elayne M., Lautrup, Sofie, Sun, Nuo, Scheibye-Knudsen, Morten, Stevnsner, Tinna, Nilsen, Hilde, Bohr, Vilhelm A., Fang, Evandro F. · 2017 · Neurochemistry International
  9. Mitochondria and Epigenetics – Crosstalk in Homeostasis and Stress
    Olli Matilainen, Pedro M. Quirós, Johan H. Auwerx · 2017 · Trends in Cell Biology
  10. Two conserved histone demethylases regulate mitochondrial stress-induced longevity
    Merkwirth, Carsten, Jovaisaite, Virginija, Durieux, Jenni, Matilainen, Olli, Jordan, Sabine D., Quiros, Pedro M., Steffen, Kristan K., Williams, Evan G., Mouchiroud, Laurent, Tronnes, Sarah U. et al. · 2016 · Cell
  11. Successful and Maladaptive T Cell Aging
    Goronzy, Jörg J., Weyand, Cornelia M. · 2017 · Immunity
  12. The role of mitochondrial <scp>ROS</scp> in the aging brain
    Stefanatos, Rhoda, Sanz, Alberto · 2018 · FEBS Letters
  13. Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses
    Benayoun, Bérénice A., Pollina, Elizabeth A., Singh, Param Priya, Mahmoudi, Salah, Harel, Itamar, Casey, Kerriann M., Dulken, Ben W., Kundaje, Anshul, Brunet, Anne · 2019 · Genome Research
  14. Senescent cells and osteoarthritis: a painful connection
    Ok Hee Jeon, Nathaniel E. David, Judith Campisi, Jennifer H. Elisseeff · 2018 · Journal of Clinical Investigation
  15. Idiopathic Pulmonary Fibrosis: An Update on Pathogenesis
    Mei, Qianru, Liu, Zhe, Zuo, He, Yang, Zhenhua, Qu, Jing · 2022 · Frontiers in Pharmacology
  16. A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup
    Justice, Jamie N., Ferrucci, Luigi, Newman, Anne B., Aroda, Vanita R., Bahnson, Judy L., Divers, Jasmin, Espeland, Mark A., Marcovina, Santica, Pollak, Michael N., Kritchevsky, Stephen B. et al. · 2018 · GeroScience
  17. Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors
    Sadegh Saghafinia, Marco Mina, Nicolò Riggi, Douglas Hanahan, Giovanni Ciriello · 2018 · Cell Reports
  18. Spermidine induces autophagy by inhibiting the acetyltransferase EP300
    Pietrocola, F, Lachkar, S, Enot, D P, Niso-Santano, M, Bravo-San Pedro, J M, Sica, V, Izzo, V, Maiuri, M C, Madeo, F, Mariño, G et al. · 2015 · Cell Death &amp; Differentiation
  19. Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue
    Deanna L. Plubell, Phillip A. Wilmarth, Yuqi Zhao, Alexandra M Fenton, Jessica Minnier, Ashok P. Reddy, John E. Klimek, Xia Yang, Larry L. David, Nathalie Pamir · 2017 · Molecular & Cellular Proteomics
  20. Quantifying resilience of humans and other animals
    Marten Scheffer, Jantina Elizabeth Bolhuis, Denny Borsboom, Timothy G. Buchman, Sanne M.W. Gijzel, Dave Goulson, Jan E. Kammenga, B. Kemp, Ingrid A. van de Leemput, Simon A. Levin et al. · 2018 · Proceedings of the National Academy of Sciences
  21. Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB–driven inflammation and cardiovascular risk
    Anthony S. Zannas, Meiwen Jia, Kathrin Hafner, Jens J Baumert, Tobias Wiechmann, Julius C. Pape, Janine Arloth, Maik Ködel, Silvia Martinelli, Maria Roitman et al. · 2019 · Proceedings of the National Academy of Sciences
  22. The role of matrix metalloproteinases in aging: Tissue remodeling and beyond
    Sandra Freitas‐Rodríguez, Alicia R. Folgueras, Carlos López-Otı́n · 2017 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  23. The integration of inflammaging in age-related diseases
    Tamàs Fülöp, Jacek Maciej Witkowski, Fabiola Olivieri, Anis Larbi · 2018 · Seminars in Immunology
  24. Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging
    Ma, Shuai, Sun, Shuhui, Geng, Lingling, Song, Moshi, Wang, Wei, Ye, Yanxia, Ji, Qianzhao, Zou, Zhiran, Wang, Si, He, Xiaojuan et al. · 2020 · Cell
  25. Naive T Cell Maintenance and Function in Human Aging
    Jörg J. Goronzy, Fengqin Fang, Mary Cavanagh, Qian Qi, Cornelia M. Weyand · 2015 · The Journal of Immunology
  26. Common genetic associations between age-related diseases
    Handan Melike Dönertaş, Daniel K. Fabian, Matías Fuentealba, Linda Partridge, Janet M. Thornton · 2021 · Nature Aging
  27. YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS–STING
    Hanna Lucie Sladitschek, Alberto Guarnieri, Giulia Brumana, Francesca Zanconato, Giusy Battilana, Romy Lucon Xiccato, Tito Panciera, Mattia Forcato, Silvio Bicciato, Vincenza Guzzardo et al. · 2022 · Nature
  28. Epigenetic clock: A promising biomarker and practical tool in aging
    Ran Duan, Qiaoyu Fu, Yu Sun, Qingfeng Li · 2022 · Ageing Research Reviews
  29. Effect of resveratrol and pterostilbene on aging and longevity
    Yi‐Rong Li, Shiming Li, Chi‐Chen Lin · 2017 · BioFactors
  30. Hallmarks of senescence and aging
    Slavica Dodig, Ivana Čepelak, Ivan Pavić · 2019 · Biochemia Medica
  31. Anti‐ageing active ingredients from herbs and nutraceuticals used in traditional Chinese medicine: pharmacological mechanisms and implications for drug discovery
    Chunyan Shen, Jian‐Guo Jiang, Li Yang, Dawei Wang, Wei Zhu · 2016 · British Journal of Pharmacology
  32. Role of Vascular Smooth Muscle Cell Phenotypic Switching and Calcification in Aortic Aneurysm Formation
    Ploingarm Petsophonsakul, Malgorzata Furmanik, Rachael O. Forsythe, Marc Richard Dweck, Geert Willem H. Schurink, Ehsan Natour, Chris P.M. Reutelingsperger, Michael J.H.M. Jacobs, Barend Mees, Leon J. Schurgers · 2019 · Arteriosclerosis Thrombosis and Vascular Biology
  33. Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B
    Paola Fisicaro, Valeria Barili, Barbara Montanini, Greta Acerbi, Manuela Ferracin, Francesca Guerrieri, Debora Salerno, Carolina Boni, Marco Massari, Maria Cristina Cavallo et al. · 2017 · Nature Medicine
  34. Exercise and mitochondrial health
    Memme, Jonathan M., Erlich, Avigail T., Phukan, Geetika, Hood, David A. · 2021 · The Journal of Physiology
  35. IPF lung fibroblasts have a senescent phenotype
    Álvarez, Diana, Cárdenes, Nayra, Sellarés, Jacobo, Bueno, Marta, Corey, Catherine, Hanumanthu, Vidya Sagar, Peng, Yating, D’Cunha, Hannah, Sembrat, John, Nouraie, Mehdi et al. · 2017 · American Journal of Physiology-Lung Cellular and Molecular Physiology
  36. The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice
    Xu, Qixia, Fu, Qiang, Li, Zi, Liu, Hanxin, Wang, Ying, Lin, Xu, He, Ruikun, Zhang, Xuguang, Ju, Zhenyu, Campisi, Judith et al. · 2021 · Nature Metabolism
  37. Neutrophil phenotypes and functions in cancer: A consensus statement
    Daniela F. Quail, Borko Amulic, Monowar Aziz, Betsy Jo Barnes, Evgeniy B. Eruslanov, Zvi Gregorio Fridlender, Helen S. Goodridge, Zvi Granot, Andrés Hidalgo, Anna Huttenlocher et al. · 2022 · The Journal of Experimental Medicine
  38. Sestrins Orchestrate Cellular Metabolism to Attenuate Aging
    Jun Hee Lee, Andrei V. Budanov, Michael Karin · 2013 · Cell Metabolism
  39. Hallmarks of the ageing lung
    Meiners, Silke, Eickelberg, Oliver, Königshoff, Melanie · 2015 · European Respiratory Journal
  40. The degree of frailty as a translational measure of health in aging
    Susan Ellen Howlett, Andrew D. Rutenberg, Kenneth J. Rockwood · 2021 · Nature Aging
  41. Metabolic changes in aging humans: current evidence and therapeutic strategies
    Allyson K. Palmer, Michael D. Jensen · 2022 · Journal of Clinical Investigation
  42. Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span
    Robbins, Paul D., Jurk, Diana, Khosla, Sundeep, Kirkland, James L., LeBrasseur, Nathan K., Miller, Jordan D., Passos, João F., Pignolo, Robert J., Tchkonia, Tamar, Niedernhofer, Laura J. · 2021 · Annual Review of Pharmacology and Toxicology
  43. Cellular senescence: at the nexus between ageing and diabetes
    Palmer, Allyson K., Gustafson, Birgit, Kirkland, James L., Smith, Ulf · 2019 · Diabetologia
  44. Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity
    Collin Y. Ewald, Jess N. Landis, Jess Porter Abate, Coleen Tara Murphy, T. Keith Blackwell · 2014 · Nature
  45. Accelerated ageing of the lung in COPD: new concepts
    Nicolas Mercado, Kazuhiro Ito, Peter John Barnes · 2015 · Thorax
  46. SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2
    Huize Pan, Di Guan, Xiaomeng Liu, Jingyi Li, Lixia Wang, Jun Wu, Junzhi Zhou, Weizhou Zhang, Ruotong Ren, Weiqi Zhang et al. · 2016 · Cell Research
  47. Interferon-induced guanylate-binding proteins: Guardians of host defense in health and disease
    Kyle Tretina, Eui‐Soon Park, Agnieszka Mamińska, John D. MacMicking · 2019 · The Journal of Experimental Medicine
  48. Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease
    Yasmine J. Liu, Rebecca L. McIntyre, Georges E. Janssens, Riekelt H. Houtkooper · 2020 · Mechanisms of Ageing and Development
  49. Osteogenesis and aging: lessons from mesenchymal stem cells
    Infante, Arantza, Rodríguez, Clara I. · 2018 · Stem Cell Research &amp; Therapy
  50. Lysosomal cathepsins and their regulation in aging and neurodegeneration
    Stoka, Veronika, Turk, Vito, Turk, Boris · 2016 · Ageing Research Reviews
  51. Whole-genome fingerprint of the DNA methylome during human B cell differentiation
    Marta Kulis, Angelika Merkel, Simon Charles Heath, Ana C. Queirós, Ronald P. Schuyler, Giancarlo Castellano, Renée Beekman, Emanuele Raineri, Anna Esteve‐Codina, Guillem Clot et al. · 2015 · Nature Genetics
  52. Antioxidant Functionalized Nanoparticles: A Combat against Oxidative Stress
    Harsh Kumar, Kanchan Bhardwaj, Eugenie Nepovimová, Kamil Kuča, Daljeet Singh Dhanjal, Sonali Bhardwaj, Shashi Kant Bhatia, Rachna Verma, Dinesh Kumar · 2020 · Nanomaterials
  53. Mechanisms of Vascular Aging, A Geroscience Perspective
    Zoltan I. Ungvari, Stefano Tarantini, Farzaneh A. Sorond, Béla Péter Merkely, Anna Csiszár · 2020 · Journal of the American College of Cardiology
  54. Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses
    Francesc Baixauli, Rebeca Acín‐Pérez, Carolina Villarroya‐Beltri, Carla Mazzeo, N. Núñez‐Andrade, Enrique Gabandé‐Rodríguez, María Dolores Ledesma, Alberto Blázquez, Miguel Angel Martín, Juan Manuel Falcón‐Pérez et al. · 2015 · Cell Metabolism
  55. The Mechanistic Links Between Proteasome Activity, Aging and Agerelated Diseases
    Isabel Sáez, David Vı́lchez · 2014 · Current Genomics
  56. Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing
    Chandel, Navdeep S., Jasper, Heinrich, Ho, Theodore T., Passegué, Emmanuelle · 2016 · Nature Cell Biology
  57. Mitochondrial dysfunction and cell senescence: deciphering a complex relationship
    Chapman, James, Fielder, Edward, Passos, João F. · 2019 · FEBS Letters
  58. Aging Atlas: a multi-omics database for aging biology
    Guang‐Hui Liu, Yīmíng Bào, Jing Tao Qu, Weiqi Zhang, Tāo Zhāng, Wang Kang, Fei Yang, Qianzhao Ji, Xiaoyu Jiang, Yingke Ma et al. · 2020 · Nucleic Acids Research
  59. Solving neurodegeneration: common mechanisms and strategies for new treatments
    Wareham, Lauren K., Liddelow, Shane A., Temple, Sally, Benowitz, Larry I., Di Polo, Adriana, Wellington, Cheryl, Goldberg, Jeffrey L., He, Zhigang, Duan, Xin, Bu, Guojun et al. · 2022 · Molecular Neurodegeneration
  60. The Role of the Immune System in Metabolic Health and Disease
    Zmora, Niv, Bashiardes, Stavros, Levy, Maayan, Elinav, Eran · 2017 · Cell Metabolism
  61. Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging
    Plaza-Zabala, Ainhoa, Sierra-Torre, Virginia, Sierra, Amanda · 2017 · International Journal of Molecular Sciences
  62. Skin Aging, Cellular Senescence and Natural Polyphenols
    Erika Csekes, Lucia Račková · 2021 · International Journal of Molecular Sciences
  63. Skin Senescence: Mechanisms and Impact on Whole-Body Aging
    Franco, Ana Catarina, Aveleira, Célia, Cavadas, Cláudia · 2022 · Trends in Molecular Medicine
  64. The DNA damage response to transcription stress
    Lans, Hannes, Hoeijmakers, Jan H. J., Vermeulen, Wim, Marteijn, Jurgen A. · 2019 · Nature Reviews Molecular Cell Biology
  65. Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases
    Kubben, Nard, Misteli, Tom · 2017 · Nature Reviews Molecular Cell Biology
  66. Molecular and biological hallmarks of ageing
    Jan Rune Aunan, Martin M. Watson, Hanne Røland Hagland, Kjetil Søreide · 2016 · British journal of surgery
  67. DNA Methylation Biomarkers in Aging and Age-Related Diseases
    Yasmeen Salameh, Yosra Bejaoui, Nady El Hajj · 2020 · Frontiers in Genetics
  68. New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary
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  70. Autophagy: a druggable process that is deregulated in aging and human disease
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  71. The role of cellular senescence in cardiac disease: basic biology and clinical relevance
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  72. Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging
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  73. Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice
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  74. Gastrointestinal Tract Disorders in Older Age
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  75. Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity
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  76. Microbiota from young mice counteracts selective age-associated behavioral deficits
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