The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Injury-Induced HDAC5 Nuclear Export Is Essential for Axon Regeneration
Open accessAbstract
SUMMARY Reactivation of a silent transcriptional program is a critical step in successful axon regeneration following injury. Yet how such program is unlocked after injury remains largely unexplored. We found that axon injury in peripheral sensory neurons elicits a back-propagating calcium wave that invades the soma and causes nuclear export of HDAC5 in a PKCµ–dependent manner. Injury-induced HDAC5 nuclear export enhances histone acetylation to activate a pro-regenerative gene expression program. HDAC5 nuclear export is required for axon regeneration, since expression of a nuclear-trapped HDAC5 mutant prevents axon regeneration, whereas enhancing HDAC5 nuclear export promotes axon regeneration in vitro and in vivo. Components of this HDAC5 pathway failed to be activated in a model of central nervous system injury. These studies reveal a signaling mechanism from the axon injury site to the soma that controls neuronal growth competence and suggest a role for HDAC5 as a transcriptional switch controlling axon regeneration.
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Neuronal Intrinsic Mechanisms of Axon Regeneration
Liu, K., Tedeschi, A., Park, K. K., & He, Z. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113723 · Cited by 458
PTMScout, a Web Resource for Analysis of High Throughput Post-translational Proteomics Studies
Naegle, K. M., Gymrek, M., Joughin, B. A., Wagner, J. P., Welsch, R. E., Yaffe, M. B., Lauffenburger, D. A., & White, F. M. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.001206 · Cited by 41
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Cited by
Mertens, J., Paquola, A. C. M., Ku, M., Hatch, E., Böhnke, L., Ladjevardi, S., McGrath, S., Campbell, B., Lee, H., Herdy, J. R., et al. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.09.001 · Cited by 765
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Kumar, V., Kundu, S., Singh, A., & Singh, S. (2022) · Current Neuropharmacology · doi:10.2174/1570159x19666210609160017 · Cited by 210
Latremoliere, A., Cheng, L., DeLisle, M., Wu, C., Chew, S., Hutchinson, E. B., Sheridan, A., Alexandre, C., Latremoliere, F., Sheu, S.-H., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.029 · Cited by 183
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Axonal Organelles as Molecular Platforms for Axon Growth and Regeneration after Injury
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In situ structural mechanism of epothilone-B-induced CNS axon regeneration
Bodakuntla, S., Taira, K., Yamada, Y., Alvarez-Brecht, P., Cada, A. K., Basnet, N., Zhang, R., Martinez-Sanchez, A., Biertümpfel, C., & Mizuno, N. (2025) · Nature · doi:10.1038/s41586-025-09654-z · Cited by 9
Metadata
- Authors
- Cho, Y., Sloutsky, R., Naegle, K. M., & Cavalli, V.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 155
- Issue
- 4
- Pages
- 894-908
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2130367422
- Cited by
- 327
- References
- 4
- FWCI
- 12.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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