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Role of the microbiota in immunity and inflammation.
Open accessAbstract
The microbiota plays a fundamental role on the induction, training, and function of the host immune system. In return, the immune system has largely evolved as a means to maintain the symbiotic relationship of the host with these highly diverse and evolving microbes. When operating optimally, this immune system-microbiota alliance allows the induction of protective responses to pathogens and the maintenance of regulatory pathways involved in the maintenance of tolerance to innocuous antigens. However, in high-income countries, overuse of antibiotics, changes in diet, and elimination of constitutive partners, such as nematodes, may have selected for a microbiota that lack the resilience and diversity required to establish balanced immune responses. This phenomenon is proposed to account for some of the dramatic rise in autoimmune and inflammatory disorders in parts of the world where our symbiotic relationship with the microbiota has been the most affected.
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“While the impact of most of these substances on human health is not entirely clear at this point, evidence suggests that they are potentially harmful, with possible carcinogenic, teratogenic, and mutagenic effects and reproductive developmental toxicity [66]; in addition, they may disrupt the normal functioning of gut microbiota [67] and the endocrine system [68].”
From Bottled Water: An Evidence-Based Overview of Economic Viability, Environmental Impact, and Social Equity (2023) · cites this paper as [67]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The microbiota in the stomach promotes gut health and immunological balance by suppressing inflammation (10).”
From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [10]
Experimental — accuracy not yet measuredIn the citing paper
“endogenous symbiont microorganisms, the so-called microbiota, can modulate gene expression, induce preferential food intake (Aydin, 2007), influence pH, redox balance and the ratio between pro-inflammatory and anti-inflammatory cytokines (Belkaid and Hand, 2014).”
From Bioactive Molecules Released in Food by Lactic Acid Bacteria: Encrypted Peptides and Biogenic Amines (2016) · cites this paper as Belkaid and Hand, 2014
In the citing paper
“The intestinal microbiota play a role in host physiology.1”
From Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation (2020) · cites this paper as [1]
In the citing paper
“The gut microbial population plays a key role in training, functioning and stimulating the host immune system, with the final effect of developing tolerance towards beneficial microbiota and eliciting immune response against gut pathogens [76].”
From Gut Microbiota and Cancer: From Pathogenesis to Therapy (2019) · cites this paper as [76]
In the citing paper
“Several studies have reported an association of dysbiosis with chronic inflammation, which may in turn result in an association with bone diseases [129,132,215,216].”
From Bone diseases in patients with chronic liver disease (2019) · cites this paper as [215]
In the citing paper
“Variations in these early interactions appear to set the tone of the mucosal and systemic immune systems into childhood and even adult life (Belkaid and Hand, 2014).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Belkaid and Hand, 2014
In the citing paper
“The gut microbiota play a critical role in the development of the intestinal architecture and mucosal immune system and are particularly important for regulation of the immune system in the gut [reviewed in [13, 14]].”
From The Gut Microbiota and Dysbiosis in Autism Spectrum Disorders (2018) · cites this paper as [13]
In the citing paper
“These mice experience immune dysfunction and are more susceptible to infections than mice kept in conventional facilities [13, 15].”
From The Gut Microbiota and Dysbiosis in Autism Spectrum Disorders (2018) · cites this paper as [13]
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Cites
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
A metagenome-wide association study of gut microbiota in type 2 diabetes
Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549
Diversity, stability and resilience of the human gut microbiota
Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K., & Knight, R. (2012) · Nature · doi:10.1038/nature11550 · Cited by 5,533
Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration
Marshall, B., & Warren, J. R. (1984) · The Lancet · doi:10.1016/s0140-6736(84)91816-6 · Cited by 5,509
The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis
Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838
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Mizutani, T., Ishizaka, A., Koga, M., Ikeuchi, K., Saito, M., Adachi, E., Yamayoshi, S., Iwatsuki‐Horimoto, K., Yasuhara, A., Kiyono, H., et al. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.01689-21 · Cited by 82
Bianchimano, P., Britton, G. J., Wallach, D. S., Smith, E. M., Cox, L. M., Liu, S., Iwanowski, K., Weiner, H. L., Faith, J. J., Clemente, J. C., et al. (2022) · Microbiome · doi:10.1186/s40168-022-01364-2 · Cited by 83
The opportunistic nature of gut commensal microbiota
Dey, P., & Chaudhuri, S. R. (2022) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2022.2133987 · Cited by 81
Qin, D., Ma, Y., Wang, Y., Hou, X., & Yu, L. (2022) · Life · doi:10.3390/life12111910 · Cited by 91
Gut Dysbiosis and Adaptive Immune Response in Diet-induced Obesity vs. Systemic Inflammation
Pindjáková, J., Sartini, C., Re, O. L., Rappa, F., Coupé, B., Lelouvier, B., Pazienza, V., & Vinciguerra, M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01157 · Cited by 82
Yang, O. O., Kelesidis, T., Cordova, R., & Khanlou, H. (2014) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2014.0181 · Cited by 81
Tuo, Y., Song, X., Song, Y., Liu, W., Tang, Y., Gao, Y., Jiang, S., Qian, F., & Mu, G. (2018) · Journal of Dairy Science · doi:10.3168/jds.2017-13654 · Cited by 82
Zhao, C., Dong, H., Zhang, Y., & Li, Y. (2019) · npj Biofilms and Microbiomes · doi:10.1038/s41522-019-0092-7 · Cited by 80
Pei, J., Li, F. R., Xie, Y., Liu, J., Tian, Y., & Feng, X. (2020) · The EPMA Journal · doi:10.1007/s13167-020-00202-5 · Cited by 80
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Fischer, F., Romero, R., Hellhund, A., Linne, U., Bertrams, W., Pinkenburg, O., Eldin, H. S., Binder, K., Jacob, R., Walker, A., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1829962 · Cited by 84
Hohman, L. S., & Osborne, L. C. (2022) · Aging Cell · doi:10.1111/acel.13700 · Cited by 89
Guo, B., Zhang, J., Zhang, W., Chen, F., & Liu, B. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2272769 · Cited by 88
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Peuß, R., Box, A., Chen, S., Wang, Y., Tsuchiya, D., Persons, J. L., Kenzior, A., Maldonado, E., Krishnan, J., Scharsack, J. P., et al. (2020) · Nature Ecology & Evolution · doi:10.1038/s41559-020-1234-2 · Cited by 80
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Chen, Y.-H., Xue, F., Yu, S.-F., Li, X.-S., Liu, L., Jia, Y., Yan, W., Tan, Q.-R., Wang, H., & Peng, Z. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.12.143 · Cited by 83
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Giordano-Kelhoffer, B., Lorca, C., March‐Llanes, J., Rábano, A., del Ser, T., Serra, A., & Gallart‐Palau, X. (2022) · Biomedicines · doi:10.3390/biomedicines10081803 · Cited by 89
Mladenović, K., Grujović, M. Ž., Koraćević, M., Nikodijević, D. D., Milutinović, M. G., Semedo‐Lemsaddek, T., & Djilas, M. D. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191811825 · Cited by 79
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Yu, H., Wang, Y., Zeng, X., Cai, S., Wang, G., Liu, L., Huang, S., Li, N., Liu, H., Ding, X., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201901717r · Cited by 79
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Zhou, A., Lei, Y., Tang, L., Hu, S., Yang, M., Wu, L., Yang, S., & Tang, B. (2020) · Journal of Bacteriology · doi:10.1128/jb.00454-20 · Cited by 80
Fakharian, F., Asgari, B., Nabavi-Rad, A., Sadeghi, A., Soleimani, N., Yadegar, A., & Zali, M. R. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.953718 · Cited by 79
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Toro-Londoño, M., Bedoya-Urrego, K., García-Montoya, G., Galván-Díaz, A. L., & Álzate, J. F. (2019) · PeerJ · doi:10.7717/peerj.6200 · Cited by 84
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Jones, B., Chonwerawong, M., Marcelino, V. R., Deshpande, A., Forster, S. C., & Starkey, M. R. (2021) · Mucosal Immunology · doi:10.1038/s41385-020-00372-5 · Cited by 82
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Yang, J., Qian, K., Wang, C., & Wu, Y. (2017) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-017-9273-y · Cited by 78
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Marizzoni, M., Provasi, S., Cattaneo, A., & Frisoni, G. B. (2017) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000496 · Cited by 79
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Gilbert, R. M., Pető, T., Lengyel, I., & Emri, E. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201801049 · Cited by 86
Bromberg, J. S., Hittle, L., Xiong, Y., Saxena, V., Smyth, E. M., Li, L., Zhang, T., Wagner, C., Fricke, W. F., Simon, T., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.121045 · Cited by 73
Computer-guided design of optimal microbial consortia for immune system modulation
Stein, R. R., Tanoue, T., Szabady, R. L., Bhattarai, S. K., Olle, B., Norman, J. M., Suda, W., Oshima, K., Hattori, M., Gerber, G. K., et al. (2018) · eLife · doi:10.7554/elife.30916 · Cited by 78
Administration of antibiotics can cause dysbiosis in fish gut
Kim, A., Kim, N., Roh, H., Chun, W., Ho, D. T., Lee, Y., & Kim, D. (2019) · Aquaculture · doi:10.1016/j.aquaculture.2019.734330 · Cited by 78
The role of the microbiome in gastrointestinal inflammation
Sanders, D. J., Inniss, S., Sebepos‐Rogers, G., Rahman, F. Z., & Smith, A. M. (2021) · Bioscience Reports · doi:10.1042/bsr20203850 · Cited by 82
The gut microbiome and efficacy of cancer immunotherapy
Roviello, G., Iannone, L. F., Bersanelli, M., Mini, E., & Catalano, M. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107973 · Cited by 77
Lee, Y., Kim, T., Kim, Y., Kim, S., Lee, S.-H., Seo, S., Zhou, B. O., Eunju, O., Kim, K. S., & Kweon, M. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00667-y · Cited by 83
Chen, X., Sun, W., Xu, B., Wu, E., Cui, Y., Hao, K., Zhang, G., Zhou, C., Xu, Y., Jiang, L., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.766296 · Cited by 76
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Lu, Q., Liang, Y., Tian, S., Jin, J., Zhao, Y., & Fan, H. (2023) · Toxics · doi:10.3390/toxics11121011 · Cited by 86
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Hauptmann, M., & Schaible, U. E. (2016) · FEBS Letters · doi:10.1002/1873-3468.12421 · Cited by 77
The interplay between microbes and the immune response in inflammatory bowel disease
Goethel, A., Croitoru, K., & Philpott, D. J. (2018) · The Journal of Physiology · doi:10.1113/jp275396 · Cited by 78
Cristofori, F., Indrio, F., Miniello, V. L., Angelis, M. D., & Francavilla, R. (2018) · Nutrients · doi:10.3390/nu10121824 · Cited by 82
Lopes, S., Pabst, L., Dory, A., Klotz, M., Gourieux, B., Michel, B., & Mascaux, C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1070076 · Cited by 75
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MacDuff, D. A., Reese, T. A., Kimmey, J. M., Weiss, L. A., Song, C., Zhang, X., Kambal, A., Duan, E., Carrero, J. A., Boisson, B., et al. (2015) · eLife · doi:10.7554/elife.04494 · Cited by 78
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Pavlová, T., Vidová, V., Vašků, J. B., Janků, P., Almáši, M., Klánová, J., & Spáčil, Z. (2017) · Analytica Chimica Acta · doi:10.1016/j.aca.2017.08.022 · Cited by 75
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Shaikh, F. Y., Gills, J. J., & Sears, C. L. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.08.076 · Cited by 76
Fujimoto, K., Kimura, Y., Shimohigoshi, M., Satoh, T., Sato, S., Tremmel, G., Uematsu, M., Kawaguchi, Y., Usui, Y., Nakano, Y., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.06.005 · Cited by 79
Golomb, S. M., Guldner, I. H., Zhao, A., Wang, Q., Palakurthi, B., Aleksandrovic, E., Lopez, J. A., Lee, S. W., Yang, K., & Zhang, S. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108438 · Cited by 77
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Martemucci, G., Fracchiolla, G., Muraglia, M., Tardugno, R., Dibenedetto, R. S., & D‘Alessandro, A. G. (2023) · Antioxidants · doi:10.3390/antiox12122091 · Cited by 89
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Ruusunen, A., Rocks, T., Jacka, F., & Loughman, A. (2019) · Psychopharmacology · doi:10.1007/s00213-018-5159-2 · Cited by 74
Soto-Perez, P., Bisanz, J. E., Berry, J. D., Lam, K. N., Bondy‐Denomy, J., & Turnbaugh, P. J. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.08.008 · Cited by 69
Haak, B. W., Argelaguet, R., Kinsella, C. M., Kullberg, R. F. J., Lankelma, J. M., Deijs, M., Klein, M., Jebbink, M. F., Hugenholtz, F., Kostidis, S., et al. (2021) · mSystems · doi:10.1128/msystems.01148-20 · Cited by 75
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Ji, N., Lei, M., Chen, Y., Tian, S., Li, C., & Zhang, B. (2023) · ASN NEURO · doi:10.1177/17590914231181037 · Cited by 84
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Kesharwani, S. S., Ahmad, R., Bakkari, M. A., Rajput, M., Dachineni, R., Valiveti, C. K., Kapur, S., Bhat, G. J., Singh, A. B., & Tummala, H. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.08.004 · Cited by 74
Saeed, M., Xu, Y., Tiantian, Z., Ren, Q., & Sun, C. (2018) · Poultry Science · doi:10.3382/ps/pey394 · Cited by 75
Periodontitis and circulating blood cell profiles: a systematic review and meta-analysis
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Mei, F., Meng, K., Gu, Z., Yun, Y., Zhang, W., Zhang, C., Zhong, Q., Pan, F., Shen, X., Xia, G., et al. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c06671 · Cited by 73
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Metadata
- Authors
- Belkaid, Y., & Hand, T. W.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Belkaid, Yasmine
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 157
- Issue
- 1
- Pages
- 121-141
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4056765
- OpenAlex
- W2077553363
- Cited by
- 5,385
- References
- 258
- Citations by year
- 2026: 492 · 2025: 632 · 2024: 666 · 2023: 593 · 2022: 573 · 2021: 685 · 2020: 471 · 2019: 410 · 2018: 306 · 2017: 250 · 2016: 157 · 2015: 105 · 2014: 45
- FWCI
- 17.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (ZIAAI001115)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- gut microbiota, host-microbe symbiosis, immune system development, immune tolerance, inflammation, autoimmune disease, antibiotic overuse, diet, helminths, microbial diversity, immune resilience
- MeSH terms
- Animals, Anti-Bacterial Agents, Bacteria, Fungi, Humans, Immune System, Inflammation, Symbiosis, Bacterial Physiological Phenomena, Microbiota
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