The DOI matches its Crossref record; 255 of the 258 references it cites were found in a registry or an index.
Role of the microbiota in immunity and inflammation.
Open accessAbstract
The microbiota plays a fundamental role on the induction, training, and function of the host immune system. In return, the immune system has largely evolved as a means to maintain the symbiotic relationship of the host with these highly diverse and evolving microbes. When operating optimally, this immune system-microbiota alliance allows the induction of protective responses to pathogens and the maintenance of regulatory pathways involved in the maintenance of tolerance to innocuous antigens. However, in high-income countries, overuse of antibiotics, changes in diet, and elimination of constitutive partners, such as nematodes, may have selected for a microbiota that lack the resilience and diversity required to establish balanced immune responses. This phenomenon is proposed to account for some of the dramatic rise in autoimmune and inflammatory disorders in parts of the world where our symbiotic relationship with the microbiota has been the most affected.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“While the impact of most of these substances on human health is not entirely clear at this point, evidence suggests that they are potentially harmful, with possible carcinogenic, teratogenic, and mutagenic effects and reproductive developmental toxicity [66]; in addition, they may disrupt the normal functioning of gut microbiota [67] and the endocrine system [68].”
From Bottled Water: An Evidence-Based Overview of Economic Viability, Environmental Impact, and Social Equity (2023) · cites this paper as [67]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The microbiota in the stomach promotes gut health and immunological balance by suppressing inflammation (10).”
From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [10]
Experimental — accuracy not yet measuredIn the citing paper
“endogenous symbiont microorganisms, the so-called microbiota, can modulate gene expression, induce preferential food intake (Aydin, 2007), influence pH, redox balance and the ratio between pro-inflammatory and anti-inflammatory cytokines (Belkaid and Hand, 2014).”
From Bioactive Molecules Released in Food by Lactic Acid Bacteria: Encrypted Peptides and Biogenic Amines (2016) · cites this paper as Belkaid and Hand, 2014
In the citing paper
“The intestinal microbiota play a role in host physiology.1”
From Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation (2020) · cites this paper as [1]
In the citing paper
“The gut microbial population plays a key role in training, functioning and stimulating the host immune system, with the final effect of developing tolerance towards beneficial microbiota and eliciting immune response against gut pathogens [76].”
From Gut Microbiota and Cancer: From Pathogenesis to Therapy (2019) · cites this paper as [76]
In the citing paper
“Several studies have reported an association of dysbiosis with chronic inflammation, which may in turn result in an association with bone diseases [129,132,215,216].”
From Bone diseases in patients with chronic liver disease (2019) · cites this paper as [215]
In the citing paper
“Variations in these early interactions appear to set the tone of the mucosal and systemic immune systems into childhood and even adult life (Belkaid and Hand, 2014).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Belkaid and Hand, 2014
In the citing paper
“The gut microbiota play a critical role in the development of the intestinal architecture and mucosal immune system and are particularly important for regulation of the immune system in the gut [reviewed in [13, 14]].”
From The Gut Microbiota and Dysbiosis in Autism Spectrum Disorders (2018) · cites this paper as [13]
In the citing paper
“These mice experience immune dysfunction and are more susceptible to infections than mice kept in conventional facilities [13, 15].”
From The Gut Microbiota and Dysbiosis in Autism Spectrum Disorders (2018) · cites this paper as [13]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
A metagenome-wide association study of gut microbiota in type 2 diabetes
Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549
Diversity, stability and resilience of the human gut microbiota
Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K., & Knight, R. (2012) · Nature · doi:10.1038/nature11550 · Cited by 5,533
Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration
Marshall, B., & Warren, J. R. (1984) · The Lancet · doi:10.1016/s0140-6736(84)91816-6 · Cited by 5,509
The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis
Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838
Flagged first, then by citations
3 of the 258 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 501–600 of 1,029
High dietary fat intake induces a microbiota signature that promotes food allergy
Hussain, M., Bonilla‐Rosso, G., Chung, C. K. C. K., Bäriswyl, L., Rodriguez, M. P., Kim, B., Engel, P., & Noti, M. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.01.043 · Cited by 137
Gut microbiota regulates lacteal integrity by inducing VEGF‐C in intestinal villus macrophages
Suh, S. H., Choe, K., Hong, S. P., Jeong, S., Mäkinen, T., Kim, K. S., Alitalo, K. K., Surh, C. D., Koh, G. Y., & Song, J. (2019) · EMBO Reports · doi:10.15252/embr.201846927 · Cited by 134
A review of heat stress in chickens. Part I: Insights into physiology and gut health
Brugaletta, G., Teyssier, J.-R., Rochell, S. J., Dridi, S., & Sirri, F. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.934381 · Cited by 150
Ling, Z., Shao, L., Liu, X., Cheng, Y., Yan, C., Mei, Y., Ji, F., & Liu, X. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00533 · Cited by 135
Alcohol-associated liver disease: A review on its pathophysiology, diagnosis and drug therapy
Subramaniyan, V., Chakravarthi, S., Jegasothy, R., Wu, Y. S., Fuloria, N. K., Fuloria, S., Hazarika, I., & Das, A. (2021) · Toxicology Reports · doi:10.1016/j.toxrep.2021.02.010 · Cited by 138
Paneth cell defects in Crohn’s disease patients promote dysbiosis
Liu, T., Gurram, B., Baldridge, M. T., Head, R. D., Lam, V., Luo, C., Cao, Y., Simpson, P. M., Hayward, M., Holtz, M. L., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.86907 · Cited by 134
Psoriasis and Microbiota: A Systematic Review
Benhadou, F., Mintoff, D., Schnebert, B., & Thio, H. B. (2018) · Diseases · doi:10.3390/diseases6020047 · Cited by 135
Correa, M. A., Matusovsky, B., Brackney, D. E., & Steven, B. T. (2018) · Nature Communications · doi:10.1038/s41467-018-07014-2 · Cited by 134
Asquith, M. J., Stauffer, P., Davin, S., Mitchell, C., Lin, P., & Rosenbaum, J. T. (2016) · Arthritis & Rheumatology · doi:10.1002/art.39681 · Cited by 131
Shan, J., Ni, Z., Cheng, W., Zhou, L., Zhai, D., Sun, S., & Yu, C. (2021) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-021-06057-z · Cited by 130
The role of gut microbiota in T cell immunity and immune mediated disorders
Shim, J. A., Ryu, J. H., Jo, Y., & Hong, C. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.79430 · Cited by 140
Turroni, S., Rampelli, S., Biagi, E., Consolandi, C., Severgnini, M., Peano, C., Quercia, S., Soverini, M., Carbonero, F. G., Bianconi, G., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0256-8 · Cited by 131
Espina, M. D. T., Gabarrini, G., Harmsen, H. J. M., Westra, J., Winkelhoff, A. J. V., & van Dijl, J. M. (2018) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuy035 · Cited by 137
Li, N., Wang, Q., Wang, Y., Sun, A., Lin, Y., Jin, Y., & Li, X. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00266 · Cited by 131
Microbial exopolysaccharides for immune enhancement: Fermentation, modifications and bioactivities
Chaisuwan, W., Jantanasakulwong, K., Wangtueai, S., Phimolsiripol, Y., Chaiyaso, T., Techapun, C., Phongthai, S., You, S., Regenstein, J. M., & Seesuriyachan, P. (2020) · Food Bioscience · doi:10.1016/j.fbio.2020.100564 · Cited by 137
Tolerance in the Age of Immunotherapy
Bluestone, J. A., & Anderson, M. S. (2020) · New England Journal of Medicine · doi:10.1056/nejmra1911109 · Cited by 137
Microbiota and host immune responses: a love–hate relationship
Tomkovich, S., & Jobin, C. (2015) · Immunology · doi:10.1111/imm.12538 · Cited by 132
Interaction between Host MicroRNAs and the Gut Microbiota in Colorectal Cancer
Yuan, C., Burns, M. B., Subramanian, S., & Blekhman, R. (2018) · mSystems · doi:10.1128/msystems.00205-17 · Cited by 132
Gut Microbiota and Mucosal Immunity in the Neonate
Dzidic, M., Boix-Amorós, A., Selma‐Royo, M., Mira, Á., & Collado, M. C. (2018) · Medical Sciences · doi:10.3390/medsci6030056 · Cited by 139
Brugman, S., Ikeda‐Ohtsubo, W., Braber, S., Folkerts, G., Pieterse, C. M. J., & Bakker, P. A. H. M. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00080 · Cited by 134
Cerovic, M., Forloni, G., & Balducci, C. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00284 · Cited by 127
Gut microbiota controlling radiation-induced enteritis and intestinal regeneration
Moraitis, I., Guiu, J., & Rubert, J. (2023) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2023.05.006 · Cited by 131
Chemokines, cytokines and exosomes help tumors to shape inflammatory microenvironment
Атретханы, К.-С. Н., Drutskaya, M. S., Nedospasov, S. A., Grivennikov, S. I., & Kuprash, D. V. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.09.011 · Cited by 131
Effects of polysaccharide from mycelia of Ganoderma lucidum on intestinal barrier functions of rats
Jin, M., Zhu, Y., Shao, D., Zhao, K., Xu, C., Li, Q., Yang, H., Huang, Q., & Shi, J. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.09.099 · Cited by 127
Microbial transmission in the social microbiome and host health and disease
Sarkar, A., McInroy, C. J. A., Harty, S., Raulo, A., Ibata, N. G. O., Valles‐Colomer, M., Johnson, K. V. ‐., Brito, I., Henrich, J., Archie, E. A., et al. (2024) · Cell · doi:10.1016/j.cell.2023.12.014 · Cited by 143
Mukherjee, S., Joardar, N., Sengupta, S., & Babu, S. P. S. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.07.010 · Cited by 129
Xie, R., Sun, Y., Wu, J., Huang, S., Jin, G., Guo, Z., Zhang, Y., Liu, T., Liu, X., Cao, X., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02608 · Cited by 126
T Cell Responses to the Microbiota
Ivanov, I. I., Tuganbaev, T., Skelly, A. N., & Honda, K. (2022) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101320-011829 · Cited by 133
Myasthenia Gravis: Paradox versus paradigm in autoimmunity
Berrih‐Aknin, S. (2014) · Journal of Autoimmunity · doi:10.1016/j.jaut.2014.05.001 · Cited by 129
Perspectives on Systems Modeling of Human Peripheral Blood Mononuclear Cells
Sen, P., Kemppainen, E., & Orešič, M. (2018) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2017.00096 · Cited by 132
Molecular Mechanisms of Obesity-Linked Cardiac Dysfunction: An Up-Date on Current Knowledge
Gutiérrez‐Cuevas, J., Sandoval-Rodriguez, A. S., Meza-Ríos, A., Monroy-Ramírez, H. C., Galicia‐Moreno, M., Garcia-Bañuelos, J. J., Santos, A., & Armendáriz‐Borunda, J. (2021) · Cells · doi:10.3390/cells10030629 · Cited by 133
Saha, P., Yeoh, B. S., Singh, R., Chandrasekar, B., Vemula, P. K., Haribabu, B., Vijay‐Kumar, M., & Jala, V. R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0156811 · Cited by 121
The genetic background of inflammatory bowel disease: from correlation to causality
Venema, W. T. U., Voskuil, M. D., Dijkstra, G. D. H., Weersma, R. K., & Festen, E. A. M. (2016) · The Journal of Pathology · doi:10.1002/path.4817 · Cited by 135
Causal effects of the microbiota on immune-mediated diseases
Round, J. L., & Palm, N. W. (2018) · Science Immunology · doi:10.1126/sciimmunol.aao1603 · Cited by 129
Dhakal, S., & Klein, S. L. (2019) · Journal of Virology · doi:10.1128/jvi.00797-19 · Cited by 127
Zhou, H., Sun, L., Zhang, S., Zhao, X. Y., Gang, X., & Wang, G. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00125 · Cited by 134
Altomare, A., Rosa, C. D., Imperia, E., Emerenziani, S., Cicala, M., & Guarino, M. P. L. (2021) · Nutrients · doi:10.3390/nu13051506 · Cited by 140
Mitra, S., Paul, S., Roy, S., Sutradhar, H., Emran, T. B., Nainu, F., Khandaker, M. U., Almalki, M., Wilairatana, P., & Mubarak, M. S. (2022) · Molecules · doi:10.3390/molecules27020555 · Cited by 141
Sadrekarimi, H., Gardanova, Z. R., Bakhshesh, M., Ebrahimzadeh, F., Yaseri, A. F., Thangavelu, L. P., Hasanpoor, Z., Zadeh, F. A., & Kahrizi, M. S. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03492-7 · Cited by 131
Review of the gut microbiome and esophageal cancer: Pathogenesis and potential clinical implications
Baba, Y., Iwatsuki, M., Yoshida, N., Watanabe, M., & Baba, H. (2017) · Annals of Gastroenterological Surgery · doi:10.1002/ags3.12014 · Cited by 123
Heterologous Immunity: Role in Natural and Vaccine-Induced Resistance to Infections
Agrawal, B. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02631 · Cited by 124
Multi ‘omic data integration: A review of concepts, considerations, and approaches
Santiago-Rodríguez, T. M., & Hollister, E. B. (2021) · Seminars in Perinatology · doi:10.1016/j.semperi.2021.151456 · Cited by 132
Wang, Y., Begum-Haque, S., Telesford, K. M., Ochoa‐Repáraz, J., Christy, M., Kasper, E. J., Kasper, D. L., Robson, S. C., & Kasper, L. H. (2014) · Gut Microbes · doi:10.4161/gmic.29797 · Cited by 126
Dierikx, T. H., Visser, D. H., Benninga, M. A., van Kaam, A. H., de Boer, N. K. H., de Vries, R., Limbergen, J. V., & de Meij, T. G. J. (2020) · Journal of Infection · doi:10.1016/j.jinf.2020.05.002 · Cited by 126
Microglia in neurodegenerative diseases
Xu, Y., Jin, M.-Z., Yang, Z., & Jin, M.-Z. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.290881 · Cited by 121
Yang, C., Du, Y., Ren, D., Yang, X., & Zhao, Y. (2021) · Food & Function · doi:10.1039/d1fo01468d · Cited by 123
Novince, C. M., Whittow, C. R., Aartun, J. D., Hathaway, J. D., Poulides, N., Chavez, M. B., Steinkamp, H. M., Kirkwood, K. A., Huang, E., Westwater, C., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-06126-x · Cited by 121
Autoimmune host–microbiota interactions at barrier sites and beyond
Ruff, W. E., & Kriegel, M. A. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.02.006 · Cited by 122
Bouyahya, A., Omari, N. E., Hachlafi, N. E., Jemli, M. E., Hakkour, M., Balahbib, A., Menyiy, N. E., Bakrim, S., Mrabti, H. N., Khouchlaa, A., et al. (2022) · Molecules · doi:10.3390/molecules27103286 · Cited by 123
Urinary Antibiotics of Pregnant Women in Eastern China and Cumulative Health Risk Assessment
Wang, H., Wang, N., Qian, J., Hu, L., Huang, P., Su, M., Yu, X., Fu, C., Jiang, F., Zhao, Q., et al. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.6b06474 · Cited by 122
Pathological Mechanisms Underlying Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Missailidis, D., Annesley, S. J., & Fisher, P. R. (2019) · Diagnostics · doi:10.3390/diagnostics9030080 · Cited by 122
Li, N., Zuo, B., Huang, S., Zeng, B., Han, D., Li, T., Liu, T., Wu, Z., Wei, H., Zhao, J., et al. (2020) · Microbiome · doi:10.1186/s40168-020-00917-7 · Cited by 120
Ma, M., Luo, J., Li, C., Eleftherianos, I., Zhang, W., & Xu, L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1329843 · Cited by 120
Huggins, M. A., Sjaastad, F. V., Pierson, M., Kucaba, T. A., Swanson, W., Staley, C., Weingarden, A. R., Jensen, I. J., Danahy, D. B., Badovinac, V. P., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.028 · Cited by 114
GLP-1 and GLP-2 Orchestrate Intestine Integrity, Gut Microbiota, and Immune System Crosstalk
Abdalqadir, N., & Adeli, K. (2022) · Microorganisms · doi:10.3390/microorganisms10102061 · Cited by 119
The composition of the microbiota modulates allograft rejection
Lei, Y. M., Chen, L., Wang, Y., Stefka, A. T., Molinero, L. L., Theriault, B. R., Aquino-Michaels, K., Sivan, A., Nagler‐Anderson, C., Gajewski, T. F., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci85295 · Cited by 119
Ling, K., Wu, H., Neish, A. S., & Champion, J. A. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.12.017 · Cited by 119
Vitamin D and microbiota: Two sides of the same coin in the immunomodulatory aspects
Malaguarnera, L. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.106112 · Cited by 120
Interactions between host genetics and gut microbiota determine susceptibility to CNS autoimmunity
Montgomery, T. L., Künstner, A., Kennedy, J. J., Fang, Q., Asarian, L., Culp‐Hill, R., D’Alessandro, A., Teuscher, C., Busch, H. S., & Krementsov, D. N. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2002817117 · Cited by 121
Roasa, J. (2021) · The Atrium (University of Guelph) · doi:10.1016/j.tifs.2021.08.027
MiMeDB: the Human Microbial Metabolome Database
Wishart, D. S., Oler, E., Peters, H., Guo, A., Girod, S., Han, S., Saha, S., Lui, V. W., LeVatte, M., Gautam, V., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac868 · Cited by 120
Mutagenesis by Microbe: the Role of the Microbiota in Shaping the Cancer Genome
Barrett, M., Hand, C. K., Shanahan, F., Murphy, T., & O’Toole, P. W. (2020) · Trends in Cancer · doi:10.1016/j.trecan.2020.01.019 · Cited by 108
Fine-Tuning Cancer Immunotherapy: Optimizing the Gut Microbiome
Pitt, J. M., Vétizou, M., Waldschmitt, N., Kroemer, G., Chamaillard, M., Boneca, I. G., & Zitvogel, L. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-0448 · Cited by 122
Microbiota in cancer development and treatment
Raza, M. H., Gul, K., Arshad, A., Riaz, N., Waheed, U., Rauf, A., Aldakheel, F. M., Alduraywish, S. A., Rehman, M. U., Abdullah, M., et al. (2018) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-018-2816-0 · Cited by 122
Potential Cross-Reactive Immunity to SARS-CoV-2 From Common Human Pathogens and Vaccines
Reche, P. A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.586984 · Cited by 117
Nowak, A., Szczuka, D., Górczyńska, A., Motyl, I., & Kręgiel, D. (2021) · Cells · doi:10.3390/cells10030701 · Cited by 126
Zhang, D., Gao, X., Li, H., Borger, D. K., Wei, Q., Yang, E. M., Xu, C., Pinho, S., & Frenette, P. S. (2022) · Cell stem cell · doi:10.1016/j.stem.2021.12.009 · Cited by 121
Foley, K. A., MacFabe, D. F., Vaz, A., Ossenkopp, K., & Kavaliers, M. (2014) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2014.04.001 · Cited by 116
Alterations in the gut microbiota and metabolite profiles of thyroid carcinoma patients
Feng, J., Zhao, F., Sun, J., Lin, B., Zhao, L., Liu, Y., Jin, Y., Li, S., Li, A., & Wei, Y. (2018) · International Journal of Cancer · doi:10.1002/ijc.32007 · Cited by 116
Caenorhabditis elegans: a model to understand host–microbe interactions
Kumar, A., Baruah, A., Tomioka, M., Iino, Y., Kalita, M. C., & Khan, M. R. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03319-7 · Cited by 126
Zhang, J., Holdorf, A. D., & Walhout, A. J. M. (2017) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2017.01.008 · Cited by 116
Impact of prior antibiotic use on the efficacy of nivolumab for non‑small cell lung cancer
Hakozaki, T., Okuma, Y., Omori, M., & Hosomi, Y. (2019) · Oncology Letters · doi:10.3892/ol.2019.9899 · Cited by 117
Gut Vibes in Parkinson's Disease: The Microbiota‐Gut‐Brain Axis
Bullich‐Vilarrubias, C., Keshavarzian, A., Garssen, J., Kraneveld, A. D., & Perez‐Pardo, P. (2019) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.12840 · Cited by 120
A designed whole-cell biosensor for live diagnosis of gut inflammation through nitrate sensing
Woo, S., Moon, S., Kim, S. K., Kim, T. H., Lim, H. S., Yeon, G.-H., Sung, B. H., Lee, C., Lee, S., Hwang, J. H., et al. (2020) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2020.112523 · Cited by 117
Urbanized microbiota in infants, immune constitution, and later risk of atopic diseases
Lehtimäki, J., Thorsen, J., Rasmussen, M. A., Hjelmsø, M., Shah, S., Mortensen, M. S., Trivedi, U., Vestergaard, G., Bønnelykke, K., Chawes, B. L., et al. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.12.621 · Cited by 116
Interleukin-17D regulates group 3 innate lymphoid cell function through its receptor CD93
Huang, J., Lee, H.-Y., Zhao, X., Han, J., Su, Y., Sun, Q., Shao, J., Ge, J., Zhao, Y., Bai, X., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.03.018 · Cited by 116
Foley, S. E., Tuohy, C. A., Dunford, M., Grey, M. J., Luca, H. E. D., Cawley, C., Szabady, R. L., Maldonado‐Contreras, A., Houghton, J. M., Ward, D. V., et al. (2021) · Microbiome · doi:10.1186/s40168-021-01137-3 · Cited by 121
Neutrality in the Metaorganism
Sieber, M., Pita, L., Weiland‐Bräuer, N., Dirksen, P., Wang, J., Mortzfeld, B. M., Franzenburg, S., Schmitz, R. A., Baines, J. F., Fraune, S., et al. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000298 · Cited by 117
Stanford, J., Charlton, K. E., Stefoska‐Needham, A., Ibrahim, R., & Lambert, K. (2020) · BMC Nephrology · doi:10.1186/s12882-020-01805-w · Cited by 123
Macrophage polarization in intestinal inflammation and gut homeostasis
Lopes, T. C. M., Mosser, D. M., & Gonçalves, R. (2020) · Inflammation Research · doi:10.1007/s00011-020-01398-y · Cited by 120
Development, Diversity, and Function of Dendritic Cells in Mouse and HumanPreprint
Anderson, D. A., MURPHY, K. M. M., & Briseño, C. G. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028613 · Cited by 120
Al-Dhabi, N. A., Ghilan, A.-K. M., & Arasu, M. V. (2018) · Nanomaterials · doi:10.3390/nano8050279 · Cited by 116
Intestinal Sensing by Gut Microbiota: Targeting Gut Peptides
Covașă, M., Stephens, R. W., Toderean, R., & Cobuz, C. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00082 · Cited by 117
Bone diseases in patients with chronic liver disease
Jeong, H., & Kim, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174270 · Cited by 113
Multimedia fate modeling and risk assessment of antibiotics in a water-scarce megacity
Chen, H., Jing, L., Teng, Y., & Wang, J. (2018) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2018.01.033 · Cited by 113
Drying technology strategies for colon-targeted oral delivery of biopharmaceuticals
Vass, P., Démuth, B., Hirsch, E., Nagy, B., Andersen, S. K., Vígh, T., Verreck, G., Csontos, I., Nagy, Z. K., & Marosi, G. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.01.023 · Cited by 119
Chen, D., Chen, G., Ding, Y., Wan, P., Peng, Y., Chen, C., Ye, H., Zeng, X., & Ran, L. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103470 · Cited by 116
Sun, M., Ma, K., Wen, J., Wang, G., Zhang, C., Li, Q., Bao, X., & Wang, H. (2020) · Journal of Alzheimer’s Disease · doi:10.3233/jad-190872 · Cited by 113
D’Urso, F., & Broccolo, F. (2024) · Applied Sciences · doi:10.3390/app14198627 · Cited by 112
Teoh, F., & Pavelka, N. (2016) · Pathogens · doi:10.3390/pathogens5010006 · Cited by 121
The role of neutrophils in trained immunity
Kalafati, L., Hatzioannou, A., Hajishengallis, G., & Chavakis, T. (2022) · Immunological Reviews · doi:10.1111/imr.13142 · Cited by 117
Phage therapy against Enterococcus faecalis in dental root canals
Khalifa, L., Shlezinger, M., Beyth, S., Houri‐Haddad, Y., Coppenhagen‐Glazer, S., Beyth, N., & Hazan, R. (2016) · Journal of Oral Microbiology · doi:10.3402/jom.v8.32157 · Cited by 112
IL-33 and the intestine: The good, the bad, and the inflammatory
Hodzic, Z., Schill, E. M., Bolock, A. M., & Good, M. L. (2017) · Cytokine · doi:10.1016/j.cyto.2017.06.017 · Cited by 110
In situ relationships between microbiota and potential pathobiota in Arabidopsis thaliana
Bartoli, C., Frachon, L., Barret, M., Rigal, M., Huard‐Chauveau, C., Mayjonade, B., Zanchetta, C., Bouchez, O., Roby, D., Carrère, S., et al. (2018) · The ISME Journal · doi:10.1038/s41396-018-0152-7 · Cited by 114
Gut-derived immune cells and the gut-lung axis in ARDS
Ziaka, M., & Exadaktylos, A. K. (2024) · Critical Care · doi:10.1186/s13054-024-05006-x · Cited by 118
Understanding Autoimmunity: Mechanisms, Predisposing Factors, and Cytokine Therapies
Yasmeen, F., Pirzada, R. H., Ahmad, B., Choi, B., & Choi, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147666 · Cited by 131
Heterochronic faecal transplantation boosts gut germinal centres in aged mice
Stebegg, M., Silva-Cayetano, A., Innocentin, S., Jenkins, T. P., Cantacessi, C., Gilbert, C., & Linterman, M. A. (2019) · Nature Communications · doi:10.1038/s41467-019-10430-7 · Cited by 107
Can we ‘seize’ the gut microbiota to treat epilepsy?
De Caro, C., Iannone, L. F., Citraro, R., Striano, P., De Sarro, G., Constanti, A., Cryan, J. F., & Russo, E. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.002 · Cited by 110
Kabouridis, P. S., & Pachnis, V. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76308 · Cited by 117
Pathogenesis of Crohn's disease
Boyapati, R. K., Satsangi, J. J., & Ho, G. (2015) · F1000Prime Reports · doi:10.12703/p7-44 · Cited by 117
Metadata
- Authors
- Belkaid, Y., & Hand, T. W.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Belkaid, Yasmine
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 157
- Issue
- 1
- Pages
- 121-141
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4056765
- OpenAlex
- W2077553363
- Cited by
- 5,385
- References
- 258
- Citations by year
- 2026: 492 · 2025: 632 · 2024: 666 · 2023: 593 · 2022: 573 · 2021: 685 · 2020: 471 · 2019: 410 · 2018: 306 · 2017: 250 · 2016: 157 · 2015: 105 · 2014: 45
- FWCI
- 17.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (ZIAAI001115)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- gut microbiota, host-microbe symbiosis, immune system development, immune tolerance, inflammation, autoimmune disease, antibiotic overuse, diet, helminths, microbial diversity, immune resilience
- MeSH terms
- Animals, Anti-Bacterial Agents, Bacteria, Fungi, Humans, Immune System, Inflammation, Symbiosis, Bacterial Physiological Phenomena, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
