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Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization
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“Liquid‐to‐gel transitions were previously suggested for condensates of the RNA binding proteins FUS (Patel et al, 2015) and hnRNPA1 (Molliex et al, 2015), and for Tau in the presence of molecular crowding by us and others (Wegmann et al, 2018; Kanaan et al, 2020).”
From Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates (2022) · cites this paper as Molliex et al, 2015
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“Biomolecular condensates of different neurodegenerative disease‐associated proteins have been shown to progressively percolate and subsequently transit into aggregates (Molliex et al, 2015; Patel et al, 2015; Ray et al, 2020).”
From Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates (2022) · cites this paper as Molliex et al, 2015
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“Whereas LLPS by hnRNPA1 occurs spontaneously in a temperature- and protein-concentration-dependent manner in the absence of a crowding agent (Figure S4A), we mapped the phase diagram in the presence of Ficoll, a typical crowding agent, to mimic the crowded cellular environment, which is thought to contain 200 mg/ml of…”
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Metadata
- Authors
- Molliex, A., Temirov, J., Lee, J., Coughlin, M., Kanagaraj, A. P., Kim, H. J., Mittag, T., & Taylor, J. P.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 163
- Issue
- 1
- Pages
- 123-133
- ISSN
- 0092-8674
- PMC
- PMC5149108
- Cited by
- 2,893
- References
- 5
- Language
- en
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