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A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells
Open accessAbstract
cDCs revealed their differences in transcription factors and external stimulus. Additionally, pro-angiogenic tumor-associated macrophages (TAMs) were characterized with diverse markers across different cancer types, and the composition of TIMs appeared to be associated with certain features of somatic mutations and gene expressions. Our results provide a systematic view of the highly heterogeneous TIMs and suggest future avenues for rational, targeted immunotherapies.
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“This is in agreement with previous observations showing low expression of Toll-like receptor (TLR) signaling genes and low innate immune activity of cDC3_LAMP348 and the “pro-inflammatory” properties of cDC2_FCN1 and cDC2_IL1B in blood51.”
From Transformer for one stop interpretable cell type annotation (2023) · cites this paper as [48]
In the citing paper
“On the cDCs populations, TOSICA reveals that the same cDC subsets from different tumor types are clustered together (Supplementary Fig. 12b), which is consistent with previous observations48.”
From Transformer for one stop interpretable cell type annotation (2023) · cites this paper as [48]
In the citing paper
“As interpretable trajectories, the diffusion map52 based on TOSICA attention embedding confirms two potential origins of the cDC3_LAMP3 from cDC1s and cDC2-CXCL9, as previously suggested48 (Fig. 4d).”
From Transformer for one stop interpretable cell type annotation (2023) · cites this paper as [48]
In the citing paper
“Furthermore, benefiting from its high resolution, TOSICA identifies several subtypes of monocytes that have not been discovered in the original publication48 (Fig. 4h), all having their own biological signatures and potentially different functions (Supplementary Fig. 12e).”
From Transformer for one stop interpretable cell type annotation (2023) · cites this paper as [48]
In the citing paper
“Furthermore, the map reveals another state transition path from cDC2 to pro-inflammatory cDC2 subtypes (Fig. 4d), which has not been observed in the previous analysis48.”
From Transformer for one stop interpretable cell type annotation (2023) · cites this paper as [48]
In the citing paper
“This dataset contains tumor infiltrating myeloid cells from multiple different tumor types [21].”
From A Deep Dive into Single-Cell RNA Sequencing Foundation Models (2023) · cites this paper as [21]
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Metadata
- Authors
- Cheng, S., Li, Z., Gao, R., Xing, B., Gao, Y., Yang, Y., Qin, S., Zhang, L., Ouyang, H., Du, P., Jiang, L., Zhang, B., Yang, Y., Wang, X., Ren, X., Bei, J.-X., Hu, X., Bu, Z., Ji, J., & Zhang, Z.
- Affiliations
- Peking University (CN)
- Peking University Cancer Hospital (CN)
- Peking University Third Hospital (CN)
- Sun Yat-sen University (CN)
- Corresponding author
- Bu, Zhaode
- Ji, Jiafu
- Zhang, Zemin
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2021-02
- Volume
- 184
- Issue
- 3
- Pages
- 792-809.e23
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W3126902084
- Cited by
- 1,601
- References
- 84
- Citations by year
- 2026: 337 · 2025: 370 · 2024: 377 · 2023: 267 · 2022: 190 · 2021: 58
- FWCI
- 87.30
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Beijing Municipal Science and Technology Commission
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- tumor-infiltrating myeloid cells, pan-cancer, single-cell transcriptomics, myeloid dendritic cells, tumor-associated macrophages, myeloid heterogeneity, somatic mutations, cancer immunotherapy, tumor microenvironment
- MeSH terms
- Dendritic Cells, Female, Humans, Macrophages, Male, Mast Cells, Monocytes, Neoplasm Proteins, Neoplasms, Transcription, Genetic, Cell Lineage, Myeloid Cells, Cell Line, Tumor, Lysosomal Membrane Proteins, Single-Cell Analysis, Transcriptome, Lysosomal-Associated Membrane Protein 3
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