Cited by 1,601Immune cells in cancerSingle-cell and spatial transcriptomicsCancer Immunotherapy and Biomarkers

The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.

A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells

Open access

Abstract

cDCs revealed their differences in transcription factors and external stimulus. Additionally, pro-angiogenic tumor-associated macrophages (TAMs) were characterized with diverse markers across different cancer types, and the composition of TIMs appeared to be associated with certain features of somatic mutations and gene expressions. Our results provide a systematic view of the highly heterogeneous TIMs and suggest future avenues for rational, targeted immunotherapies.

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Crossref · 10.1016/j.cell.2021.01.010

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Metadata

Authors
Cheng, S., Li, Z., Gao, R., Xing, B., Gao, Y., Yang, Y., Qin, S., Zhang, L., Ouyang, H., Du, P., Jiang, L., Zhang, B., Yang, Y., Wang, X., Ren, X., Bei, J.-X., Hu, X., Bu, Z., Ji, J., & Zhang, Z.
Affiliations
  • Peking University (CN)
  • Peking University Cancer Hospital (CN)
  • Peking University Third Hospital (CN)
  • Sun Yat-sen University (CN)
Corresponding author
  • Bu, Zhaode
  • Ji, Jiafu
  • Zhang, Zemin
Venue
Cell
Publisher
Elsevier BV
Published
2021-02
Volume
184
Issue
3
Pages
792-809.e23
ISSN
0092-8674 (ISSN-L)
OpenAlex
W3126902084
Cited by
1,601
References
84
Citations by year
2026: 337 · 2025: 370 · 2024: 377 · 2023: 267 · 2022: 190 · 2021: 58
FWCI
87.30
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China
  • Beijing Municipal Science and Technology Commission
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords
tumor-infiltrating myeloid cells, pan-cancer, single-cell transcriptomics, myeloid dendritic cells, tumor-associated macrophages, myeloid heterogeneity, somatic mutations, cancer immunotherapy, tumor microenvironment
MeSH terms
Dendritic Cells, Female, Humans, Macrophages, Male, Mast Cells, Monocytes, Neoplasm Proteins, Neoplasms, Transcription, Genetic, Cell Lineage, Myeloid Cells, Cell Line, Tumor, Lysosomal Membrane Proteins, Single-Cell Analysis, Transcriptome, Lysosomal-Associated Membrane Protein 3

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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