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Scenic: single-cell regulatory network inference and clustering.

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Single cell transcriptome profiling reveals pathogenesis of bullous pemphigoid

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The dynamic immune behavior of primary and metastatic ovarian carcinoma

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Single-cell and bulk transcriptome analyses reveal elevated amino acid metabolism promoting tumor-directed immune evasion in colorectal cancer

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SIRPα blockade therapy potentiates immunotherapy by inhibiting PD-L1+ myeloid cells in hepatocellular carcinoma

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Microphysiological Systems in Cancer Research: Advancing Immunotherapy through Tumor Microenvironment‐Integrated Organ‐On‐Chip Models

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Epigenomic preconditioning of peripheral monocytes determines their transcriptional response to the tumor microenvironment

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Lactylation: A new direction for tumor-targeted therapy

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Single-cell RNA sequencing: enhancing the predictive accuracy of tumor immunotherapy efficacy

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T Cell Exhaustion and Dendritic Cell‐Mediated Tertiary Lymphoid Structures (TLSs) Modulation Affect Response to Neoadjuvant Chemoradiotherapy in Microsatellite Stable Rectal Cancer

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Single-cell transcriptomics of the myeloid milieu reveals an angiogenic niche in triple-negative breast cancer

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Pan-Cancer Single-Cell RNA Sequencing Analysis Refines Multi-Origin Monocyte and Macrophage Lineages

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Dissecting genetic and immune drivers of heterogeneous responses to neoadjuvant immunochemotherapy in gastric cancer

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Deciphering Innate Immune Cell-Tumor Microenvironment Crosstalk at a Single-Cell Level

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Single-cell transcriptomic analysis identifies a highly replicating Cd168+ skeletal stem/progenitor cell population in mouse long bones

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Decoding Human Biology and Disease Using Single-Cell Omics Technologies

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Summary data‐based Mendelian randomization and single‐cell RNA sequencing analyses identify immune associations with low‐level LGALS9 in sepsis

Yang, Y., Dong, L., Li, Y., Huang, Y., & Zeng, X. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18559 · Cited by 10

Distinct Patterns of Myeloid Cell Infiltration in Patients With hrHPV-Positive and hrHPV-Negative Penile Squamous Cell Carcinoma: The Importance of Assessing Myeloid Cell Densities Within the Spatial Context of the Tumor

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Breaking the Immune Complexity of the Tumor Microenvironment Using Single-Cell Technologies

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Effect of M2-like macrophages of the injured-kidney cortex on kidney cancer progression

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Breast Cancer Macrophage Heterogeneity and Self-renewal are Determined by Spatial LocalizationPreprint

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PGR-KITLG signaling drives a tumor-mast cell regulatory feedback to modulate apoptosis of breast cancer cells

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Integrated analysis of single-cell and bulk RNA sequencing data reveals a myeloid cell-related regulon predicting neoadjuvant immunotherapy response across cancers

Liu, H., Sima, X., Xiao, B., Gulizeba, H., Zhao, S., Zhou, T., & Huang, Y. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05123-9 · Cited by 9

Spatial transcriptomics of gastric cancer brain metastasis reveals atypical vasculature strategies with supportive immune profiles

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Integrated single-cell transcriptome and TCR profiles of hepatocellular carcinoma highlight the convergence on interferon signaling during immunotherapy

Li, T., Guo, S., Xu, C., Zhang, M., Lyu, C., Xu, H., Hou, Z., Zhang, M., Li, X., Ren, J., et al. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-010534 · Cited by 9

Elucidating the tumor microenvironment interactions in breast, cervical, and ovarian cancer through single-cell RNA sequencing

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Function and mechanism of lactylation in health and diseases: a comprehensive review

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SPP1+ tumor-associated macrophages define a high-risk subgroup and inform personalized therapy in hepatocellular carcinoma

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Targeting tumor-associated CCR2 + macrophages to inhibit pancreatic cancer recurrence following irreversible electroporation

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New trend in molecular diagnostics: Insights from the tumor microenvironment

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Decoding tumor heterogeneity: A spatially informed pan-cancer analysis of the tumor microenvironment

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Dalbergia odorifera T.C. Chen leaf extract promotes microglial energy expenditure to phagocytize neutrophils after cerebral ischemia-reperfusion

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Single-cell deconstruction of medulloblastoma microenvironment elucidates subtype-specific immune architectures and prognostic molecular signatures

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Uncovering the immune mechanisms underlying the emergence of immunotherapy-induced pneumonitis in lung cancer patients

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CD47 expression in solid tumors correlates with phagocytic tumor-associated macrophage gene signature

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DC subsets and states unraveled across human juxtatumoral and malignant tissues

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Hypoxia-driven remodeling of SELENOP+ macrophages shapes T cell dynamics and promotes ovarian cancer metastasis

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Spatial single-cell landscape of tumor-associated macrophages and their crosstalk with the tumor microenvironment

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Single-Cell RNA Sequencing Unravels Distinct Tumor Microenvironment of Different Components of Lung Adenocarcinoma Featured as Mixed Ground-Glass Opacity

He, Y., Yu, F., Tian, Y., Hu, Q., Wang, B., Wang, L., Hu, Y. W., Tao, Y., Chen, X., & Peng, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.903513 · Cited by 9

The end of the beginning: application of single-cell sequencing to chronic lymphocytic leukemia

Nagler, A., & Wu, C. J. (2022) · Blood · doi:10.1182/blood.2021014669 · Cited by 9

Co-enrichment of CD8-positive T cells and macrophages is associated with clinical benefit of tislelizumab in solid tumors

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LAMP3 expression in the liver is involved in T cell activation and adaptive immune regulation in hepatitis B virus infection

Wang, Z., Wang, X., Jin, R., Liu, F., Rao, H., Wei, L., Chen, H., & Feng, B. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1127572 · Cited by 9

Bv8 mediates myeloid cell migration and enhances malignancy of colorectal cancer

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Comparative immunological landscape between pre- and early-stage LUAD manifested as ground-glass nodules revealed by scRNA and scTCR integrated analysis

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Altered tumor signature and T‐cell profile after chemotherapy reveal new therapeutic opportunities in high‐grade serous ovarian carcinoma

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Integrated multiomic analysis reveals disulfidptosis subtypes in glioblastoma: implications for immunotherapy, targeted therapy, and chemotherapy

Yang, X., Cai, Z., Wang, C., Jiang, C., Li, J., Chen, F., & Li, W. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1362543 · Cited by 9

Integrating bulk and single-cell sequencing data to construct a Scissor+ dendritic cells prognostic model for predicting prognosis and immune responses in ESCC

Cheng, M., Xiong, J., Liu, Q., Zhang, C., Li, K., Wang, X., & Chen, S. (2024) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-024-03683-9 · Cited by 10

Differential expression of ST6GALNAC1 and ST6GALNAC2 and their clinical relevance to colorectal cancer progression

Ahmad, M. S., Braoudaki, M., & Siddiqui, S. S. (2024) · PLoS ONE · doi:10.1371/journal.pone.0311212 · Cited by 9

Role of glutaminyl-peptide cyclo-transferase-like protein (QPCTL) in cancer: From molecular mechanisms to immunotherapy

Oghenemaro, E. F., Uthirapathy, S., Nathiya, D., Kaur, P., Kumar, M., & Verma, A. K. (2024) · Gene · doi:10.1016/j.gene.2024.149153 · Cited by 9

CD56neg CD16+ cells represent a distinct mature NK cell subset with altered phenotype and are associated with adverse clinical outcome upon expansion in AML

Chretien, A.-S., Wlosik, J., Orlanducci, F., Richaud, M., Demerle, C., Amara, A. B., Rouviere, M.-S., Livrati, P., Gorvel, L., Dulphy, N., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1487792 · Cited by 9

Clinical Trials with Biologic Primary Endpoints in Immuno-oncology: Concepts and Usage

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A Prognostic Model of Colon Cancer Based on the Microenvironment Component ScoreviaSingle Cell Sequencing

Liu, Y., Liu, X., Xu, Q.-L., Gao, X., & Linghu, E. (2022) · In Vivo · doi:10.21873/invivo.12762 · Cited by 9

Single-cell transcriptome analysis reveals T-cell exhaustion in denosumab-treated giant cell tumor of bone

Yang, M., Wang, F., Lu, G., Cheng, M., Zhao, W., & Zou, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.934078 · Cited by 10

A single-cell RNA-seq dataset describing macrophages in NSCLC tumor and peritumor tissues

Li, A., Wang, H., Zhang, L., Zhao, Q., Yang, Y., Zhang, Y., & Li, Y. (2024) · Scientific Data · doi:10.1038/s41597-024-03885-x · Cited by 9

Single-cell dissection of prognostic architecture and immunotherap response in Helicobacter pylori infection-associated gastric cancer

Zhang, X., Zhang, G., Sang, S., Fei, Y., Cao, X., Song, W., Liu, F., Che, J., Tao, H., Wang, H., et al. (2024) · eLife · doi:10.7554/elife.99337 · Cited by 9

Improved ClickTags enable live-cell barcoding for highly multiplexed single cell sequencing

Zhao, X., Sun, S., Yu, W., Zhu, W., Zhao, Z., Zhou, Y., Ding, X., Fang, N., Yang, R., & Li, J. P. (2022) · RSC Chemical Biology · doi:10.1039/d2cb00046f · Cited by 8

Emerging roles for tumor stroma in antigen presentation and anti-cancer immunity

Papadas, A., Huang, Y., Cicala, A., Dou, Y., Fields, M., Gibbons, A., Hong, D., Lagal, D. J., Quintana, V., Rizo, A., et al. (2023) · Biochemical Society Transactions · doi:10.1042/bst20221083 · Cited by 8

Host-functionalization of macrin nanoparticles to enable drug loading and control tumor-associated macrophage phenotype

Sarkar, B., Arlauckas, S. P., Cuccarese, M. F., Garris, C., Weissleder, R., & Rodell, C. B. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1331480 · Cited by 8

Cellular and molecular determinants of bacterial burden in leprosy granulomas revealed by single-cell multimodal omics

Mi, Z., Wang, Z., Wang, Y., Xue, X., Liao, X., Wang, C., Sun, L., Lin, Y., Wang, J., Guo, D., et al. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105342 · Cited by 8

Spatial mapping of the HCC landscape identifies unique intratumoral perivascular-immune neighborhoods

Marsh‐Wakefield, F., Santhakumar, C., Ferguson, A. L., Ashhurst, T. M., Shin, J., Guan, F. H. X., Shields, N. J., Platt, B. J., Putri, G., Gupta, R., et al. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000540 · Cited by 9

Comparison of Lean, Obese, and Weight-Loss Models Reveals TREM2 Deficiency Attenuates Breast Cancer Growth Uniquely in Lean Mice and Alters Clonal T-cell Populations

Pierro, E. W., Cottam, M. A., An, H., Lehmann, B. D., Pietenpol, J. A., Wellen, K. E., Makowski, L., Rathmell, J. C., Fingleton, B., & Hasty, A. H. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-3511 · Cited by 8

Dendritic cell-based immunotherapy for head and neck squamous cell carcinoma: advances and challenges

Chen, W., Li, Z., Tang, J., & Liu, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1573635 · Cited by 8

Putative Role of Tie2-Expressing Monocytes/Macrophages in Colorectal Cancer Progression Through Enhancement of Angiogenesis and Metastasis

Ali, E. A. M., Altaie, A. M., Talaat, I. M., & Hamoudi, R. (2025) · Cancers · doi:10.3390/cancers17172856 · Cited by 8

Myeloid Cell Reprogramming and Immune Suppression

Grover, A., Tcyganov, E. N., & Gabrilovich, D. I. (2025) · Annual Review of Physiology · doi:10.1146/annurev-physiol-050824-111031 · Cited by 8

Single-cell transcriptomics uncovering a critical AKT-LONP1-STAR axis in ovarian hyperandrogenism of PCOS

Zhang, C., Lin, Z., Lin, Y., & Ma, H. (2025) · Journal of Ovarian Research · doi:10.1186/s13048-025-01837-6 · Cited by 8

Single-cell analysis identifies inflammatory and tissue remodeling tumor-associated macrophages distinct from M1/M2 paradigm

López-Huerta, E., Portales‐Pérez, D. P., Martínez-Leija, M. E., Ortiz-Navarrete, V. F., & Fuentes‐Pananá, E. M. (2025) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiaf176 · Cited by 8

A pan-cancer single cell landscape reveals heterogeneity and functional diversity of double-negative T cells

Hao, Q., Zhou, T. Y., Yan, H., Ren, Z., Mao, W., Huang, L., Chen, Y.-Y., Wang, Y., Xiao, M., He, Y., et al. (2026) · Molecular Cancer · doi:10.1186/s12943-025-02548-8 · Cited by 9

Immunosuppressive immune microenvironment landscapes in VISTA-high gastric cancer

Luo, Y., Peng, H., Yao, Q., Xie, Y., Liu, D., Wang, Y., Peng, Z., Shen, L., Sun, Y., Zhang, X., et al. (2026) · British Journal of Cancer · doi:10.1038/s41416-025-03290-0 · Cited by 8

Targeting LRRC15 in Cancer-Associated Fibroblasts Modifies the Extracellular Matrix and Enhances Tumor Immune Responses to Suppress Lung Cancer Progression

Qi, L., Dang, G., Ling, X., Miao, Y., Bo, Y., Zhai, Y., Chen, X., Zhai, Q., Zheng, L., Zhang, Y., et al. (2026) · Cancer Research · doi:10.1158/0008-5472.can-25-2871 · Cited by 9

Homeostatic maturation programs drive human cDC2s into a tolerogenic state

Lu, M., Han, R. H., Yang, H. Y., Yang, L., Zhao, Q., Wang, J., Yu, Z., Liu, N. K., Xu, Y., Luo, F., et al. (2026) · Immunity · doi:10.1016/j.immuni.2026.01.028 · Cited by 8

Targeting SPP1 + TAMs associated with liver metastasis reverses immunosuppression and synergizes with immunotherapy in colorectal cancer

Lin, Y., Chen, Z., Zhao, S., Zhao, L., Yang, C., Zhu, M., Ye, Y., Wang, S., & Shen, Z. (2026) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2025-014128 · Cited by 8

Pathophysiological roles of monocytes and macrophages in cancer

Ji, L., Li, J., Hsu, T.-W., & Li, M. O. (2026) · Nature reviews. Immunology · doi:10.1038/s41577-026-01296-0 · Cited by 9

Regulatory T cells in cancer and inflammation

Yang, H., Zhang, H., Xia, N., & Cheng, X. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02584-w · Cited by 8

The expression characteristics of transmembrane protein genes in pancreatic ductal adenocarcinoma through comprehensive analysis of bulk and single-cell RNA sequence

Ye, C., Ren, S., Sadula, A., Guo, X., Meng, Y., Meng, M., Li, G., Zhang, X., & Yuan, C. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1047377 · Cited by 8

Thyroid Cancers Exhibit Oncogene-Enhanced Macropinocytosis that Is Restrained by IGF1R and Promote Albumin–Drug Conjugate Response

Hu, H., Ng, T. S. C., Kang, M., Scott, E., Li, R., Quintana, J. M., Matvey, D., Vantaku, V. R., Weissleder, R., Parangi, S., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-2976 · Cited by 8

Dendritic cell maturation in the tumor microenvironment

Miao, Y., Liu, Y., Tang, H., & Zhang, Z. (2023) · National Science Open · doi:10.1360/nso/20220053 · Cited by 9

Human fetal dermal fibroblast-myeloid cell diversity is characterized by dominance of pro-healing Annexin1-FPR1 signaling

Srivastava, R., Singh, K., Abouhashem, A. S., Kumar, M., Kaçar, S., Verma, S. S., Mohanty, S. K., Sinha, M., Ghatak, S., Xuan, Y., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107533 · Cited by 8

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DUSP4 inhibited tumor cell proliferation by downregulating glycolysis via p-ERK/p-PGK1 signaling in ovarian cancer

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Single-Nucleus Transcriptomics Reveals Glial Metabolic–Immune Rewiring and Intercellular Signaling Disruption in Chronic Migraine

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Integrative Single‐Cell Analysis Reveals Iron Overload‐Induced Senescence and Metabolic Reprogramming in Ovarian Endometriosis‐Associated Infertility

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Positive and negative roles of myeloid cells in cancer immunotherapy

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Tumor-associated macrophage clusters linked to immunotherapy in a pan-cancer census

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Abstract 7280: Pan-cancer single-cell RNA sequencing analysis refines multiorigin monocyte and macrophage lineages

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