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Lobular Carcinoma of the Breast: A Comprehensive Review with Translational Insights

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Rebuilding the microenvironment of primary tumors in humans: a focus on stroma

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Single cell analyses reveal the PD-1 blockade response-related immune features in hepatocellular carcinoma

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Unravelling monocyte functions: from the guardians of health to the regulators of disease

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The Spatial Organization of cDC1 with CD8+ T Cells is Critical for the Response to Immune Checkpoint Inhibitors in Patients with Melanoma

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Single-cell RNA sequencing dissects the immunosuppressive signatures in Helicobacter pylori-infected human gastric ecosystem

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Spatially resolved C1QC+ macrophage-CD4+ T cell niche in colorectal cancer microenvironment: implications for immunotherapy response

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Single-cell multi-omic landscape reveals anatomical-specific immune features in adult and pediatric sepsis

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Integrated transcriptional analysis reveals macrophage heterogeneity and macrophage-tumor cell interactions in the progression of pancreatic ductal adenocarcinoma

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The estrogen response in fibroblasts promotes ovarian metastases of gastric cancer

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Single-cell and spatial transcriptomics profile the interaction of SPP1+ macrophages and FAP+ fibroblasts in non-small cell lung cancer

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MIF is a critical regulator of mononuclear phagocytic infiltration in hepatocellular carcinoma

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Homologous recombination deficiency in triple-negative breast cancer: Multi-scale transcriptomics reveals distinct tumor microenvironments and limitations in predicting immunotherapy response

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Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18

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C5aR1 inhibition reprograms tumor associated macrophages and reverses PARP inhibitor resistance in breast cancer

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Tumor draining lymph nodes connected to cold triple-negative breast cancers are characterized by Th2-associated microenvironment

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The Dual Role of Cellular Senescence in Macrophages: Unveiling the Hidden Driver of Age-Related Inflammation in Kidney Disease

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Tumour-derived microparticles obtained through microwave irradiation induce immunogenic cell death in lung adenocarcinoma

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Focusing on the interplay between tumor-associated macrophages and tumor microenvironment: from mechanism to intervention

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Multi-modal spatial characterization of tumor immune microenvironments identifies targetable inflammatory niches in diffuse large B cell lymphoma

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TAMs in Brain Metastasis: Molecular Signatures in Mouse and Man

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Dual TLR9 and PD-L1 targeting unleashes dendritic cells to induce durable antitumor immunity

Fernandez-Rodriguez, L., Cianciaruso, C., Bill, R., Trefny, M. P., Klar, R., Kirchhammer, N., Buchi, M., Festag, J., Michel, S., Köhler, R. H., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-006714 · Cited by 28

Single-Cell Transcriptomics Reveals the Heterogeneity of the Immune Landscape of IDH–Wild-Type High-Grade Gliomas

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Integrated Single Cell Analysis Reveals An Atlas of Tumor Associated Macrophages in Hepatocellular Carcinoma

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Embracing diversity: macrophage complexity in cancer

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Mast cells: key players in digestive system tumors and their interactions with immune cells

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Single-cell and spatial RNA sequencing identify divergent microenvironments and progression signatures in early- versus late-onset prostate cancer

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Peritoneal resident macrophages constitute an immunosuppressive environment in peritoneal metastasized colorectal cancer

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Lipid Metabolism Reprogramming in Cancer: Insights into Tumor Cells and Immune Cells Within the Tumor Microenvironment

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Mature and migratory dendritic cells promote immune infiltration and response to anti-PD-1 checkpoint blockade in metastatic melanoma

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Tumor-associated macrophages: untapped molecular targets to improve T cell-based immunotherapy

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Sensitized mast cells for targeted drug delivery and augmented cancer immunotherapy

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Fluorescent tracking identifies key migratory dendritic cells in the lymph node after radiotherapy

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Influencing tumor-associated macrophages in malignant melanoma with monoclonal antibodies

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Mast cells inhibit colorectal cancer development by inducing ER stress through secreting Cystatin C

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Stromal circuits involving tumor-associated macrophages and cancer-associated fibroblasts

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Mapping cell types across human tissues

Liu, Z., & Zhang, Z. (2022) · Science · doi:10.1126/science.abq2116 · Cited by 28

Single-cell RNA sequencing reveals recruitment of the M2-like CCL8high macrophages in Lewis lung carcinoma-bearing mice following hypofractionated radiotherapy

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Single-cell analyses reveal evolution mimicry during the specification of breast cancer subtype

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TCF1-positive and TCF1-negative TRM CD8 T cell subsets and cDC1s orchestrate melanoma protection and immunotherapy response

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Syndecan-1 inhibition promotes antitumor immune response and facilitates the efficacy of anti-PD1 checkpoint immunotherapy

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Expression, regulation, and function of PD-L1 on non-tumor cells in the tumor microenvironment

Hu, L., Sun, C., Yuan, K., & Yang, P. (2024) · Drug Discovery Today · doi:10.1016/j.drudis.2024.104181 · Cited by 27

Single cell atlas reveals multilayered metabolic heterogeneity across tumour types

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Distant Metastases of Breast Cancer Resemble Primary Tumors in Cancer Cell Composition but Differ in Immune Cell Phenotypes

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Single-cell RNA sequencing reveals multiple immune cell subpopulations promote the formation of abnormal bone microenvironment in osteoporosis

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Gut bacterial L-lysine alters metabolism and histone methylation to drive dendritic cell tolerance

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The impact of the tumor microenvironment on macrophages

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Mitochondrial complex IV remodeling in tumor-associated macrophages amplifies interferon signaling and promotes anti-tumor immunity

Clark, M. L., Simeonov, K. P., Mowel, W. K., Michieletto, M. F., Joannas, L. D., Wright, J. M., Erickson, I., Johnson, L. R., Krishnan, R., de la Fuente‐Núñez, C., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.06.006 · Cited by 29

SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

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MetaTiME integrates single-cell gene expression to characterize the meta-components of the tumor immune microenvironment

Zhang, Y., Xiang, G., Jiang, A. Y., Lynch, A. W., Zeng, Z., Wang, C., Zhang, W., Fan, J., Kang, J., Gu, S. S., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38333-8 · Cited by 27

Single-cell characterization of macrophages in uveal melanoma uncovers transcriptionally heterogeneous subsets conferring poor prognosis and aggressive behavior

Li, K., Sun, L., Wang, Y., Cen, Y., Zhao, J., Liao, Q., Wu, W., Sun, J., & Zhou, M. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01115-9 · Cited by 27

GITR and TIGIT immunotherapy provokes divergent multicellular responses in the tumor microenvironment of gastrointestinal cancers

Sathe, A., Ayala, C. I., Bai, X., Grimes, S. M., Lee, B., Kin, C., Shelton, A. A., Poultsides, G. A., & Ji, H. P. (2023) · Genome Medicine · doi:10.1186/s13073-023-01259-3 · Cited by 28

Single-cell RNA sequencing in donor and end-stage heart failure patients identifies NLRP3 as a therapeutic target for arrhythmogenic right ventricular cardiomyopathy

Fu, M., Hua, X., Shu, S., Xu, X., Zhang, H., Peng, Z., Mo, H., Liu, Y., Chen, X., Yang, Y., et al. (2024) · BMC Medicine · doi:10.1186/s12916-023-03232-8 · Cited by 27

The Role of Macrophages in Various Types of Tumors and the Possibility of Their Use as Targets for Antitumor Therapy

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Cellular interactions within the immune microenvironment underpins resistance to cell cycle inhibition in breast cancers

Griffiths, J. I., Cosgrove, P. A., Medina, E. F., Nath, A., Chen, J., Adler, F. R., Chang, J. T., Khan, Q. J., & Bild, A. H. (2025) · Nature Communications · doi:10.1038/s41467-025-56279-x · Cited by 29

Dendritic cells instruct T cell anti-tumor immunity and immunotherapy response

Xiao, Z., Wang, J., Yang, J., Guo, F., Zhang, L., & Zhang, L. (2025) · The Innovation Medicine · doi:10.59717/j.xinn-med.2025.100128 · Cited by 27

Immunotherapeutic Approaches for the Treatment of HPV-Associated (Pre-)Cancer of the Cervix, Vulva and Penis

Rafael, T. S., Rotman, J., Brouwer, O. R., van der Poel, H. G., Mom, C. H., Kenter, G. G., de Gruijl, T. D., & Jordanova, E. S. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11041101 · Cited by 27

Single-cell chemokine receptor profiles delineate the immune contexture of tertiary lymphoid structures in head and neck squamous cell carcinoma

Zhang, B., Li, H., Li, H., Xiong, D., Zhang, L., & Sun, Z. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216105 · Cited by 27

Deciphering tumor-infiltrating dendritic cells in the single-cell era

Huang, Q., Wang, F., Di, H., Li, X., Li, X., Lei, T., Yue, J., & Liu, C. (2023) · Experimental Hematology and Oncology · doi:10.1186/s40164-023-00459-2 · Cited by 27

TSG-6+ cancer-associated fibroblasts modulate myeloid cell responses and impair anti-tumor response to immune checkpoint therapy in pancreatic cancer

Anandhan, S., Herbrich, S. M., Goswami, S., Guan, B., Chen, Y., Macaluso, M. D., Jindal, S., Natarajan, S. M., Andrewes, S. W., Xiong, L., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49189-x · Cited by 28

METI: deep profiling of tumor ecosystems by integrating cell morphology and spatial transcriptomics

Jiang, J., Liu, Y., Qin, J., Chen, J., Wu, J., Pizzi, M. P., Lazcano, R., Yamashita, K., Xu, Z., Pei, G., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51708-9 · Cited by 26

Sex differences in bladder cancer: understanding biological and clinical implications

Chaudhary, P., Singha, B., Abdel-Hafiz, H. A., Velegraki, M., Sundi, D., Satturwar, S. P., Parwani, A. V., Grivennikov, S. I., You, S., Goodridge, H. S., et al. (2025) · Biology of Sex Differences · doi:10.1186/s13293-025-00715-6 · Cited by 25

Multi-omic analysis of gallbladder cancer identifies distinct tumor microenvironments associated with disease progression

Zhou, T., Wu, Y., Li, S., Qiu, X., Liu, E., Xie, Z., Shi, X., Zhang, Y., Ma, G., Guo, W., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02236-9 · Cited by 25

Understanding the complexity of tumor-associated macrophages: Druggable and therapeutic insights

Li, A.-Q., Huang, F., Talaiti, S., Yang, X. Y., Bi, H., & Fang, J. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.07.021 · Cited by 26

Tumor-Associated Macrophages Produce PGE2 to Promote CD8+ T-cell Exhaustion and Drive Resistance to PD-L1 Blockade in Microsatellite-Stable Colorectal Cancer

Fumet, J.-D., Latour, C., Nuttin, L., Dérangère, V., Ilie, A., Russo, P., Hampe, L., Daumoine, S., Thibaudin, M., Truntzer, C., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-25-0079 · Cited by 25

Tumour-reactive heterotypic CD8 T cell clusters from clinical samples

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Immunotherapy in the Treatment of Urothelial Bladder Cancer: Insights From Single-Cell Analysis

Zang, J., Ye, K., Yang, F., Zhang, R., Chen, H., & Zhuang, G. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.696716 · Cited by 25

Pan-cancer analysis identifies RNA helicase DDX1 as a prognostic marker

Gao, B., Li, X., Li, S., Wang, S., Wu, J., & Li, J. (2022) · Phenomics · doi:10.1007/s43657-021-00034-x · Cited by 25

Matrix proteoglycans in tumor inflammation and immunity

Deb, G., Cicala, A., Papadas, A., & Asimakopoulos, F. A. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00023.2022 · Cited by 26

Single-cell dissection of tumor microenvironmental response and resistance to cancer therapy

Luo, Y., & Liang, H. (2023) · Trends in Genetics · doi:10.1016/j.tig.2023.07.005 · Cited by 25

Cell therapy using ex vivo reprogrammed macrophages enhances antitumor immune responses in melanoma

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PI3K/mTOR inhibition induces tumour microenvironment remodelling and sensitises pS6high uterine leiomyosarcoma to PD‐1 blockade

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Multi-omics analyses reveal interactions between GREM1+ fibroblasts and SPP1+ macrophages in gastric cancer

Qiu, L., Zhao, X. Q., Yao, S., Fei, Y., Gong, Y., Zhou, Z., Jiao, S., & Xu, J. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-00967-w · Cited by 25

Implications for Immunotherapy of Breast Cancer by Understanding the Microenvironment of a Solid Tumor

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Anti-PD-L1 antibody enhances curative effect of cryoablation via antibody-dependent cell-mediated cytotoxicity mediating PD-L1highCD11b+ cells elimination in hepatocellular carcinoma

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Efferocytosis Drives Myeloid NLRP3 Dependent Inflammasome Signaling and Gasdermin D Independent Secretion of IL-1β to Promote Tumor Growth

Lang, C., Roy, S., Wang, Y., Graves, D. K., Xu, Y., Serezani, C. H., Korrer, M. J., & Kim, Y. J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.993771 · Cited by 24

Concomitant inhibition of PPARγ and mTORC1 induces the differentiation of human monocytes into highly immunogenic dendritic cells

Díaz, F. A. E., Mazzitelli, I. G., Bleichmar, L., Melucci, C., Thibodeau, A., Dalotto‐Moreno, T., Marcheş, R., Rabinovich, G. A., Ucar, D., & Geffner, J. R. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112156 · Cited by 25

MAIT cells confer resistance to Lenvatinib plus anti-PD1 antibodies in hepatocellular carcinoma through TNF-TNFRSF1B pathway

Zhou, C., Sun, B., Zhou, P., Yang, Z., Wang, Z.-T., Liu, G., Gan, W., Wang, Z., Zhou, J., Fan, J., et al. (2023) · Clinical Immunology · doi:10.1016/j.clim.2023.109770 · Cited by 24

The immune cell landscape of glioblastoma patients highlights a myeloid-enriched and immune suppressed microenvironment compared to metastatic brain tumors

Musca, B., Russo, M. G., Tushe, A., Magri, S., Battaggia, G., Pinton, L., Bonaudo, C., Puppa, A. D., & Mandruzzato, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1236824 · Cited by 24

Targeting myeloid checkpoint Siglec-10 reactivates antitumor immunity and improves anti-programmed cell death 1 efficacy in gastric cancer

Lv, K., Sun, M., Fang, H., Wang, J., Lin, C., Liu, H., Zhang, H., Li, H., He, H., Gu, Y., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-007669 · Cited by 24

Dataset related to article "High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis"

Cortese, N., Carriero, R., Barbagallo, M., Putignano, A. R., Costa, G., Giavazzi, F., Grizzi, F., Pasqualini, F., Peano, C., Basso, G., et al. (2023) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.10224041 · Cited by 36

The single cell immunogenomic landscape after neoadjuvant immunotherapy combined chemotherapy in esophageal squamous cell carcinoma

Wang, Z., Zhao, Y., Wo, Y., Peng, Y., Hu, W., Wu, Z., Liu, P., Shang, Y., Liu, C., Chen, X., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216951 · Cited by 23

Single-cell transcriptomic landscape deciphers olfactory neuroblastoma subtypes and intra-tumoral heterogeneity

Yang, J., Song, X., Zhang, H., Liu, Q., Wei, R., Guo, L., Yuan, C., Fu, C., Xue, K., Lai, Y., et al. (2024) · Nature Cancer · doi:10.1038/s43018-024-00855-5 · Cited by 24

Prognostic value of CD163+ macrophages in solid tumor malignancies: A scoping review

Mathiesen, H., Juul‐Madsen, K., Tramm, T., Vorup‐Jensen, T., Møller, H. J., Etzerodt, A., & Andersen, M. N. (2025) · Immunology Letters · doi:10.1016/j.imlet.2025.106970 · Cited by 23

The tumor microenvironment and dendritic cells: Developers of pioneering strategies in colorectal cancer immunotherapy?

Ghorbaninezhad, F., Nour, M. A., Farzam, O. R., Saeedi, H., Vanan, A. G., Bakhshivand, M., Jafarlou, M., Hatami‐Sadr, A., & Baradaran, B. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189281 · Cited by 26

Single-Cell RNA Sequencing of Ewing Sarcoma Tumors Demonstrates Transcriptional Heterogeneity and Clonal Evolution

Goodspeed, A. E., Bodlak, A., Duffy, A. B., Nelson-Taylor, S., Oike, N., Porfilio, T. E., Shirai, R., Walker, D., Treece, A., Black, J. O., et al. (2025) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-24-2040 · Cited by 24

Integrative multi-omics and machine learning reveal critical functions of proliferating cells in prognosis and personalized treatment of lung adenocarcinoma

Wang, S., Hu, D., Wang, R., Huang, J., & Wang, B. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-01027-z · Cited by 24

Myeloid checkpoints for cancer immunotherapy

Qian, Y., Yang, T., Liang, H., & Deng, M. (2022) · Chinese Journal of Cancer Research · doi:10.21147/j.issn.1000-9604.2022.05.07 · Cited by 24

Dendritic Cell Subsets in Melanoma: Pathophysiology, Clinical Prognosis and Therapeutic Exploitation

Cuevas, E. S., Saas, P., & Aspord, C. (2023) · Cancers · doi:10.3390/cancers15082206 · Cited by 24

Intratumoral erythroblastic islands restrain anti-tumor immunity in hepatoblastoma

Wang, Y., Xiang, X., Chen, H., Zhou, L., Chen, S., Zhang, G., Liu, X., Ren, X., Liu, J., Kuang, M., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101044 · Cited by 26

Targeting cGAS/STING signaling-mediated myeloid immune cell dysfunction in TIME

Kumar, V., Bauer, C., & Stewart, J. H. (2023) · Journal of Biomedical Science · doi:10.1186/s12929-023-00942-2 · Cited by 23

Architecting the metabolic reprogramming survival risk framework in LUAD through single-cell landscape analysis: three-stage ensemble learning with genetic algorithm optimization

Sun, X., Nong, M.-Y., Meng, F., Xiaojuan, S., Jiang, L., Li, Z., & Zhang, P. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05138-2 · Cited by 23

High-Content Label-Free Single-Cell Analysis with a Microfluidic Device Using Programmable Scanning Electrochemical Microscopy

Shi, M., Wang, L., Xie, Z., Zhao, L., Zhang, X., & Zhang, M. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c02507 · Cited by 23

Identification of Siglec-10 as a new dendritic cell checkpoint for cervical cancer immunotherapy

Wang, C., He, L., Peng, J., Lu, C., Zhang, M., Qi, X., Zhang, M., & Wang, Y. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-009404 · Cited by 22

Identification of a novel subtype of SPP1 + macrophages expressing SIRPα: implications for tumor immune evasion and treatment response prediction

Chen, K., Li, Y., Ni, J., Yang, X., Zhou, Y., Pang, Y., Ye, R., Chen, H., Yu, S., Wang, P., et al. (2024) · Experimental Hematology and Oncology · doi:10.1186/s40164-024-00587-3 · Cited by 22

Mapping immunotherapy potential: spatial transcriptomics in the unraveling of tumor-immune microenvironments in head and neck squamous cell carcinoma

Choi, S.-W., Kim, J. H., Hong, J., & Kwon, M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1568590 · Cited by 22

Intratumoral Brevibacillus parabrevis enhances antitumor immunity by inhibiting NK cell ferroptosis in hepatocellular carcinoma

Pan, B., Zhang, X., Ye, D., Yao, Y., Zhang, Z., Luo, Y., Wu, H., Wang, X., & Tang, N. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07733-7 · Cited by 22

CD200R1-CD200 checkpoint inhibits phagocytosis differently from SIRPα-CD47 to suppress tumor growth

Li, J., Wang, Z., Qin, X., Zhong, M., Tang, Z.-H., Qian, J., Dou, J., Hussell, T., King, P. D., Nunès, J. A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60456-3 · Cited by 22

Spatial and genomic profiling of residual breast cancer after neoadjuvant chemotherapy unveil divergent fates for each breast cancer subtype

Seo, E. S., Park, S., Cho, E. Y., Lee, J. E., Jung, H. H., Hyeon, J., An, S., Kim, S. W., Shin, J., Ahn, J. S., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102164 · Cited by 23

Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity

You, Z., Kim, J., Guo, C., Hu, H., Chapman, N. M., Meng, X., Shi, H., Wang, Y., Guy, C. S., Anil, K. C., et al. (2026) · Science · doi:10.1126/science.adv6582 · Cited by 22

Tumor-associated macrophage clusters linked to immunotherapy in a pan-cancer census

Wei, C., Ma, Y., Wang, M., Wang, S., Yu, W., Dong, S., Deng, W., Bie, L., Zhang, C., Shen, W., et al. (2024) · npj Precision Oncology · doi:10.1038/s41698-024-00660-4 · Cited by 55

Abstract 7280: Pan-cancer single-cell RNA sequencing analysis refines multiorigin monocyte and macrophage lineages

Nguyen, T. D., Lee, A., Park, H. J., Shah, N., Mandzhieva, B., Lee, D., Jung, I., & Park, W.-Y. (2026) · Cancer Research · doi:10.1158/1538-7445.am2026-7280

A single-cell pan-cancer analysis to show the variability of tumor-infiltrating myeloid cells in immune checkpoint blockade

Li, W., Pan, L., Hong, W., Ginhoux, F., Zhang, X., Xiao, C., & Li, X. (2024) · Nature Communications · doi:10.1038/s41467-024-50478-8 · Cited by 46

The Tumor Microenvironment Shapes Lineage, Transcriptional, and Functional Diversity of Infiltrating Myeloid Cells

Elpek, K. G., Cremasco, V., Shen, H., Harvey, C. J., Wucherpfennig, K. W., Goldstein, D. R., Monach, P. A., & Turley, S. J. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-13-0209 · Cited by 77

Macrophage diversity in human cancers: New insight provided by single-cell resolution and spatial context

Rakina, M. A., Larionova, I., & Kzhyshkowska, J. G. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e28332 · Cited by 82