A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells

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Crosstalk between tumor-associated macrophages and the B7/CD28 family in immune checkpoint inhibitor-induced immunotherapy

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Blocking CCR1+ macrophages overcomes resistance to immune checkpoint inhibitors in melanoma

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MARCO+ macrophages drive immunosuppressive remodeling and metastasis in chemotherapy-associated steatohepatitis

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Oligoclonal tumor-specific CD8 T-cell revival and IRE1α/XBP1-GDF15-mediated immunosuppressive niches determine neoadjuvant chemoimmunotherapy efficacy in cervical cancer

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CD48 is a novel immune checkpoint on tumour‐associated macrophages in hepatocellular carcinoma

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A pan-cancer single-cell transcriptomic atlas of human bone metastases

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SPP1 + Macrophage‐ POSTN + Fibroblast‐Endothelial Triad Dictates Immunotherapy Response in Bladder Cancer

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Pan-cancer analysis of spatial transcriptomics reveals heterogeneous tumor spatial microenvironment

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Using Single Cell Transcriptomics to Elucidate the Myeloid Compartment in Pancreatic Cancer

Kadiyala, P., Elhossiny, A. M., & Carpenter, E. S. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.881871 · Cited by 7

Melanomas and mast cells: an ambiguous relationship

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Single-cell RNA-seq reveals the metabolic status of immune cells response to immunotherapy in triple-negative breast cancer

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scCancer2: data-driven in-depth annotations of the tumor microenvironment at single-level resolution

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A comprehensive survey on deep learning-based identification and predicting the interaction mechanism of long non-coding RNAs

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Synergistic action of Hedyotis diffusa Willd and Andrographis paniculata in Nasopharyngeal Carcinoma: Downregulating AKT1 and upregulating VEGFA to curb tumorigenesis

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Heterogeneity of myeloid cells in common cancers: Single cell insights and targeting strategies

Jing, Z.-Q., Luo, Z.-Q., Chen, S.-R., & Sun, Z. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112253 · Cited by 7

Potential predictive value of immune-related genes FUCA1 and NCKAP1L for osteosarcoma metastasis

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Potential crosstalk between Naïve CD4+ T cells and SPP1+ Macrophages is associated with clinical outcome and therapeutic response in hepatocellular carcinoma

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Knowledge-based inductive bias and domain adaptation for cell type annotation

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The role of macrophage migratory behavior in development, homeostasis and tumor invasion

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The molecular and immune microenvironmental landscape of brain metastases: Implications for novel treatment options

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ScRNA-Seq Analysis of Tongue Tissues in Chronic Hyperplastic Candidiasis

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Single‐Cell RNA Sequencing Reveals the Tumor Heterogeneity and Immunosuppressive Microenvironment in Urothelial Carcinoma

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Identification of novel metabolism-related biomarkers of Kawasaki disease by integrating single-cell RNA sequencing analysis and machine learning algorithms

Feng, C., Wei, Z., & Li, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1541939 · Cited by 7

Identification of Key Transcription Factors and Immune Infiltration Patterns Associated With Breast Cancer Prognosis Using WGCNA and Cox Regression Analysis

Yin, X., Liu, J., Wang, X., Yang, T., Li, G. L., Shang, Y., Teng, X., Yu, H., Wang, S., & Huang, W. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.742792 · Cited by 7

A multiomics disease progression signature of low-risk ccRCC

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Significance of Nano-drug Delivery in Cancer Therapy, Application of Nanoparticles in Overcoming Drug Resistance, Targeted Therapy, and Immunotherapy

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Unraveling the underlying pathogenic factors driving nonalcoholic steatohepatitis and hepatocellular carcinoma: an in-depth analysis of prognostically relevant gene signatures in hepatocellular carcinoma

Ni, Y., Lu, M., Li, M., Hu, X., Li, F., Wang, Y., & Xue, D. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-04885-6 · Cited by 8

The crosstalk between lung cancer and the bone marrow niche fuels emergency myelopoiesis

Calderon-Espinosa, E., Ridder, K. D., Benoot, T., Jansen, Y. J. L., Vanhonacker, D., Heestermans, R., Becker, A. D., Riet, I. V., Decoster, L., & Goyvaerts, C. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1397469 · Cited by 6

Characterizing macrophage diversity in colorectal malignancies through single-cell genomics

Zhao, T., Luo, Y., Sun, Y., & Wei, Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1526668 · Cited by 7

scGraPhT: Merging Transformers and Graph Neural Networks for Single-Cell Annotation

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Liver metastasis or peritoneal metastasis: single-cell RNA sequencing reveals the organotropism in colorectal cancer is driven by distinct partial-EMT processes

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Targeting ribosomes reprograms the tumour microenvironment and augments cancer immunotherapy

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In vivo neutrophils hitchhiking for tumor targeting and microenvironment regulation boosts oncolytic virus therapy

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Myeloid landscape profiling identifies DLBCL-specific suppressive macrophages colocalized with blood endothelial cells

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Single-cell transcriptomic profiling reveals liver fibrosis in colorectal cancer liver metastasis

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Fusobacterium nucleatum drives gastric cancer metastasis via Gbp-CypA-NF-κB-mediated CXCL8 crosstalk between tumor cells and mast cells

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Mapping heterogeneity in the tumor microenvironment of renal cell carcinoma through single-cell omics

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Pulmonary macrophage-targeted RNAi and mRNA co-delivery via SORT lipid nanoparticles enhances immunotherapy in lung cancer

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Siglec-14-LGALS3BP glycoimmune axis shapes tumor-associated macrophage polarization and confers poor outcome in colorectal cancer

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Single-cell landscape of peripheral and tumor-infiltrating immune cells in HPV-negative HNSCC

Galvani, R. G. A., Hidalgo, A. A. R., de Biagi, C. A. O., Matuck, B. F., Krol, J. M. M., Rupp, B., Kumar, N., Huynh, K., Liu, J., Sheth, S. H., et al. (2025) · OncoImmunology · doi:10.1080/2162402x.2025.2605741 · Cited by 6

Host-derived interleukin-1α drives tumor immunosuppression by reprogramming tumor-associated myeloid cells

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Activated CD38+ mast cells promote gastric cancer progression by suppressing CD8+ T cell cytotoxic activity through adenosine metabolism

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Unraveling pancreatic ductal adenocarcinoma at single-cell resolution with spatial insights: From mechanisms to clinical translation

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Decoding tumor immune microenvironment heterogeneity by single-cell and spatial multi-omics: From immunotherapy resistance to translational biomarkers

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Ganglioglioma deep transcriptomics reveals primitive neuroectoderm neural precursor-like population

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Clinicopathological Features and Molecular Signatures of Lateral Neck Lymph Node Metastasis in Papillary Thyroid Microcarcinoma

Lim, J., Lee, H. S., Heo, J. H., & Song, Y. S. (2024) · Endocrinology and Metabolism · doi:10.3803/enm.2023.1885 · Cited by 6

Integrated analysis of tumor-associated macrophages and M2 macrophages in CRC: unraveling molecular heterogeneity and developing a novel risk signature

Shi, L., Mao, H., & Ma, J. (2024) · BMC Medical Genomics · doi:10.1186/s12920-024-01881-z · Cited by 6

Intracellular Osteopontin Promotes the Release of TNFα by Mast Cells to Restrain Neuroendocrine Prostate Cancer

Sulsenti, R., Scialpi, G. B., Frossi, B., Botti, L., Ferri, R., Tripodi, I., Piva, A., Sangaletti, S., Pernici, D., Cancila, V., et al. (2024) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-23-0792 · Cited by 6

Characterization of unique pattern of immune cell profile in patients with nasopharyngeal carcinoma through flow cytometry and machine learning

Liao, L., Tsai, C., Li, P., Lee, C., Lin, S., Lai, W., Chen, I., Chang, C., Lee, J., & Chiu, Y. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18404 · Cited by 6

Mast cell heparanase promotes breast cancer stem-like features via MUC1/estrogen receptor axis

Bongiorno, R., Lecchi, M., Botti, L., Bosco, O., Ratti, C., Fontanella, E., Mercurio, N., Pratesi, P., Chiodoni, C., Verderio, P., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07092-9 · Cited by 6

CXCR6 expression predicts prognosis and immunotherapeutic benefit in muscle-invasive bladder cancer

Lu, X., Ge, L., Liu, Z., Zhu, Y., Ye, D., & Chang, Y. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1498579 · Cited by 6

Machine learning identifies immune-based biomarkers that predict efficacy of anti-angiogenesis-based therapies in advanced lung cancer

Chen, P., Cheng, L., Zhao, C., Tang, Z., Wang, H., Shi, J., Li, X., & Zhou, C. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113588 · Cited by 6

DC-T cell power couples in rheumatoid arthritis joints

Higashioka, K., & Rao, D. A. (2024) · Immunity · doi:10.1016/j.immuni.2024.11.012 · Cited by 6

Single-cell transcriptomics reveals the heterogeneity and function of mast cells in human ccRCC

Song, X., Jiao, J., Qin, J., Zhang, W., Qin, W., & Ma, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1494025 · Cited by 6

Molecular characterization of HER2-negative breast cancers reveals a distinct patient subgroup with 17q12 deletion and heterozygous loss of ERBB2

Qiu, X., Tarantino, P., Li, R., Grinshpun, A., Gupta, H. V., Hughes, M. E., Kirkner, G. J., Scholl, L., Johnson, B. E., Meyerson, M. M., et al. (2025) · ESMO Open · doi:10.1016/j.esmoop.2024.104111 · Cited by 6

Immunoglobulin‐like transcript 5 polarizes M2 ‐like tumor‐associated macrophages for immunosuppression in non‐small cell lung cancer

Xu, H., Fu, X., Wang, S., Ge, Y., Zhang, L., Li, J., Zhang, F., Yang, Y., He, Y., Sun, Y., et al. (2025) · International Journal of Cancer · doi:10.1002/ijc.35360 · Cited by 6

Single-cell RNA sequencing revealed changes in the tumor microenvironment induced by radiotherapy for cervical cancer and the molecular mechanism of mast cells in immunosuppression

Xue, L., Gao, L., Zhou, S., Yan, C., Zhang, X., Lin, W., Hu, L., Shen, Y., & Wang, X. (2025) · Functional & Integrative Genomics · doi:10.1007/s10142-025-01564-7 · Cited by 6

Cell-type-specific subtyping of epigenomes improves prognostic stratification of cancer

Luo, Q., & Teschendorff, A. E. (2025) · Genome Medicine · doi:10.1186/s13073-025-01453-5 · Cited by 6

Syndecan-3 positively regulates the pro-inflammatory function of macrophages

Lee, S. Y., Prieto‐Fernández, E., Egia‐Mendikute, L., Antoñana-Vildosola, A., Velasco-Beltrán, P., Bosch, A., Jiménez-Lasheras, B., de Blas, A., de Durana, J. E.-D., Valdaliso-Díez, E., et al. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05649-1 · Cited by 6

Unveiling the heterogeneity and immunotherapy potency of tumor-associated neutrophils in the tumor microenvironment of gastric cancer

Qi, T., Zhou, S.-J., Zhu, Y., Li, Y., & Chen, J. (2025) · BMC Gastroenterology · doi:10.1186/s12876-025-03920-0 · Cited by 8

Sustained Macrophage Reprogramming Is Required for CD8+ T cell–Dependent Long-Term Tumor Eradication

Jardim, C., Bica, M., Reis-Sobreiro, M., da Mota, A. T., Lopes, R., Pinto, M. F., Sousa, N. S., Mensurado, S., Boekhoff, H., Scolaro, T., et al. (2025) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-24-0797 · Cited by 6

Cell-GraphCompass: modeling single cells with graph structure foundation model

Fang, C., Cui, W., Hu, Z., Liu, W., Chen, S., Chang, S., Long, Q., Li, C., Liu, Y., Jiang, H., et al. (2025) · National Science Review · doi:10.1093/nsr/nwaf255 · Cited by 6

Non-genetic stratification reveals epigenetic heterogeneity and identifies vulnerabilities of glycolysis addiction in lung adenocarcinoma subtype

Song, X., Zhang, T., Ding, H., Feng, Y., Yang, W., Yin, X., Chen, B., Liang, Y., Mao, Q., Xia, W., et al. (2022) · Oncogenesis · doi:10.1038/s41389-022-00436-0 · Cited by 6

Preclinical evaluation of the efficacy of an antibody to human SIRPα for cancer immunotherapy in humanized mouse models

Saito, Y., Iida‐Norita, R., Afroj, T., Refaat, A., Hazama, D., Komori, S., Ohata, S., Takai, T., Oduori, O. S., Kotani, T., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1294814 · Cited by 6

A detailed insight into macrophages' role in shaping lung carcinogenesis

Aktar, T., Modak, S., Majumder, D., & Maiti, D. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122896 · Cited by 6

Focal Adhesion-Related Signatures Predict the Treatment Efficacy of Chemotherapy and Prognosis in Patients with Gastric Cancer

Tang, X., Wu, X., Guo, T., Jia, F., Hu, Y., Xing, X., Gao, X., & Li, Z. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.808817 · Cited by 6

The pleiotropic mode and molecular mechanism of macrophages in promoting tumor progression and metastasis

Zhang, X., Bai, W., Hu, L., Ha, H., Du, Y., Xiong, W., Wang, H., & Shang, P. (2022) · Clinical & Translational Oncology · doi:10.1007/s12094-022-02932-6 · Cited by 7

Infiltration of Apoptotic M2 Macrophage Subpopulation Is Negatively Correlated with the Immunotherapy Response in Colorectal Cancer

Liu, R., Han, C., Hu, J., Zhang, B., Luo, W., & Ling, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911014 · Cited by 6

Tumor-intrinsic LKB1-LIF signaling axis establishes a myeloid niche to promote immune evasion and tumor growthPreprint

Rashidfarrokhi, A., Pillai, R., Yuan, H., Wu, W., Karadal-Ferrena, B., Dimitriadoy, S. G., Cross, M. J., Yeaton, A. H., Huang, S. M., Bhutkar, A. J., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.15.549147 · Cited by 6

Fundamental Limitations of Foundation Models in Single-Cell TranscriptomicsPreprint

Atti, S., & Subramaniam, S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.26.661767 · Cited by 7

High-dimensional deconstruction of HNSC reveals clinically distinct cellular states and ecosystems that are associated with prognosis and therapy response

Xiao, L., Shen, Z., Pan, Z., Qiu, Y., Huang, D., Liu, Y., Liu, C., & Zhang, X. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06299-4 · Cited by 5

Selective Glycopolymer Inhibitors of Galectin-3: Supportive Anti-Cancer Agents Protecting Monocytes and Preserving Interferon-Gamma Function

Filipová, M., Tavares, M. R., Hovorková, M., Heine, V., Nekvasilová, P., Vladimír Křen, A., Etrych, T., Chytil, P., & Bojarová, P. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s503381 · Cited by 5

Functional Genetic Screens Reveal Key Pathways Instructing the Molecular Phenotypes of Tumor-Associated Macrophages

Lu, Y., Luo, C., Huang, L., Wu, G., Zhong, L., Chu, J., Wang, F., Zeng, Z., & Pan, D. (2025) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-25-0488 · Cited by 5

FPR3 sustains the immunosuppression of tumor-associated macrophages and accelerates the progression of gastric adenocarcinoma

Sun, M., Tan, Z., Lin, K., Chang, Z., Yang, Z., Yang, X., Tang, G., Liu, Y., Li, C., Zhu, J., et al. (2025) · Oncogene · doi:10.1038/s41388-025-03578-8 · Cited by 5

CCL5 hi Macrophages Interact with CD8 + T Cells and Potentiate Responsiveness to PD‐1 Blockade Plus Chemotherapy in Esophageal Squamous Cell Carcinoma

Ma, Y., Su, X., Zeng, T., Zhou, C., Yang, G., Xia, Z., Zeng, C., Zhan, J., Guan, X., Zhang, X., et al. (2025) · Advanced Science · doi:10.1002/advs.202409187 · Cited by 5

Comprehensive single-cell RNA analysis reveals intertumoral microenvironment heterogeneity and hub niche of carcinogenesis in thyroid cancer

Xu, H., Ma, J., Li, N., Xuan, H., Lin, S., Shen, Y., Yin, L., Wang, P., & Xu, Q. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-00924-7 · Cited by 7

Retinoic Acid Reprograms Mast Cells Toward a Proinflammatory State to Enhance Antitumor Immunity

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An IL-12 partial agonist sustains intratumoral lymphocyte activation and detoxifies systemic IL-12 therapy

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