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Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research
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“Nonetheless, it would be prudent to keep in mind that SQSTM1 contains domains that interact with several signaling molecules [590], and SQSTM1 may be part of MTORC1 [591].”
From Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 (2021) · cites this paper as [591]
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Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.
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“The Tet-On/Tet-Off system employs a tetracycline, doxycycline, to activate or inactivate the tetracycline-responsive promoter (Gossen and Bujard, 1992).”
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BackgroundTranscriptional Activation by Tetracyclines in Mammalian Cells
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“In Tet-On systems, doxycycline binds the tetracycline transactivator protein and thereby allows binding to a tetracycline response element and transcriptional activation to occur (Gossen et al., 1995).”
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Cited by
Sorted by citations
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,897
Self-citationQuirós, P. M., Prado, M. A., Zamboni, N., D’Amico, D., Williams, R. W., Finley, D., Gygi, S. P., & Auwerx, J. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201702058 · Cited by 832
Self-citationMitonuclear communication in homeostasis and stress
Quirós, P. M., Mottis, A., & Auwerx, J. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.23 · Cited by 787
Self-citationEnhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity
Sorrentino, V., Romani, M., Mouchiroud, L., Beck, J. S., Zhang, H., D’Amico, D., Moullan, N., Potenza, F., Schmid, A. W., Rietsch, S., et al. (2017) · Nature · doi:10.1038/nature25143 · Cited by 630
Self-citationTet-On Systems For Doxycycline-inducible Gene Expression
T. Das, A., Tenenbaum, L., & Berkhout, B. (2016) · Current Gene Therapy · doi:10.2174/1566523216666160524144041 · Cited by 434
“For example, rtTAs with an increased dox-sensitivity will require less dox, which will avoid cellular side effects due to the inhibitory effect of high tetracycline levels on mitochondrial translation [17].”
Background
Metadata
- Authors
- Moullan, N., Mouchiroud, L., Wang, X., Ryu, D., Williams, E. G., Mottis, A., Jovaisaite, V., Frochaux, M. V., Quiros, P. M., Deplancke, B., Houtkooper, R. H., & Auwerx, J.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 10
- Issue
- 10
- Pages
- 1681-1691
- ISSN
- 2211-1247
- PMC
- PMC4565776
- Cited by
- 470
- References
- 11
- Language
- en
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