Blockade of 2-arachidonoylglycerol hydrolysis produces antidepressant-like effects and enhances adult hippocampal neurogenesis and synaptic plasticity

Short-Term Synaptic Plasticity

Zucker, R. S., & Regehr, W. G. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.092501.114547 · Cited by 5,068 · see citing works

Depression: a new animal model sensitive to antidepressant treatments

PORSOLT, R. D., LE PICHON, M., & JALFRE, M. (1977) · Nature · doi:10.1038/266730a0 · Cited by 4,451 · see citing works

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants

Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321 · see citing works

Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus

Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09104.2000 · Cited by 3,111 · see citing works

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2010) · Science · doi:10.1126/science.1190287 · Cited by 2,881 · see citing works

Functional neurogenesis in the adult hippocampus

van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H. (2002) · Nature · doi:10.1038/4151030a · Cited by 2,853 · see citing works

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

Cravatt, B. F., Giang, D. K., Mayfield, S. P., Boger, D. L., Lerner, R. A., & Gilula, N. B. (1996) · Nature · doi:10.1038/384083a0 · Cited by 2,125 · see citing works

Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant

Willner, P., Towell, A., Sampson, D., Sophokleous, S., & Muscat, R. (1987) · Psychopharmacology · doi:10.1007/bf00187257 · Cited by 1,993 · see citing works

The molecular logic of endocannabinoid signalling

Piomelli, D. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1247 · Cited by 1,957 · see citing works

ADULT NEUROGENESIS IN THE MAMMALIAN CENTRAL NERVOUS SYSTEM

Ming, G., & Song, H. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.051804.101459 · Cited by 1,829 · see citing works

Chronic Mild Stress (CMS) Revisited: Consistency and Behavioural-Neurobiological Concordance in the Effects of CMS

Willner, P. (2005) · Neuropsychobiology · doi:10.1159/000087097 · Cited by 1,605 · see citing works

Transient expression of doublecortin during adult neurogenesis

Brown, J. P., Couillard‐Després, S., Cooper‐Kuhn, C. M., Winkler, J., Aigner, L., & Kuhn, H. G. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10874 · Cited by 1,494 · see citing works

Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus

Schmidt-Hieber, C., Jonas, P., & Bischofberger, J. (2004) · Nature · doi:10.1038/nature02553 · Cited by 1,292 · see citing works

Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression

David, D. J., Samuels, B. A., Rainer, Q., Wang, J.-W., Marsteller, D., Mendez, I., Drew, M., Craig, D. A., Guiard, B. P., Guilloux, J.-P., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.04.017 · Cited by 1,267 · see citing works

GABA regulates synaptic integration of newly generated neurons in the adult brain

Ge, S., Goh, E. L. K., Sailor, K. A., Kitabatake, Y., Ming, G., & Song, H. (2005) · Nature · doi:10.1038/nature04404 · Cited by 1,261 · see citing works

Adult hippocampal neurogenesis in depression

Sahay, A., & Hen, R. (2007) · Nature Neuroscience · doi:10.1038/nn1969 · Cited by 1,206 · see citing works

BDNF Regulates the Maturation of Inhibition and the Critical Period of Plasticity in Mouse Visual Cortex

Huang, Z. J., Kirkwood, A., Pizzorusso, T., Porciatti, V., Morales, B., Bear, M. F., Maffei, L., & Tonegawa, S. (1999) · Cell · doi:10.1016/s0092-8674(00)81509-3 · Cited by 1,198 · see citing works

A Comprehensive Profile of Brain Enzymes that Hydrolyze the Endocannabinoid 2-Arachidonoylglycerol

Blankman, J. L., Simon, G. M., & Cravatt, B. F. (2007) · Chemistry & Biology · doi:10.1016/j.chembiol.2007.11.006 · Cited by 1,177 · see citing works

Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain

Bisogno, T., Howell, F., Williams, G., Minassi, A., Cascio, M. G., Ligresti, A., Matias, I., Schiano-Moriello, A., Paul, P., Williams, E.-J., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200305129 · Cited by 1,039 · see citing works

Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus

Saxe, M. D., Battaglia, F., Wang, J.-W., Malleret, G., David, D. J., Monckton, J. E., Garcia, A. D. R., Sofroniew, M. V., Kandel, E. R., Santarelli, L., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607207103 · Cited by 1,020 · see citing works

Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice

Kempermann, G., Gast, D., Kronenberg, G., Yamaguchi, M., & Gage, F. H. (2002) · Development · doi:10.1242/dev.00203 · Cited by 983 · see citing works

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

Long, J. Z., Li, W., Booker, L., Burston, J. J., Kinsey, S. G., Schlosburg, J. E., Pavón, F. J., Serrano, A., Selley, D. E., Parsons, L. H., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.129 · Cited by 938 · see citing works

A Critical Period for Enhanced Synaptic Plasticity in Newly Generated Neurons of the Adult Brain

Ge, S., Yang, C.-H., Hsu, K.-S., Ming, G.-L., & Song, H. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.002 · Cited by 927 · see citing works

IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress

Koo, J. W., & Duman, R. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708092105 · Cited by 862 · see citing works

Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

Nomura, D. K., Morrison, B. E., Blankman, J. L., Long, J. Z., Kinsey, S. G., Marcondes, M. C. G., Ward, A. M., Hahn, Y. K., Lichtman, A. H., Conti, B., et al. (2011) · Science · doi:10.1126/science.1209200 · Cited by 727 · see citing works

The Endocannabinoid System Controls Key Epileptogenic Circuits in the Hippocampus

Monory, K., Massa, F., Egertová, M., Eder, M., Blaudzun, H., Westenbroek, R., Kelsch, W., Jacob, W., Marsch, R., Ekker, M., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.006 · Cited by 706 · see citing works

Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action

Marzo, V. D., Melck, D. J., Bisogno, T., & PETROCELLIS, L. D. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01283-1 · Cited by 704 · see citing works

Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis

Gobbi, G., Bambico, F. R., Mangieri, R. A., Bortolato, M., Campolongo, P., Solinas, M., Cassano, T., Morgese, M. G., Debonnel, G., Duranti, A., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509591102 · Cited by 676 · see citing works

Effects of Adult Neurogenesis on Synaptic Plasticity in the Rat Dentate Gyrus

Snyder, J. S., Kee, N., & Wojtowicz, J. M. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.6.2423 · Cited by 619 · see citing works

Opiates inhibit neurogenesis in the adult rat hippocampus

Eisch, A. J., Barrot, M., Schad, C. A., Self, D. W., & Nestler, E. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.120552597 · Cited by 599 · see citing works

Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells

Wang, J.-W., David, D. J., Monckton, J. E., Battaglia, F., & Hen, R. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3632-07.2008 · Cited by 550 · see citing works

Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects

Jiang, W. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25509 · Cited by 527 · see citing works

Molecular Composition of the Endocannabinoid System at Glutamatergic Synapses

Katona, I., Urbán, G. M., Wallace, M., Ledent, C., Jung, K.-M., Piomelli, D., Mackie, K., & Freund, T. F. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0309-06.2006 · Cited by 511 · see citing works

Loss of Retrograde Endocannabinoid Signaling and Reduced Adult Neurogenesis in Diacylglycerol Lipase Knock-out Mice

Gao, Y., Vasilyev, D. V., Goncalves, M. B., Howell, F. V., Hobbs, C., Reisenberg, M., Shen, R., Zhang, M.-Y., Strassle, B. W., Lu, P., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5693-09.2010 · Cited by 473 · see citing works

Pharmacological Evaluation of Cannabinoid Receptor Ligands in a Mouse Model of Anxiety: Further Evidence for an Anxiolytic Role for Endogenous Cannabinoid Signaling

Patel, S., & Hillard, C. J. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.101287 · Cited by 390 · see citing works

BrdU assay for neurogenesis in rodents

Wojtowicz, J. M., & Kee, N. (2006) · Nature Protocols · doi:10.1038/nprot.2006.224 · Cited by 349 · see citing works

Antidepressant-like Activity of the Fatty Acid Amide Hydrolase Inhibitor URB597 in a Rat Model of Chronic Mild Stress

Bortolato, M., Mangieri, R. A., Fu, J., Kim, J. H., Arguello, O., Duranti, A., Tontini, A., Mor, M., Tarzia, G., & Piomelli, D. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.12.001 · Cited by 347 · see citing works

Evidence for two physiologically distinct perforant pathways to the fascia dentata

McNaughton, B. L. (1980) · Brain Research · doi:10.1016/0006-8993(80)90226-7 · Cited by 336 · see citing works

Behavioural and biochemical evidence for interactions between Δ9‐tetrahydrocannabinol and nicotine

Valjent, E., Mitchell, J., Besson, M., Caboche, J., & Maldonado, R. J. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704479 · Cited by 321 · see citing works

DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212

Kim, J. Y., Duan, X., Liu, C. Y., Jang, M.-H., Guo, J. U., Pow-anpongkul, N., Kang, E., Song, H., & Ming, G.-L. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.008 · Cited by 319 · see citing works

The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system

Campos, A. C., Ortega, Z., Palazuelos, J., Fogaça, M. V., Aguiar, D. C., Díaz-Alonso, J., Ortega-Gutiérrez, S., Vázquez-Villa, H., Moreira, F. A., Guzmán, M., et al. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712001502 · Cited by 313 · see citing works

Behavioral Effects of Chronic Fluoxetine in BALB/cJ Mice Do Not Require Adult Hippocampal Neurogenesis or the Serotonin 1A Receptor

Holick, K. A., Lee, D. C., Hen, R., & Dulawa, S. C. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301399 · Cited by 313 · see citing works

Repeated cocaine exposure in vivo facilitates LTP induction in midbrain dopamine neurons

Liu, Q.-S., Pu, L., & Poo, M. (2005) · Nature · doi:10.1038/nature04050 · Cited by 305 · see citing works

Characterization of Monoacylglycerol Lipase Inhibition Reveals Differences in Central and Peripheral Endocannabinoid Metabolism

Long, J. Z., Nomura, D. K., & Cravatt, B. F. (2009) · Chemistry & Biology · doi:10.1016/j.chembiol.2009.05.009 · Cited by 305 · see citing works

Depression, Antidepressants, and Neurogenesis: A Critical Reappraisal

Hanson, N. D., Owens, M. J., & Nemeroff, C. B. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.220 · Cited by 302 · see citing works

Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses

Busquets-Garcia, A., Puighermanal, E., Pastor, A., de la Torre, R., Maldonado, R., & Ozaita, A. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.04.022 · Cited by 273 · see citing works

Monoacylglycerol Lipase Is a Therapeutic Target for Alzheimer's Disease

Chen, R., Zhang, J., Wu, Y., Wang, D., Feng, G., Tang, Y., Teng, Z., & Chen, C. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.09.030 · Cited by 272 · see citing works

Defective Adult Neurogenesis in CB1 Cannabinoid Receptor Knockout Mice

Jin, K., Xie, L., Kim, S. H., Parmentier‐Batteur, S., Sun, Y., Mao, X. O., Childs, J., & Greenberg, D. A. (2004) · Molecular Pharmacology · doi:10.1124/mol.66.2.204 · Cited by 271 · see citing works

The Growing Role of mTOR in Neuronal Development and Plasticity

Jaworski, J., & Sheng, M. (2006) · Molecular Neurobiology · doi:10.1385/mn:34:3:205 · Cited by 268 · see citing works

Behavioral, neurochemical, and electrophysiological characterization of a genetic mouse model of depression

Yacoubi, M. E., Bouali, S., Popa, D., Naudon, L., Leroux‐Nicollet, I., Hamon, M., Costentin, J., Adrien, J., & Vaugeois, J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1034823100 · Cited by 263 · see citing works

BUdR as an S-phase marker for quantitative studies of cytokinetic behaviour in the murine cerebral ventricular zone

Takahashi, T., Nowakowski, R. S., & Caviness, V. S. (1992) · Journal of Neurocytology · doi:10.1007/bf01194977 · Cited by 237 · see citing works

A Dysregulated Endocannabinoid-Eicosanoid Network Supports Pathogenesis in a Mouse Model of Alzheimer's Disease

Piro, J. R., Benjamin, D. I., Duerr, J. M., Pi, Y., Gonzales, C., Wood, K. M., Schwartz, J. W., Nomura, D. K., & Samad, T. A. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.05.001 · Cited by 223 · see citing works

Involvement of the opioid system in the anxiolytic-like effects induced by Δ9-tetrahydrocannabinol

Berrendero, F., & Maldonado, R. J. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1144-9 · Cited by 221 · see citing works

Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis

Wolf, S. A., Bick-Sander, A., Fabel, K., Leal-Galicia, P., Tauber, S., Ramirez-Rodriguez, G., Müller, A., Melnik, A., Waltinger, T. P., Ullrich, O., et al. (2010) · Cell Communication and Signaling · doi:10.1186/1478-811x-8-12 · Cited by 208 · see citing works

Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats

Sciolino, N. R., Zhou, W., & Hohmann, A. G. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.04.010 · Cited by 179 · see citing works

The Therapeutic Potential of the Endocannabinoid System for the Development of a Novel Class of Antidepressants

Hill, M. N., Hillard, C. J., Bambico, F. R., Patel, S., Gorzalka, B. B., & Gobbi, G. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.06.006 · Cited by 172 · see citing works

Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay

Kinsey, S. G., O'Neal, S. T., Long, J. Z., Cravatt, B. F., & Lichtman, A. H. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.12.002 · Cited by 170 · see citing works

Repeated Low-Dose Administration of the Monoacylglycerol Lipase Inhibitor JZL184 Retains Cannabinoid Receptor Type 1–Mediated Antinociceptive and Gastroprotective Effects

Kinsey, S. G., Wise, L. E., Ramesh, D., Abdullah, R., Selley, D. E., Cravatt, B. F., & Lichtman, A. H. (2013) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.201426 · Cited by 169 · see citing works

The CB1 Cannabinoid Receptor Mediates Excitotoxicity-induced Neural Progenitor Proliferation and Neurogenesis

Aguado, T., Romero, E., Monory, K., Palazuelos, J., Sendtner, M., Marsicano, G., Lutz, B., Guzmán, M., & Galve‐Roperh, I. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700678200 · Cited by 166 · see citing works

Functional circuits of new neurons in the dentate gyrus

Vivar, C., & van Praag, H. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00015 · Cited by 150 · see citing works

Alterations of Endocannabinoid Signaling, Synaptic Plasticity, Learning, and Memory in Monoacylglycerol Lipase Knock-out Mice

Pan, B., Wang, W., Zhong, P., Blankman, J. L., Cravatt, B. F., & Liu, Q.-S. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2075-11.2011 · Cited by 147 · see citing works

Opposing actions of chronic Δ9-tetrahydrocannabinol and cannabinoid antagonists on hippocampal long-term potentiationPreprint

Hoffman, A. F., Oz, M., Yang, R., Lichtman, A. H., & Lupica, C. R. (2007) · Learning & Memory · doi:10.1101/lm.439007 · Cited by 146 · see citing works

Endocannabinoid Signaling Mediates Cocaine-Induced Inhibitory Synaptic Plasticity in Midbrain Dopamine Neurons

Pan, B., Hillard, C. J., & Liu, Q.-S. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4033-07.2008 · Cited by 142 · see citing works

Monoacylglycerol Lipase Inhibition Blocks Chronic Stress-Induced Depressive-Like Behaviors via Activation of mTOR Signaling

Zhong, P., Wang, W., Pan, B., Liu, X., Zhang, Z., Long, J. Z., Zhang, H., Cravatt, B. F., & Liu, Q.-S. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.24 · Cited by 137 · see citing works

Endogenous cannabinoid signaling is required for voluntary exercise‐induced enhancement of progenitor cell proliferation in the hippocampus

Hill, M. N., Titterness, A. K., Morrish, A. C., Carrier, E. J., Lee, T. T. ‐., Gil‐Mohapel, J., Gorzalka, B. B., Hillard, C. J., & Christie, B. R. (2009) · Hippocampus · doi:10.1002/hipo.20647 · Cited by 129 · see citing works

The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair

Corsini, N. S., Sancho-Martinez, I., Laudenklos, S., Glagow, D., Kumar, S., Letellier, E., Koch, P., Teodorczyk, M., Kleber, S., Klussmann, S., et al. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.05.004 · Cited by 129 · see citing works

Dendritic properties of hippocampal CA1 pyramidal neurons in the rat: Intracellular staining in vivo and in vitro

Pyapali, G. K., Attila Gabor, S. I. K., Penttonen, M., Buzsáki, G., & Turner, D. A. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980216)391:3 · Cited by 128 · see citing works

Reversible gating of endocannabinoid plasticity in the amygdala by chronic stress: a potential role for monoacylglycerol lipase inhibition in the prevention of stress-induced behavioral adaptation

Sumislawski, J. J., Ramikie, T. S., & Patel, S. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.166 · Cited by 124 · see citing works

Deficiency in Endocannabinoid Signaling in the Nucleus Accumbens Induced by Chronic Unpredictable Stress

Wang, W., Sun, D., Pan, B., Roberts, C. J., Sun, X., Hillard, C. J., & Liu, Q.-S. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.99 · Cited by 124 · see citing works

Elevation of endogenous anandamide impairs LTP, learning, and memory through CB1 receptor signaling in mice

Basavarajappa, B. S., Nagre, N. N., Xie, S., & Subbanna, S. (2014) · Hippocampus · doi:10.1002/hipo.22272 · Cited by 109 · see citing works

mTOR Inhibition Ameliorates Cognitive and Affective Deficits Caused by Disc1 Knockdown in Adult-Born Dentate Granule Neurons

Zhou, M., Li, W., Huang, S., Song, J., Kim, J. Y., Tian, X., Kang, E., Sano, Y., Liu, C. M., Balaji, J., et al. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.033 · Cited by 99 · see citing works

Reduced expression of glutamate receptors and phosphorylation of CREB are responsible for in vivoΔ9‐THC exposure‐impaired hippocampal synaptic plasticity

Fan, N., Yang, H., Zhang, J., & Chen, C. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06489.x · Cited by 93 · see citing works

The cannabinoid CB 1 receptor and the endocannabinoid anandamide: possible antidepressant targets

Bambico, F. R., & Gobbi, G. (2008) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.12.11.1347 · Cited by 80 · see citing works

Endocannabinoid Signaling in the Etiology and Treatment of Major Depressive Illness

Hillard, C. J., & Liu, Q.-S. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660735 · Cited by 79 · see citing works

Effects of self-generated sad mood on regional cerebral activity: A PET study in normal subjects

Gemar, M. C., Kapur, S., Segal, Z. V., Brown, G. M., & Houle, S. (1996) · Depression · doi:10.1002/(sici)1522-7162(1996)4:2 · Cited by 57 · see citing works

Correction for Gobbi et al., Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis

Gobbi, G., Bambico, F., Mangieri, R. A., Bortolato, M., Campolongo, P., Solinas, M., Cassano, T., Morgese, M. G., Debonnel, G., Duranti, A., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511247103 · Cited by 22 · see citing works

Gap junctional coupling between progenitor cells of regenerating retina in the adult newt

Chiba, C., & Saito, T. (2000) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(20000205)42:2 · Cited by 19 · see citing works

Neurobiological Interactions Between Stress and the Endocannabinoid System

Morena, M., Patel, S., Bains, J. S., & Hill, M. N. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.166 · Cited by 663 · see citing works

The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex

Liu, W., Ge, T., Leng, Y., Pan, Z., Fan, J., Yang, W., & Cui, R. (2017) · Neural Plasticity · doi:10.1155/2017/6871089 · Cited by 640 · see citing works

From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology

Ligresti, A., PETROCELLIS, L. D., & Marzo, V. D. (2016) · Physiological Reviews · doi:10.1152/physrev.00002.2016 · Cited by 484 · see citing works

The endocannabinoid system as a target for novel anxiolytic drugs

Patel, S., Hill, M. N., Cheer, J. F., Wotjak, C. T., & Holmes, A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.033 · Cited by 233 · see citing works

Monoacylglycerol lipase inhibitors: modulators for lipid metabolism in cancer malignancy, neurological and metabolic disorders

Deng, H., & Li, W. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.10.006 · Cited by 182 · see citing works

Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years

Maccarrone, M., Di Marzo, V., Gertsch, J., Grether, U., Howlett, A. C., Hua, T., Makriyannis, A., Piomelli, D., Ueda, N., & van der Stelt, M. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000600 · Cited by 183 · see citing works

Anxiety, stress, and fear response in mice with reduced endocannabinoid levels

Jenniches, I., Ternes, S., Albayram, O., Otte, D. M., Bach, K., Bindila, L., Michel, K., Lutz, B., Bilkei-Gorzo, A., & Zimmer, A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.03.033 · Cited by 169 · see citing works

Monoacylglycerol lipase (MAGL) as a promising therapeutic target

Gil-Ordóñez, A., Martín‐Fontecha, M., Ortega‐Gutiérrez, S., & López-Rodríguez, M. L. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.07.036 · Cited by 142 · see citing works

Endocannabinoid System Components as Potential Biomarkers in Psychiatry

Navarrete, F., García‐Gutiérrez, M. S., Barba, R. J., Rubio, G., Gasparyan, A., Austrich-Olivares, A., & Manzanares, J. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00315 · Cited by 134 · see citing works

Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N-Acylethanolamine Acid Amidase Inhibitors

Tuo, W., Leleu‐Chavain, N., Spencer, J., Sansook, S., Millet, R., & Chavatte, P. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00538 · Cited by 114 · see citing works

Neurobiology of cannabinoid receptor signaling

Lutz, B. (2020) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2020.22.3/blutz · Cited by 112 · see citing works

Anhedonia in depression symptomatology: appetite dysregulation and defective brain reward processing

Coccurello, R. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112041 · Cited by 106 · see citing works

Chronic Stress Induces Anxiety via an Amygdalar Intracellular Cascade that Impairs Endocannabinoid Signaling

Qin, Z., Zhou, X. C., Pandey, N. R., Vecchiarelli, H. A., Stewart, C. A., Zhang, X., Lagace, D. C., Brunel, J. M., Béïque, J.-C., Stewart, A. F. R., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.015 · Cited by 105 · see citing works

Endocannabinoid-Mediated plasticity in nucleus accumbens controls vulnerability to anxiety after social defeat stress

Bosch-Bouju, C., Larrieu, T., Linders, L., Manzoni, O. J., & Layé, S. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.082 · Cited by 100 · see citing works

Emerging evidence for the antidepressant effect of cannabidiol and the underlying molecular mechanisms

Silote, G. P., Sartim, A. G., Sales, A. J., Eskelund, A., Guimarães, F. S., Wegener, G., & Joca, S. R. L. (2019) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2019.04.006 · Cited by 93 · see citing works

Potential application of endocannabinoid system agents in neuropsychiatric and neurodegenerative diseases—focusing on FAAH/MAGL inhibitors

Ren, S., Wang, Z., Zhang, Y., & Chen, N. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-0385-7 · Cited by 88 · see citing works

Reviewing the Role of the Endocannabinoid System in the Pathophysiology of Depression

Gallego‐Landin, I., García-Baos, A., Castro‐Zavala, A., & Valverde, O. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.762738 · Cited by 84 · see citing works

2-Arachidonoylglycerol Modulation of Anxiety and Stress Adaptation: From Grass Roots to Novel Therapeutics

Bedse, G., Hill, M. N., & Patel, S. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.01.015 · Cited by 75 · see citing works

Inhibiting degradation of 2-arachidonoylglycerol as a therapeutic strategy for neurodegenerative diseases

Chen, C. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108394 · Cited by 75 · see citing works

Stress-Related Dysfunction of Adult Hippocampal Neurogenesis—An Attempt for Understanding Resilience?

Leschik, J., Lutz, B., & Gentile, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147339 · Cited by 70 · see citing works

Cannabinoid Modulation of the Stressed Hippocampus

Scarante, F. F., Vila-Verde, C., Lopes, V. D., Ferreira‐Junior, N. C., Guimarães, F. S., & Campos, A. C. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00411 · Cited by 64 · see citing works

Monoacylglycerol lipase inhibitors produce pro- or antidepressant responses via hippocampal CA1 GABAergic synapses

Wang, Y., Gu, N., Duan, T., Kesner, P., Blaskovits, F., Liu, J., Lu, Y., Li, T., Gao, F., Harris, C. S., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.22 · Cited by 60 · see citing works

Inhibitors of lipogenic enzymes as a potential therapy against cancer

Montesdeoca, N., López, M., Ariza, X., Herrero, L., & Makowski, K. (2020) · The FASEB Journal · doi:10.1096/fj.202000705r · Cited by 59 · see citing works

High Times for Painful Blues: The Endocannabinoid System in Pain-Depression Comorbidity

Fitzgibbon, M., Finn, D. P., & Roche, M. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv095 · Cited by 57 · see citing works

Role of endocannabinoid signaling in a septohabenular pathway in the regulation of anxiety- and depressive-like behavior

Vickstrom, C. R., Liu, X., Liu, S., Hu, M.-M., Mu, L., Hu, Y., Yu, H., Love, S. L., Hillard, C. J., & Liu, Q.-S. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00905-1 · Cited by 54 · see citing works

Endocannabinoid system and adult neurogenesis: a focused review

Oddi, S., Scipioni, L., & Maccarrone, M. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.11.002 · Cited by 53 · see citing works

The potential of inhibitors of endocannabinoid metabolism as anxiolytic and antidepressive drugs—A practical view

Fowler, C. J. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.02.005 · Cited by 52 · see citing works

Integrating endocannabinoid signaling in the regulation of anxiety and depression

Yin, A., Wang, F., & Zhang, X. (2018) · Acta Pharmacologica Sinica · doi:10.1038/s41401-018-0051-5 · Cited by 52 · see citing works

Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase: New Targets for Future Antidepressants

Ogawa, S., & Kunugi, H. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150612225212 · Cited by 48 · see citing works

Inhibition of 2-Arachidonoylglycerol Metabolism Alleviates Neuropathology and Improves Cognitive Function in a Tau Mouse Model of Alzheimer’s Disease

Hashem, J., Hu, M., Zhang, J., Gao, F., & Chen, C. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02400-2 · Cited by 48 · see citing works

Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice

Forte, N. R., Boccella, S., Tunisi, L., Fernández-Rilo, A. C., Imperatore, R., Iannotti, F. A., Risi, M. D., Iannotta, M., Piscitelli, F., Capasso, R., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26388-4 · Cited by 47 · see citing works

Endocannabinoid System Alterations in Posttraumatic Stress Disorder: A Review of Developmental and Accumulative Effects of Trauma

Nia, A. B., Bender, R. L., & Harpaz‐Rotem, I. (2019) · Chronic Stress · doi:10.1177/2470547019864096 · Cited by 47 · see citing works

Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology

Rodrigues, R. S., Lourenço, D. M., Paulo, S. L., Mateus, J. M., Ferreira, M. F., Mouro, F. M., Moreira, J. B., Ribeiro, F. F., Sebastião, A. M., & Xapelli, S. (2019) · Molecules · doi:10.3390/molecules24071350 · Cited by 45 · see citing works

Inhibition of Diacylglycerol Lipase Impairs Fear Extinction in Mice

Cavener, V. S., Gaulden, A. D., Pennipede, D., Jagasia, P., Uddin, J., Marnett, L. J., & Patel, S. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00479 · Cited by 41 · see citing works

Cannabinoid signalling in embryonic and adult neurogenesis: possible implications for psychiatric and neurological disorders

de Oliveira, R. M. W., de Oliveira, C. L., Guimarães, F. S., & Campos, A. C. (2018) · Acta Neuropsychiatrica · doi:10.1017/neu.2018.11 · Cited by 38 · see citing works

Role of endocannabinoid system in dopamine signalling within the reward circuits affected by chronic pain

Mlost, J., Wąsik, A., & Starowicz, K. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.02.029 · Cited by 36 · see citing works

Can Ocimum basilicum relieve chronic unpredictable mild stress-induced depression in mice?

Ayuob, N. N., Firgany, A. E. L., El‐Mansy, A. A., & Ali, S. S. (2017) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2017.08.007 · Cited by 35 · see citing works

Repetitive high-frequency transcranial magnetic stimulation reverses depressive-like behaviors and protein expression at hippocampal synapses in chronic unpredictable stress-treated rats by enhancing endocannabinoid signaling

Xue, S., Xue, F., Ma, Q., Wang, S., Wang, Y., Tan, Q., Wang, H., Zhou, C., & Peng, Z. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.172738 · Cited by 35 · see citing works

Inhibition of Fatty Acid Amide Hydrolase Improves Depressive-Like Behaviors Independent of Its Peripheral Antinociceptive Effects in a Rat Model of Neuropathic Pain

Jiang, H., Ke, B., Liu, J., Ma, G., Hai, K., Gong, D., Yang, Z., & Zhou, C. (2018) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000003563 · Cited by 34 · see citing works

Diacylglycerol Lipase-Alpha Regulates Hippocampal-Dependent Learning and Memory Processes in Mice

Schurman, L. D., Carper, M., Moncayo, L. V., Ogasawara, D., Richardson, K., Yu, L., Liu, X., Poklis, J. L., Liu, Q.-S., Cravatt, B. F., et al. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1353-18.2019 · Cited by 32 · see citing works

Roles of the Cannabinoid System in the Basal Ganglia in Parkinson’s Disease

Wang, M., Liu, H., & Ma, Z. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.832854 · Cited by 35 · see citing works

Task-specific enhancement of hippocampus-dependent learning in mice deficient in monoacylglycerol lipase, the major hydrolyzing enzyme of the endocannabinoid 2-arachidonoylglycerol

Kishimoto, Y., Cagniard, B., Yamazaki, M., Nakayama, J., Sakimura, K., Kirino, Y., & Kano, M. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00134 · Cited by 33 · see citing works

A systematic, integrative review of the effects of the endocannabinoid system on inflammation and neurogenesis in animal models of affective disorders

Giacobbe, J., Marrocu, A., Benedetto, M. G. D., Pariante, C. M., & Borsini, A. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.12.024 · Cited by 35 · see citing works

Contribution of Neuronal and Glial Two-Pore-Domain Potassium Channels in Health and Neurological Disorders

Luo, Y., Huang, L., Liao, P. S., & Jiang, R. (2021) · Neural Plasticity · doi:10.1155/2021/8643129 · Cited by 31 · see citing works

Adult Cellular Neuroadaptations Induced by Adolescent THC Exposure in Female Rats Are Rescued by Enhancing Anandamide Signaling

Cuccurazzu, B., Zamberletti, E., Nazzaro, C., Prini, P., Trusel, M., Grilli, M., Parolaro, D., Tonini, R., & Rubino, T. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy057 · Cited by 32 · see citing works

Proteomic Analysis of the Hippocampus in Mouse Models of Trigeminal Neuralgia and Inescapable Shock-Induced Depression

Guo, Q., Tong, Q., Lü, N., Cao, H., Liu, Y., & Zhang, Y. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0131-4 · Cited by 31 · see citing works

Targeting 2‐arachidonoylglycerol signalling in the neurobiology and treatment of depression

Silveira, K. M., Wegener, G., & Joca, S. R. L. (2021) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13595 · Cited by 30 · see citing works

Dissecting the Signaling Pathways Involved in the Crosstalk between Metabotropic Glutamate 5 and Cannabinoid Type 1 Receptors

Olmo, I. G., Ferreira-Vieira, T. H., & Ribeiro, F. M. (2016) · Molecular Pharmacology · doi:10.1124/mol.116.104372 · Cited by 28 · see citing works

Endocannabinoid signaling in adult hippocampal neurogenesis: A mechanistic and integrated perspective

Oddi, S., Fiorenza, M. T., & Maccarrone, M. (2023) · Progress in Lipid Research · doi:10.1016/j.plipres.2023.101239 · Cited by 26 · see citing works

Antidepressant-like effects of transcorneal electrical stimulation in rat models

Yu, W. S., Tse, A. C.-K., Guan, L., Chiu, J. L. Y., Tan, S. Z. K., Khairuddin, S., Agadagba, S. K., Lo, A., Fung, M., Chan, Y., et al. (2022) · Brain stimulation · doi:10.1016/j.brs.2022.05.018 · Cited by 23 · see citing works

Regulating membrane lipid levels at the synapse by small-molecule inhibitors of monoacylglycerol lipase: new developments in therapeutic and PET imaging applications

Grimsey, N. L., Savinainen, J. R., Attili, B. N. N. R., & Ahamed, M. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.10.004 · Cited by 22 · see citing works

The Endocannabinoid Reuptake Inhibitor WOBE437 Is Orally Bioavailable and Exerts Indirect Polypharmacological Effects via Different Endocannabinoid Receptors

Reynoso-Moreno, I., Chicca, A., Flores-Soto, M. E., Paredes, J. M. V., & Gertsch, J. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00180 · Cited by 20 · see citing works

Selective inhibition of monoacylglycerol lipase is associated with passive coping behavior and attenuation of stress-induced dopamine release in the medial prefrontal cortex

Pavón, F. J., Polis, I. Y., Stouffer, D. G., Cravatt, B. F., Roberto, M., Martin‐Fardon, R., de Fonseca, F. R., Parsons, L. H., & Serrano, A. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100293 · Cited by 19 · see citing works

The antidepressant and anxiolytic effects of cannabinoids in chronic unpredictable stress: a preclinical systematic review and meta-analysis

Reuveni, N., Carlson, C. A., Schwartz, S., Meter, D. J., Barrett, T. S., & Freeman, S. M. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01967-1 · Cited by 19 · see citing works

Cannabinoids: Emerging sleep modulator

Low, Z. X. B., Lee, X. R., Soga, T., Goh, B. H., Alex, D., & Kumari, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115102 · Cited by 17 · see citing works

The Endocannabinoid 2-Arachidonoylglycerol Bidirectionally Modulates Acute and Protracted Effects of Predator Odor Exposure

Kondev, V., Morgan, A., Najeed, M., Winters, N. D., Kingsley, P. J., Marnett, L. J., & Patel, S. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.05.012 · Cited by 15 · see citing works

Sexually dimorphic effects of monoacylglycerol lipase inhibitor MJN110 on stress‐related behaviour and drinking in Marchigian Sardinian alcohol‐preferring rats

Vozella, V., Cruz, B., Feldman, H. C., Bullard, R., Bianchi, P., Natividad, L. A., Cravatt, B. F., Zorrilla, E. P., Ciccocioppo, R., & Roberto, M. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16197 · Cited by 14 · see citing works

Integrated Excitatory/Inhibitory Imbalance and Transcriptomic Analysis Reveals the Association between Dysregulated Synaptic Genes and Anesthetic-Induced Cognitive Dysfunction

Yan, Y., Logan, S., Liu, X., Chen, B., Jiang, C., Arzua, T., Ramchandran, R., Liu, Q.-S., & Bai, X. (2022) · Cells · doi:10.3390/cells11162497 · Cited by 13 · see citing works

Region-specific dysregulation of endocannabinoid system in learned helplessness model of depression

Huang, W., Ke, Y., & Chen, R. (2021) · Neuroreport · doi:10.1097/wnr.0000000000001601 · Cited by 10 · see citing works

Cannabinoids as Regulators of Neural Development and Adult Neurogenesis

Campos, A. C., Paraíso‐Luna, J., Fogaça, M. V., Guimarães, F. S., & Galve‐Roperh, I. (2017) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-49343-5_6 · Cited by 10 · see citing works

Role of endocannabinoid neurotransmission in the insular cortex on cardiovascular, autonomic and behavioral responses evoked by acute restraint stress in rats

Belém-Filho, I. J. A., de Godoy, A. C. V., Busnardo, C., Frias, A. T., Zangrossi, H., Borges, B. D. B., Herval, A. C. F., Corrêa, F. M. D. A., Crestani, C. C., & Alves, F. H. F. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110404 · Cited by 9 · see citing works

Augmentation of 2-arachidonoylglycerol signaling in astrocytes maintains synaptic functionality by regulation of miRNA-30b

Zhu, D., Zhang, J., Gao, F., Hu, M., Hashem, J., & Chen, C. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114292 · Cited by 9 · see citing works

Severe hydroxymethylbilane synthase deficiency causes depression-like behavior and mitochondrial dysfunction in a mouse model of homozygous dominant acute intermittent porphyria

Berger, S., Stattmann, M., Cicvaric, A., Monje, F. J., Coiro, P., Hoťka, M., Ricken, G., Hainfellner, J. A., Greber‐Platzer, S., Yasuda, M., et al. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-00910-z · Cited by 9 · see citing works

Early Consumption of Cannabinoids: From Adult Neurogenesis to Behavior

Netzahualcoyotzi, C., Rodríguez–Serrano, L. M., Chávez–Hernández, M. E., & Buenrostro-Jáuregui, M. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147450 · Cited by 9 · see citing works

Endocannabinoid Degradation Enzyme Inhibitors as Potential Antipsychotics: A Medicinal Chemistry Perspective

Mangiatordi, G. F., Cavalluzzi, M. M., Delre, P., Lamanna, G., Lumuscio, M. C., Saviano, M., Majoral, J., Mignani, S. M., Duranti, A., & Lentini, G. (2023) · Biomedicines · doi:10.3390/biomedicines11020469 · Cited by 8 · see citing works

Endocannabinoid Metabolism and Transport as Drug Targets

Ciaramellano, F., Fanti, F., Scipioni, L., Maccarrone, M., & Oddi, S. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2728-0_16 · Cited by 6 · see citing works

Putative effects of cannabidiol in depression and synaptic plasticity

Joca, S. R. L., Silote, G. P., Sartim, A. G., Sales, A. J., Guimarães, F. S., & Wegener, G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817933-8.00052-9 · Cited by 5 · see citing works

Histological and molecular techniques utilized to investigate animal models of depression. An updated review

Ayuob, N. N., & Balgoon, M. J. (2018) · Microscopy Research and Technique · doi:10.1002/jemt.23105 · Cited by 5 · see citing works

Potential of Heterogeneous Compounds as Antidepressants: A Narrative Review

Hu, G., Zhang, M., Wang, Y., Yu, M., & Zhou, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213776 · Cited by 4 · see citing works

Microbiota-driven gut-brain signaling underlies antidepressant effects of a GLP-1 analog

Bian, L., Cai, Y., Zhang, Y., Shen, L., Wang, H., Gao, F., Cai, N., Chen, W., You, C., Yang, Y., et al. (2026) · Cell Host & Microbe · doi:10.1016/j.chom.2026.05.003 · Cited by 3 · see citing works

Bridging the gap: The endocannabinoid system as a functional fulcrum for benzodiazepines in a novel frontier of anxiety pharmacotherapy

Pakkhesal, S., Shakouri, M., Mosaddeghi-Heris, R., Kiani-Nasab, S., Salehi, N., Sharafi, A., & Ahmadalipour, A. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108799 · Cited by 2 · see citing works

Chemical Genetic Approaches for the Investigation of Neutral Lipid Metabolism

Doler, C., Schweiger, M., Zimmermann, R., & Breinbauer, R. (2015) · ChemBioChem · doi:10.1002/cbic.201500501 · Cited by 2 · see citing works

Cannabinoid-Based Medicine: Pharmacology and Drug Interactions

Davis, M. P. (2022) · Springer eBooks · doi:10.1007/978-3-030-89918-9_2 · Cited by 2 · see citing works

Inhibitors of lipogenic enzymes as a potential therapy against cancer

Montesdeoca, N., López, M., Ariza, X., Herrero, L., & Makowski, K. (2020) · doi:10.26226/morressier.5f6c5f439b74b699bf390b40 · Cited by 2 · see citing works

Synthesis and biological evaluation of methylene spacer incorporated 4-methylsulfonyl phenyl semicarbazones as dual FAAH-MAGL inhibitors

Jaiswal, S., & Ayyannan, S. R. (2025) · Phosphorus, sulfur, and silicon and the related elements · doi:10.1080/10426507.2025.2467438 · Cited by 1 · see citing works

Temporal multi-omic exploration of the ventral tegmental area in chronic pain and passive coping behaviors

Diezel, C. C., Majuta, L. A., Bahramnejad, E., Karlage, K. L., Partin, J. L., Barbour, S. M. D., Peterson, I. L., Flowers, M., von Hippel, S. T., Haveman, R., et al. (2026) · iScience · doi:10.1016/j.isci.2026.116085 · Cited by 1 · see citing works

Reply to: The Anxiolytic Actions of 2-Arachidonoylglycerol: Converging Evidence From Two Recent Genetic Endocannabinoid Deficiency Models

Jenniches, I., & Zimmer, A. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.024 · Cited by 1 · see citing works

Morphine Induced Osteolysis and Hyperalgesia in Models of Traumatic and Pathologic Fracture: Potential for Cannabinoid-Based Therapeutics

Thompson, A. L. (2020) · UA Campus Repository (The University of Arizona)

Envolvimento dos receptores CB1 nos efeitos comportamentais e pró-neurogênicos da venlafaxina

de Araujo, M. R. (2019) · doi:10.11606/d.17.2019.tde-01062020-072523

Behavioural and molecular effects induced by Cannabidiol in animal models of depression

Silote, G. P. (2021) · doi:10.11606/t.60.2021.tde-29092021-060118

Role of endocannabinoids in the escalation of alcohol use following traumatic brain injury

Molina, P. E., Stielper, Z. F., Edwards, S., & Gilpin, N. W. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823036-7.00007-4

Overview of the Endogenous Cannabinoid Signaling System

Stollenwerk, T. M., Ramirez, C. E. M., & Hillard, C. J. (2025) · Springer eBooks · doi:10.1007/978-3-031-87990-6_3

FIGURES 45. Axinyssa djiferi spec. nov. 4 in A new species of Axinyssa Lendenfeld, 1897 (Porifera, Demospongiae, Halichondrida) from the Senegalese coast

Boury‐Esnault, N., Marschal, C., Probst, J.-M. K., & Barnathan, G. (2002) · INFM-OAR (INFN Catania) · doi:10.5281/zenodo.155630

Additional file 2 of Severe hydroxymethylbilane synthase deficiency causes depression-like behavior and mitochondrial dysfunction in a mouse model of homozygous dominant acute intermittent porphyria

Berger, S., Stattmann, M., Cicvaric, A., Monje, F. J., Coiro, P., Hoťka, M., Ricken, G., Hainfellner, J., Greber-Platzer, S., Yasuda, M., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12015282

Additional file 4 of Severe hydroxymethylbilane synthase deficiency causes depression-like behavior and mitochondrial dysfunction in a mouse model of homozygous dominant acute intermittent porphyria

Berger, S., Stattmann, M., Cicvaric, A., Monje, F. J., Coiro, P., Hoťka, M., Ricken, G., Hainfellner, J., Greber-Platzer, S., Yasuda, M., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12015294

Additional file 1 of Severe hydroxymethylbilane synthase deficiency causes depression-like behavior and mitochondrial dysfunction in a mouse model of homozygous dominant acute intermittent porphyria

Berger, S., Stattmann, M., Cicvaric, A., Monje, F. J., Coiro, P., Hoťka, M., Ricken, G., Hainfellner, J., Greber-Platzer, S., Yasuda, M., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12015273

Additional file 3 of Severe hydroxymethylbilane synthase deficiency causes depression-like behavior and mitochondrial dysfunction in a mouse model of homozygous dominant acute intermittent porphyria

Berger, S., Stattmann, M., Cicvaric, A., Monje, F. J., Coiro, P., Hoťka, M., Ricken, G., Hainfellner, J., Greber-Platzer, S., Yasuda, M., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12015288

Chronic suppression of monoacylglycerol lipase restores adult neurogenesis in the septal but not the temporal DG in Ts65Dn mouse model of Down syndrome

Fozoonmayeh, D., Sankaran, M., Yu, J., Walsh, M., Tyrtyshnaia, A. A., & Kleschevnikov, A. M. (2026) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2026.111721

CB1 receptor signaling at the cingulate-striatal circuit is anxiogenic

Kelly, T. J., Liu, X., Huang, Y., Hu, Y., Friedman, V., Hillard, C. J., & Liu, Q.-S. (2026) · Nature Communications · doi:10.1038/s41467-026-71574-x

BindingDB Entry 50001937: Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N-Acylethanolamine Acid Amidase Inhibitors.

BindingDB (2020) · UC San Diego · doi:10.7270/q2348nzc

Monoacylglycerol Lipase Inhibition Blocks Chronic Stress-Induced Depressive-Like Behaviors via Activation of mTOR Signaling

Zhong, P., Wang, W., Pan, B., Liu, X., Zhang, Z., Long, J. Z., Zhang, H., Cravatt, B. F., & Liu, Q.-S. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.24 · Cited by 137 · see citing works

Monoacylglycerol lipase inhibitors produce pro- or antidepressant responses via hippocampal CA1 GABAergic synapses

Wang, Y., Gu, N., Duan, T., Kesner, P., Blaskovits, F., Liu, J., Lu, Y., Li, T., Gao, F., Harris, C. S., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.22 · Cited by 60 · see citing works

Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats

Sciolino, N. R., Zhou, W., & Hohmann, A. G. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.04.010 · Cited by 179 · see citing works

Long-Term Monoacylglycerol Lipase Inhibitor Treatment Decelerates Pathological Changes in APP/PS1-21 Mice, but Behavioral Improvements Require Early-Stage Treatment Onset—Short Report

Pihlaja, R., Lindgrén, N., Torittu, A., Snellman, A., Haaparanta‐Solin, M., & Rinne, J. O. (2018) · World Journal of Neuroscience · doi:10.4236/wjns.2018.82014

Monoacylglycerol Lipase Inhibitor JZL184 Improves Behavior and Neural Properties in Ts65Dn Mice, a Model of Down Syndrome

Lysenko, L. V., Kim, J., Henry, C. L., Tyrtyshnaia, A. A., Kohnz, R. A., Madamba, F., Simon, G. M., Kleschevnikova, N. E., Nomura, D. K., Ezekowitz, R. A. B., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114521 · Cited by 57 · see citing works