Lipid Metabolism and Ferroptosis

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691 · see citing works

Regulation of Ferroptotic Cancer Cell Death by GPX4

Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713 · see citing works

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

Ayala, A., Muñoz, M., & Argüelles, S. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/360438 · Cited by 6,557 · see citing works

Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases

Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455 · see citing works

AMPK: a nutrient and energy sensor that maintains energy homeostasis

Hardie, D. G., Ross, F. A., & Hawley, S. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3311 · Cited by 4,602 · see citing works

Ferroptosis: molecular mechanisms and health implications

Tang, D., Chen, X., Kang, R., & Kroemer, G. (2020) · Cell Research · doi:10.1038/s41422-020-00441-1 · Cited by 4,332 · see citing works

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732 · see citing works

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

Bersuker, K., Hendricks, J. M., Li, Z., Magtanong, L., Ford, B., Tang, P. H., Roberts, M. A., Tong, B., Maimone, T. J., Zoncu, R., et al. (2019) · Nature · doi:10.1038/s41586-019-1705-2 · Cited by 3,703 · see citing works

ROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis

D'Autréaux, B., & Toledano, M. B. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2256 · Cited by 3,642 · see citing works

Ferroptosis as a p53-mediated activity during tumour suppression

Jiang, L., Kon, N., Li, T., Wang, S.-J., Su, T., Hibshoosh, H., Baer, R., & Gu, W. (2015) · Nature · doi:10.1038/nature14344 · Cited by 3,398 · see citing works

FSP1 is a glutathione-independent ferroptosis suppressor

Doll, S., Freitas, F. P., Shah, R., Aldrovandi, M., da Silva, M. C., Ingold, I., Goya Grocin, A., Xavier da Silva, T. N., Panzilius, E., Scheel, C. H., et al. (2019) · Nature · doi:10.1038/s41586-019-1707-0 · Cited by 3,341 · see citing works

LXXIII.—Oxidation of tartaric acid in presence of iron

Fenton, H. J. H. (1894) · J. Chem. Soc., Trans. · doi:10.1039/ct8946500899 · Cited by 3,179 · see citing works

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Kagan, V. E., Mao, G., Qu, F., Angeli, J. P. F., Doll, S., Croix, C. S., Dar, H. H., Liu, B., Tyurin, V. A., Ritov, V. B., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2238 · Cited by 3,029 · see citing works

Targeting Ferroptosis to Iron Out Cancer

Hassannia, B., Vandenabeele, P., & Berghe, T. V. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.04.002 · Cited by 2,483 · see citing works

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

Yang, W. S., Kim, K. J., Gaschler, M. M., Patel, M., Shchepinov, M. S., & Stockwell, B. R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1603244113 · Cited by 2,329 · see citing works

Antioxidants Maintain Cellular Redox Homeostasis by Elimination of Reactive Oxygen Species

He, L., He, T., Farrar, S., Ji, L., Liu, T., & Ma, X. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000485089 · Cited by 2,142 · see citing works

Glutaminolysis and transferrin regulate ferroptosis

Gao, M., Monian, P., Quadri, N., Ramasamy, R., & Jiang, X. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.06.011 · Cited by 2,069 · see citing works

Activation of the p62–Keap1–NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

Sun, X., Ou, Z., Chen, R., Niu, X., Chen, D., Kang, R., & Tang, D. (2016) · Hepatology · doi:10.1002/hep.28251 · Cited by 2,012 · see citing works

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

Viswanathan, V. S., Ryan, M. J., Dhruv, H. D., Gill, S., Eichhoff, O. M., Seashore-Ludlow, B., Kaffenberger, S. D., Eaton, J. K., Shimada, K., Aguirre, A. J., et al. (2017) · Nature · doi:10.1038/nature23007 · Cited by 2,011 · see citing works

ROS signalling in the biology of cancer

Moloney, J. N., & Cotter, T. G. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.05.023 · Cited by 1,983 · see citing works

Free Radical Lipid Peroxidation: Mechanisms and Analysis

Yin, H., Xu, L., & Porter, N. A. (2011) · Chemical Reviews · doi:10.1021/cr200084z · Cited by 1,952 · see citing works

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

Hangauer, M. J., Viswanathan, V. S., Ryan, M. J., Bole, D., Eaton, J. K., Matov, A., Galeas, J., Dhruv, H. D., Berens, M. E., Schreiber, S. L., et al. (2017) · Nature · doi:10.1038/nature24297 · Cited by 1,799 · see citing works

Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects

Li, H., Yang, Y., Hong, W., Huang, M., Wu, M., & Zhao, X. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0089-y · Cited by 1,771 · see citing works

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

Seiler, A., Schneider, M., Förster, H., Roth, S., Wirth, E. K., Culmsee, C., Plesnila, N., Kremmer, E., Rådmark, O., Wurst, W., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.07.005 · Cited by 1,470 · see citing works

Targeting metastasis-initiating cells through the fatty acid receptor CD36

Pascual, G., Avgustinova, A., Mejetta, S., Martı́n, M., Castellanos‐Martín, A., Attolini, C. S., Berenguer, A., Prats, N., Toll, A., Hueto-Madrid, J. A., et al. (2016) · Nature · doi:10.1038/nature20791 · Cited by 1,430 · see citing works

Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State

Magtanong, L., Ko, P., To, M., Cao, J. Y., Forcina, G. C., Tarangelo, A., Ward, C. C., Cho, K., Patti, G. J., Nomura, D. K., et al. (2019) · Cell chemical biology · doi:10.1016/j.chembiol.2018.11.016 · Cited by 1,168 · see citing works

Energy-stress-mediated AMPK activation inhibits ferroptosis

Lee, H., Zandkarimi, F., Zhang, Y., Meena, J. K., Kim, J., Zhuang, L., Tyagi, S., Ma, L., Westbrook, T. F., Steinberg, G. R., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0461-8 · Cited by 1,138 · see citing works

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

Forcina, G. C., & Dixon, S. J. (2019) · PROTEOMICS · doi:10.1002/pmic.201800311 · Cited by 1,080 · see citing works

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

Zilka, O., Shah, R., Li, B., Angeli, J. P. F., Grießer, M., Conrad, M., & Pratt, D. A. (2017) · ACS Central Science · doi:10.1021/acscentsci.7b00028 · Cited by 1,052 · see citing works

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

Dixon, S. J., Winter, G. E., Musavi, L. S., Lee, E. D., Snijder, B., Rebsamen, M., Superti-Furga, G., & Stockwell, B. R. (2015) · ACS Chemical Biology · doi:10.1021/acschembio.5b00245 · Cited by 1,043 · see citing works

The chemical basis of ferroptosis

Conrad, M., & Pratt, D. A. (2019) · Nature Chemical Biology · doi:10.1038/s41589-019-0408-1 · Cited by 1,027 · see citing works

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

Shimada, K., Skouta, R., Kaplan, A., Yang, W. S., Hayano, M., Dixon, S. J., Brown, L. M., Valenzuela, C. A., Wolpaw, A. J., & Stockwell, B. R. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2079 · Cited by 1,017 · see citing works

Lipid peroxidation: Physiological levels and dual biological effects

Niki, E. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.05.032 · Cited by 1,006 · see citing works

The selenoenzyme phospholipid hydroperoxide glutathione peroxidase

Ursini, F., Maiorino, M., & Gregolin, C. (1985) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(85)90182-5 · Cited by 992 · see citing works

PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals

Wenzel, S. E., Tyurina, Y. Y., Zhao, J., Croix, C. M. S., Dar, H. H., Mao, G., Tyurin, V. A., Anthonymuthu, T. S., Kapralov, A. A., Amoscato, A. A., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.044 · Cited by 960 · see citing works

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

Xie, Y., Zhu, S., Song, X., Sun, X., Fan, Y., Liu, J., Zhong, M., Yuan, H., Zhang, L., Billiar, T. R., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.07.055 · Cited by 952 · see citing works

Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP

Yeung, K. C., Seitz, T., Li, S.-F., Janosch, P., McFerran, B., Kaiser, C., Fee, F., Katsanakis, K. D., Rose, D., Mischak, H., et al. (1999) · Nature · doi:10.1038/43686 · Cited by 909 · see citing works

Lymph protects metastasizing melanoma cells from ferroptosis

Ubellacker, J. M., Tasdogan, A., Ramesh, V., Shen, B., Mitchell, E. C., Martin-Sandoval, M. S., Gu, Z., McCormick, M. L., Durham, A. B., Spitz, D. R., et al. (2020) · Nature · doi:10.1038/s41586-020-2623-z · Cited by 902 · see citing works

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

Chu, B., Kon, N., Chen, D., Li, T., Liu, T., Jiang, L., Song, S., Tavana, O., & Gu, W. J. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0305-6 · Cited by 885 · see citing works

The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice

Guillou, H., Zadravec, D., Martin, P. G. P., & Jacobsson, A. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.12.002 · Cited by 867 · see citing works

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

Hu, W., Zhang, C., Wu, R., Sun, Y., Levine, A., & Feng, Z. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001006107 · Cited by 862 · see citing works

Plasticity of ether lipids promotes ferroptosis susceptibility and evasion

Zou, Y., Henry, W. S., Ricq, E. L., Graham, E. T., Phadnis, V. V., Maretich, P., Paradkar, S., Boehnke, N., Deik, A., Reinhardt, F., et al. (2020) · Nature · doi:10.1038/s41586-020-2732-8 · Cited by 849 · see citing works

Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors

Xu, S., Chaudhary, O., Rodríguez-Morales, P., Sun, X., Chen, D., Zappasodi, R., Xu, Z. Z., Pinto, A. F. M., Williams, A. E., Schulze, I., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.05.003 · Cited by 815 · see citing works

The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults

Yant, L. J., Ran, Q., Rao, L., Van Remmen, H., Shibatani, T., Belter, J. G., Motta, L., Richardson, A., & Prolla, T. A. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01360-6 · Cited by 797 · see citing works

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

Shah, R., Shchepinov, M. S., & Pratt, D. A. (2018) · ACS Central Science · doi:10.1021/acscentsci.7b00589 · Cited by 782 · see citing works

Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses

Ou, Y., Wang, S.-J., Li, D., Chu, B., & Gu, W. J. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607152113 · Cited by 775 · see citing works

Membrane Fatty Acid Transporters as Regulators of Lipid Metabolism: Implications for Metabolic Disease

Glatz, J. F. C., Luiken, J. J. F. P., & Bonen, A. (2010) · Physiological Reviews · doi:10.1152/physrev.00003.2009 · Cited by 757 · see citing works

Fatty acid transport protein 2 reprograms neutrophils in cancer

Veglia, F., Tyurin, V. A., Blasi, M., Leo, A. D., Kossenkov, A. V., Donthireddy, L., To, T. K. J., Schug, Z. T., Basu, S., Wang, F., et al. (2019) · Nature · doi:10.1038/s41586-019-1118-2 · Cited by 757 · see citing works

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

Song, X., Zhu, S., Chen, P., Hou, W., Wen, Q., Liu, J., Xie, Y., Liu, J., Klionsky, D. J., Kroemer, G., et al. (2018) · Current Biology · doi:10.1016/j.cub.2018.05.094 · Cited by 753 · see citing works

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

Zou, Y., Li, H., Graham, E. T., Deik, A., Eaton, J. K., Wang, W., Sandoval-Gomez, G., Clish, C. B., Doench, J. G., & Schreiber, S. L. (2020) · Nature Chemical Biology · doi:10.1038/s41589-020-0472-6 · Cited by 740 · see citing works

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

Kamphorst, J. J., Cross, J. R., Fan, J., de Stanchina, E., Mathew, R., White, E. P., Thompson, C. B., & Rabinowitz, J. D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307237110 · Cited by 726 · see citing works

The interaction between ferroptosis and lipid metabolism in cancer

Li, D., & Li, Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00216-5 · Cited by 713 · see citing works

Metabolic control of cell death

Green, D. R., Galluzzi, L., & Kroemer, G. (2014) · Science · doi:10.1126/science.1250256 · Cited by 661 · see citing works

Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death

Kapralov, A. A., Yang, Q., Dar, H. H., Tyurina, Y. Y., Anthonymuthu, T. S., Kim, R., Croix, C. M. S., Mikulska‐Ruminska, K., Liu, B., Shrivastava, I. H., et al. (2020) · Nature Chemical Biology · doi:10.1038/s41589-019-0462-8 · Cited by 657 · see citing works

Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1

Yan, B., Ai, Y., Sun, Q., Ma, Y., Cao, Y., Wang, J., Zhang, Z., & Wang, X. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.11.024 · Cited by 651 · see citing works

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

Hassannia, B., Wiernicki, B., Ingold, I., Qu, F., Herck, S. V., Tyurina, Y. Y., Bayır, H., Abhari, B. A., Angeli, J. P. F., Choi, S. M., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci99032 · Cited by 626 · see citing works

Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma

Rodrı́guez, P. C., Hernandez, C. P., Quiceno, D. G., Dubinett, S. M., Zabaleta, J., Ochoa, J. B., Gilbert, J., & Ochoa, A. C. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050715 · Cited by 609 · see citing works

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

Tarangelo, A., Magtanong, L., Bieging-Rolett, K. T., Li, Y., Ye, J., Attardi, L. D., & Dixon, S. J. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.077 · Cited by 564 · see citing works

Regulation of lipid peroxidation and ferroptosis in diverse species

Conrad, M., Kagan, V. E., Bayir, H., Pagnussat, G. C., Head, B., Traber, M. G., & Stockwell, B. R. (2018) · Genes & Development · doi:10.1101/gad.314674.118 · Cited by 544 · see citing works

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity

Vriens, K., Christen, S., Parik, S., Broekaert, D., Yoshinaga, K., Talebi, A., Dehairs, J., Escalona‐Noguero, C., Schmieder, R., Cornfield, T., et al. (2019) · Nature · doi:10.1038/s41586-019-0904-1 · Cited by 477 · see citing works

Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer

Lee, J.-Y., Nam, M., Son, H. Y., Hyun, K., Jang, S. Y., Kim, J. W., Kim, M. W., Jung, Y., Jang, E., Yoon, S., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2006828117 · Cited by 475 · see citing works

The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma

Yang, W., Ding, C. C., Sun, T., Rupprecht, G., Lin, C., Hsu, D. S., & Chi, J. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.107 · Cited by 457 · see citing works

Lipoxygenase‐mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3

Shintoku, R., Takigawa, Y., Yamada, K., Kubota, C., Yoshimoto, Y., Takeuchi, T., Koshiishi, I., & Torii, S. (2017) · Cancer Science · doi:10.1111/cas.13380 · Cited by 453 · see citing works

Pathological aspects of lipid peroxidation

Nègre‐Salvayre, A., Augè, N., Ayala, V., Başağa, H., Boada, J., Brenke, R., Chapple, S. J., Cohen, G., Fehér, J., Grune, T., et al. (2010) · Free Radical Research · doi:10.3109/10715762.2010.498478 · Cited by 451 · see citing works

Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death

García‐Bermúdez, J., Baudrier, L., Bayraktar, E. C., Shen, Y., La, K., Guarecuco, R., Yücel, B., Fiore, D., Tavora, B., Freinkman, E., et al. (2019) · Nature · doi:10.1038/s41586-019-0945-5 · Cited by 425 · see citing works

Phospholipase A2, reactive oxygen species, and lipid peroxidation in cerebral ischemia

Rao, A. M., & Hatcher, J. F. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.08.044 · Cited by 392 · see citing works

Chemistry of phospholipid oxidation

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Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes

Park, T.-J., Park, J. H., Lee, G. S., Lee, J.-Y., Shin, J. H., Kim, M. W., Kim, Y. S., Kim, J., Oh, K., Han, B.-S., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-2061-8 · Cited by 369 · see citing works

Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity

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Ferroptosis in Cancer Cell Biology

Bebber, C. M., Müller, F., Clemente, L. P., Weber, J., & von Karstedt, S. (2020) · Cancers · doi:10.3390/cancers12010164 · Cited by 360 · see citing works

Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells

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Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma

Nath, A., Li, I., Roberts, L. R., & Chan, C. (2015) · Scientific Reports · doi:10.1038/srep14752 · Cited by 336 · see citing works

Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer

Watt, M. J., Clark, A. K., Selth, L. A., Haynes, V. R., Lister, N. L., Rebello, R. J., Porter, L. H., Niranjan, B., Whitby, S., Lo, J. C. Y., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau5758 · Cited by 324 · see citing works

Neurological Benefits of Omega-3 Fatty Acids

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A TAZ–ANGPTL4–NOX2 Axis Regulates Ferroptotic Cell Death and Chemoresistance in Epithelial Ovarian Cancer

Yang, W., Huang, Z., Wu, J., Ding, C. C., Murphy, S. K., & Chi, J. (2019) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-19-0691 · Cited by 302 · see citing works

Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm

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Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis

Wiernicki, B., Dubois, H., Tyurina, Y., Hassannia, B., Bayır, H., Kagan, V., Vandenabeele, P., Wullaert, A., & Berghe, T. V. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03118-0 · Cited by 257 · see citing works

Targeting tumor cell metabolism with statins

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The structural basis for specificity in lipoxygenase catalysis

Newcomer, M. E., & BRASH, A. R. (2014) · Protein Science · doi:10.1002/pro.2626 · Cited by 226 · see citing works

Alterations of Lipid Metabolism in Cancer: Implications in Prognosis and Treatment

Fernández, L. P., de Cedrón, M. G., & de Molina, A. R. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.577420 · Cited by 226 · see citing works

LKB1-AMPK axis negatively regulates ferroptosis by inhibiting fatty acid synthesis

Li, C., Dong, X., Du, W., Shi, X. G., Chen, K., Zhang, W., & Gao, M. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00297-2 · Cited by 222 · see citing works

Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells

Wang, K., Zhang, Z., Tsai, H., Liu, Y., Gao, J., Wang, M., Song, L., Cao, X., Xu, Z., Chen, H., et al. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-00644-4 · Cited by 208 · see citing works

Inhibition of selenoprotein synthesis by selenocysteine tRNA[Ser]Sec lacking isopentenyladenosine

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Liposomes embedded with PEGylated iron oxide nanoparticles enable ferroptosis and combination therapy in cancer

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Inhibition of GPX4 or mTOR overcomes resistance to Lapatinib via promoting ferroptosis in NSCLC cells

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Review and Chemoinformatic Analysis of Ferroptosis Modulators with a Focus on Natural Plant Products

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Energy metabolic mechanisms for high altitude sickness: Downregulation of glycolysis and upregulation of the lactic acid/amino acid-pyruvate-TCA pathways and fatty acid oxidation

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Exosomes from osteoarthritic fibroblast-like synoviocytes promote cartilage ferroptosis and damage via delivering microRNA-19b-3p to target SLC7A11 in osteoarthritis

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Vitamin D 3 attenuates cisplatin-induced intestinal injury by inhibiting ferroptosis, oxidative stress, and ROS-mediated excessive mitochondrial fission

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Regulated necrosis role in inflammation and repair in acute kidney injury

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Sonodynamic therapy: transforming sound into light for hard-to-treat tumours

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Ferroptosis triggers airway inflammation in asthma

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Ferroptosis in the ageing retina: A malevolent fire of diabetic retinopathy

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Nodal promotes colorectal cancer survival and metastasis through regulating SCD1-mediated ferroptosis resistance

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Broadening horizons: ferroptosis as a new target for traumatic brain injury

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Ferroptosis exacerbates hyperlipidemic acute pancreatitis by enhancing lipid peroxidation and modulating the immune microenvironment

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"Mitophagy, Ferritinophagy and Ferroptosis in Retinal Pigment Epithelial Cells Under High Glucose Conditions: Implications for Diabetic Retinopathy and Age-Related Retinal Diseases"

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The Regulation of Ferroptosis by Noncoding RNAs

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Lipid metabolism in ferroptosis and ferroptosis-based cancer therapy

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Ferroptosis: A New Development Trend in Periodontitis

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Ferroptosis in Pulmonary Disease and Lung Cancer: Molecular Mechanisms, Crosstalk Regulation, and Therapeutic Strategies

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The Emerging Role of Heat Shock Factor 1 (HSF1) and Heat Shock Proteins (HSPs) in Ferroptosis

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SBFI26 induces triple‐negative breast cancer cells ferroptosis via lipid peroxidation

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Research progress on the mechanism of ferroptosis and its role in diabetic retinopathy

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Ferroptosis in organ ischemia–reperfusion injuries: recent advancements and strategies

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Firing up “cold” tumors: Ferroptosis causes immune activation by improving T cell infiltration

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Ferroptosis in Cancer and Inflammatory Diseases: Mechanisms and Therapeutic Implications

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Fatty acid synthase: a druggable driver of breast cancer brain metastasis

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The interplay of miRNAs and ferroptosis in diseases related to iron overload

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Pomegranate polyphenol punicalagin improves learning memory deficits, redox homeostasis, and neuroinflammation in aging mice

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Ferroptosis and central nervous system demyelinating diseases

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Role of Ferroptosis in Fibrotic Diseases

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A review on the relationship between Arachidonic acid 15-Lipoxygenase (ALOX15) and diabetes mellitus

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Curcumin promotes ferroptosis in hepatocellular carcinoma via upregulation of ACSL4

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Iron-based nanozymes induced ferroptosis for tumor therapy

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Ponicidin suppresses pancreatic cancer growth by inducing ferroptosis: Insight gained by mass spectrometry-based metabolomics

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Inhibition of Fatty Acid β-Oxidation by Fatty Acid Binding Protein 4 Induces Ferroptosis in HK2 Cells Under High Glucose Conditions

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Radiotherapy-activated NBTXR3 nanoparticles promote ferroptosis through induction of lysosomal membrane permeabilization

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Therapeutic Approaches with Iron Oxide Nanoparticles to Induce Ferroptosis and Overcome Radioresistance in Cancers

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Abietic acid induces ferroptosis via the activation of the HO-1 pathway in bladder cancer cells

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Targeting iron-metabolism:a potential therapeutic strategy for pulmonary fibrosis

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The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

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Phytochemicals Targeting Ferroptosis: Therapeutic Opportunities and Prospects for Treating Breast Cancer

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Exosomal ACADM sensitizes gemcitabine-resistance through modulating fatty acid metabolism and ferroptosis in pancreatic cancer

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Brief guide to detecting ferroptosis

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New insights in ferroptosis: Potential therapeutic targets for the treatment of ischemic stroke

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Verbascoside exerts an anti-atherosclerotic effect by regulating liver glycerophospholipid metabolism

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Urolithin C reveals anti-NAFLD potential via AMPK-ferroptosis axis and modulating gut microbiota

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Compounds targeting ferroptosis in breast cancer: progress and their therapeutic potential

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Ochratoxin A Induces Renal Cell Ferroptosis by Disrupting Iron Homeostasis and Increasing ROS

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Therapeutic potential of resveratrol through ferroptosis modulation: insights and future directions in disease therapeutics

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Melatonin: a ferroptosis inhibitor with potential therapeutic efficacy for the post-COVID-19 trajectory of accelerated brain aging and neurodegeneration

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An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis

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A tale of two lipids: Lipid unsaturation commands ferroptosis sensitivity

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Polyunsaturated Fatty Acids Drive Lipid Peroxidation during Ferroptosis

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Ferroptosis: The Demise of Cells Through Phospholipid Peroxidation

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Ferroptosis at the intersection of lipid metabolism and cellular signaling

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