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The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress
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“For example, loss of PIN1 -a prolyl isomerase essential to preserve heterochromatin -is associated with premature aging and neurodegeneration in different species from Drosophila to mammals 64 (Table 1) .”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [64]
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Nuclear envelope rupture and repair during cancer cell migration
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L1 drives IFN in senescent cells and promotes age-associated inflammation
De Cecco, M., Ito, T., Petrashen, A. P., Elias, A. E., Skvir, N. J., Criscione, S. W., Caligiana, A., Brocculi, G., Adney, E. M., Boeke, J. D., et al. (2019) · Nature · doi:10.1038/s41586-018-0784-9 · Cited by 1,255
The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein
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James, T. C., & Elgin, S. C. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.11.3862 · Cited by 643
Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease
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Tau promotes neurodegeneration through global chromatin relaxation
Frost, B., Hemberg, M., Lewis, J., & Feany, M. B. (2014) · Nature Neuroscience · doi:10.1038/nn.3639 · Cited by 495
The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production
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Activation of transposable elements during aging and neuronal decline in Drosophila
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Hallmarks of aging: An expanding universe
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023) · Cell · doi:10.1016/j.cell.2022.11.001 · Cited by 6,549
Metadata
- Authors
- Napoletano, F., Ferrari Bravo, G., Voto, I. A. P., Santin, A., Celora, L., Campaner, E., Dezi, C., Bertossi, A., Valentino, E., Santorsola, M., Rustighi, A., Fajner, V., Maspero, E., Ansaloni, F., Cancila, V., Valenti, C. F., Santo, M., Artimagnella, O. B., Finaurini, S., Gioia, U., Polo, S., Sanges, R., Tripodo, C., Mallamaci, A., Gustincich, S., d’Adda di Fagagna, F., Mantovani, F., Specchia, V., & Del Sal, G.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2021-09
- Volume
- 36
- Issue
- 11
- Pages
- 109694
- ISSN
- 2211-1247
- Cited by
- 36
- References
- 10
- Language
- en
- Licence
- Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Associazione Italiana per la Ricerca sul Cancro
- Airc Italian Foundation for Cancer Research (22174, 22759)
- Fondazione Cariplo (2014-0812)
- Ministero della Salute (RBFR10V8K6, RF-2019-12368718)
- European Research Council (21762, TELORNAGING 835103)
- Fondazione Telethon (21091, 5x1000, FIREQUENCER 875139, GGP17111)
- Horizon 2020
- Fondazione per la Ricerca Biomedica (EJP RD COFUND-EJP 825575)
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