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Systems-wide Studies Uncover Commander, a Multiprotein Complex Essential to Human Development

Mallam, Anna L., Marcotte, Edward M.·2017·Cell Systems
DOI 10.1016/j.cels.2017.04.006PMC PMC5541947
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  • The CCC complex comprises twelve components: CCDC22, CCDC93, and ten COMMD family members COMMD1-COMMD10.

    “The CCC complex comprises twelve components, the coiled coil domain-containing proteins CCDC22 and CCDC93 and ten COMMD (copper metabolism MURR1 [Mouse U2af1-rs1 region 1) domain) family members COMMD1-COMMD10.2,16,17,18,19”

    From Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome (2023) · cites this paper as [2]

    In “Discovery of the 14-subunit Commander complex” (page unavailable), the paper describes CCC as a three-subunit complex of a COMMD protein, CCDC22, and CCDC93, with different COMMD proteins observed in variants. It lists COMMD1–COMMD10, CCDC22, and CCDC93 among the proposed components of the larger Commander complex, not as twelve components of CCC. (LLM, conf=0.86)

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  • Commander comprises two sub-assemblies: Retriever and the CCC complex.

    “It comprises two sub-assemblies: Retriever composed of VPS35L, VPS26C, and VPS29; and the CCC complex which contains twelve subunits: COMMD1-COMMD10 and the coiled-coil domain-containing (CCDC) proteins CCDC22 and CCDC93.”

    From Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome (2023) · cites this paper as [2]

    The section on discovery of the 14-subunit Commander complex identifies CCC as a Commander subcomplex and lists COMMD1–10, CCDC22, and CCDC93 among Commander’s proposed components (page not provided). It does not describe a second subassembly called Retriever; the section on trafficking and transport instead identifies VPS29 as a retromer component. Thus the source supports the CCC portion, but not the stated two-subassembly composition. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Retriever, together with the dodecameric CCDC22, CCDC93, COMMD (CCC) complex and DENND10, forms the 16-subunit Commander super-assembly.

    “that together with the dodecameric CCDC22, CCDC93, COMMD (CCC) complex and DENND10, forms the 16-subunit Commander super-assembly7–12”

    From Mechanism and regulation of cargo entry into the Commander endosomal recycling pathway (2024) · cites this paper as [8]

    In “Discovery of the 14-subunit Commander complex” (page unavailable), the paper identifies a Commander complex containing the COMMD proteins, CCDC22, CCDC93, DSCR3, and C16orf62, and describes CCC as a subcomplex. It calls Commander putatively 14-member, not 16-subunit, and the passages do not establish the claimed Retriever–DENND10 assembly. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Retriever is a stable heterotrimer of VPS26C, VPS35L and VPS29.

    “Retriever is an essential cargo sorting complex and is a stable heterotrimer of VPS26C, VPS35L and VPS29”

    From Mechanism and regulation of cargo entry into the Commander endosomal recycling pathway (2024) · cites this paper as [8]

    The section ‘Commander’s role in trafficking and transport’ describes a three-protein retromer cargo-recognition complex containing VPS26, VPS29 and VPS35, not the claimed Retriever complex. Searches for Retriever and for VPS26C, VPS35L and VPS29 together found no passage in our copy establishing Retriever’s composition or stability. (LLM, conf=0.75)

    Experimental — accuracy not yet measured

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Metadata

Authors
Mallam, A. L., & Marcotte, E. M.
Venue
Cell Systems
Publisher
Elsevier BV
Published
2017-05
Volume
4
Issue
5
Pages
483-494
ISSN
2405-4712
DOI
10.1016/j.cels.2017.04.006
PMC
PMC5541947
Cited by
94
References
7
Language
en
Licence
Funders
  • National Institutes of Health (DP1 GM106408, R01 DK110520, R01 HD085901)
  • National Science Foundation
  • Welch Foundation (F1515)

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