The DOI matches its Crossref record; 113 of the 113 references it cites were found in a registry or an index.
Intestinal Permeability Defects: Is It Time to Treat?
Open accessAbstract
An essential role of the intestinal epithelium is to separate luminal contents from the interstitium, a function primarily determined by the integrity of the epithelium and the tight junction that seals the paracellular space. Intestinal tight junctions are selectively permeable, and intestinal permeability can be increased physiologically in response to luminal nutrients or pathologically by mucosal immune cells and cytokines, the enteric nervous system, and pathogens. Compromised intestinal barrier function is associated with an array of clinical conditions, both intestinal and systemic. Although most available data are correlative, some studies support a model where cycles of increased intestinal permeability, intestinal immune activation, and subsequent immune-mediated barrier loss contribute to disease progression. This model is applicable to intestinal and systemic diseases. However, it has not been proven, and both mechanistic and therapeutic studies are ongoing. Nevertheless, the correlation between increased intestinal permeability and disease has caught the attention of the public, leading to a rise in popularity of the diagnosis of "leaky gut syndrome," which encompasses a range of systemic disorders. Proponents claim that barrier restoration will cure underlying disease, but this has not been demonstrated in clinical trials. Moreover, human and mouse studies show that intestinal barrier loss alone is insufficient to initiate disease. It is therefore uncertain whether increased permeability in these patients is a cause or effect of the underlying disorder. Although drug targets that may mediate barrier restoration have been proposed, none have been proven effective. As such, current treatments for barrier dysfunction should target the underlying disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“LGS allows microbial components like lipopolysaccharide (LPS), toxic metabolites, and inflammatory agents to enter the bloodstream [44,45].”
From The Gut–Brain–Microbiota Connection and Its Role in Autism Spectrum Disorders (2025) · cites this paper as [44]
In the citing paper
“Dysbiosis can compromise this barrier, leading to increased intestinal permeability, commonly referred to as “leaky gut” syndrome (LGS).”
From The Gut–Brain–Microbiota Connection and Its Role in Autism Spectrum Disorders (2025) · cites this paper as [44]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Intestinal mucosal barrier function in health and disease
Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952
Self-citationMicrobial translocation is a cause of systemic immune activation in chronic HIV infection
Brenchley, J. M., Price, D. A., Schacker, T. W., Asher, T. E., Silvestri, G., Rao, S., Kazzaz, Z., Bornstein, E., Lambotte, O., Altmann, D., et al. (2006) · Nature Medicine · doi:10.1038/nm1511 · Cited by 3,559
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
Johansson, M. E. V., Phillipson, M., Petersson, J., Velcich, A., Holm, L., & Hansson, G. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803124105 · Cited by 2,200
Innate immunity and intestinal microbiota in the development of Type 1 diabetes
Wen, L., Ley, R. E., Volchkov, P. Y., Stranges, P. B., Avanesyan, L., Stonebraker, A. C., Hu, C., Wong, F. S., Szot, G. L., Bluestone, J. A., et al. (2008) · Nature · doi:10.1038/nature07336 · Cited by 1,921
Van der Sluis, M., De Koning, B. A. E., De Bruijn, A. C. J. M., Velcich, A., Meijerink, J. P. P., Van Goudoever, J. B., Büller, H. A., Dekker, J., Van Seuningen, I., Renes, I. B., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.04.020 · Cited by 1,684
Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells
Wu, H.-J., Ivanov, I. I., Darce, J., Hattori, K., Shima, T., Umesaki, Y., Littman, D. R., Benoist, C., & Mathis, D. (2010) · Immunity · doi:10.1016/j.immuni.2010.06.001 · Cited by 1,577
Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis
Lee, Y. K., Menezes, J. S., Umesaki, Y., & Mazmanian, S. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000082107 · Cited by 1,323
Heller, F., Florian, P., Bojarski, C., Richter, J. F., Christ, M., Hillenbrand, B., Mankertz, J., Gitter, A. H., Bürgel, N., Fromm, M., et al. (2005) · Gastroenterology · doi:10.1016/j.gastro.2005.05.002 · Cited by 1,232
Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor
Smith, M. I., Yatsunenko, T., Manary, M. J., Trehan, I., Mkakosya, R., Cheng, J., Kau, A. L., Rich, S. S., Concannon, P., Mychaleckyj, J. C., et al. (2013) · Science · doi:10.1126/science.1229000 · Cited by 1,173
Taurog, J. D., Richardson, J. A., Croft, J. T., Simmons, W. A., Zhou, M., FERNÁNDEZ-SUEIRO, J. L., Balish, E., & Hammer, R. E. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.6.2359 · Cited by 1,156
Research works printed but not linked: 2
- Jodal, 1994, Effect of glucose on passive transport of extracellular probes across the rat small intestinal epithelium in vivo, Gastroenterology, 107, A241
- May, 1992, Lactulose/mannitol permeability is increased in relatives of patients with Crohn's disease, Gastroenterology, 102, A934
Cited by
Sorted by citations
Items 101–200 of 366
Intestinal permeability in a patient with liver cirrhosis
Aguirre-Valádez, J., Rivera-Espinosa, L., Méndez-Guerrero, O., Chávez-Pacheco, J. L., Juárez, I. G., & Torre, A. (2016) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s115902 · Cited by 52
Intestinal Barrier Function in Health and Disease—Any Role of SARS-CoV-2?
Sharma, L., & Riva, A. (2020) · Microorganisms · doi:10.3390/microorganisms8111744 · Cited by 49
Rizzo, V., Ferlazzo, N., Currò, M., Isola, G., Matarese, M., Bertuccio, M. P., Caccamo, D., Matarese, G., & Ientile, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052315 · Cited by 48
Forlano, R., Mullish, B. H., Roberts, L. A., Thursz, M. R., & Manousou, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020662 · Cited by 52
Wasiak, J., & Gawlik-Kotelnicka, O. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114459 · Cited by 47
Gut microbiota in ALS: possible role in pathogenesis?
McCombe, P. A., Henderson, R. D., Lee, A., Lee, J. D., Woodruff, T. M., Restuadi, R., McRae, A., Wray, N. R., Ngo, S., & Steyn, F. J. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1623026 · Cited by 46
Han, H., You, Y., Cha, S., Kim, T., Sohn, M., & Park, J. (2023) · Microorganisms · doi:10.3390/microorganisms11030656 · Cited by 47
Claudin Barriers on the Brink: How Conflicting Tissue and Cellular Priorities Drive IBD Pathogenesis
Capaldo, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108562 · Cited by 50
Mast Cells in Human Health and Disease
DeBruin, E., Gold, M., Lo, B. C., Snyder, K., Cait, A., Lasic, N., Lopez, M., McNagny, K. M., & Hughes, M. R. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-1568-2_7 · Cited by 45
Role of Gut Microbiota in Combating Oxidative Stress
Dam, B., Misra, A., & Banerjee, S. (2019) · Springer eBooks · doi:10.1007/978-981-13-8763-0_4 · Cited by 47
Onyimba, F. U., Crowe, S. E., Johnson, S., & Leung, J. (2021) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2021.01.025 · Cited by 48
He, S., Cui, S., Song, W., Jiang, Y., Chen, H., Liao, D., Lu, X., Li, J., Chen, X., & Peng, L. (2022) · mBio · doi:10.1128/mbio.03688-21 · Cited by 46
The Gut–Brain–Microbiota Connection and Its Role in Autism Spectrum Disorders
Młynarska, E., Barszcz, E., Budny, E., Gajewska, A., Kopeć, K., Wasiak, J., Rysz, J., & Franczyk, B. (2025) · Nutrients · doi:10.3390/nu17071135 · Cited by 44
Type I IFNs and CD8 T cells increase intestinal barrier permeability after chronic viral infection
Labarta-Bajo, L., Nilsen, S. P., Humphrey, G., Schwartz, T., Sanders, K., Swafford, A. D.-E., Knight, R. D., Turner, J. R., & Zúñiga, E. I. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20192276 · Cited by 42
Self-citationEffects of heavy metals on gut barrier integrity and gut microbiota
Ghosh, S., Nukavarapu, S. P., & Jala, V. R. (2023) · Microbiota and Host · doi:10.1530/mah-23-0015 · Cited by 49
Pedersen, C., Ijaz, U. Z., Gallagher, E., Horton, F., Ellis, R. J., Jaiyeola, E., Duparc, T., Russell-Jones, D. L., Hinton, P. J., Cani, P. D., et al. (2018) · Physiological Reports · doi:10.14814/phy2.13649 · Cited by 42
The anti-inflammatory and immune-modulatory effects of OEA limit DSS-induced colitis in mice
Lama, A., Provensi, G., Amoriello, R., Pirozzi, C., Rani, B., Mollica, M. P., Raso, G. M., Ballerini, C., Meli, R., & Passani, M. B. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110368 · Cited by 43
Fecal and Circulating Biomarkers for the Non-Invasive Assessment of Intestinal Permeability
Pérez-Díaz-del-Campo, N., Castelnuovo, G., Ribaldone, D. G., & Caviglia, G. P. (2023) · Diagnostics · doi:10.3390/diagnostics13111976 · Cited by 48
Intestinal Permeability in Disorders of Gut–Brain Interaction: From Bench to Bedside
Grover, M., Vanuytsel, T., & Chang, L. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.08.033 · Cited by 43
Gokulan, K., Cerniglia, C. E., Thomas, C., Piñeiro, S. A., & Khare, S. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.09.004 · Cited by 43
Hou, Q., Huang, Y., Zhu, Z., Liao, L., Chen, X., Han, Q., & Liu, F. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2749-4 · Cited by 42
The overlap between IBS and IBD – what is it and what does it mean?
Stanišić, V., & Quigley, E. M. M. (2014) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2014.876361 · Cited by 41
de Vallière, C., Vidal, S., Clay, I., Jurisic, G., Tcymbarevich, I., Lang, S., Ludwig, M., Okoniewski, M. J., Eloranta, J. J., Kullak-Ublick, G. A., et al. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00408.2014 · Cited by 41
Orr, S. E., Gokulan, K., Boudreau, M. D., Cerniglia, C. E., & Khare, S. (2019) · Journal of Nanobiotechnology · doi:10.1186/s12951-019-0499-6 · Cited by 41
Pre-eclampsia renamed and reframed: Intra-abdominal hypertension in pregnancy
Sawchuck, D., & Wittmann, B. K. (2014) · Medical Hypotheses · doi:10.1016/j.mehy.2014.08.001 · Cited by 41
Ursodeoxycholic acid inhibits TNFα-induced IL-8 release from monocytes
O’Dwyer, A. M., Lajczak, N., Keyes, J. A., Ward, J. B. J., Greene, C. M., & Keely, S. J. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00406.2015 · Cited by 41
The gut microbiome and frailty
Piggott, D. A., & Tuddenham, S. (2020) · Translational research · doi:10.1016/j.trsl.2020.03.012 · Cited by 43
Galena, A. E., Chai, J., Zhang, J., Bednarzyk, M. S., Perez, D., Ochrietor, J. D., Jahan-Mihan, A., & Arikawa, A. Y. (2022) · PLoS ONE · doi:10.1371/journal.pone.0275275 · Cited by 41
Towards a Food Pharmacy: Immunologic Modulation through Diet
Molendijk, I., van der Marel, S., & Maljaars, J. (2019) · Nutrients · doi:10.3390/nu11061239 · Cited by 42
Ilan, Y. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2015.47 · Cited by 39
Springler, A., Vrubel, G.-J., Mayer, E., Schatzmayr, G., & Novak, B. (2016) · Toxins · doi:10.3390/toxins8110345 · Cited by 38
Watari, A., Sakamoto, Y., Hisaie, K., Iwamoto, K., Fueta, M., Yagi, K., & Kondoh, M. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000472367 · Cited by 37
Dynamic role of single‐celled fungi in ruminal microbial ecology and activities
Elghandour, M. M. M. Y., Khusro, A., Adegbeye, M. J., Tan, Z., Hafsa, S. H. A., Greiner, R., Ugbogu, E. A., Anele, U. Y., & Salem, A. Z. M. (2019) · Journal of Applied Microbiology · doi:10.1111/jam.14427 · Cited by 43
Intestinal barrier in chronic gut and liver diseases: Pathogenesis and therapeutic targets
Zhang, Y., Liu, Y., Liang, X., Wen, Y., Zhao, J., He, Y., Xie, Q., & Xie, C. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.08.028 · Cited by 40
Fan, X., Li, S., Wu, Z., Dai, Z., Li, J., Wang, X., & Wu, G. (2018) · Amino Acids · doi:10.1007/s00726-018-2681-9 · Cited by 36
Doudakmanis, C., Bouliaris, K., Kolla, C., Efthimiou, M., & Koukoulis, G. (2021) · World Journal of Gastrointestinal Pathophysiology · doi:10.4291/wjgp.v12.i6.106 · Cited by 36
What is the leaky gut? Clinical considerations in humans
Camilleri, M. (2021) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000778 · Cited by 36
Yang, L., Chang, J., Wang, P., Yin, Q., Huang, W.-W., Liu, C., Bai, X., Zhu, Q., Gao, T., & Zhou, P. (2019) · AMB Express · doi:10.1186/s13568-019-0863-9 · Cited by 34
Di Caro, V., Alcamo, A. M., Cummings, J. L., Clark, R. S. B., Novak, E. A., Mollen, K. P., Morowitz, M. J., & Aneja, R. K. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224838 · Cited by 32
Zhang, Z.-Q., Wang, S.-B., Wang, R.-G., Zhang, W., Wang, P.-L., & Su, X.-O. (2016) · Toxins · doi:10.3390/toxins8100270 · Cited by 32
Kwak, S.-Y., Shim, S., Park, S., Kim, H., Lee, S., Kim, M., Jang, W., Kim, Y.-H., & Jang, H. (2020) · Phytomedicine · doi:10.1016/j.phymed.2020.153424 · Cited by 32
The role of goblet cells in Crohn’ s disease
Wang, Z., & Shen, J. (2024) · Cell & Bioscience · doi:10.1186/s13578-024-01220-w · Cited by 35
López-Posadas, R., Fastancz, P., Martínez-Sánchez, L. D. C., Panteleev-Ivlev, J., Thonn, V., Kisseleva, T., Becker, L. S., Schulz-Kuhnt, A., Zundler, S., Wirtz, S. J., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.07.007 · Cited by 31
Moradi, K., Ashraf‐Ganjouei, A., Tavolinejad, H., Bagheri, S., & Akhondzadeh, S. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110091 · Cited by 30
Cui, M., He, Q., Wang, Z., Yu, Y., Gao, H., Liu, Z., Wang, H., Wang, H., Zhang, X., Li, D., et al. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.121808 · Cited by 32
Diabetes mellitus type 2 as an underlying, comorbid or consequent state of mental disorders
Borovčanin, M., Vesić, K., Petrović, I., Jovanović, I., & Mijailović, N. R. (2023) · World Journal of Diabetes · doi:10.4239/wjd.v14.i5.481 · Cited by 34
The role of IgG hypersensitivity in the pathogenesis and therapy of depressive disorders
Karakuła‐Juchnowicz, H., Szachta, P., Opolska, A., Morylowska-Topolska, J., Gałęcka, M., Juchnowicz, D., Krukow, P., & Lasik, Z. (2014) · Nutritional Neuroscience · doi:10.1179/1476830514y.0000000158 · Cited by 31
Olivier, S., Pochard, C., Ilchmann-Diounou, H., Castillo, V., Divoux, J., Alcantara, J. A., Leclerc, J., Guilmeau, S., Huet, C., Charifi, W., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101183 · Cited by 31
The Role of Diet Modification in Atopic Dermatitis: Navigating the Complexity
Rustad, A. M., Nickles, M. A., Bilimoria, S. N., & Lio, P. (2021) · American Journal of Clinical Dermatology · doi:10.1007/s40257-021-00647-y · Cited by 30
The multifaceted role of macrophages during acute liver injury
Hassan, G. S., Molina, M. F., & Shoukry, N. H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1237042 · Cited by 30
Liu, F., Zhang, X., & Ji, Y. (2020) · Medical Science Monitor · doi:10.12659/msm.920170 · Cited by 29
Chung, H. K., Chen, Y., Rao, J. N., Liu, L., Xiao, L., Turner, D. J., Yang, P., Gorospe, M., & Wang, J. (2015) · Molecular Medicine · doi:10.2119/molmed.2015.00147 · Cited by 29
Gokulan, K., Kolluru, P., Cerniglia, C. E., & Khare, S. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00474 · Cited by 28
Grosse, L., & Bulavin, D. V. (2020) · Aging · doi:10.18632/aging.103492 · Cited by 27
Urolithin A attenuates arsenic-induced gut barrier dysfunction
Ghosh, S., Banerjee, M., Haribabu, B., & Jala, V. R. (2022) · Archives of Toxicology · doi:10.1007/s00204-022-03232-2 · Cited by 27
Humphreys, C. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-43044-9.00019-4 · Cited by 28
Vanuytsel, T., Vanormelingen, C., Vanheel, H., Masaoka, T., Rasoel, S. S., Tóth, J. G., Houben, E., Verbeke, K., Hertogh, G. D., Berghe, P. V., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111132 · Cited by 27
Aguanno, D., Coquant, G., Postal, B. G., Osinski, C., Wieckowski, M., Stockholm, D., Grill, J.-P., Carrière, V., Seksik, P., & Thenet, S. (2020) · Tissue Barriers · doi:10.1080/21688370.2020.1832877 · Cited by 28
In-Vitro Cell Culture for Efficient Assessment of Mycotoxin Exposure, Toxicity and Risk Mitigation
Xu, R., Karrow, N. A., Shandilya, U. K., Sun, L.-H., & Kitazawa, H. (2020) · Toxins · doi:10.3390/toxins12030146 · Cited by 28
Osteoarthritis and gut microbiome
Binvignat, M., Sokol, H., Mariotti‐Ferrandiz, E., Berenbaum, F., & Sellam, J. (2021) · Joint Bone Spine · doi:10.1016/j.jbspin.2021.105203 · Cited by 26
Diet, Probiotics and Physical Activity: The Right Allies for a Healthy Microbiota
Divella, R., Palma, G. D., Tufaro, A., Pelagio, G., Gadaleta‐Caldarola, G., Bringiotti, R., & Paradiso, A. (2021) · Anticancer Research · doi:10.21873/anticanres.15057 · Cited by 27
Deciphering internal and external factors influencing intestinal junctional complexes
Markovich, Z., Abreu, A., Sheng, Y., Han, S. M., & Xiao, R. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2389320 · Cited by 26
Li, L., Xiong, L., Yao, J., Zhuang, X., Zhang, S., Yu, Q., Xiao, Y., Cui, Y., & Chen, M. (2016) · Digestive and Liver Disease · doi:10.1016/j.dld.2016.05.002 · Cited by 25
Gastrointestinal microbiota alteration induced by Mucor circinelloides in a murine model
Mueller, K. D., Zhang, H., Serrano, C. R., Billmyre, R. B., Huh, E. Y., Wiemann, P., Keller, N. P., Wang, Y., Heitman, J., & Lee, S. C. (2019) · The Journal of Microbiology · doi:10.1007/s12275-019-8682-x · Cited by 25
Mucosal healing - how deep is enough?
Iacucci, M., & Ghosh, S. (2016) · Digestive Diseases · doi:10.1159/000443133 · Cited by 24
Kang, T. H., & Lee, S. I. (2024) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-023-00976-4 · Cited by 25
Clinical relevance of intestinal barrier dysfunction in common gastrointestinal diseases
Muehler, A. R., Slizgi, J. R., Kohlhof, H., Groeppel, M., Peelen, E., & Vitt, D. (2020) · World Journal of Gastrointestinal Pathophysiology · doi:10.4291/wjgp.v11.i6.114 · Cited by 25
DiGuilio, K. M., Rybakovsky, E., Abdavies, R., Chamoun, R. S., Flounders, C. A., Shepley‐McTaggart, A., Harty, R. N., & Mullin, J. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23062995 · Cited by 29
Nullens, S., Staessens, M., Peleman, C., Plaeke, P., Malhotra‐Kumar, S., Francque, S., Man, J. G. D., & Winter, B. Y. D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152914 · Cited by 26
Knight, E. L., Majd, M., Graham‐Engeland, J. E., Smyth, J. M., Sliwinski, M. J., & Engeland, C. G. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2019.100013 · Cited by 24
Li, T., Chen, J., Xu, Y., Ji, W., Yang, S., & Wang, X. D. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c07965 · Cited by 23
Interleukin-28A induces epithelial barrier dysfunction in CD patient-derived intestinal organoids
Xu, P., Becker, H. E. F., Elizalde, M., Pierik, M. J., Masclee, A., & Jonkers, D. M. A. E. (2021) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00064.2020 · Cited by 23
Scuderi, S. A., Casili, G., Lanza, M., Ardizzone, A., Pantaleo, L., Campolo, M., Paterniti, I., Cucinotta, L., Cuzzocrea, S., & Esposito, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042269 · Cited by 25
RetractedXin, X., Dai, W., Wu, J., Fang, L., Zhao, M., Zhang, P., & Chen, M. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3493 · Cited by 23
Early Life Glucocorticoid Exposure Modulates Immune Function in Zebrafish (Danio rerio) Larvae
van den Bos, R., Cromwijk, S., Tschigg, K., Althuizen, J., Zethof, J., Whelan, R., Flik, G., & Schaaf, M. J. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00727 · Cited by 20
Increased Intestinal Permeability: An Avenue for the Development of Autoimmune Disease?
English, J., Connolly, L., & Stewart, L. D. (2023) · Exposure and Health · doi:10.1007/s12403-023-00578-5 · Cited by 27
Review article: Prevention of inflammatory bowel disease—The path forward
Bronze, S. M. T., Agrawal, M., Colombel, J., Torres, J., & Ungaro, R. C. (2024) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.18263 · Cited by 22
Hegan, P. S., Chandhoke, S. K., Barone, C., Egan, M. E., Bähler, M., & Mooseker, M. S. (2016) · Cytoskeleton · doi:10.1002/cm.21292 · Cited by 22
Genser, L., Poitou, C., Brot‐Laroche, E., Rousset, M., Vaillant, J., Clément, K., Thenet, S., & Leturque, A. (2016) · médecine/sciences · doi:10.1051/medsci/20163205012 · Cited by 22
The GS-nitroxide JP4-039 improves intestinal barrier and stem cell recovery in irradiated mice
Liang, W., Leibowitz, B. J., Epperly, M. W., Bi, C., Li, A., Steinman, J., Wipf, P., Li, S., Zhang, L., Greenberger, J. S., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-20370-9 · Cited by 22
Filtered Kombucha tea ameliorates the leaky gut syndrome in young and old mice model of colitis.
Pakravan, N., Kermanian, F., & Mahmoudi, E. (2019) · PubMed Central · doi:10.22038/ijbms.2019.36189.8622 · Cited by 21
Phytogenic Compounds for Enhancing Intestinal Barrier Function in Poultry–A Review
Latek, U., Chłopecka, M., Karlik, W., & Mendel, M. (2021) · Planta Medica · doi:10.1055/a-1524-0358 · Cited by 21
Food as Treatment of Inflammatory Bowel Diseases
Maldonado‐Contreras, A. (2022) · Infection and Immunity · doi:10.1128/iai.00583-21 · Cited by 24
Intestinal health in Atlantic salmon post-smolt (Salmo salar) when fed low- and high HUFA diets
Løvmo, S. D., Sundh, H., Whatmore, P., Nordvi, M. F., Sigholt, T., Madaro, A., Bardal, T., & Olsen, R. E. (2022) · Aquaculture · doi:10.1016/j.aquaculture.2022.738318 · Cited by 20
Intestinal permeability measurements: general aspects and possible pitfalls.
Teixeira, T. F. S., Moreira, A. P. B., Souza, N. C., Frías, R., & Pelúzio, M. D. C. G. (2014) · PubMed · doi:10.3305/nh.2014.29.2.7076 · Cited by 21
IBS with intestinal microbial dysbiosis: a new and clinically relevant subgroup?
Simrén, M. (2014) · Gut · doi:10.1136/gutjnl-2013-306434 · Cited by 21
Pongkorpsakol, P., Satianrapapong, W., Wongkrasant, P., Steinhagen, P., Tuangkijkul, N., Pathomthongtaweechai, N., & Muanprasat, C. (2021) · Methods in molecular biology · doi:10.1007/7651_2021_347 · Cited by 20
A spotlight on intestinal permeability and inflammatory bowel diseases
Räth, T., Atreya, R. N., & Neurath, M. F. (2023) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2023.2242772 · Cited by 21
Wang, J., Sung, F., Men, M., Wang, K. A., Lin, C., & Kao, C. (2017) · Pain · doi:10.1097/j.pain.0000000000000994 · Cited by 21
Yuan, Y., Wu, X., Hong, Y., Zhang, X., Wang, Z., & Yan, H. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111311 · Cited by 20
Qian, W., Li, W., Chen, X., Cui, L., Liu, X., Yao, J., Wang, X., Liu, Y., Li, C., Wang, Y., et al. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154653 · Cited by 19
Rao, K., Qin, S., Yang, Y., Zhan, K., Wu, H., Zheng, H., & Huang, S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.883918 · Cited by 19
Avagliano, C., Caro, C. D., Cuozzo, M., Liguori, F. M., Rana, G. L., Micheli, L., Mannelli, L. D. C., Ghelardini, C., Paciello, O., & Russo, R. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.930832 · Cited by 19
Associations of Microbiota and Nutrition with Cognitive Impairment in Diseases
Młynarska, E., Jakubowska, P., Frąk, W., Gajewska, A., Sornowska, J., Skwira, S., Wasiak, J., Rysz, J., & Franczyk, B. (2024) · Nutrients · doi:10.3390/nu16203570 · Cited by 19
A Viewpoint on the Leaky Gut Syndrome to Treat Allergic Asthma: A Novel Opinion
Farshchi, M. K., Azad, F. J., Salari, R., Mirsadraee, M., & Anushiravani, M. (2016) · Journal of Evidence-Based Complementary & Alternative Medicine · doi:10.1177/2156587216682169 · Cited by 19
Cai, Y., Deng, W., Yang, Q., Pan, G., Liang, Z., Yang, X., Li, S., & Xiao, X. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111783 · Cited by 18
Baxter, M. F. A., Dridi, S., Koltes, D. A., Latorre, J. D., Bottje, W. G., Greene, E. S., Bickler, S. W., Kim, J. H., Merino-Guzmán, R., Hernández-Velasco, X., et al. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00480 · Cited by 19
Liu, S., Lin, Z., Mao, X., Ge, L., Hou, L., Le, G., Gan, F., Wen, L., & Huang, K. (2021) · Research in Veterinary Science · doi:10.1016/j.rvsc.2021.02.002 · Cited by 18
Diviccaro, S., Falvo, E., Piazza, R., Cioffi, L., Herian, M., Brivio, P., Calabrese, F., Giatti, S., Caruso, D., & Melcangi, R. C. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109405 · Cited by 19
Xue, Y., Li, F., Li, R., Zhang, X., Guo, H., & Wang, C. (2024) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-024-01119-z · Cited by 20
Metadata
- Authors
- Odenwald, M. A., & Turner, J. R.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Turner, Jerrold R.
- Venue
- Clinical Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 11
- Issue
- 9
- Pages
- 1075-1083
- ISSN
- 1542-3565 (ISSN-L)
- PMC
- PMC3758766
- OpenAlex
- W2014385625
- Cited by
- 366
- References
- 111
- Citations by year
- 2026: 15 · 2025: 27 · 2024: 35 · 2023: 42 · 2022: 32 · 2021: 38 · 2020: 41 · 2019: 30 · 2018: 13 · 2017: 23 · 2016: 29 · 2015: 17 · 2014: 23
- FWCI
- 3.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Clinical Gastroenterology and Hepatology (acceptedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Crohn's and Colitis Foundation (252879)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK068271, R01DK061931)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD007009)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Keywords
- intestinal permeability, leaky gut, intestinal barrier function, tight junctions, intestinal epithelium, cytokines, enteric nervous system, systemic disease
- MeSH terms
- Gastrointestinal Diseases, Humans, Intestinal Mucosa, Permeability
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
