Cited by 897Gut microbiota and healthT-cell and B-cell ImmunologyMicrobial Metabolites in Food Biotechnology

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Gut Microbial Metabolites Fuel Host Antibody Responses

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Kim, Myunghoo, Qie, Yaqing, Park, Jeongho, Kim, Chang H.·2016·Cell Host & Microbe

DOI 10.1016/j.chom.2016.07.001PMC PMC4982788

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Abstract

Antibody production is a metabolically demanding process that is regulated by gut microbiota, but the microbial products supporting B cell responses remain incompletely identified. We report that short-chain fatty acids (SCFAs), produced by gut microbiota as fermentation products of dietary fiber, support host antibody responses. In B cells, SCFAs increase acetyl-CoA and regulate metabolic sensors to increase oxidative phosphorylation, glycolysis, and fatty acid synthesis, which produce energy and building blocks supporting antibody production. In parallel, SCFAs control gene expression to express molecules necessary for plasma B cell differentiation. Mice with low SCFA production due to reduced dietary fiber consumption or microbial insufficiency are defective in homeostatic and pathogen-specific antibody responses, resulting in greater pathogen susceptibility. However, SCFA or dietary fiber intake restores this immune deficiency. This B cell-helping function of SCFAs is detected from the intestines to systemic tissues and conserved among mouse and human B cells, highlighting its importance.

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“SCFAs increase colonic FoxP3+ Tregs (Furusawa et al., 2013; Smith et al., 2013).”
Background
Role of the microbiota in immunity and inflammation.
Belkaid, Y., & Hand, T. W. (2014) · Cell · doi:10.1016/j.cell.2014.03.011 · Cited by 5,385 · cited 1×
“A mounting body of evidence indicates that gut microbiota profoundly influences the host immune system (Alexander et al., 2014; Belkaid and Hand, 2014).”
Background
The gut microbiota shapes intestinal immune responses during health and disease
Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029 · cited 1×
“For example, germ-free mice are variably impaired in epithelial integrity, gut-associated lymphoid tissue development, innate and adaptive immunity, and immune tolerance (Round and Mazmanian, 2009).”
Background
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838 · cited 1×
“SCFAs support epithelial cell integrity, innate immune functions, and the generation of regulatory and effector T cells (Arpaia et al., 2013; Furusawa et al., 2013; Kim et al., 2013; Park et al., 2015; Sakata, 1987; Schauber et al., 2003).”
Background
Functional interactions between the gut microbiota and host metabolism
Tremaroli, V., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature11552 · Cited by 4,387 · cited 2×
“…and analyzed data and drafted the manuscript with MK. anuscript A uthor M anuscript Keywords Short chain fatty acids; antibody; B cells; metabolism INTRODUCTION Host and gut microbial flora functionally interact in the gut for mutual benefits (Brown et al., 2013; Tremaroli and Backhed, 2012).”
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Background
Short chain fatty acids in human large intestine, portal, hepatic and venous blood
Cummings, J. H., Pomare, E. W., Branch, W. J., Naylor, C. P., & Macfarlane, G. T. (1987) · Gut · doi:10.1136/gut.28.10.1221 · Cited by 3,119 · cited 3×
“The total luminal SCFA concentration in humans reaches ~130 mmol/Kg in the colon and ~15 mmol/Kg in the small intestine (SI) (Cummings et al., 1987).”
BackgroundInfluential
Energy contributions of volatile fatty acids from the gastrointestinal tract in various species
Bergman, E. N. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.567 · Cited by 2,750 · cited 12×
“Moreover, SCFAs enhanced the mitochondrial ATP production and maximal respiration rates in B cells (Figure 4C).”
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Regulation of short-chain fatty acid production
Macfarlane, S., & Macfarlane, G. T. (2003) · Proceedings of the Nutrition Society · doi:10.1079/pns2002207 · Cited by 1,939 · cited 1×
“Short chain fatty acid (SCFAs) are the major microbial metabolites of DF (Macfarlane and Macfarlane, 2003).”
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Costantini, C. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822564-6.00008-2 · Cited by 4
Do common antibiotic treatments influence emotional processing?
Johnson, K. V. ‐., & Steenbergen, L. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113900 · Cited by 4
Resistant potato starch fuels beneficial host-microbe interactions in the gutPreprint
Trachsel, J., Briggs, C., Gabler, N. K., Allen, H. K., & Loving, C. L. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/389007 · Cited by 4
“Figure 9: A network depicting correlations among cecal immune cells, 16S rRNA gene OTUs, cecal SCFA concentrations, cecal host mRNA expression, and cecal IgA concentrations.”
BackgroundInfluential
Prediction Correction Topic Evolution Research for Metabolic Pathways of the Gut Microbiota
Li, N., Lifang, P., & He, H. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.600720 · Cited by 4
“SCFAs are the microbial metabolites implicated in colorectal cancer, and other metabolic and neurological disorders, such as Kidney disease or Central nervous system dysfunction (Kim et al., 2016; Barton et al., 2018).”
Background
Metformin Alleviates Dextran Sulfate Sodium-Induced Colitis in a Mouse Model by Increasing IgA Secretion in Intestinal B cells
Xinjian, D., Zhou, Z., Yang, L., Zhao, J., & Liao, S. (2023) · International Journal of Pharmacology · doi:10.3923/ijp.2023.222.229 · Cited by 3
Comprehensive analysis of gene expressions in ileal mucosa of chickens fed paddy rice and their IgA response to oral vaccination
Yamamoto, M., Ueno, A., Watanabe, H., Okamoto, M., Furukawa, K., & Murai, A. (2025) · Poultry Science · doi:10.1016/j.psj.2025.104823 · Cited by 3
“One possible mechanism is that SCFAs stimulate the energy production required for immunoglobulin production by B cells in gut-associated and secondary lymphoid tissues and promote differentiation into IgG-or IgA-producing plasma cells (Kim et al., 2016).”
The role of intestinal microbiota in the humoral response to SARS-CoV-2 after mRNA-1273 vaccination
Tarriño-León, M., Gutiérrez‐Bautista, J. F., Durán, M. J. O., García-Díaz, A., Cabrera-Serrano, A. J., Sáinz, J., Cobo, F., Rodríguez, T., Reguera, J. A., Bernal, M., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-11103-w · Cited by 3
“Through this pathway, SCFAs indirectly regulate B cell function and contribute to the orchestration of robust antibody responses 57 .”
Influential
Gut mucosal immune responses – Implications for celiac disease and food allergy
Abadie, V. (2025) · Seminars in Immunology · doi:10.1016/j.smim.2025.101984 · Cited by 4
CD8+ T cells mediate the impact of gut dysbiosis and short-chain fatty acid deficiency on accelerated arthritis progression in collagen-induced arthritis mice
Zhao, X., Song, Y., Zhao, W., Shang, L., Fan, C., & Xie, J.-F. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1702792 · Cited by 3
Nanotechnology – Microbiota synergy in cancer immunotherapy
Yang, J., Wang, J., Li, J., & Cui, J. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.105018 · Cited by 3
Restriction of IgA secretion in gut plasma cells is driven by a tissue-specific glycolytic program
Zoccoli-Rodriguez, V., Iwaniec, J., & Wilmore, J. R. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkaf310 · Cited by 3
Genetic diversity of Collaborative Cross mice implicates FFAR3 as a target for ILC2 anti-inflammatory reprogramming
Rusznak, M., Toki, S., Hao, Y. B., Todd, M. J. C., Malone, L., Goodhead, J. F., DuPuy, C., Zhou, W., Babin, D., Warren, C. M., et al. (2026) · Nature Communications · doi:10.1038/s41467-025-67813-2 · Cited by 3
“SCFAs have a signi ﬁ cant role in immune modi ﬁ cation, through effects on epithelial barrier function 48,49 , macrophages 50 , B cells and plasma cells 51,52 , helper T cell effector function 53 , and regulatory T cell differentiation 54,55 .”
Phlorotannins and glycolipid metabolism: comprehensive regulatory roles mediated by the gut microbiota
Wu, S., Sui, Z., Pan, J., Men, X., Li, X., Xue, D., Meng, Q., Han, X., & Shen, Y. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1750434 · Cited by 3
Osteoporosis and gut microbiota: current understandings
Liu, Y., Lü, S., Bai, R., Han, P., Zha, Y., & Jiang, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1761421 · Cited by 3
Gut microbial metabolites and immune-related diseases
Guo, J., Yin, X., Wang, K., & Jiang, C. (2026) · Immunity & Inflammation · doi:10.1007/s44466-026-00031-7 · Cited by 5
Modulation of Gut Microbiota Through Dietary Fibers to Enhance Regulatory T Cell-Based Immunotherapy in GVHD Following Hematopoietic Stem Cell Transplantation
Asayesh, M., Nazarzadeh, A., Jamshidi, S., Keramat, S., Ryszkiel, I., & Stanek, A. (2026) · Nutrients · doi:10.3390/nu18081216 · Cited by 3
Mucosal Vaccine Development: From Adjuvant Design to Next-Generation Delivery Strategies
Lee, W.-H., & Kim, E. (2026) · Biomedicines · doi:10.3390/biomedicines14051060 · Cited by 5
“Commensal bacteria produce metabolites, including short-chain fatty acids and bile acid derivatives, that modulate immune cell function and can enhance or suppress vaccine responses depending on the context [106,107].”
Increased Production of Short-Chain Fatty Acids in Microbacteria Fermentation Treated by Fullerenols
Sun, H., Zhang, J., Kong, J., Yuan, H. Y., Liang, Y., Chen, K., Bai, X., Chang, Y., Li, J., & Xing, G. (2021) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2021.19341 · Cited by 3
Non-alcoholic fatty liver disease and intestinal immune status: a narrative review
Wu, H., Lei, Y., & Mao, J. (2022) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2022.2032320 · Cited by 3
“In B cells, SCFAs increase acetyl-CoA, oxidative phosphorylation, glycolysis, and fatty acid synthesis as well as regulate gene expression of molecules, which support antibody production, sIgA secretion and plasma B cell differentiation [60].”
Background
Baseline Gut Microbiota Was Associated with Long-Term Immune Response at One Year Following Three Doses of BNT162b2
Zhang, L., Tan, J. T., Ng, H. Y., Liao, Y., Zhang, R., Chan, K., Hung, I. F., Lam, T. T., & Cheung, K. S. (2024) · Vaccines · doi:10.3390/vaccines12080916 · Cited by 3
“…with pattern-recognition receptors (PRRs) [11] to influence the activities of antigen-presenting cells (APCs) and produce immunoregulatory metabolites, including flagellin [12], lipopolysaccharides (LPS) [13], peptidoglycans [14], short-chain fatty acids (SCFAs) [15] and secondary bile acids [16].”
Background
Unveiling the role of the upper respiratory tract microbiome in susceptibility and severity to COVID-19
Lovison, O. V. A., Volpato, F. C. Z., Weber, L. G., Barth, A. L., Coitinho, A. S., & Martins, A. F. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1531084 · Cited by 6
“…et al., 2021), and dendritic cells (Schaupp et al., 2020) beyond the anti-in ﬂ ammatory activity of Short-Chain Fatty Acids (SCFA) (Fukuda et al., 2011) and regulation of immunoglobulin expression (Corbett et al., 2014; Kim et al., 2016; Dalile et al., 2019; Parrot et al., 2020; Wang et al., 2022).”
The role of short-chain fatty acids in the prehabilitation before colorectal surgery
Włodarczyk, J., Dziki, Ł. A., Harmon, J. W., & Fichna, J. (2025) · Current Problems in Surgery · doi:10.1016/j.cpsurg.2025.101810 · Cited by 5
Dysfunctional circadian-driven dynamics in gut microbiota and tumor microenvironment
Peng, T., Wan, Y., Sun, Y., Ren, Y., Shi, F., Lv, Y., Wen, X., Chen, Q., Yang, X., Xu, S., et al. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2526716 · Cited by 4
“61 SCFAs such as butyrate can enhance B10 cell generation and function by inhibiting HDAC activity, which promotes B cell differentiation into regulatory B cells that produce IL-10.”
The Role of Gut Microbiota in Food Allergies and the Potential Role of Probiotics for Their Treatment
Magrone, T., Magrone, M., Notaristefano, R., Gaxhja, E., Rezaeinezhad, N., Topi, S., Santacroce, L., & Colella, M. (2025) · Applied Sciences · doi:10.3390/app15179590 · Cited by 3
Pentanoate modulates B cells to suppress allergic contact hypersensitivity
Alhmoudi, S., Kader, H. A., Alia, K., Shiek, S. S., Saraswathiamma, D., Sugathan, S., Waheed, Y., Karam, S. M., Dhaheri, Y. A., & Muhammad, K. (2025) · Scientific Reports · doi:10.1038/s41598-025-19886-8 · Cited by 3
“These genes are involved in the differentiation of B cells and promote transformation of B cells into plasma cells 23,24 .”
Absence of colon as the predominant risk factor for liver fibrosis in adults requiring home parenteral nutrition
Christensen, S. R., Olesen, A. L. K., Kristensen, L. H., Jensen, M. H., Rasmussen, H. H., Køhler, M., Schmidt, S. E., Vinter‐Jensen, L., & Holst, M. (2019) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2019.10.012 · Cited by 3
Enhancing Pathogen Resistance: The Gut Microbiota and Malaria
Moore, J. M., & Aparicio, J. C. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819265-8.00097-8 · Cited by 3
Effects of Bacterial Metabolites on the Immune System: Enemies and Friends
AL-Jabri, Z., Al‐Reesi, I., Shizawi, N. A., Al-Balushi, M. S., Al-Jabri, A. A., & Said, E. A. (2021) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530321666211119150231 · Cited by 3
Effects of production system on the gut microbiota diversity and IgA distribution of Kampong chickens, Indonesia
Susanti, R., & Christijanti, W. (2022) · Biodiversitas Journal of Biological Diversity · doi:10.13057/biodiv/d230252 · Cited by 5
“Secretory IgA (SIgA) in the intestine increases bacterial displacement to lymphoid tissue to promote antigen presentation (Palm et al. 2014; Fransen et al. 2015; Kubinak and Round 2016).”
Background
A Bayesian method for identifying associations between response variables and bacterial community composition
Verster, A. J., Petronella, N., Green, J., Matias, F. M. G., & Brooks, S. P. J. (2022) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1010108 · Cited by 4
“Short chain fatty acids, and in particular butyrate, are a focus of attention because they have been implicated in the development and maintenance of immunity [13, 14] and inflammation [15, 16].”
Background
Research progress on adaptive modifications of the gut microflora and regulation of host glucose and lipid metabolism by cold stimulation
Wei, W., Zhang, G., Zhang, Y., Zhang, L., Wu, S., Li, X., & Yang, D. (2023) · Frigid Zone Medicine · doi:10.2478/fzm-2023-0003 · Cited by 3
Metabolism of Dietary Substrates by Intestinal Bacteria and Consequences for the Host Intestine
Blachier, F. (2023) · Springer eBooks · doi:10.1007/978-3-031-26322-4_3 · Cited by 4
Chia flour combined with a high fat diet increases propionic acid production and improves the microbial richness and diversity in female Wistar rats
Mishima, M. D. V., da Silva, B. P., Gomes, M. J. C., Toledo, R. C. L., Silva, R. R., Tako, E., Costa, N. M. B., & Martino, H. S. D. (2023) · Food & Function · doi:10.1039/d3fo01764h · Cited by 3
Homogeneity Gut microbiome Characteristics in Autoimmune Epithelitis: Primary Biliary Cholangitis and Primary Sjögren’s Syndrome.
Liu, B. (2024) · Journal of Immunology · doi:10.52338/immunology.2024.3917 · Cited by 3
“In B cells, SCFA accelerates cellular metabolism, producing energy and building blocks to support antibody production [45].”
Background
How infection-triggered pathobionts influence virulence evolution
Franz, M., Regoes, R. R., & Rolff, J. (2024) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2023.0067 · Cited by 3
“The gut microbiota of metazoans plays a significant role for host fitness via nutrition and maintaining metabolic homeostasis of the host [1,2].”
Background
Gut microbial features may influence antiviral IgG levels after vaccination against viral respiratory infectious diseases: the evidence from two-sample bidirectional mendelian randomization
Tu, J., Wang, Y., Ye, X., Wang, Y., Zou, Y., Jia, L., Yang, S., Yu, R., Liu, W. Y., & Huang, P. (2024) · BMC Infectious Diseases · doi:10.1186/s12879-024-09189-0 · Cited by 3
“Vaccines mediate protection by inducing B cells which produce antigen-specific antibodies [7].”
Background
Electron transport chain capacity expands yellow fever vaccine immunogenicity
Mok, D. Z. L., Tng, D. J., Yee, J. X., Chew, V. S. Y., Tham, C. Y. L., Ooi, J. S. G., Tan, H. C., Zhang, S. L.-X., Lin, L. Z., Ng, W. C., et al. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00065-7 · Cited by 3
“More recently, studies have demonstrated that alterations in gut microbiota composition and microbiota-produced short-chain fatty acids (SCFAs) levels can impact vaccination-induced humoral responses (Hagan et al, 2019; Kim et al, 2016).”
Background
Functional regulation of cytotoxic T Cells by gut microbial metabolites
Kim, C. H. (2025) · Gut Microbes Reports · doi:10.1080/29933935.2025.2454002 · Cited by 4
Self-citation
Characteristics of an In Vitro Mesenteric Lymph Node Cell Suspension Model and Its Possible Association with In Vivo Functional Evaluation
Feng, S., Li, J., Qu, D., Tian, F., Yu, L., Zhang, H., Chen, W., Zhao, J., & Zhai, Q. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23021003 · Cited by 3
“Metabolically, short fatty acids have been reported to strengthen the gut immune response through fueling the cells, interacting with G-protein-coupled receptors, and regulating activities of histone deacetylase or acetylase [2,8].”
Background
Fueling IgA production
Fehervari, Z. T. (2016) · Nature Immunology · doi:10.1038/ni.3570 · Cited by 3
Dietary Fiber and Aging
Abdolghaffari, A. H., Farzaei, M. H., Lashgari, N., Roudsari, N. M., Haddadi, N., Singh, A. K., Rana, H. K., Pandey, A. K., & Momtaz, S. (2020) · Springer eBooks · doi:10.1007/978-981-15-3552-9_6 · Cited by 5
Importance of intestinal microbiota in foodborne diseases
Parlak, L., & Dikmen, D. (2020) · Turkish Bulletin of Hygiene and Experimental Biology · doi:10.5505/turkhijyen.2019.54926 · Cited by 2
«Gut-brain» axis and multiple sclerosis
Omarova, М. А., & Boyko, A. N. (2023) · Neurology neuropsychiatry Psychosomatics · doi:10.14412/2074-2711-2023-6-122-127 · Cited by 2
B-Cell Metabolism
Jellusova, J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95895-0.00010-6 · Cited by 2

Authors: Kim, M., Qie, Y., Park, J., & Kim, C. H.
Affiliations: Purdue University West Lafayette (US)
Corresponding author: Kim, Chang H.
ORCID: Kim, Myunghoo
Park, Jeongho
Kim, Chang H.
Venue: Cell Host & Microbe
Publisher: Elsevier BV
Published: 2016-08
Volume: 20
Issue: 2
Pages: 202-214
ISSN: 1931-3128 (ISSN-L)
DOI: 10.1016/j.chom.2016.07.001
PMC: PMC4982788
OpenAlex: W2491805933
Cited by: 893
References: 59
Citations by year: 2026: 92 · 2025: 129 · 2024: 110 · 2023: 110 · 2022: 107 · 2021: 106 · 2020: 90 · 2019: 61 · 2018: 47 · 2017: 32 · 2016: 8
FWCI: 25.63
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 374 d)
Locations: Cell Host & Microbe (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Seoul National University Open Repository (Seoul National University) (submittedVersion)
Funders: National Multiple Sclerosis Society
Purdue University Center for Cancer Research
National Institutes of Health
National Cancer Institute (P30CA023168)
National Institute of Allergy and Infectious Diseases (R01AI121302, R01AI080769, R01AI074745)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK076616)
National Center for Research Resources (S10RR028293)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords: short-chain fatty acids, gut microbiota, antibody production, B cells, dietary fiber, acetyl-CoA, oxidative phosphorylation, glycolysis, fatty acid synthesis, plasma cell differentiation, immunodeficiency, microbial metabolites
MeSH terms: Gastrointestinal Microbiome, Animals, Antibody Formation, B-Lymphocytes, Cell Differentiation, Dietary Fiber, Fatty Acids, Volatile, Fermentation, Gene Expression Regulation, Mice, Inbred C57BL, Gastrointestinal Tract, Metabolic Networks and Pathways

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Gut Microbial Metabolites Fuel Host Antibody Responses

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