Cited by 897Gut microbiota and healthT-cell and B-cell ImmunologyMicrobial Metabolites in Food Biotechnology

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Gut Microbial Metabolites Fuel Host Antibody Responses

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Kim, Myunghoo, Qie, Yaqing, Park, Jeongho, Kim, Chang H.·2016·Cell Host & Microbe

DOI 10.1016/j.chom.2016.07.001PMC PMC4982788

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Abstract

Antibody production is a metabolically demanding process that is regulated by gut microbiota, but the microbial products supporting B cell responses remain incompletely identified. We report that short-chain fatty acids (SCFAs), produced by gut microbiota as fermentation products of dietary fiber, support host antibody responses. In B cells, SCFAs increase acetyl-CoA and regulate metabolic sensors to increase oxidative phosphorylation, glycolysis, and fatty acid synthesis, which produce energy and building blocks supporting antibody production. In parallel, SCFAs control gene expression to express molecules necessary for plasma B cell differentiation. Mice with low SCFA production due to reduced dietary fiber consumption or microbial insufficiency are defective in homeostatic and pathogen-specific antibody responses, resulting in greater pathogen susceptibility. However, SCFA or dietary fiber intake restores this immune deficiency. This B cell-helping function of SCFAs is detected from the intestines to systemic tissues and conserved among mouse and human B cells, highlighting its importance.

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Authors: Kim, M., Qie, Y., Park, J., & Kim, C. H.
Affiliations: Purdue University West Lafayette (US)
Corresponding author: Kim, Chang H.
ORCID: Kim, Myunghoo
Park, Jeongho
Kim, Chang H.
Venue: Cell Host & Microbe
Publisher: Elsevier BV
Published: 2016-08
Volume: 20
Issue: 2
Pages: 202-214
ISSN: 1931-3128 (ISSN-L)
DOI: 10.1016/j.chom.2016.07.001
PMC: PMC4982788
OpenAlex: W2491805933
Cited by: 893
References: 59
Citations by year: 2026: 92 · 2025: 129 · 2024: 110 · 2023: 110 · 2022: 107 · 2021: 106 · 2020: 90 · 2019: 61 · 2018: 47 · 2017: 32 · 2016: 8
FWCI: 25.63
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 374 d)
Locations: Cell Host & Microbe (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Seoul National University Open Repository (Seoul National University) (submittedVersion)
Funders: National Multiple Sclerosis Society
Purdue University Center for Cancer Research
National Institutes of Health
National Cancer Institute (P30CA023168)
National Institute of Allergy and Infectious Diseases (R01AI121302, R01AI080769, R01AI074745)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK076616)
National Center for Research Resources (S10RR028293)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords: short-chain fatty acids, gut microbiota, antibody production, B cells, dietary fiber, acetyl-CoA, oxidative phosphorylation, glycolysis, fatty acid synthesis, plasma cell differentiation, immunodeficiency, microbial metabolites
MeSH terms: Gastrointestinal Microbiome, Animals, Antibody Formation, B-Lymphocytes, Cell Differentiation, Dietary Fiber, Fatty Acids, Volatile, Fermentation, Gene Expression Regulation, Mice, Inbred C57BL, Gastrointestinal Tract, Metabolic Networks and Pathways

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Gut Microbial Metabolites Fuel Host Antibody Responses

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